LOCUS       NM_152595               6604 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens piggyBac transposable element derived 4 (PGBD4), mRNA.
ACCESSION   NM_152595
VERSION     NM_152595.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6604)
  AUTHORS   Sarkar,A., Sim,C., Hong,Y.S., Hogan,J.R., Fraser,M.J.,
            Robertson,H.M. and Collins,F.H.
  TITLE     Molecular evolutionary analysis of the widespread piggyBac
            transposon family and related 'domesticated' sequences
  JOURNAL   Mol Genet Genomics 270 (2), 173-180 (2003)
   PUBMED   12955498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AK057200.1, BC130441.1 and AC079203.9.
            
            On Nov 22, 2018 this sequence version replaced NM_152595.4.
            
            Summary: The piggyBac family of proteins, found in diverse animals,
            are transposases related to the transposase of the canonical
            piggyBac transposon from the moth, Trichoplusia ni. This family
            also includes genes in several genomes, including human, that
            appear to have been derived from the piggyBac transposons. This
            gene belongs to the subfamily of piggyBac transposable element
            derived (PGBD) genes. The PGBD proteins appear to be novel, with no
            obvious relationship to other transposases, or other known protein
            families. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803612.211800.1,
                                        SRR1803616.208950.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397766.4/ ENSP00000380872.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1865              AK057200.1         12-1876
            1866-2308           BC130441.1         1857-2299
            2309-6604           AC079203.9         40669-44964
FEATURES             Location/Qualifiers
     source          1..6604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q14"
     gene            1..6604
                     /gene="PGBD4"
                     /note="piggyBac transposable element derived 4"
                     /db_xref="GeneID:161779"
                     /db_xref="HGNC:HGNC:19401"
     exon            1..6604
                     /gene="PGBD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..2207
                     /gene="PGBD4"
                     /codon_start=1
                     /product="piggyBac transposable element-derived protein 4"
                     /protein_id="NP_689808.2"
                     /db_xref="CCDS:CCDS10033.1"
                     /db_xref="GeneID:161779"
                     /db_xref="HGNC:HGNC:19401"
                     /translation="MSNPRKRSIPMRDSNTGLEQLLAEDSFDESDFSEIDDSDNFSDS
                     ALEADKIRPLSHLESDGKSSTSSDSGRSMKWSARAMIPRQRYDFTGTPGRKVDVSDIT
                     DPLQYFELFFTEELVSKITRETNAQAALLASKPPGPKGFSRMDKWKDTDNDELKVFFA
                     VMLLQGIVQKPELEMFWSTRPLLDTPYLRQIMTGERFLLLFRCLHFVNNSSISAGQSK
                     AQISLQKIKPVFDFLVNKFSTVYTPNRNIAVDESLMLFKGPLAMKQYLPTKRVRFGLK
