LOCUS       NM_002630               1371 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens progastricsin (PGC), transcript variant 1, mRNA.
ACCESSION   NM_002630
VERSION     NM_002630.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1371)
  AUTHORS   Sanchez-Lopez,J.Y., Vazquez-Ibarra,K.C., Garcia-Muro,A.M.,
            Garcia-Ruvalcaba,A., Pacheco-Sotelo,S., Diaz-Herrera,L.C. and
            Marin-Contreras,M.E.
  TITLE     Medium and large alleles of the PGC gene are risk factors for
            gastric cancer
  JOURNAL   Tumour Biol 45 (1), 15-21 (2023)
   PUBMED   37038800
  REMARK    GeneRIF: Medium and large alleles of the PGC gene are risk factors
            for gastric cancer.
REFERENCE   2  (bases 1 to 1371)
  AUTHORS   Di Mario,F., Crafa,P., Barchi,A., Franzoni,L., Franceschi,M.,
            Russo,M., Bricca,L., Brozzi,L., Rodriguez Castro,K. and Rugge,M.
  TITLE     Pepsinogen II in gastritis and Helicobacter pylori infection
  JOURNAL   Helicobacter 27 (2), e12872 (2022)
   PUBMED   34997989
  REMARK    GeneRIF: Pepsinogen II in gastritis and Helicobacter pylori
            infection.
            Review article
REFERENCE   3  (bases 1 to 1371)
  AUTHORS   Yan,L.R., Ding,H.X., Shen,S.X., Lu,X.D., Yuan,Y. and Xu,Q.
  TITLE     Pepsinogen C expression-related lncRNA/circRNA/mRNA profile and its
            co-mediated ceRNA network in gastric cancer
  JOURNAL   Funct Integr Genomics 21 (5-6), 605-618 (2021)
   PUBMED   34463892
  REMARK    GeneRIF: Pepsinogen C expression-related lncRNA/circRNA/mRNA
            profile and its co-mediated ceRNA network in gastric cancer.
REFERENCE   4  (bases 1 to 1371)
  AUTHORS   Li,M., Zheng,G., Yu,L., Tan,L.L., Li,X., Li,M.J., Li,C., Li,S.,
            Liang,J., Zhong,Z. and Li,Z.M.
  TITLE     Diagnostic value of MRI-DWI signal intensity value combined with
            serum PGI, PGII and CA199 in early gastric cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (2), 95-100 (2021)
   PUBMED   34817333
  REMARK    GeneRIF: Diagnostic value of MRI-DWI signal intensity value
            combined with serum PGI, PGII and CA199 in early gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1371)
  AUTHORS   Sanchez,L.M., Freije,J.P., Merino,A.M., Vizoso,F., Foltmann,B. and
            Lopez-Otin,C.
  TITLE     Isolation and characterization of a pepsin C zymogen produced by
            human breast tissues
  JOURNAL   J Biol Chem 267 (34), 24725-24731 (1992)
   PUBMED   1280267
REFERENCE   6  (bases 1 to 1371)
  AUTHORS   Athauda,S.B., Tanji,M., Kageyama,T. and Takahashi,K.
  TITLE     A comparative study on the NH2-terminal amino acid sequences and
            some other properties of six isozymic forms of human pepsinogens
            and pepsins
  JOURNAL   J Biochem 106 (5), 920-927 (1989)
   PUBMED   2515193
REFERENCE   7  (bases 1 to 1371)
  AUTHORS   Pals,G., Azuma,T., Mohandas,T.K., Bell,G.I., Bacon,J.,
            Samloff,I.M., Walz,D.A., Barr,P.J. and Taggart,R.T.
  TITLE     Human pepsinogen C (progastricsin) polymorphism: evidence for a
            single locus located at 6p21.1-pter
  JOURNAL   Genomics 4 (2), 137-148 (1989)
   PUBMED   2567697
REFERENCE   8  (bases 1 to 1371)
  AUTHORS   Taggart,R.T., Cass,L.G., Mohandas,T.K., Derby,P., Barr,P.J.,
            Pals,G. and Bell,G.I.
  TITLE     Human pepsinogen C (progastricsin). Isolation of cDNA clones,
            localization to chromosome 6, and sequence homology with pepsinogen
            A
  JOURNAL   J Biol Chem 264 (1), 375-379 (1989)
   PUBMED   2909526
REFERENCE   9  (bases 1 to 1371)
  AUTHORS   Hayano,T., Sogawa,K., Ichihara,Y., Fujii-Kuriyama,Y. and
            Takahashi,K.
  TITLE     Primary structure of human pepsinogen C gene
  JOURNAL   J Biol Chem 263 (3), 1382-1385 (1988)
   PUBMED   3335549
  REMARK    Erratum:[J Biol Chem 1988 Oct 5;263(28):14592]
REFERENCE   10 (bases 1 to 1371)
  AUTHORS   Foltmann,B. and Jensen,A.L.
