LOCUS       NM_005023               9550 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens protein geranylgeranyltransferase type I subunit beta
            (PGGT1B), mRNA.
ACCESSION   NM_005023
VERSION     NM_005023.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9550)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 9550)
  AUTHORS   Hao,Z., Lian,N., Gu,H. and Chen,M.
  TITLE     The diagnostic significance of PGGT1B in psoriasis
  JOURNAL   Dermatol Ther 34 (2), e14854 (2021)
   PUBMED   33548109
  REMARK    GeneRIF: The diagnostic significance of PGGT1B in psoriasis.
REFERENCE   3  (bases 1 to 9550)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9550)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   5  (bases 1 to 9550)
  AUTHORS   Zhou,X., Liu,Z., Shi,Q., Jiao,J., Bian,W., Song,X., Mo,J., Sang,B.,
            Xu,Y., Qian,J., Chao,Y. and Yu,R.
  TITLE     Geranylgeranyltransferase I regulates HIF-1alpha promoting
            glioblastoma cell migration and invasion
  JOURNAL   J Neurooncol 112 (3), 365-374 (2013)
   PUBMED   23475391
  REMARK    GeneRIF: our study showed, for the first time, that HIF-1alpha was
            regulated by protein prenylation transferase GGTI and mediated the
            effect of GGTI on glioma cell migration and invasion
REFERENCE   6  (bases 1 to 9550)
  AUTHORS   Reid,T.S., Terry,K.L., Casey,P.J. and Beese,L.S.
  TITLE     Crystallographic analysis of CaaX prenyltransferases complexed with
            substrates defines rules of protein substrate selectivity
  JOURNAL   J Mol Biol 343 (2), 417-433 (2004)
   PUBMED   15451670
  REMARK    GeneRIF: Results suggest that all peptide substrates adopt a common
            binding mode in the protein farnesyltransferase and
            geranylgeranyltransferase active site.
REFERENCE   7  (bases 1 to 9550)
  AUTHORS   Kusama,T., Mukai,M., Tatsuta,M., Matsumoto,Y., Nakamura,H. and
            Inoue,M.
  TITLE     Selective inhibition of cancer cell invasion by a
            geranylgeranyltransferase-I inhibitor
  JOURNAL   Clin Exp Metastasis 20 (6), 561-567 (2003)
   PUBMED   14598891
  REMARK    GeneRIF: results suggest that geranylgeranylation of RhoA is
            critical for cancer cell invasion
REFERENCE   8  (bases 1 to 9550)
  AUTHORS   Armstrong,S.A., Hannah,V.C., Goldstein,J.L. and Brown,M.S.
  TITLE     CAAX geranylgeranyl transferase transfers farnesyl as efficiently
            as geranylgeranyl to RhoB
  JOURNAL   J Biol Chem 270 (14), 7864-7868 (1995)
   PUBMED   7713879
REFERENCE   9  (bases 1 to 9550)
  AUTHORS   Zhang,F.L., Diehl,R.E., Kohl,N.E., Gibbs,J.B., Giros,B., Casey,P.J.
            and Omer,C.A.
  TITLE     cDNA cloning and expression of rat and human protein
            geranylgeranyltransferase type-I
  JOURNAL   J Biol Chem 269 (5), 3175-3180 (1994)
   PUBMED   8106351
REFERENCE   10 (bases 1 to 9550)
  AUTHORS   Adamson,P., Marshall,C.J., Hall,A. and Tilbrook,P.A.
  TITLE     Post-translational modifications of p21rho proteins
  JOURNAL   J Biol Chem 267 (28), 20033-20038 (1992)
   PUBMED   1400319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008494.8, DA024020.1, AL520655.1 and AW382606.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005023.3.
