LOCUS       NM_002629               1802 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens phosphoglycerate mutase 1 (PGAM1), transcript variant
            1, mRNA.
ACCESSION   NM_002629 XM_012219
VERSION     NM_002629.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Zhang,D., Wang,M., Ma,S., Liu,M., Yu,W., Zhang,X., Liu,T., Liu,S.,
            Ren,X. and Sun,Q.
  TITLE     Phosphoglycerate mutase 1 promotes breast cancer progression
            through inducing immunosuppressive M2 macrophages
  JOURNAL   Cancer Gene Ther 31 (7), 1018-1033 (2024)
   PUBMED   38750301
  REMARK    GeneRIF: Phosphoglycerate mutase 1 promotes breast cancer
            progression through inducing immunosuppressive M2 macrophages.
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Qiu,Z., Wang,C., Huang,P., Yuan,Y., Shi,Y., Lin,Z., Huang,Z.,
            Zuo,D., Qiu,J., He,W., Shen,J., Niu,Y., Yuan,Y. and Li,B.
  TITLE     RFX6 facilitates aerobic glycolysis-mediated growth and metastasis
            of hepatocellular carcinoma through targeting PGAM1
  JOURNAL   Clin Transl Med 13 (12), e1511 (2023)
   PUBMED   38093528
  REMARK    GeneRIF: RFX6 facilitates aerobic glycolysis-mediated growth and
            metastasis of hepatocellular carcinoma through targeting PGAM1.
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   Zheng,Y., Wang,Y., Lu,Z., Wan,J., Jiang,L., Song,D., Wei,C.,
            Gao,C., Shi,G., Zhou,J., Fan,J., Ke,A., Zhou,L. and Cai,J.
  TITLE     PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with
            Anti-PD-1 Immunotherapy
  JOURNAL   Adv Sci (Weinh) 10 (29), e2301928 (2023)
   PUBMED   37705495
  REMARK    GeneRIF: PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes
            with Anti-PD-1 Immunotherapy.
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Luo,J.Q., Yang,T.W., Wu,J., Lai,H.H., Zou,L.B., Chen,W.B.,
            Zhou,X.M., Lv,D.J., Cen,S.R., Long,Z.N., Mao,Y.Y., Zheng,P.X.,
            Su,X.H., Xian,Z.Y., Shu,F.P. and Mao,X.M.
  TITLE     Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis
            by interacting with ACTG1
  JOURNAL   Cell Death Dis 14 (8), 502 (2023)
   PUBMED   37542027
  REMARK    GeneRIF: Exosomal PGAM1 promotes prostate cancer angiogenesis and
            metastasis by interacting with ACTG1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1802)
  AUTHORS   Weng,Y., Duan,W., Yu,X., Wu,F., Yang,D., Jiang,Y., Wu,J., Wang,M.,
            Wang,X., Shen,Y., Zhang,Y. and Xu,H.
  TITLE     MicroRNA-324-3p inhibits osteosarcoma progression by suppressing
            PGAM1-mediated aerobic glycolysis
  JOURNAL   Cancer Sci 114 (6), 2345-2359 (2023)
   PUBMED   36880587
  REMARK    GeneRIF: MicroRNA-324-3p inhibits osteosarcoma progression by
            suppressing PGAM1-mediated aerobic glycolysis.
REFERENCE   6  (bases 1 to 1802)
  AUTHORS   Blouquit,Y., Calvin,M.C., Rosa,R., Prome,D., Prome,J.C.,
            Pratbernou,F., Cohen-Solal,M. and Rosa,J.
  TITLE     Sequence of the human erythrocyte phosphoglycerate mutase by
            microsequencer and mass spectrometry
  JOURNAL   J Biol Chem 263 (32), 16906-16910 (1988)
   PUBMED   2846554
REFERENCE   7  (bases 1 to 1802)
  AUTHORS   Sakoda,S., Shanske,S., DiMauro,S. and Schon,E.A.
  TITLE     Isolation of a cDNA encoding the B isozyme of human
            phosphoglycerate mutase (PGAM) and characterization of the PGAM
            gene family
  JOURNAL   J Biol Chem 263 (32), 16899-16905 (1988)
   PUBMED   2846553
REFERENCE   8  (bases 1 to 1802)
  AUTHORS   Shanske,S., Sakoda,S., Hermodson,M.A., DiMauro,S. and Schon,E.A.
  TITLE     Isolation of a cDNA encoding the muscle-specific subunit of human
            phosphoglycerate mutase
  JOURNAL   J Biol Chem 262 (30), 14612-14617 (1987)
   PUBMED   2822696
REFERENCE   9  (bases 1 to 1802)
  AUTHORS   Omenn,G.S. and Cheung,S.C.
  TITLE     Phosphoglycerate mutase isozyme marker for tissue differentiation
            in man
  JOURNAL   Am J Hum Genet 26 (3), 393-399 (1974)
   PUBMED   4827367
REFERENCE   10 (bases 1 to 1802)
  AUTHORS   Chen,S.H., Anderson,J., Giblett,E.R. and Lewis,M.
