LOCUS       NM_002632               1740 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens placental growth factor (PGF), transcript variant 1,
            mRNA.
ACCESSION   NM_002632
VERSION     NM_002632.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Arakaza,A., Liu,X., Zhu,J. and Zou,L.
  TITLE     Assessment of serum levels and placental bed tissue expression of
            IGF-1, bFGF, and PLGF in patients with placenta previa complicated
            with placenta accreta spectrum disorders
  JOURNAL   J Matern Fetal Neonatal Med 37 (1), 2305264 (2024)
   PUBMED   38247274
  REMARK    GeneRIF: Assessment of serum levels and placental bed tissue
            expression of IGF-1, bFGF, and PLGF in patients with placenta
            previa complicated with placenta accreta spectrum disorders.
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Li,S., Wu,K., Zhou,S., Yin,B., Bai,X. and Zhu,B.
  TITLE     Predictive value of maternal serum placental growth factor levels
            for discordant fetal growth in twins: a retrospective cohort study
  JOURNAL   BMC Pregnancy Childbirth 24 (1), 10 (2024)
   PUBMED   38166739
  REMARK    GeneRIF: Predictive value of maternal serum placental growth factor
            levels for discordant fetal growth in twins: a retrospective cohort
            study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Wu,L.Y., Chong,J.R., Chong,J.P.C., Hilal,S., Venketasubramanian,N.,
            Tan,B.Y., Richards,A.M., Chen,C.P. and Lai,M.K.P.
  TITLE     Serum Placental Growth Factor as a Marker of Cerebrovascular
            Disease Burden in Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 97 (3), 1289-1298 (2024)
   PUBMED   38217598
  REMARK    GeneRIF: Serum Placental Growth Factor as a Marker of
            Cerebrovascular Disease Burden in Alzheimer's Disease.
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Li,P., Jiang,Y. and You,Y.
  TITLE     Serum placental growth factor, total cholesterol, and triglycerides
            for prediction of intrahepatic cholestasis of pregnancy
  JOURNAL   Medicine (Baltimore) 102 (50), e36178 (2023)
   PUBMED   38115361
  REMARK    GeneRIF: Serum placental growth factor, total cholesterol, and
            triglycerides for prediction of intrahepatic cholestasis of
            pregnancy.
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Mattei,M.G., Borg,J.P., Rosnet,O., Marme,D. and Birnbaum,D.
  TITLE     Assignment of vascular endothelial growth factor (VEGF) and
            placenta growth factor (PLGF) genes to human chromosome 6p12-p21
            and 14q24-q31 regions, respectively
  JOURNAL   Genomics 32 (1), 168-169 (1996)
   PUBMED   8786112
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Park,J.E., Chen,H.H., Winer,J., Houck,K.A. and Ferrara,N.
  TITLE     Placenta growth factor. Potentiation of vascular endothelial growth
            factor bioactivity, in vitro and in vivo, and high affinity binding
            to Flt-1 but not to Flk-1/KDR
  JOURNAL   J Biol Chem 269 (41), 25646-25654 (1994)
   PUBMED   7929268
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Maglione,D., Guerriero,V., Viglietto,G., Ferraro,M.G.,
            Aprelikova,O., Alitalo,K., Del Vecchio,S., Lei,K.J., Chou,J.Y. and
            Persico,M.G.
  TITLE     Two alternative mRNAs coding for the angiogenic factor, placenta
            growth factor (PlGF), are transcribed from a single gene of
            chromosome 14
  JOURNAL   Oncogene 8 (4), 925-931 (1993)
   PUBMED   7681160
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Maglione,D., Guerriero,V., Rambaldi,M., Russo,G. and Persico,M.G.
  TITLE     Translation of the placenta growth factor mRNA is severely affected
            by a small open reading frame localized in the 5' untranslated
            region
  JOURNAL   Growth Factors 8 (2), 141-152 (1993)
   PUBMED   8466755
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Hauser,S. and Weich,H.A.
  TITLE     A heparin-binding form of placenta growth factor (PlGF-2) is
            expressed in human umbilical vein endothelial cells and in placenta
  JOURNAL   Growth Factors 9 (4), 259-268 (1993)
   PUBMED   8148155
REFERENCE   10 (bases 1 to 1740)
  AUTHORS   Maglione,D., Guerriero,V., Viglietto,G., Delli-Bovi,P. and
            Persico,M.G.
  TITLE     Isolation of a human placenta cDNA coding for a protein related to
            the vascular permeability factor
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9267-9271 (1991)
   PUBMED   1924389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006530.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 27, 2020 this sequence version replaced NM_002632.5.
