LOCUS       NM_032507               3080 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens piggyBac transposable element derived 1 (PGBD1),
            transcript variant 2, mRNA.
ACCESSION   NM_032507
VERSION     NM_032507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3080)
  AUTHORS   Rasko,T., Pande,A., Radscheit,K., Zink,A., Singh,M., Sommer,C.,
            Wachtl,G., Kolacsek,O., Inak,G., Szvetnik,A., Petrakis,S.,
            Bunse,M., Bansal,V., Selbach,M., Orban,T.I., Prigione,A.,
            Hurst,L.D. and Izsvak,Z.
  TITLE     A Novel Gene Controls a New Structure: PiggyBac Transposable
            Element-Derived 1, Unique to Mammals, Controls Mammal-Specific
            Neuronal Paraspeckles
  JOURNAL   Mol Biol Evol 39 (10) (2022)
   PUBMED   36205081
  REMARK    GeneRIF: A Novel Gene Controls a New Structure: PiggyBac
            Transposable Element-Derived 1, Unique to Mammals, Controls
            Mammal-Specific Neuronal Paraspeckles.
REFERENCE   2  (bases 1 to 3080)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   3  (bases 1 to 3080)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3080)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3080)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3080)
  AUTHORS   Li,T., Li,Z., Chen,P., Zhao,Q., Wang,T., Huang,K., Li,J., Li,Y.,
            Liu,J., Zeng,Z., Feng,G., He,L. and Shi,Y.
  TITLE     Common variants in major histocompatibility complex region and TCF4
            gene are significantly associated with schizophrenia in Han Chinese
  JOURNAL   Biol Psychiatry 68 (7), 671-673 (2010)
   PUBMED   20673877
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3080)
  AUTHORS   Corneveaux,J.J., Myers,A.J., Allen,A.N., Pruzin,J.J., Ramirez,M.,
            Engel,A., Nalls,M.A., Chen,K., Lee,W., Chewning,K., Villa,S.E.,
            Meechoovet,H.B., Gerber,J.D., Frost,D., Benson,H.L., O'Reilly,S.,
            Chibnik,L.B., Shulman,J.M., Singleton,A.B., Craig,D.W., Van
            Keuren-Jensen,K.R., Dunckley,T., Bennett,D.A., De Jager,P.L.,
            Heward,C., Hardy,J., Reiman,E.M. and Huentelman,M.J.
  TITLE     Association of CR1, CLU and PICALM with Alzheimer's disease in a
            cohort of clinically characterized and neuropathologically verified
            individuals
  JOURNAL   Hum Mol Genet 19 (16), 3295-3301 (2010)
   PUBMED   20534741
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 3080)
  AUTHORS   Agapkina,Iu.V., Nikitin,A.G., Brovkin,A.N., Pushkov,A.A.,
            Evdokimova,M.A., Kudriashova,O.Iu., Osmolovskaia,V.S.,
            Minushkina,L.O., Kochkina,M.S., Selezneva,N.D., Dankovtseva,E.N.,
            Chumakova,O.S., Baklanova,T.N., Talyzin,P.A., Reznichenko,N.E.,
            Donetskaia,O.P., Tereshchenko,S.N., Krasil'nikova,E.S.,
            Dzhaiani,N.A., Akatova,E.V., Glezer,M.G., Galiavich,A.S.,
            Zakirova,V.B., Kaziolova,N.A., Timofeeva,I.V., Iagoda,A.V.,
            Boeva,O.I., Katel'nitskaia,L.I., Khorolets,E.V., Shlyk,S.V.,
            Volkova,E.G., Margarian,M.P., Guz',I.O., Konstantinov,V.O.,
            Timofeeva,A.N., Sidorenko,B.A., Zateishchikiov,D.A. and
            Nosikov,V.V.
  TITLE     [Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene
            PROC and genetic predisposition to unfavorable outcomes patients
            undergoing acute coronary syndrome]
  JOURNAL   Mol Biol (Mosk) 44 (4), 613-619 (2010)
   PUBMED   20873219
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3080)
  AUTHORS   Schjeide,B.M., McQueen,M.B., Mullin,K., DiVito,J., Hogan,M.F.,
            Parkinson,M., Hooli,B., Lange,C., Blacker,D., Tanzi,R.E. and
            Bertram,L.
  TITLE     Assessment of Alzheimer's disease case-control associations using
            family-based methods
  JOURNAL   Neurogenetics 10 (1), 19-25 (2009)
   PUBMED   18830724
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3080)
  AUTHORS   Sarkar,A., Sim,C., Hong,Y.S., Hogan,J.R., Fraser,M.J.,
            Robertson,H.M. and Collins,F.H.
  TITLE     Molecular evolutionary analysis of the widespread piggyBac
            transposon family and related 'domesticated' sequences
  JOURNAL   Mol Genet Genomics 270 (2), 173-180 (2003)
   PUBMED   12955498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AL021997.1.