                     LYVLCESQSGYVWNALVHTGPGMNLKDSADGLKSSRIVLTLVNDLLGQGYCVFLDNFN
                     ISPMLFRELHQNRTDAVGTARLNRKQIPNDLKKRIAKGTTVARFCGELMALKWCDGKE
                     VTMLSTFHNDTVIEVNNRNGKKTKRPRVIVDYNENMGAVDSADQMLTSYPSERKRHKV
                     WYKKFFHHLLHITVLNSYILFKKDNPEHTMSHINFRLALIERMLEKHHKPGQQHLRGR
                     PCSDDVTPLRLSGRHFPKSIPATSGKQNPTGRCKICCSQYDKDGKKIRKETRYFCAEC
                     DVPLCVVPCFEIYHTKKNY"
     regulatory      5548..5553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGBD4"
                     /note="hexamer: AATAAA"
     polyA_site      5570
                     /gene="PGBD4"
                     /note="major polyA site"
     regulatory      6583..6588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGBD4"
                     /note="hexamer: AATAAA"
     polyA_site      6604
                     /gene="PGBD4"
ORIGIN      
        1 gcctatgaag gggactgccc atgaagtgaa agtcaagtgt gtgttgctgc ggcagccacg
       61 gaggccaagg acctcacggg agtaaaagat gacgagactg gcttcgggag aaacaccatc
      121 cagaagagac ctttcaaaaa acttctagag actccccaag acgtatgaga tgaaaggctt
      181 cttctgtctg tgtgcgttta actcatttct ccttagcccc gagattacgc gctgctgtgc
      241 ctgcgactgc agcgtttacg ccgagataac tcgtggatta cagtgccaac cttactccca
      301 aagtttgcca cgaaatatct cgcttctgtt attttcgcat ggttctggta tattgacttt
      361 tgaaacaaaa gacatcattc tgtttatagc attctgtttt tagtagtggg atttccatct
      421 acaaaatata gtaattctcg atcgctgaaa tgtcaaatcc tagaaaacgt agcattccta
      481 tgcgtgatag taataccggt ctcgaacagt tgttggctga agattcattt gatgaatctg
      541 atttttcgga aatagatgat tctgataatt tttcggatag tgctttagaa gccgataaga
      601 tcaggcctct gtcccattta gaatctgatg gaaagagctc tacatcaagt gactcagggc
      661 gctccatgaa atggtcagct cgtgctatga ttccacgtca aaggtatgac tttaccggca
      721 cacctggcag aaaagtcgat gtcagtgata tcactgaccc attgcagtat tttgaactgt
      781 tctttactga ggaattagtt tcaaaaatta ctagagaaac aaatgcccaa gctgccttgt
      841 tggcttcaaa gccaccgggt ccgaaaggat tttcgcgaat ggataaatgg aaagacactg
      901 acaatgacga gctcaaagtc ttttttgcag taatgttact gcaaggtatt gtgcagaaac
      961 ctgagctgga gatgttttgg tcaacaaggc ctcttttgga tacaccttat ctcaggcaaa
     1021 ttatgactgg tgaaagattt ttacttttgt ttcggtgcct gcattttgtc aacaattctt
     1081 ctatatctgc tggtcaatca aaggcccaga tttcattgca gaagatcaaa cctgtgttcg
     1141 actttcttgt aaataaattt tccactgtat atactccaaa cagaaacatt gcagttgatg
     1201 aatcactgat gctgttcaag gggccattag ctatgaagca gtacctcccg acaaaacgag
     1261 tacgatttgg tctgaagcta tatgtacttt gtgaaagtca gtctggttat gtgtggaatg
     1321 cgcttgttca cacagggcct ggcatgaatt tgaaagattc agcggatggc ctgaaatcat
     1381 cacgcattgt tcttaccttg gtcaatgacc ttcttggcca agggtattgt gtcttcctcg
     1441 ataactttaa tatatctccc atgcttttca gagaattaca tcaaaatagg actgatgcag
     1501 ttgggacagc tcgtttgaac agaaaacaga ttccaaatga tctgaaaaaa aggattgcaa
     1561 aggggacgac tgtagccaga ttctgtggtg aacttatggc actgaaatgg tgtgacggca
     1621 aggaggtgac aatgttgtca acattccaca atgatactgt gattgaagta aacaatagaa
     1681 atggaaagaa aactaaaagg ccacgtgtca ttgtggatta taacgagaat atgggagcag
