LOCUS       NP_115896                809 aa            linear   PRI 21-SEP-2024
DEFINITION  piggyBac transposable element-derived protein 1 [Homo sapiens].
ACCESSION   NP_115896
VERSION     NP_115896.1
DBSOURCE    REFSEQ: accession NM_032507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 809)
  AUTHORS   Rasko,T., Pande,A., Radscheit,K., Zink,A., Singh,M., Sommer,C.,
            Wachtl,G., Kolacsek,O., Inak,G., Szvetnik,A., Petrakis,S.,
            Bunse,M., Bansal,V., Selbach,M., Orban,T.I., Prigione,A.,
            Hurst,L.D. and Izsvak,Z.
  TITLE     A Novel Gene Controls a New Structure: PiggyBac Transposable
            Element-Derived 1, Unique to Mammals, Controls Mammal-Specific
            Neuronal Paraspeckles
  JOURNAL   Mol Biol Evol 39 (10) (2022)
   PUBMED   36205081
  REMARK    GeneRIF: A Novel Gene Controls a New Structure: PiggyBac
            Transposable Element-Derived 1, Unique to Mammals, Controls
            Mammal-Specific Neuronal Paraspeckles.
REFERENCE   2  (residues 1 to 809)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   3  (residues 1 to 809)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 809)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 809)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 809)
  AUTHORS   Li,T., Li,Z., Chen,P., Zhao,Q., Wang,T., Huang,K., Li,J., Li,Y.,
            Liu,J., Zeng,Z., Feng,G., He,L. and Shi,Y.
  TITLE     Common variants in major histocompatibility complex region and TCF4
            gene are significantly associated with schizophrenia in Han Chinese
  JOURNAL   Biol Psychiatry 68 (7), 671-673 (2010)
   PUBMED   20673877
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 809)
  AUTHORS   Corneveaux,J.J., Myers,A.J., Allen,A.N., Pruzin,J.J., Ramirez,M.,
            Engel,A., Nalls,M.A., Chen,K., Lee,W., Chewning,K., Villa,S.E.,
            Meechoovet,H.B., Gerber,J.D., Frost,D., Benson,H.L., O'Reilly,S.,
            Chibnik,L.B., Shulman,J.M., Singleton,A.B., Craig,D.W., Van
            Keuren-Jensen,K.R., Dunckley,T., Bennett,D.A., De Jager,P.L.,
            Heward,C., Hardy,J., Reiman,E.M. and Huentelman,M.J.
  TITLE     Association of CR1, CLU and PICALM with Alzheimer's disease in a
            cohort of clinically characterized and neuropathologically verified
            individuals
  JOURNAL   Hum Mol Genet 19 (16), 3295-3301 (2010)
   PUBMED   20534741
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (residues 1 to 809)
  AUTHORS   Agapkina,Iu.V., Nikitin,A.G., Brovkin,A.N., Pushkov,A.A.,
            Evdokimova,M.A., Kudriashova,O.Iu., Osmolovskaia,V.S.,
            Minushkina,L.O., Kochkina,M.S., Selezneva,N.D., Dankovtseva,E.N.,
            Chumakova,O.S., Baklanova,T.N., Talyzin,P.A., Reznichenko,N.E.,
            Donetskaia,O.P., Tereshchenko,S.N., Krasil'nikova,E.S.,
            Dzhaiani,N.A., Akatova,E.V., Glezer,M.G., Galiavich,A.S.,
            Zakirova,V.B., Kaziolova,N.A., Timofeeva,I.V., Iagoda,A.V.,
            Boeva,O.I., Katel'nitskaia,L.I., Khorolets,E.V., Shlyk,S.V.,
            Volkova,E.G., Margarian,M.P., Guz',I.O., Konstantinov,V.O.,
            Timofeeva,A.N., Sidorenko,B.A., Zateishchikiov,D.A. and
            Nosikov,V.V.
  TITLE     [Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene
            PROC and genetic predisposition to unfavorable outcomes patients
            undergoing acute coronary syndrome]
  JOURNAL   Mol Biol (Mosk) 44 (4), 613-619 (2010)
   PUBMED   20873219
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (residues 1 to 809)
  AUTHORS   Schjeide,B.M., McQueen,M.B., Mullin,K., DiVito,J., Hogan,M.F.,
            Parkinson,M., Hooli,B., Lange,C., Blacker,D., Tanzi,R.E. and
            Bertram,L.
