LOCUS       NM_001170543            2811 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens PGAM family member 5, mitochondrial serine/threonine
            protein phosphatase (PGAM5), transcript variant 1, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001170543
VERSION     NM_001170543.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2811)
  AUTHORS   Yan,S., Yu,L., Chen,Z., Xie,D., Huang,Z. and Ouyang,S.
  TITLE     ZBP1 promotes hepatocyte pyroptosis in acute liver injury by
            regulating the PGAM5/ROS pathway
  JOURNAL   Ann Hepatol 29 (4), 101475 (2024)
   PUBMED   38331384
  REMARK    GeneRIF: ZBP1 promotes hepatocyte pyroptosis in acute liver injury
            by regulating the PGAM5/ROS pathway.
REFERENCE   2  (bases 1 to 2811)
  AUTHORS   Chen,Y., Huang,J., Zhou,H., Lin,J. and Tao,J.
  TITLE     Pgam5 aggravates hyperglycemia-induced myocardial dysfunction
            through disrupting Phb2-dependent mitochondrial dynamics
  JOURNAL   Int J Med Sci 21 (7), 1194-1203 (2024)
   PUBMED   38818468
  REMARK    GeneRIF: Pgam5 aggravates hyperglycemia-induced myocardial
            dysfunction through disrupting Phb2-dependent mitochondrial
            dynamics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2811)
  AUTHORS   Liu,Y., Hao,R., Lv,J., Yuan,J., Wang,X., Xu,C., Ma,D., Duan,Z.,
            Zhang,B., Dai,L., Cheng,Y., Lu,W. and Zhang,X.
  TITLE     Targeted knockdown of PGAM5 in synovial macrophages efficiently
            alleviates osteoarthritis
  JOURNAL   Bone Res 12 (1), 15 (2024)
   PUBMED   38433252
  REMARK    GeneRIF: Targeted knockdown of PGAM5 in synovial macrophages
            efficiently alleviates osteoarthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2811)
  AUTHORS   Ma,C., Gao,Q., Zhang,L., Li,C., Wu,G. and Yang,L.
  TITLE     The Effect of PGAM5 on Regulating Mitochondrial Dysfunction in
            Ischemic Stroke
  JOURNAL   Discov Med 35 (179), 1123-1133 (2023)
   PUBMED   38058078
  REMARK    GeneRIF: The Effect of PGAM5 on Regulating Mitochondrial
            Dysfunction in Ischemic Stroke.
REFERENCE   5  (bases 1 to 2811)
  AUTHORS   Fu,G., Li,S.T., Jiang,Z., Mao,Q., Xiong,N., Li,X., Hao,Y. and
            Zhang,H.
  TITLE     PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism
            and liver cancer proliferation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (9), 1370-1379 (2023)
   PUBMED   37580952
  REMARK    GeneRIF: PGAM5 deacetylation mediated by SIRT2 facilitates lipid
            metabolism and liver cancer proliferation.
REFERENCE   6  (bases 1 to 2811)
  AUTHORS   Lo,S.C. and Hannink,M.
  TITLE     PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the
            redox-regulated Keap1-dependent ubiquitin ligase complex
  JOURNAL   J Biol Chem 281 (49), 37893-37903 (2006)
   PUBMED   17046835
  REMARK    GeneRIF: The N terminus of the PGAM5 protein contains a conserved
            NXESGE motif that binds to the substrate binding pocket in the
            Kelch domain of Keap1.
REFERENCE   7  (bases 1 to 2811)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 2811)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   9  (bases 1 to 2811)
  AUTHORS   Hammond,P.W., Alpin,J., Rise,C.E., Wright,M. and Kreider,B.L.
  TITLE     In vitro selection and characterization of Bcl-X(L)-binding
            proteins from a mix of tissue-specific mRNA display libraries
  JOURNAL   J Biol Chem 276 (24), 20898-20906 (2001)
   PUBMED   11283018
REFERENCE   10 (bases 1 to 2811)
  AUTHORS   Okubo,K., Yoshii,J., Yokouchi,H., Kameyama,M. and Matsubara,K.