            
            Summary: Protein geranylgeranyltransferase type I (GGTase-I)
            transfers a geranylgeranyl group to the cysteine residue of
            candidate proteins containing a C-terminal CAAX motif in which 'A'
            is an aliphatic amino acid and 'X' is leucine (summarized by Zhang
            et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD
            alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded
            by the PGGT1B gene. The FNTA gene encodes the alpha subunit for
            both GGTase-I and the related enzyme farnesyltransferase.[supplied
            by OMIM, Mar 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.41166.1,
                                           SRR3476690.950674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419445.6/ ENSP00000404676.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC008494.8         132133-132137       c
            6-571               DA024020.1         1-566
            572-733             AL520655.1         671-832             c
            734-764             AW382606.1         5-35                c
            765-1326            AL520655.1         78-639              c
            1327-2732           AC008494.8         80090-81495         c
            2733-9550           AC008494.8         73272-80089         c
FEATURES             Location/Qualifiers
     source          1..9550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.3"
     gene            1..9550
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /note="protein geranylgeranyltransferase type I subunit
                     beta"
                     /db_xref="GeneID:5229"
                     /db_xref="HGNC:HGNC:8895"
                     /db_xref="MIM:602031"
     exon            1..166
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1160
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /EC_number="2.5.1.59"
                     /note="GGTase-I-beta; geranylgeranyltransferase type I
                     beta subunit; geranylgeranyl transferase type I subunit
                     beta; CTC-428G20.3; type I protein
                     geranyl-geranyltransferase subunit beta; protein
                     geranylgeranyltransferase type I, beta subunit"
                     /codon_start=1
                     /product="geranylgeranyl transferase type-1 subunit beta"
                     /protein_id="NP_005014.2"
                     /db_xref="CCDS:CCDS4116.1"
                     /db_xref="GeneID:5229"
                     /db_xref="HGNC:HGNC:8895"
                     /db_xref="MIM:602031"
                     /translation="MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLE
                     TSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLG
                     IPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGS
                     FCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLES
                     HGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWV
                     GATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEE
                     SGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST"
     exon            167..285