     1741 tggactcggc tgatcaaatg cttacttctt atccatctga gcgcaaaaga cacaaggttt
     1801 ggtataagaa attctttcac catcttctac acattacagt gctgaactcc tacatcctgt
     1861 tcaagaagga taatcctgag cacacgatga gccatataaa cttcagactg gcattgattg
     1921 aaagaatgct ggaaaagcat cacaagccag ggcagcaaca tcttcgaggt cgtccttgct
     1981 ccgatgatgt cacacctctt cgtctgtctg gaagacattt ccccaagagc ataccagcaa
     2041 cgtccgggaa acagaatcca actggtcgct gcaaaatttg ctgctcccaa tacgacaagg
     2101 atggcaagaa gatccggaaa gaaacgcgct atttttgtgc cgaatgtgat gttccgcttt
     2161 gtgttgttcc gtgctttgaa atttaccaca cgaaaaaaaa ttattaaata ccgatcatca
     2221 tacacatctg ttccattagg attagagaca agttctgttt agaaataact ccaagattgg
     2281 gaggccgacc tgggtggatc acctgagatc aggaattcaa gaccagcctg gccaacatgg
     2341 tgaaaccctg tctctactaa aaatacaaca attagctgga tgtggtggca catgcctgta
     2401 atccaagcta cttgggaggc tgaggcagga gaattgcttg aacccatgag gcggaggttg
     2461 cagtgagctg agatcacacc actgcactcc agcctgggtg acatagcgag actccatctc
     2521 aaaaaaaaga aataactcca agaacagttt tgttgttttt gttttgtttt gttttgtttt
     2581 gagacggagt ttcactcttg ttgcccaggc tggagtgcaa tggcatgata ttggctcact
     2641 gtaacctcca cctcccaggt tcaagcgatt ctcgtgcctc agcctcccta gtagctggga
     2701 ttacaggcat gtgccaccac acccacctaa ttttgcattt ttagtagaga ctgggtttat
     2761 ccatgttggt caggctagtc ttgacctccc gacctcaggt gatccgccta tctgggcctc
     2821 acaaagtcct gggattatag gcatgagcca ctgcgcctag caccaagaac agtttttata
     2881 ttttattttc acattgaaaa tcagtcagat ttgcttcagc ctcaaagagg gtgtttatgt
     2941 aaaactaaat gagtgcaggc agcgagctac actttttttt ttcctaaatg gaaaatggga
     3001 aggagatact gtctctgaac aaaaatagct ggaaaaacac ataactgtta actaagggtt
     3061 gcctctagtg aaaaggattg gaagacaatt tatctgatgc tacactattc ttcctgttgt
     3121 gattgtttta ctgtgaacat aacaaggttg tattggggag gagggcaggg gttgattgct
     3181 gccaatgttg attgctgagg ccttagccaa gatttcaggc atcatttgct ccagtccttt
     3241 cattttcttt atggtggaaa gtgaagtgac ttgcccaaga tctttgttgg ccctaaacat
     3301 cgctgtctct gctacagatt cctattgaga gcaatgcatg ttttagcctt gtgcactctt
     3361 agagtcagca tcatgggaaa gagtaacagc aattgaaaaa agagattcaa gagccaagta
     3421 ctcagccctg gcaggggatg gggacatgat gcccagagcc acccctatac tccagtctcc
     3481 ctggcatcag ctactgcagt actggggtac ttgccttcat cttttttctg aagatagtta
     3541 cttcttcata tttgatcatc ggaaggagca gcattgctca gaaacacaca cacacacaca
     3601 cacacttgac tttcttgtct gccaaataaa tttcttattt gctagggaac tggtaatcta
     3661 ggctcaagaa gtgtgtggag aaggtttatt ttcattcttt ttactttaaa atatgcctta
     3721 gtttttgaat agataagaca ttcaagtgtc agaaagtaaa agtcagttca ggactgagaa
     3781 aggaaagatc agtgctgatt ttaatcagac tgtaatgtac caactagata cagacagggc
     3841 cagtggcaag gccatcagaa aacttcttcc caaggccaca ccacacctgc aaaatgccta
     3901 acaaccttct tcttttcagt gattaccact ttcttaccaa tgacttcgct ttgttcctcg
     3961 tgcctctgaa cagactgctg agatacccaa tcaagagcca atccttgctt ccctagactc
     4021 tcctcaatca ttcaacagaa gcccaaatct tgtaaaagtt cctttctggg ccgggcacag
     4081 tggctcacgc ctgtaatccc agcactttgg aaggccgaga tgggcgaatc acaaggtcag
     4141 gagtttgaga ctagcctggc caacatggtg aaaccctgtc tctactaaaa atacaaaaaa