            
            Transcript Variant: This variant (1) encodes isoform 1 (also known
            as PlGF-2, PLGF-2 or PGF-2) and contains a 21 amino acid region
            that is thought to bind heparin (PMID:8148155).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001422.2, SRR14038197.1585016.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555567.6/ ENSP00000451040.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 8466755
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC006530.4         105570-105999       c
            431-473             AC006530.4         104306-104348       c
            474-670             AC006530.4         99759-99955         c
            671-747             AC006530.4         98909-98985         c
            748-777             AC006530.4         96781-96810         c
            778-840             AC006530.4         96615-96677         c
            841-1740            AC006530.4         92236-93135         c
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1740
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /note="placental growth factor"
                     /db_xref="GeneID:5228"
                     /db_xref="HGNC:HGNC:8893"
                     /db_xref="MIM:601121"
     exon            1..430
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /inference="alignment:Splign:2.1.0"
     regulatory      304..351
                     /regulatory_class="uORF"
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:8466755]"
                     /note="this uORF is predicted to encode a 15 aa peptide
                     (PMID:8466755)"
     CDS             356..868
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; placental growth factor, vascular endothelial
                     growth factor-related protein"
                     /codon_start=1
                     /product="placenta growth factor isoform 1 precursor"
                     /protein_id="NP_002623.2"
                     /db_xref="CCDS:CCDS9835.1"
                     /db_xref="GeneID:5228"
                     /db_xref="HGNC:HGNC:8893"
                     /db_xref="MIM:601121"
                     /translation="MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQ
                     EVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANV
                     TMQLLKIRSGDRPSYVELTFSQHVRCECRPLREKMKPERRRPKGRGKRRREKQRPTDC
                     HLCGDAVPRR"
     exon            431..473
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /inference="alignment:Splign:2.1.0"
     exon            474..670
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /inference="alignment:Splign:2.1.0"
     exon            671..747
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /inference="alignment:Splign:2.1.0"
     exon            748..777
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /inference="alignment:Splign:2.1.0"
     exon            778..840
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1740
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1718..1723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /note="hexamer: AATAAA"
     polyA_site      1740
                     /gene="PGF"
                     /gene_synonym="D12S1900; PGFL; PIGF; PLGF; PlGF-2;
                     SHGC-10760"
                     /note="major polyA site"
ORIGIN      
        1 agaagggagc tgctgtctgc ggaggaaact gcatcgacgg acggccgccc agctacggga
       61 ggacctggag tggcactggg cgcccgacgg accatccccg ggacccgcct gcccctcggc
      121 gccccgcccc gccgggccgc tccccgtcgg gttccccagc cacagcctta cctacgggct
      181 cctgactccg caaggcttcc agaagatgct cgaaccaccg gccggggcct cggggcagca
      241 gtgagggagg cgtccagccc cccactcagc tcttctcctc ctgtgccagg ggctccccgg
      301 gggatgagca tggtggtttt ccctcggagc cccctggctc gggacgtctg agaagatgcc
      361 ggtcatgagg ctgttccctt gcttcctgca gctcctggcc gggctggcgc tgcctgctgt
      421 gcccccccag cagtgggcct tgtctgctgg gaacggctcg tcagaggtgg aagtggtacc
      481 cttccaggaa gtgtggggcc gcagctactg ccgggcgctg gagaggctgg tggacgtcgt
      541 gtccgagtac cccagcgagg tggagcacat gttcagccca tcctgtgtct ccctgctgcg
      601 ctgcaccggc tgctgcggcg atgagaatct gcactgtgtg ccggtggaga cggccaatgt
      661 caccatgcag ctcctaaaga tccgttctgg ggaccggccc tcctacgtgg agctgacgtt
      721 ctctcagcac gttcgctgcg aatgccggcc tctgcgggag aagatgaagc cggaaaggag
      781 gagacccaag ggcaggggga agaggaggag agagaagcag agacccacag actgccacct
      841 gtgcggcgat gctgttcccc ggaggtaacc caccccttgg aggagagaga ccccgcaccc
      901 ggctcgtgta tttattaccg tcacactctt cagtgactcc tgctggtacc tgccctctat
      961 ttattagcca actgtttccc tgctgaatgc ctcgctccct tcaagacgag gggcagggaa
     1021 ggacaggacc ctcaggaatt cagtgccttc aacaacgtga gagaaagaga gaagccagcc
     1081 acagacccct gggagcttcc gctttgaaag aagcaagaca cgtggcctcg tgaggggcaa
     1141 gctaggcccc agaggccctg gaggtctcca ggggcctgca gaaggaaaga agggggccct
     1201 gctacctgtt cttgggcctc aggctctgca cagacaagca gcccttgctt tcggagctcc
     1261 tgtccaaagt agggatgcgg atcctgctgg ggccgccacg gcctggctgg tgggaaggcc
     1321 ggcagcgggc ggaggggatc cagccacttc cccctcttct tctgaagatc agaacattca
     1381 gctctggaga acagtggttg cctgggggct tttgccactc cttgtccccc gtgatctccc
     1441 ctcacacttt gccatttgct tgtactggga cattgttctt tccggccaag gtgccaccac
     1501 cctgcccccc ctaagagaca catacagagt gggccccggg ctggagaaag agctgcctgg
     1561 atgagaaaca gctcagccag tggggatgag gtcaccaggg gaggagcctg tgcgtcccag
     1621 ctgaaggcag tggcagggga gcaggttccc caagggccct ggcaccccca caagctgtcc
     1681 ctgcagggcc atctgactgc caagccagat tctcttgaat aaagtattct agtgtggaaa
//