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     exon            286..353
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     exon            354..505
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     exon            506..638
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     exon            639..684
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     exon            685..869
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     exon            870..978
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     exon            979..9550
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9524..9529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /note="hexamer: AATAAA"
     polyA_site      9550
                     /gene="PGGT1B"
                     /gene_synonym="BGGI; GGTI"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggacg tcgcttccgg agcagcatgg cggccactga ggatgagagg ctagcaggga
       61 gcggtgaggg agagcggctg gatttcttac gggatcggca cgtgcgattt ttccagcgct
      121 gcctccaggt tttgccggag cgctattctt cactcgagac aagcaggttg acaattgcat
      181 tttttgcact ctccgggctg gatatgttgg attccttaga tgtggtgaac aaagatgata
      241 taatagagtg gatttattcc ctgcaggtcc ttcccacaga agacagatca aatctaaatc
      301 gctgtggttt ccgaggctct tcatacctgg gtattccgtt caatccatca aaggctcctg
      361 gaacagctca tccttatgat agtggccaca ttgcaatgac ctacactggc ctctcatgct
      421 tagttattct tggagacgac ttaagccgag taaataaaga agcttgctta gcgggcttga
      481 gagcccttca gctggaagat gggagttttt gtgcagtacc tgaaggcagt gaaaatgaca
      541 tgcgatttgt gtactgtgct tcctgtattt gctatatgct caacaactgg tcaggcatgg
      601 atatgaaaaa agccatcacc tatattagaa ggagtatgtc ctatgacaat ggactggcac
      661 agggagctgg acttgaatct catggaggat caactttttg tggcattgcc tcactatgtc
      721 tgatgggtaa actagaagaa gttttttcag aaaaagaatt gaacaggata aagaggtggt
      781 gtataatgag gcaacaaaat ggttatcatg gaagacctaa taagcctgta gacacctgtt
      841 attctttttg ggtgggagca actctgaagc ttctaaaaat tttccaatac actaactttg
      901 agaaaaatag aaattacatc ttatcaactc aagatcgcct tgtaggggga tttgccaagt
      961 ggccagacag tcatccagat gctttgcatg catactttgg gatctgtggc ctgtcactaa
     1021 tggaggaaag tggaatttgt aaagttcatc ctgctctgaa tgtaagcaca cggacttctg
     1081 aacgccttct agatctccat caaagctgga aaaccaagga ctctaaacaa tgctcagaga
     1141 atgtacatat ctccacatga ctgattttag attgggaggg tggggggatt tgtagcataa
     1201 ctgtagctca agtttaaaag ccatgtataa ccaagtgtgc tcttttttta aaaggtagag
     1261 tcttacaatc aaatctcctg ctgatttcac tttgggatat ggtcttgagc cagtaatctt
     1321 tatactgggt ttcaagaaaa tctttgttga agtttgaacc acaactttgt cgtggttctt
     1381 aaatgtttat actgtatttc taagaagttg tttgaggcaa attaactgta tgtgtgtagg
     1441 ttatcttttt aaaaactctt cagtgcaaat tgtatcttat tataaaatgg acacaaattt
     1501 tcaagtttac acttcatata gcattgataa tcttcaggtg aacacttagt gatcatttaa
     1561 aaagctcact gctgatcgta gaaaatttgc tttaattaat taagtatctg ggattattct
     1621 ttgaaaacag atgaccataa ttttttttaa agaagagtga cttattttgt cttattctta
     1681 agtaaagtgt gccaattaaa cctgtgtggc ctatataaat gaagttaata acttcatagt
     1741 aagaataaat aggtttaact aatgtgatag ttttctaaaa ggagattgtt tgaagacaac
     1801 tattatgtaa ctgagggaaa agcaacttaa ctgtatgtga ttgtgaatga gaaagttttg