  TITLE     An expression profile of active genes in human colonic mucosa
  JOURNAL   DNA Res 1 (1), 37-45 (1994)
   PUBMED   7584027
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135586.8, EU249757.1 and D25830.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001170543.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU249757.1, SRR1163655.242351.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000498926.7/
                                                  ENSP00000438465.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC135586.8         38079-38110         c
            33-1345             EU249757.1         56-1368
            1346-2771           AC135586.8         26258-27683         c
            2772-2811           D25830.1           27-66
FEATURES             Location/Qualifiers
     source          1..2811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..2811
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /note="PGAM family member 5, mitochondrial
                     serine/threonine protein phosphatase"
                     /db_xref="GeneID:192111"
                     /db_xref="HGNC:HGNC:28763"
                     /db_xref="MIM:614939"
     exon            1..226
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..905
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein phosphatase PGAM5, mitochondrial;
                     Bcl-XL-binding protein v68; phosphoglycerate mutase family
                     member 5; PGAM family member 5, serine/threonine protein
                     phosphatase, mitochondrial"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial isoform 1"
                     /protein_id="NP_001164014.1"
                     /db_xref="CCDS:CCDS53845.1"
                     /db_xref="GeneID:192111"
                     /db_xref="HGNC:HGNC:28763"
                     /db_xref="MIM:614939"
                     /translation="MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEP
                     PAWAGGARPGPGVWDPNWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFL
                     IRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDII
                     SRHLPGVCKVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADAR
                     QEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLG
                     DTGFMPPDKITRS"
     exon            227..405
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /inference="alignment:Splign:2.1.0"
     exon            406..531
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /inference="alignment:Splign:2.1.0"
     exon            532..620
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /inference="alignment:Splign:2.1.0"
     exon            621..754
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /inference="alignment:Splign:2.1.0"
     exon            755..2811
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /note="hexamer: ATTAAA"
     polyA_site      1393
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /note="major polyA site"
     regulatory      2786..2791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /note="hexamer: AATAAA"
     polyA_site      2811
                     /gene="PGAM5"
                     /gene_synonym="BXLBV68"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcctgc gcgggccggc gcgggagcaa gcggcatggc gttccggcag gcgctgcagc
       61 tggcggcctg cgggctggcc gggggctcgg ccgccgtgct cttctcggcc gtggcggtag
      121 ggaagccgcg cgcaggcggg gacgcggagc cacgcccggc tgagccgccg gcctgggcgg
      181 ggggcgcgcg gccgggcccc ggtgtctggg accccaactg ggacaggcga gaaccactgt
      241 ctctgatcaa cgtgcggaag aggaacgtgg aatctgggga agaagagctg gcgtccaagc
      301 tggaccacta caaagccaag gccacgcggc acatcttcct catcaggcat tcccagtacc
      361 acgtggatgg ctccctggag aaggaccgca ctctgacccc gctgggtcgg gagcaggctg
      421 aactcactgg gctccgcctg gcaagcttgg ggttgaagtt taataaaatc gtccattcgt
      481 ctatgacgcg cgccatagag accaccgata tcatcagccg gcacctgcca ggcgtctgca
      541 aagtcagcac agatctgctg cgggaaggcg cccccatcga gccagacccg cccgtgtctc
      601 attggaagcc ggaagctgtg cagtattacg aagacggagc ccggatcgag gccgccttcc
      661 ggaactacat ccaccgcgca gatgccaggc aggaggagga cagttacgag atcttcatct
      721 gtcacgccaa cgtcatccgc tacatcgtgt gcagagcact gcagtttcct cctgaaggct
      781 ggctccggct ctccctcaat aatggcagca tcacccacct ggtgatccga cccaacggcc
      841 gagttgcgct caggaccctc ggggacacgg ggttcatgcc tcccgacaag atcactcgat
      901 cctgagggct ccggcctctc cttccctctg tcctccctgc acaggccgca cacacttaac
      961 gttttgttcc caaggagacc ggcggaaagt agaaacctgc aatgctgcat ctgggaactg
     1021 acttgtgacc aggctgagaa ggggagagtt gggatcagac agcctgactt ctctgcaggg
     1081 ttttatacct gaccatgaac ccccaggatg gcgtggggtt taaggtgaaa gcgtctcacg
     1141 cacaagtcag gcctgttgtg gggacttgaa agaggcctga cccagaccac catgttcgca
     1201 cccacagctg acccgtgctg agggtccagg ctccattggc aaagccggtc aggcacgagg
     1261 gcgactgagg cacgtggatg aggagggcac ccaggttctg ttcacaactc acttcacttc
     1321 atacatcctt ttaatttctt aaaaccctct tgtcccttaa atatttgtca attaaagatt
     1381 ttctggctgg gcacagtggc tcacacctgt attcccagct actcaggagg ccagggtggg
     1441 aggatcactt gagctcagga gttcaagacc agcctggaca aggcaacata gcgagaccct
     1501 gtctctacta aaaatacaga acttagctgg gtgtgtcgtg ggcatctaga gtcccagcta
     1561 cttgggaggc tgaggtgggt ggatcacttg ggcccgggag ctggaggctg cagtgagctg
     1621 tgattgtgtc actgcactcc agcctgggca agcgagggag acttaaagca attttttctt
     1681 ttgaaacgga gtttcactct tgttgcccag gctggagtgc agtggtgcga tctcggctca
     1741 ccgcaacctc tgcctcctgg gttcaagtga ttctcctgcc tcagctcccg agtagctggg
     1801 attacagtcg cccaccacca tacctggcta attttttgta tttttagtaa agacagggtt
     1861 tcatggagaa accaatatag aattgttcag gctggtctcg aactcccaac ctcaggtgat
     1921 tcacccacct tggcctccca aagtgctggg attaaaggtg tgagccatcg tgcctggcct
     1981 aaaaaatttt tttttcttca tctgggtttt tgctttgaaa acaagtttct ccaaatttac
     2041 agatttcctg atgatgttgg gtctgaactc accaacttga ttaggtcttt aggggccgag
     2101 ggactagcca gctgcacagg tgactggatg ggggaggggc aggtgaggtg ggtctacaga
     2161 ggtggcttcg cctttgacct tcatgctggt ctcggctgag gtgacacgct agtgacagcc
     2221 caataggggg ttacccttat tgagtaaaat acttcagatt gacagctcaa tcttagtttg
     2281 cctccagtta atcttttatg cttagggatt aaatgtgtgg tttttttttt gttttttttt
     2341 ttttggagac ggagtctcgc tctgtcaccc aggctggagt gcagtggcgc gatctcggct
     2401 cactgcaacc tctgcctcct gggttcaaac gattctcctg cctcagcctc ccaagtagct
     2461 gggattatag gcgcccacca ccatgcctgg ctaatttttt atttttagta gagatggggt
     2521 ttcaccgtgt tggccaggct ggtctcgaac tcctgacctc gtgatctacc cacctcggcc
     2581 tccccaagtg ctgggattac aggcgtgagc tagcatgcct ggccagggat taaaatattc
     2641 aaacatgttg tgtgtaccca gatatgctgt taatttagga aaaacagtac aatttctatg
     2701 aagtggttgt gactattttc tgtagtcaat acagttggga tatctgatct atttctctgt
     2761 ctactttgga aatgattgca taataaataa aattttactg tttttttaaa a
//
