LOCUS       NM_170725               2717 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens piggyBac transposable element derived 2 (PGBD2),
            transcript variant 1, mRNA.
ACCESSION   NM_170725
VERSION     NM_170725.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Sarkar,A., Sim,C., Hong,Y.S., Hogan,J.R., Fraser,M.J.,
            Robertson,H.M. and Collins,F.H.
  TITLE     Molecular evolutionary analysis of the widespread piggyBac
            transposon family and related 'domesticated' sequences
  JOURNAL   Mol Genet Genomics 270 (2), 173-180 (2003)
   PUBMED   12955498
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Xiang,Z., Morse,E., Hu,X.L., Flint,J., Chi,H.C., Grady,D.L.,
            Moyzis,R.K. and Riethman,H.C.
  TITLE     A sequence-ready map of the human chromosome 1q telomere
  JOURNAL   Genomics 72 (1), 105-107 (2001)
   PUBMED   11247672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AL672183.3, AK123219.1, BC063785.1 and AI038307.1.
            
            On Nov 22, 2018 this sequence version replaced NM_170725.2.
            
            Summary: The piggyBac family of proteins, found in diverse animals,
            are transposases related to the transposase of the canonical
            piggyBac transposon from the moth, Trichoplusia ni. This family
            also includes genes in several genomes, including human, that
            appear to have been derived from the piggyBac transposons. This
            gene belongs to the subfamily of piggyBac transposable element
            derived (PGBD) genes. The PGBD proteins appear to be novel, with no
            obvious relationship to other transposases, or other known protein
            families. The exact function of this gene is not known. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.75726.1,
                                           SRR1660809.28849.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329291.6/ ENSP00000331643.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL672183.3         32656-32663         c
            9-172               AK123219.1         48-211
            173-2144            BC063785.1         170-2141
            2145-2716           AK123219.1         1507-2078
            2717-2717           AI038307.1         4-4                 c
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..2717
                     /gene="PGBD2"
                     /note="piggyBac transposable element derived 2"
                     /db_xref="GeneID:267002"
                     /db_xref="HGNC:HGNC:19399"
     exon            1..108
                     /gene="PGBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            109..172
                     /gene="PGBD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1934
                     /gene="PGBD2"
                     /note="isoform a is encoded by transcript variant 1;
                     piggyBac transposable element-derived protein 2"
                     /codon_start=1
                     /product="piggyBac transposable element-derived protein 2
                     isoform a"
                     /protein_id="NP_733843.1"
                     /db_xref="CCDS:CCDS31128.1"
                     /db_xref="GeneID:267002"
                     /db_xref="HGNC:HGNC:19399"
                     /translation="MASTSRDVIAGRGIHSKVKSAKLLEVLNAMEEEESNNNREEIFI
                     APPDNAAGEFTDEDSGDEDSQRGAHLPGSVLHASVLCEDSGTGEDNDDLELQPAKKRQ
                     KAVVKPQRIWTKRDIRPDFGSWTASDPHIEDLKSQELSPVGLFELFFDEGTINFIVNE
                     TNRYAWQKNVNLSLTAQELKCVLGILILSGYISYPRRRMFWETSPDSHHHLVADAIRR
                     DRFELIFSYLHFADNNELDASDRFAKVRPLIIRMNCNFQKHAPLEEFYSFGESMCEYF
                     GHRGSKQLHRGKPVRLGYKIWCGTTSRGYLVWFEPSQGTLFTKPDRSLDLGGSMVIKF
                     VDALQERGFLPYHIFFDKVFTSVKLMSILRKKGVKATGTVREYRTERCPLKDPKELKK
                     MKRGSFDYKVDESEEIIVCRWHDSSVVNICSNAVGIEPVRLTSRHSGAAKTRTQVHQP
                     SLVKLYQEKVGGVGRMDQNIAKYKVKIRGMKWYSSFIGYVIDAALNNAWQLHRICCQD
