LOCUS       NM_012088               1008 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens 6-phosphogluconolactonase (PGLS), mRNA.
ACCESSION   NM_012088
VERSION     NM_012088.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1008)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1008)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   3  (bases 1 to 1008)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1008)
  AUTHORS   Miclet,E., Stoven,V., Michels,P.A., Opperdoes,F.R., Lallemand,J.Y.
            and Duffieux,F.
  TITLE     NMR spectroscopic analysis of the first two steps of the
            pentose-phosphate pathway elucidates the role of
            6-phosphogluconolactonase
  JOURNAL   J Biol Chem 276 (37), 34840-34846 (2001)
   PUBMED   11457850
REFERENCE   5  (bases 1 to 1008)
  AUTHORS   Collard,F., Collet,J.F., Gerin,I., Veiga-da-Cunha,M. and Van
            Schaftingen,E.
  TITLE     Identification of the cDNA encoding human
            6-phosphogluconolactonase, the enzyme catalyzing the second step of
            the pentose phosphate pathway(1)
  JOURNAL   FEBS Lett 459 (2), 223-226 (1999)
   PUBMED   10518023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG764228.1 and AJ243972.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012088.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014006.2, GQ472229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252603.7/ ENSP00000252603.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BG764228.1         28-34
            8-1008              AJ243972.1         1-1001
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1008
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /note="6-phosphogluconolactonase"
                     /db_xref="GeneID:25796"
                     /db_xref="HGNC:HGNC:8903"
                     /db_xref="MIM:604951"
     exon            1..312
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..801
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /EC_number="3.1.1.31"
                     /note="epididymis secretory protein Li 304; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="6-phosphogluconolactonase"
                     /protein_id="NP_036220.1"
                     /db_xref="CCDS:CCDS12361.1"
                     /db_xref="GeneID:25796"
                     /db_xref="HGNC:HGNC:8903"
                     /db_xref="MIM:604951"
                     /translation="MAAPAPGLISVFSSSQELGAALAQLVAQRAACCLAGARARFALG
                     LSGGSLVSMLARELPAAVAPAGPASLARWTLGFCDERLVPFDHAESTYGLYRTHLLSR
                     LPIPESQVITINPELPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFP
                     DHPLLQEREKIVAPISDSPKPPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILED
                     QEENPLPAALVQPHTGKLCWFLDEAAARLLTVPFEKHSTL"
     exon            313..420
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /inference="alignment:Splign:2.1.0"
     exon            421..522
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /inference="alignment:Splign:2.1.0"
     exon            523..663
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /inference="alignment:Splign:2.1.0"
     exon            664..1008
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /inference="alignment:Splign:2.1.0"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /note="hexamer: ATTAAA"
     polyA_site      1008
                     /gene="PGLS"
                     /gene_synonym="6PGL; HEL-S-304"
                     /note="major polyA site"
ORIGIN      
        1 ctcctccccg ccgccgccct cgccatggcc gcgccggccc cgggcctcat ctcggtgttc
       61 tcgagttccc aggagctggg tgcggcgcta gcgcagctgg tggcccagcg cgcagcatgc
      121 tgcctggcag gggcccgcgc ccgtttcgcg ctcggcctgt cgggcgggag cctcgtctcg
      181 atgctagccc gcgagctacc cgccgccgtc gcccctgccg ggccagctag cttagcgcgc
      241 tggacgctgg gcttctgcga cgagcgcctc gtgcccttcg atcacgccga gagcacgtac
      301 ggcctctacc ggacgcatct tctctccaga ctgccgatcc cagaaagcca ggtgatcacc
      361 attaaccccg agctgcctgt ggaggaggcg gctgaggact acgccaagaa gctgagacag
      421 gcattccaag gggactccat cccggttttc gacctgctga tcctgggggt gggccccgat
      481 ggtcacacct gctcactctt cccagaccac cccctcctac aggagcggga gaagattgtg
      541 gctcccatca gtgactcccc gaagccaccg ccacagcgtg tgaccctcac actacctgtc
      601 ctgaatgcag cacgaactgt catctttgtg gcaactggag aaggcaaggc agctgttctg
      661 aagcgcattt tggaggacca ggaggaaaac ccgctgcccg ccgccctggt ccagccccac
      721 accgggaaac tgtgctggtt cttggacgag gcggccgccc gcctcctgac cgtgcccttc
      781 gagaagcatt ccactttgta gctggccaga gggacgccgc agctgggacc aggcacgcgg
      841 cccatggggc tgggcccctg ctggccgcca ctctccgggc tctcctttca aaaagccacg
      901 tcgtgctgct gctggaagcc aacagcctcc ggccagcagc cctacccggg gctcaacaca
      961 caggctgtgg ctctggacat ccggatatta aaaggagcgt tgctggaa
//