     4201 aaattagctg ggcatagtgg tgggtgcctg taatcccagc tacttgggag gctgagacag
     4261 gagaatcact tgaacccggg aggcagaggt tgcagtgagc caagatcgca ccactgcact
     4321 ccagccctgg cgacagagtg agactccatc tcaaaaaata aaaaagtttc cttctgttcc
     4381 ctcttactgt tatatccttg gtttctctgg tgtggggtct tccttacagc agcaagctca
     4441 taaacttaac ttgaccgcag gtgtgttcct tggtggtctt tatctgatag actttgtcac
     4501 atggtacaat attcaaaagg cacatggtac aatattcaaa aggcacatgg tacaatattc
     4561 aaaaggtatg agtatacaaa aaaaatctcc cacctacttc tctccctagt cacccaattc
     4621 tcaagaggca atcactgttg ccattttcct gagtattctt ccacagatag tcaactatct
     4681 acagaaaaat atatacatta aaaataaggc caggcacagt ggcatgcctg tagtcccagc
     4741 tactcagaag gttgaagcag gaggatcact tgaggccagg agggccagga atttgaagct
     4801 gtagtgtgct atgatagcag gcctgtgaat agccattgca ctccatcctg ggcaacatag
     4861 ccagaccctg tctctaaaaa aaaaaaaaaa aaaaaaaaag acaaaaaaac aaatccatat
     4921 atacatatat atgtatatat atagtatgct accagttgtg tgaaaaaagg ggcaaaatat
     4981 atatttattt aacttatata caaataacat tctagaaata aattgtttaa tataaaatac
     5041 actaatatat aataatgtat tacctaacat atgattatat ataactataa tgtgtactgt
     5101 tttacataca tatttccaaa gtatactata aatgcacttc cgcactttgc tctttttact
     5161 aaatatatct tggaaatcat cctttattcg tacataaaaa gcttcatagt tcctttttat
     5221 ggctgcaaaa tgttccagct tatggatgga ctgattctct atcgagcaac attaagattg
     5281 tgtcctattt tactattcct aattttgctg aagtgaattt cttttgccat gtgatttcca
     5341 caggtgtata tatgtagcgt aattagtact agtagaaagt agaattgcta gatcaaagag
     5401 tatgtgcctt tgtaattttg atgatattgt gaaatcttct tccacagaag ttgttgcaac
     5461 tttcactctc accagcaatg tgtaagataa cttgcttctt cataccctca ccaacaatga
     5521 gctatcaaat gttatttttg ccaagcaaat aaattaaaag tgatatctca gtttttgttt
     5581 gtttgtttgt tttttgagac agagtttcac tctttgttgc ccaggctgga gtgcagtggc
     5641 gtgatctcgg ctcactgtaa cctccgcctc ccaggttcaa acgattctcc tgtctcaccc
     5701 tcccgagtag ctgggattac aggcacctgc caccacaccc agttaatttt tgtattttta
     5761 gtagagacag ggtttcacca tgttggctag gctgacctcg aactcctaac ctcaggtgat
     5821 ccacctgcct cggcctccca aagtgctgga attacaggcg tgagccacca tgcctggctc
     5881 ttcttgcttg tttgttttga gacagagtct tgctctgtca gccaggctgg agtgcagtgg
     5941 cacgatattg gctcactgca acctctgtct cccaggctca agcaattctc ctgcctcagc
     6001 ctcctgagta gctaggatta cagatgtgtg ccaccacgcc tggctaattt ttgtactttt
     6061 agtagagacg gagtttcacc atgttggcca ggctggtctc aaactcctga cctcaggtaa
     6121 tccgcctgcc ttggcctccc aaagtgctgg gatgacaggc gtgagccacc acgctgggcc
     6181 tcttcttggt tttttaatcc atcttctgcc atatggtgaa ttaaatctaa gttgtattgt
     6241 aggattaatg gagagcagct aaagaggaat aaagccatgt gttcagccaa ggatagttat
     6301 catgaaggat aaaagcctca aaatcctgat tttgaaatac aaagtgctga ttttaaaatc
     6361 agtacatgtt gagctgagcc ctgaggcctt tgtttcagtc ccaaccagag cagaagtaag
     6421 cattgttgaa accgtagtaa aaagattatt tgagaaataa tggaatggga caaaggatta
     6481 taatgtgcta cagccctctg accattacac tttctaaact attaataaaa ttttactttt
     6541 caaaaatgat ttcaaaaatt gcaaaattta gaaatatgct gaaataaaaa cagcttcatc
     6601 ccaa
//