  TITLE     Assessment of Alzheimer's disease case-control associations using
            family-based methods
  JOURNAL   Neurogenetics 10 (1), 19-25 (2009)
   PUBMED   18830724
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (residues 1 to 809)
  AUTHORS   Sarkar,A., Sim,C., Hong,Y.S., Hogan,J.R., Fraser,M.J.,
            Robertson,H.M. and Collins,F.H.
  TITLE     Molecular evolutionary analysis of the widespread piggyBac
            transposon family and related 'domesticated' sequences
  JOURNAL   Mol Genet Genomics 270 (2), 173-180 (2003)
   PUBMED   12955498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AL021997.1.
            
            Summary: The piggyBac family of proteins, found in diverse animals,
            are transposases related to the transposase of the canonical
            piggyBac transposon from the moth, Trichoplusia ni. This family
            also includes genes in several genomes, including human, that
            appear to have been derived from the piggyBac transposons. This
            gene belongs to the subfamily of piggyBac transposable element
            derived (PGBD) genes. The PGBD proteins appear to be novel, with no
            obvious relationship to other transposases, or other known protein
            families. This gene product is specifically expressed in the brain,
            however, its exact function is not known. Alternative splicing
            results in multiple transcript variants encoding the same
            protein.[provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291228.1, BC128585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682144.1/ ENSP00000506997.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..809
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     Protein         1..809
                     /product="piggyBac transposable element-derived protein 1"
                     /note="cerebral protein 4"
                     /calculated_mol_wt=92384
     Region          40..142
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          170..199
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96JS3.1)"
     Region          271..297
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96JS3.1)"
     Site            360
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (Q96JS3.1)"
     Region          418..775
                     /region_name="DDE_Tnp_1_7"
                     /note="Transposase IS4; pfam13843"
                     /db_xref="CDD:433521"
     CDS             1..809
                     /gene="PGBD1"
                     /gene_synonym="dJ874C20.4; HUCEP-4; SCAND4"
                     /coded_by="NM_032507.4:386..2815"
                     /db_xref="CCDS:CCDS4648.1"
                     /db_xref="GeneID:84547"
                     /db_xref="HGNC:HGNC:19398"
ORIGIN      
        1 myealpgpap enedglvkvk eedptweqvc nsqegsshtq eicrlrfrhf cyqeahgpqe
       61 alaqlrelch qwlrpemhtk eqimellvle qfltilpkel qpcvktyple sgeeavtvle
      121 nletgsgdtg qqasvyiqgq dmhpmvaeyq gvslecqslq llpgittlkc eppqrpqgnp
      181 qevsgpvphg sahlqeknpr dkavvpvfnp vrsqtlvkte eetaqavaae kwshlsltrr
      241 nlcgnsaqet vmslspmtee ivtkdrlfka kqetseemeq sgeasgkpnr ecapqipcst
      301 piatertvah lntlkdrhpg dlwarmhiss leyaagditr kgrkkdkarv sellqglsfs
      361 gdsdvekdne peiqpaqkkl kvscfpeksw tkrdikpnfp swsaldsgll nlkseklnpv
      421 elfelffdde tfnlivnetn nyasqknvsl evtvqemrcv fgvlllsgfm rhprremywe
      481 vsdtdqnlvr dairrdrfel ifsnlhfadn ghldqkdkft klrplikqmn knfllyaple
      541 eyycfdksmc ecfdsdqfln gkpirigyki wcgtttqgyl vwfepyqees tmkvdedpdl
      601 glggnlvmnf advllergqy pyhlcfdsff tsvkllsalk kkgvratgti renrtekcpl
      661 mnvehmkkmk rgyfdfriee nneiilcrwy gdgiislcsn avgiepvnev sccdadneei
      721 pqisqpsivk vydeckegva kmdqiiskyr vrirskkwys ilvsymidva mnnawqlhra
      781 cnpgasldpl dfrrfvahfy lehnahlsd
//