     1861 tgctatgtgg gtcatttatc tagacattgc tgtggtgaat accagttatg tttgatttta
     1921 ttctcaaatc attagttgcc tttttttttt tttttttttt tttgctttct aggaagaaaa
     1981 caatcttttt tatctagaag gaaagatact ttgtgttttc atttttagcc atttgaagtt
     2041 tttaatttat tgcccccagt gtgttagctg ctctaatttc aaactaatac ttttctaatt
     2101 tttttcaaat taaataagta aaaaatacaa aaacagaacc attcaaacag attcagtggt
     2161 gtaactcaat acatggtcat ttttattctc atattttcag gtaagtgaaa gggaaatgcg
     2221 accatttaga gggtaagaaa tagggttttg tttttgttca ttgttttgtt ttaagtctat
     2281 gaactagcta attataaagg aggtagtata aaaactcttc attagtaatt aatttatcaa
     2341 taactcatat ccgttacttg ctcagtgaca ttcagaacta ttgcgtctag tactgaaatg
     2401 gggaaagaaa tctcttcact aaaggagttg gctttaagtt agtcttggtg ataataaatg
     2461 ttgaaataca agtatcagta taaaaactgg attactggta tcactgttta ggcattgtaa
     2521 tactttaaat gttatctttt tttctaaatc agagggaaaa aaatgttgtg aaataacagt
     2581 ccttcccaag ggaaacactg tgtacttgga gaaatgattg atttattatt ggcatgctta
     2641 gttttaaacc tgagtttgcc aactgtatgt tttttaatta gaaataaaat aaatcttctg
     2701 atggtggggg aaaaagtaag cttaataaca gatgttatcc gtctatgggt tattccagtt
     2761 gctactattt aaatcctggc agattaagac atccatatct caaactaagt catctcttag
     2821 acattggaag ttaaagtagc atatatataa tggctttagg actatataaa aagcccaaat
     2881 tgttttttct gtatcaccaa gaaaggttag aaggcaataa aggtagtaac agtgatttta
     2941 ttcataaatg ttagagaaaa attccaatct aaaagtattt cataaggcta aatattttct
     3001 aactcctgat aatttaatac cataagatta taaattttag tatgcttcta attgatacac
     3061 ttgtgggaga ctttcttgtg aaactttatg gactagtaaa tgttcacatt ccacagcaac
     3121 tgaattgacc agaaaatagc agcccagtgt gaattgtgga gaaactattt ctaacttttc
     3181 taaatagtta tttacaagaa aagcatttat cgattaaata aattataagc aatatttcac
     3241 atatacactt tattccttaa caggagcgat gtaatgaggg aaaatacgaa gtccgaaatc
     3301 tcaaaaagct ctgttaccta ctctatactt gtctccttcc cgccccctaa ttttgtggca
     3361 tttttttttt agaaggtagg aggaggagct ttattttgag catctgtgta caaatgagat
     3421 taatcagatc atatggccta atttaacctg tttatcattt cagtgttttt agatttgatc
     3481 tataatatat atgtgttatt agatctttag ttatttatat ttaatctaaa ttcatataga
     3541 aatcttgctg acagtggtat ataatttgaa aactgttgga cctgatcatt tttgagagac
     3601 agttaatgag gaggtgctct ggaatcagat gacctgggtt taaatcccag atttgccagt
     3661 tcagcagcat gatcttggac cctaactctg ccgtggataa aataagggta aaacctaaca
     3721 cacagggttt aggattaaat gagataatac agataaagca cttaggatag tacctggaat
     3781 acagcaaatt tcaaattata ggttctttat aatgatcata aaattatttt tgtaattaaa
     3841 acctctcttc tacaacagaa agaggtctta acagtttaac ctcagggaaa atgatgacaa
     3901 cagtgttgtt ttctaatctc cccataagaa tacagagcaa ctaggatagc cacagacact
     3961 attacaacgc tagatgacaa ggtatctcta tgaacttcaa aatacaacta agtgaggaca
     4021 aaccactgaa ccacatagtt tcagtatctg tgggaggaag tagaaggaag gcagctggtt
     4081 tctgacagct ctgcaaattg gagaactaca acactgccca cagtttctca actacaaagt
     4141 gcagcgggcc aatctaagaa cagacactga aactgggaag tgactacaga atctcatttg
     4201 cagatgaatg ttaaagcaat atgataaggt ctgctgattg cattagagct gtctgggttt
     4261 tacgctgtgt acctcttgaa gcttatgaga caaagcccag cactgaggac aaacttctag
     4321 aattagaatc caaatgggca ggatgggtaa aataggacaa aggaaagaag atctagataa
     4381 gtattgggaa gaaaggccaa gacacagaga cattatatat gtgtattttc atatatatat