            
            On Aug 5, 2020 this sequence version replaced NM_032507.3.
            
            Summary: The piggyBac family of proteins, found in diverse animals,
            are transposases related to the transposase of the canonical
            piggyBac transposon from the moth, Trichoplusia ni. This family
            also includes genes in several genomes, including human, that
            appear to have been derived from the piggyBac transposons. This
            gene belongs to the subfamily of piggyBac transposable element
            derived (PGBD) genes. The PGBD proteins appear to be novel, with no
            obvious relationship to other transposases, or other known protein
            families. This gene product is specifically expressed in the brain,
            however, its exact function is not known. Alternative splicing
            results in multiple transcript variants encoding the same
            protein.[provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291228.1, BC128585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682144.1/ ENSP00000506997.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AL021997.1         82159-82505         c
            348-781             AL021997.1         79868-80301         c
            782-938             AL021997.1         78370-78526         c
            939-1027            AL021997.1         76909-76997         c
            1028-1157           AL021997.1         67132-67261         c
            1158-1254           AL021997.1         66086-66182         c
            1255-3080           AL021997.1         61528-63353         c
FEATURES             Location/Qualifiers
     source          1..3080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3080
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /note="piggyBac transposable element derived 1"
                     /db_xref="GeneID:84547"
                     /db_xref="HGNC:HGNC:19398"
     exon            1..347
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /inference="alignment:Splign:2.1.0"
     exon            348..781
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..2815
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /note="cerebral protein 4"
                     /codon_start=1
                     /product="piggyBac transposable element-derived protein 1"
                     /protein_id="NP_115896.1"
                     /db_xref="CCDS:CCDS4648.1"
                     /db_xref="GeneID:84547"
                     /db_xref="HGNC:HGNC:19398"
                     /translation="MYEALPGPAPENEDGLVKVKEEDPTWEQVCNSQEGSSHTQEICR
                     LRFRHFCYQEAHGPQEALAQLRELCHQWLRPEMHTKEQIMELLVLEQFLTILPKELQP
                     CVKTYPLESGEEAVTVLENLETGSGDTGQQASVYIQGQDMHPMVAEYQGVSLECQSLQ
                     LLPGITTLKCEPPQRPQGNPQEVSGPVPHGSAHLQEKNPRDKAVVPVFNPVRSQTLVK
                     TEEETAQAVAAEKWSHLSLTRRNLCGNSAQETVMSLSPMTEEIVTKDRLFKAKQETSE
                     EMEQSGEASGKPNRECAPQIPCSTPIATERTVAHLNTLKDRHPGDLWARMHISSLEYA
                     AGDITRKGRKKDKARVSELLQGLSFSGDSDVEKDNEPEIQPAQKKLKVSCFPEKSWTK
                     RDIKPNFPSWSALDSGLLNLKSEKLNPVELFELFFDDETFNLIVNETNNYASQKNVSL
                     EVTVQEMRCVFGVLLLSGFMRHPRREMYWEVSDTDQNLVRDAIRRDRFELIFSNLHFA
                     DNGHLDQKDKFTKLRPLIKQMNKNFLLYAPLEEYYCFDKSMCECFDSDQFLNGKPIRI
                     GYKIWCGTTTQGYLVWFEPYQEESTMKVDEDPDLGLGGNLVMNFADVLLERGQYPYHL
                     CFDSFFTSVKLLSALKKKGVRATGTIRENRTEKCPLMNVEHMKKMKRGYFDFRIEENN
                     EIILCRWYGDGIISLCSNAVGIEPVNEVSCCDADNEEIPQISQPSIVKVYDECKEGVA
                     KMDQIISKYRVRIRSKKWYSILVSYMIDVAMNNAWQLHRACNPGASLDPLDFRRFVAH
                     FYLEHNAHLSD"
     exon            782..938
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1027
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1157
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1254
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..3080
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3080