                     AQVDLLAFRRYIACVYLESNADTTSQGRRSRRLETESRFDMIGHWIIHQDKRTRCALC
                     HSQTNTRCEKCQKGVHAKCFREYHIR"
     exon            173..2717
                     /gene="PGBD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2195..2200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGBD2"
                     /note="hexamer: AATAAA"
     polyA_site      2217
                     /gene="PGBD2"
                     /note="major polyA site"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGBD2"
                     /note="hexamer: ATTAAA"
     polyA_site      2717
                     /gene="PGBD2"
ORIGIN      
        1 ggacgttgcg cggccgcgac gcccgacgcc aacgcaggcg cagcgctccg attcggcgcg
       61 gctcatggtc cggttcgggc tcgcgagtct ccgtctgggg tagggcaggt tcttagactc
      121 tgtgagtaaa gacagcttca tcttcccagt tcatcatggc ttcaacatcc agagatgtca
      181 ttgctgggag aggtatccac tcaaaggtga agtctgcaaa gctgcttgag gttctgaatg
      241 ctatggagga ggaagagtcc aacaacaaca gggaagagat tttcattgca cctcccgaca
      301 atgctgcggg ggaattcact gatgaggact caggggatga agacagccag cgaggtgctc
      361 acctacctgg cagtgtgctg catgcttcag tcctgtgtga ggactctggc accggggagg
      421 ataatgacga cctggagctg cagccagcca agaagaggca gaaagcagtt gtgaaacctc
      481 agcgcatttg gaccaaaaga gatattcgtc cagactttgg cagttggact gcatcagatc
      541 ctcatattga ggatctgaaa agccaagagc tgagtcccgt gggccttttt gagttgtttt
      601 ttgatgaagg aacaattaat ttcattgtta atgaaaccaa tcgttatgct tggcagaaaa
      661 atgtcaattt gagtcttacg gctcaggaat tgaagtgtgt tttgggcatt ttgattttaa
      721 gtgggtacat ctcttatcca aggagaagga tgttctggga aacctctccc gattcacatc
      781 atcatcttgt ggctgatgca attagaaggg acagatttga actaatcttc tcatacttac
      841 attttgcaga taacaacgaa cttgatgcaa gtgataggtt tgccaaggtc agacctctca
      901 tcatccggat gaactgcaat ttccagaagc atgcaccctt ggaagagttc tacagctttg
      961 gcgagtctat gtgtgagtac tttgggcacc gggggtccaa gcagctgcac agggggaagc
     1021 ctgtgcgact tggctacaag atttggtgtg ggacaaccag cagaggctac ttggtgtggt
     1081 ttgagccctc acagggcaca ctgtttacca agccagacag gagcttggat ctaggaggca
     1141 gtatggtaat aaaatttgtg gatgcgcttc aggagcgtgg ttttctgcca tatcacatat
     1201 tttttgacaa ggttttcaca agtgttaaac tgatgtccat tttgaggaaa aagggggtga
     1261 aagccacagg aactgttcgt gagtacagga ctgagcgatg tcccctaaaa gaccccaaag
     1321 aactgaaaaa aatgaagagg ggttcatttg attacaaagt cgatgagagt gaggagatca
     1381 tcgtgtgccg ctggcacgat agcagcgtgg tcaacatttg ctccaatgct gtgggcatag
     1441 agccagtgag gctgaccagt cgtcactctg gagcagctaa aacgcggact caggtccacc
     1501 agccatcact ggtgaagctg tatcaggaga aggtgggtgg cgttggtagg atggatcaga
     1561 atattgccaa gtacaaggtg aagatccgag gcatgaagtg gtactcaagc tttattggct
     1621 atgtcattga tgctgccctc aacaatgcat ggcagctgca tagaatctgc tgccaagatg
     1681 cccaggtgga cctccttgcc ttccggagat acattgcctg tgtgtatctg gagagcaatg
     1741 ctgacacaac atctcaaggg aggcgaagca ggcggttgga gactgagagc cgcttcgata
     1801 tgattgggca ctggattatc catcaggaca agaggacccg gtgtgccctc tgccactcac
     1861 agaccaacac ccggtgtgag aagtgccaga agggtgtcca tgccaaatgc ttcagggagt
     1921 accacatccg gtgacatcat gagacatgct tctttggttt ataatgagat gtttacagtt
     1981 aaatacagat ggcagttgag cacttctgtt ttgtgttgga aaaaagacct gaatttctaa
     2041 tgacttgatt ttctattttc tccctaccca caatacagtt atctttttta ttgtgttgtg
     2101 ttatgcctac atgtgatata aattaatatt tatattcatt tatatttata tttttgaact
     2161 tatttattta aagttatgga tcacttttta ttcaaataaa agttgtgctt tggggtatat
     2221 ttgaatccta gcaagaataa tcaaaggaaa acttgcaaga acagtaagaa gactttacca
     2281 ttgcatgcca tggtttataa tctaagatag gcaatagtgt ataaatatca tgtaaatgtg
     2341 atggatttct taatcatatt tatttcatat taatccaagt ttatcaaact tttgagggat
     2401 aatctgcctt gtatttagtc agagggctag aggtgcagat ttcatatttt cttaatgaaa
     2461 atattttcct aatacacata tatcaatgtg agattcattt ttgtaaaaaa aattattttt
     2521 ttaattttgt gggtacatag taggagtgta tttttatggg ttacatgaga tattctgata
     2581 caaacatgca atgtataaaa atcacatcag ggtaaatggg gtatccatct tgtcaaacac
     2641 ttgtcctttg tgtttcaaac aatccaatta tactgttagt tattttaaaa tgtgcaatta
     2701 aattattttt aactata
//