     4441 atattctttt aaatcactgt gaaaatggga gctctaaggc tgtgaagtca tcctagagcc
     4501 actccttcct cctaaaagta cagaaaaact catttcagtt aaggggaaaa aaagagtaag
     4561 tgagccagga ttacagtcca actccagtca aagttagtat aagaaataag agaataaata
     4621 gatcaacatc ctcacagaca atgaaagcac accggaagga catgaccaca agacagataa
     4681 aaacctaata tttgccaaaa aataaaatgc aaatatgaca ggaaatttat attaattagt
     4741 acagttatca ataaaagtag gaaaagggga aaattaacca agtaccaaac acttggagta
     4801 aaaagcaaaa taaagcagaa ggaaggaatt aataaaagca aaaaagaatt actagtagaa
     4861 aaccaaaaca atagaggcaa taataaatcc aagttggtga tgggtagtgc ggggagttga
     4921 gtcagataaa ctaccagcta acctatttaa gaaaaaaagg aggaagcaca aatacaaaaa
     4981 tttaaatgac aagggggaaa tagtaaaaca ggaaatttgt ttaaattgac tattttgagc
     5041 aattttacac aataaattca aaaactattt tgagaaaaat gcaaattgcc aaaatttact
     5101 ctaggtagat aaagtcacaa caaaccaatt accgtagaag aaacaaatag ttaaaagtac
     5161 cccttaccaa aagaagcatc aagcccagat tgtttcaagg ggatttctac caaacctttt
     5221 aagattaaat aatcccattc ttgcttaaac aattgcagag actaggaaaa gaatcttgaa
     5281 cctcaaagtg ccaaaaaaag aaaaaaaaca aataaagaaa aactcctgaa ttcattttat
     5341 aaaatgaatg taatagcatt gattcaaaaa cctgacaaag atggtaccaa aaagaaaata
     5401 tagagcaatc tcatgaatat taataaaaag ttttaatgat aacattagca aacaatccaa
     5461 cagcactttc aaaaggtaat catgactaag ttgggtttat tgtaagaatg caagggtagt
     5521 tcaatactag ataatctgtt actattcata ttaagagtta aaaaatatct tcatctttgc
     5581 agaaaagaca tgatagaatt gagcactcac ttatgttaac tatactaagt agaaattgat
     5641 gaataatcta ttaacattgt acctctacct aaaagccagc atcttaaatt tcaaagcaaa
     5701 ggagactttc cagctgaagt caggaacaag acatgcccac taactcctct gctacttaac
     5761 aatgtgttga gagttatagc caatgaagtt agacaaaata aagacgtgaa ttggaaagga
     5821 agaggtaaaa ctatttgcag atatgaatat gtatctagaa agcccaaagg aacttgttga
     5881 aaaactaaac aataaaagaa cttagtaaag tagctattaa atacaattta cataaaaata
     5941 tcagtaggct tcaccagaca caagtgcata ctttgattcc atttcggtga agttcaaaac
     6001 agacagcatc tatgtatggt gtcagaaatc agcaccctct ttcagtcact acctctcttc
     6061 ccaaaggtaa gtgctgtcaa aattaccatc aattagtttt gtctgttttt gaattttata
     6121 tgagtggaac catatagtat acattatttt tcaactggct ttaactcagt aggactgaaa
     6181 gagggtacaa gggagactct gcggtgctgg taatgttctg tttcatgatc taggtgctgg
     6241 ttacgtaggt gcattcacct tatgaatatt tatcaagctg tatatgattt gtgcactttt
     6301 ctgtatgtat aattatagct cagtaaaaat gtttactaaa aagagtaaca agactatata
     6361 tatatatata tatatatata tgtatgtata tgcaaaccta aactagttag aagatacttg
     6421 aagagaagac cacctttgtg atagcaaaag taaaaagaaa acttaatgtg taaatttaag
     6481 acacatctaa aatctgtatg aggaaaacta aaaaaactct tgagaggcaa aaatgtagat
     6541 tccaccaaat ggaaagatac atgatattct tagatagaca acatcaaaac atgtctttcc
     6601 ccacttaggt tcatttataa attcagtgcc attccaataa aaattatatt gttatttgag
     6661 agaacatact agaataacca tggaaactga aaagaattag aggggaccag ccatatccga
     6721 cactaaaaca tactctaaat cctccatggc agaagctatc agaatttttt aaagtgtgca
     6781 cactttttgg cccagatact ctctatctat agatttagca taaagaaaca tgcaaatagg
     6841 caatgataca ttttcaagga tctcacagcc acatttttgt aattgtgaaa aataagacac
     6901 attatgatac atttatgtaa ctcaatacta tgcaactgtt aaagtatgga tattggaagg
     6961 cattcgtaat gttgaataaa tgaaaagttt tgtattggca cataaatagg aagtccaatg