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /note="major polyA site"
ORIGIN      
        1 gtacccgccc agctgctgga ggcgccggca gcgcccgcca gacccgccag cccagcggcc
       61 cgggctctgg ggaaaccggc gctcccgaca ggggagcacc gggcctctga gctccctcgg
      121 gagcctttca cgaggtcagc tacgtctttg ttgtgcgcgt tcctgaactt ttggtccatt
      181 aaccaacaat tagacacgcc ggtattcagt gcctggcgcg gtgctagatg ctgggtgtaa
      241 tctcagaaaa atacattcag gggcgcgcct gagggtgctg gctgctggca tctcaggtgc
      301 tttacgtgca ttcgtgaaga agcccatcag tatttcttga ataccagacc ccaagctaag
      361 tgaagcttta gcctctaagc tcaacatgta tgaagctttg ccaggccctg ctcctgaaaa
      421 tgaagatggc cttgtgaaag tgaaggagga agatcccacc tgggagcagg tgtgcaactc
      481 acaggagggc agctcccaca ctcaggagat ttgccgcctg cgctttcggc acttctgcta
      541 ccaggaggct cacggacccc aggaagctct ggcccaactc cgagaacttt gtcatcaatg
      601 gctgagaccg gagatgcaca ccaaggaaca gataatggaa ctgctggtgc tggagcagtt
      661 cctgaccatc ctgcccaagg agctccagcc ctgtgtgaag acatatcctc tggagagtgg
      721 agaggaggca gtgacagtgc tggagaatct agagacagga agtggagaca caggacaaca
      781 ggcctctgtc tatattcagg gacaggacat gcacccaatg gtggcagaat atcaaggagt
      841 ctctttggag tgtcagagcc tccagctcct gcctgggata accaccctga agtgtgaacc
      901 tccacagcgt cctcaaggga acccccaaga agtgagtggg cctgttcccc acggatcagc
      961 tcatctccag gaaaaaaacc ccagagacaa ggctgtagtg cctgtgttta acccagtcag
     1021 gtcccagaca ttggtgaaga ctgaggaaga aacagcccag gccgttgctg cagagaagtg
     1081 gtcacatctg agtctgactc ggaggaacct ctgtgggaac tcagctcagg agacagttat
     1141 gagcctcagt ccgatgactg aagaaattgt aactaaagat agattgttta aagcaaagca
     1201 agaaacttct gaagaaatgg aacaaagtgg agaagcctca ggaaagccca acagagagtg
     1261 tgcaccccag attccttgta gtactcctat tgctactgaa aggacagttg cacatttgaa
     1321 cactctgaag gaccgtcacc caggtgattt gtgggcccgc atgcacatct catccctgga
     1381 atatgctgca ggagacatta cccgaaaagg gagaaaaaaa gacaaagctc gagtgagtga
     1441 actgctccaa ggcctctcat tctctggtga ctcagatgtg gaaaaagata atgagcctga
     1501 gatccagcct gctcaaaaga agttaaaggt atcatgtttc ccagaaaaga gttggaccaa
     1561 aagagacatt aaacccaatt ttccaagctg gtcagcactg gattctggac ttttgaatct
     1621 caagagcgaa aagttgaacc cagtagagct ttttgaatta ttttttgatg atgaaacatt
     1681 caacttaatt gtcaatgaaa ccaataatta tgcttctcag aaaaatgtca gcttggaagt
     1741 cacagttcag gaaatgaggt gtgtgtttgg tgtcttactt ttgagtggat ttatgaggca
     1801 tcctagaagg gaaatgtatt gggaagtctc tgacaccgat cagaacctgg ttagagatgc
     1861 aatcagaagg gacagatttg aattgatttt ctcaaacctg cactttgcag ataatggcca
     1921 cctagatcaa aaagataagt ttacaaagtt gagacctctc ataaaacaaa tgaataaaaa
     1981 tttcctcttg tatgctcccc tggaagaata ctattgcttt gataagtcaa tgtgtgaatg
     2041 ctttgatagt gaccaattcc tgaatggaaa gcctattaga attggctata aaatttggtg
     2101 tggtacaacc acacagggtt atctggtttg gtttgaaccc tatcaagaag aatcaactat
     2161 gaaggtagat gaggatcctg atcttgggtt aggtggaaat ctagtgatga acttcgctga
     2221 tgttctttta gagagaggtc agtatcccta tcacctgtgt tttgatagct tctttacaag
     2281 tgtcaaattg ttgtcagcct tgaaaaagaa gggggtgagg gcaacaggaa caattcgtga
     2341 gaacaggacc gaaaaatgtc cccttatgaa tgtagaacat atgaaaaaaa tgaagagagg
     2401 gtattttgat ttccgaatag aagaaaacaa tgagataatt ttgtgtcgtt ggtatgggga
     2461 tggcattatc agtctgtgct ccaatgctgt gggcatagaa ccagtcaatg aggtaagctg
     2521 ttgtgatgct gataacgaag aaatccctca gataagtcaa ccatccatag taaaagtgta
     2581 tgatgaatgc aaggaaggtg tagctaaaat ggatcaaatt atttcgaaat acagggtgag
     2641 gataagaagc aagaaatggt actcaatttt ggtgagctac atgattgatg tagccatgaa
     2701 caatgcatgg caactacaca gagcctgtaa cccaggtgct tctctagacc ccttggattt
     2761 tcggagattt gttgcacatt tctacttgga acacaatgct catctgtcag attagggtac
     2821 ataaaatgga catagtgcag acattaataa gacatagaaa aataataatt atacatgctg
     2881 ttgtaccctc ccaaagtaaa tctgatatat gtaatgaagt tattaaataa tacttttaaa
     2941 aatcagacat ttatatagag tttcaaagac tattgtaaca agtaatgtta aaaattgtct
     3001 gtgagaatgt tgaactgtag tacctttctc tatgtcaagt tttgtgtcag acatgggaaa
     3061 tcatgtattt gttcaattga
//