  TITLE     Human progastricsin. Analysis of intermediates during activation
            into gastricsin and determination of the amino acid sequence of the
            propart
  JOURNAL   Eur J Biochem 128 (1), 63-70 (1982)
   PUBMED   6816595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365205.35 and BC073740.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002630.3.
            
            Summary: This gene encodes an aspartic proteinase that belongs to
            the peptidase family A1. The encoded protein is a digestive enzyme
            that is produced in the stomach and constitutes a major component
            of the gastric mucosa. This protein is also secreted into the
            serum. This protein is synthesized as an inactive zymogen that
            includes a highly basic prosegment. This enzyme is converted into
            its active mature form at low pH by sequential cleavage of the
            prosegment that is carried out by the enzyme itself. Polymorphisms
            in this gene are associated with susceptibility to gastric cancers.
            Serum levels of this enzyme are used as a biomarker for certain
            gastric diseases including Helicobacter pylori related gastritis.
            Alternate splicing results in multiple transcript variants. A
            pseudogene of this gene is found on chromosome 1. [provided by
            RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073740.1, U75272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373025.7/ ENSP00000362116.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL365205.35        17668-17681         c
            15-1371             BC073740.1         1-1357
FEATURES             Location/Qualifiers
     source          1..1371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1371
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /note="progastricsin"
                     /db_xref="GeneID:5225"
                     /db_xref="HGNC:HGNC:8890"
                     /db_xref="MIM:169740"
     exon            1..122
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1230
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /EC_number="3.4.23.3"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; gastricsin; pepsin C; pepsinogen group II;
                     preprogastricsin; pepsinogen C"
                     /codon_start=1
                     /product="gastricsin isoform 1 preproprotein"
                     /protein_id="NP_002621.1"
                     /db_xref="CCDS:CCDS4859.1"
                     /db_xref="GeneID:5225"
                     /db_xref="HGNC:HGNC:8890"
                     /db_xref="MIM:169740"
                     /translation="MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLR
                     THKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSV
                     YCQSQACTSHSRFNPSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEF
                     GLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQ
                     GSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVD
                     TGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSS
                     YILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA"
     exon            123..273
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     exon            274..391
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     exon            392..510
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     exon            511..710
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     exon            711..830
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     exon            831..978
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1077
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1371
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /note="hexamer: AATAAA"
     polyA_site      1371
                     /gene="PGC"
                     /gene_synonym="PEPC; PGII"
                     /note="major polyA site"
ORIGIN      
        1 actccactgc gactgcagaa ctcagagctg ctcttcctct gtggccagtt ggggaccagc
       61 atcatgaagt ggatggtggt ggtcttggtc tgcctccagc tcttggaggc agcagtggtc
      121 aaagtgcccc tgaagaaatt taagtctatc cgtgagacca tgaaggagaa gggcttgctg
      181 ggggagttcc tgaggaccca caagtatgat cctgcttgga agtaccgctt tggtgacctc
      241 agcgtgacct acgagcccat ggcctacatg gatgctgcct actttggtga gatcagcatc
      301 gggactccac cccagaactt cctggtcctt tttgacaccg gctcctccaa cttgtgggtg
      361 ccctctgtct actgccagag ccaggcctgc accagtcact cccgcttcaa ccccagcgag
      421 tcgtccacct actccaccaa tgggcagacc ttctccctgc agtatggcag tggcagcctc
      481 accggcttct ttggctatga caccctgact gtccagagca tccaggtccc caaccaggag
      541 ttcggcttga gtgagaatga gcctggtacc aacttcgtct atgcgcagtt tgatggcatc
      601 atgggcctgg cctaccctgc tctgtccgtg gatgaggcca ccacagctat gcagggcatg
      661 gtgcaggagg gcgccctcac cagccccgtc ttcagcgtct acctcagcaa ccagcagggc
      721 tccagcgggg gagcggttgt ctttgggggt gtggatagca gcctgtacac ggggcagatc
      781 tactgggcgc ctgtcaccca ggaactctac tggcagattg gcattgaaga gttcctcatc
      841 ggcggccagg cctccggctg gtgttctgag ggttgccagg ccatcgtgga cacaggcacc
      901 tctctgctca ctgtgcccca gcagtacatg agtgctcttc tgcaggccac aggggcccag
      961 gaggatgagt atggacagtt tctcgtgaac tgtaacagca ttcagaatct gcccagcttg
     1021 accttcatca tcaatggtgt ggagttccct ctgccacctt cctcctatat cctcagtaac
     1081 aacggctact gcaccgtggg agtcgagccc acctacctgt cctcccagaa cggccagccc
     1141 ctgtggatcc tcggggatgt cttcctcagg tcctactatt ccgtctacga cttgggcaac
     1201 aacagagtag gctttgccac tgccgcctag acttgctgcc tcgacacgtg ggctcccctc
     1261 ttcctcttga ccctgcaccc tcctagggca ttgtatctgt ctttccactc tggattcagc
     1321 cttctttttc tggactctgg actttctcta ataataaata gttcttcttt a
//