     7021 gaacagaaga ggaattccag aaatagactc agtggcattt agaatacagt aaaggcagca
     7081 tctcaagtta gtgagaaaat gaacttttaa gtaagtgcta ttgagattac tggtgcttaa
     7141 ttattcagat atttacaatt ttaaaaaata tatagcttat ttcactttga accttttttt
     7201 aaaatggtca tttagtttta taatttaaag aaaaatgata gttctctccc catcccagcc
     7261 tatactatac ccacagccta tacttcctgg aggtaaacac cactgttgca tacatctttc
     7321 agacctttaa tctctgtata tagagatata gaaatagaga atattcttta aatatctgaa
     7381 catttaagta ttactcatcc caatacaata tatacttata caaatagata tatgtatgta
     7441 tactatacat aaagatctga ggtactaaat attccatggt tttttttcat tcaacaatgt
     7501 attatgaatg cctttcaata gccatacttt aatagttgca tagtatcacg ttgcataaac
     7561 atattaggtc agtgcataag taattgcact ttttaccatt ttaatggcaa atgaggcact
     7621 gattaatcag tgccttattt ttcacaacta caaaaatatt gctgtgagat ccttgaaaat
     7681 gtataattgc ccatttgcat gtttctttaa atttatagat aaggaattac tggggcaaaa
     7741 agtgtgcaca atttaaattt gatgtttttg tttttgccaa gctgcttttt aagaaggttg
     7801 tactaatgca cacttttatc ttgacactaa gattttaaat atgatcagaa aatgggtttc
     7861 tgatagtaaa actgtctact tgtaataatt gtggcattag aaaagacctt tgtggcttcg
     7921 ttcctcaaac tcatttacga attataaatc tgaattccaa atatgaatta actcacacaa
     7981 gataaagctt taacagttag tagcagtact gtaactagag tgcatgtttt ctgtctccag
     8041 aaataacatt ctttttatgc cacatttttt taactgaggt gatcattctc caccctcttc
     8101 tttccatgtt tttccatgtt tgttcaaact tttcattaaa tatcttgagg ctctaactaa
     8161 attaagggtg gccattaaaa ttgtatgtgg gattccctga accaactggt aatgcactac
     8221 cagcatataa ggtgtcctca ttaaagcagt tggtgattgg tacatgggac ctcactcatg
     8281 tatgtttgca tctacttgtg agtcaaaaag ttttcttaaa gtataggtgg gatcatgaaa
     8341 gacatacaat tcactggaga aattgtgaaa aagtaaaaga ttatgaattt aggctcaaag
     8401 ccaatttccc tctcatttaa ttctacatga gcaagtcaag gagtttggta gagctttatg
     8461 aaatctctaa agattgaagg aaaacaatca ctaaaatcga tttgataaag tgcaactaag
     8521 tagtatgcta gcctgttaat ggattttcat cttgtcattt aagtttcagc aattgagtac
     8581 cacactagaa cacccacaaa tgagattctg ttacagagta tcttttttct actacagaac
     8641 atactgtaga cagttattca gtggttaact tgtggaaata atcagaagat gcttttcact
     8701 tttatgactg gatatatttt aatatttatc atattaagag aaacttaggt tacttacagc
     8761 tcataaacgt tgctatgaac atcattcatt tattcactta tttattttta tggtgttcct
     8821 agaaagaatt tcctggacta aaggatttat gctttaaaaa tattggtagt tactgccaag
     8881 aattgccatc cagaaacagt gtagccattc ataaactcaa caacaaggta tgagagtgcc
     8941 tgtttcctca tatcctttgt gacaccggat tttatcaagc ttaaagtttt ttcattctag
     9001 gtgggtgaaa atggtattcc gttattgata atgtgtggaa atcaagttct aataagtttg
     9061 gggggaggtt aattctttat atgtgctgta tgaattaatg ccaactgtat gcctttgaga
     9121 gtgaaatcag aataatgtct ctccactaaa gcaggactta gagcactagt tttccaaatg
     9181 ttgtctacag atggaaacac tagcatcacc tgggtactcg ttagaaagtg cagattctct
     9241 ggcggtacct tagacctcct gaattagaaa ctctgggggt agggttagac atttgtgttt
     9301 taaacaagcc ctccaagtgg tttcaatgca cattcaaagt tgagaaccaa tcactgatag
     9361 agaaaaagca gcttgggtag aaacagttga ttatttgcaa atttatattt taaaaagata
     9421 ggattcttaa cagtaagctc tttataattc aacaatgtga tctttactcc tacccccgaa
     9481 aaactaatat gattttagtg tgtggtagct ggatcgaaaa cataataaat actcagatat
     9541 gcaaagaaaa
//