  TITLE     Phosphoglyceric acid mutase: rare genetic variants and tissue
            distribution
  JOURNAL   Am J Hum Genet 26 (1), 73-77 (1974)
   PUBMED   4811757
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA270129.1, AK292216.1 and
            CA307301.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002629.3.
            
            Summary: The protein encoded by this gene is a mutase that
            catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to
            2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.137605.1,
                                           SRR3476690.775878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334828.6/ ENSP00000359991.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA270129.1         67-99
            34-1508             AK292216.1         1-1475
            1509-1802           CA307301.1         19-312              c
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..1802
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /note="phosphoglycerate mutase 1"
                     /db_xref="GeneID:5223"
                     /db_xref="HGNC:HGNC:8888"
                     /db_xref="MIM:172250"
     exon            1..256
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..882
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /EC_number="5.4.2.4"
                     /EC_number="5.4.2.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BPG-dependent PGAM 1; phosphoglycerate mutase A, nonmuscle
                     form; phosphoglycerate mutase isozyme B; epididymis
                     secretory protein Li 35; phosphoglycerate mutase 1
                     (brain)"
                     /codon_start=1
                     /product="phosphoglycerate mutase 1 isoform 1"
                     /protein_id="NP_002620.1"
                     /db_xref="CCDS:CCDS7458.1"
                     /db_xref="GeneID:5223"
                     /db_xref="HGNC:HGNC:8888"
                     /db_xref="MIM:172250"
                     /translation="MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQA
                     LRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAE
                     TAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTI
                     ARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVY
                     ELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK"
     exon            257..531
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            532..712
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1802
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1445..1450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /note="hexamer: ATTAAA"
     polyA_site      1475
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /note="major polyA site"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /note="hexamer: AATAAA"
     polyA_site      1802
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
ORIGIN      
        1 gagaacttgc gcgggagccg gactgagcgg tgcgagcgcg caggcgcggc cgacggggcg
       61 ggctgctact ccggaatctg ctaatcccag tcggtgccgc atccccagcc cgccgccatg
      121 gccgcctaca aactggtgct gatccggcac ggcgagagcg catggaacct ggagaaccgc
      181 ttcagcggct ggtacgacgc cgacctgagc ccggcgggcc acgaggaggc gaagcgcggc
      241 gggcaggcgc tacgagatgc tggctatgag tttgacatct gcttcacctc agtgcagaag
      301 agagcgatcc ggaccctctg gacagtgcta gatgccattg atcagatgtg gctgccagtg
      361 gtgaggactt ggcgcctcaa tgagcggcac tatgggggtc taaccggtct caataaagca
      421 gaaactgctg caaagcatgg tgaggcccag gtgaagatct ggaggcgctc ctatgatgtc
      481 ccaccacctc cgatggagcc cgaccatcct ttctacagca acatcagtaa ggatcgcagg
      541 tatgcagacc tcacagaaga tcagctaccc tcctgtgaga gtctgaagga tactattgcc
      601 agagctctgc ccttctggaa tgaagaaata gttccccaga tcaaggaggg gaaacgtgta
      661 ctgattgcag cccatggcaa cagcctccgg ggcattgtca agcatctgga gggtctctct
      721 gaagaggcta tcatggagct gaacctgccg actggtattc ccattgtcta tgaattggac
      781 aagaacttga agcctatcaa gcccatgcag tttctggggg atgaagagac ggtgcgcaaa
      841 gccatggaag ctgtggctgc ccagggcaag gccaagaagt gaaggccggc ggggaggata
      901 ctgtccccag gagcaccctc cctgcccgtc ttgtccctct gcccctccca cctgcacatg
      961 tcacactgac cacatctgta gacatcttga gttgtagctg cagacgggga ccagtggctc
     1021 ccattttcat tttagccatt ttgtcgcctg cacccactcc cttcatacaa tctagtcaga
     1081 atagcagttc tagagcacag gttctcagtc taagctatgg aaaagctccc cttatccaac
     1141 agagtttaaa agtagtgact tgggtttttg cgagtgcttt gtttactaag gactttgggg
     1201 aggaaccatg ctaagccatg accagtgagg agaagcaaca gagcctgtct gtccccatga
     1261 gcggagtctg tcctctgctc ttctgcagtc aggtcactgc ctactgcctg ggggctctag
     1321 tcattccagt ggaagacgaa tgtaacctgc gtggtgatgt gacaactgtt tcctccctga
     1381 ccccagagga tctggctcta ggttgggatc aatcctgaat ttcgttatgt gttaatttac
     1441 ttttattaaa aaagtatagt atatataata caaaacaata acccttctgg ggtttcttgt
     1501 ggcggttgaa atagtcccac atgtggtcat cagaaaataa gccattcctc ataccaatat
     1561 aggatcagct ccttgacctc tgaggggcag gagtgcttcc tggtgtgtgt attagaatcc
     1621 cttcctgcct tgtttcatgg cagtgaaatg cctcttggtc ctgtccaagt gtatctttca
     1681 ctgatttctg aatcatgttc tagttgcttg accctgccac atgggtccag tgttcatctg
     1741 agcataactg tactaaatcc tttttccata tcagtataat aaaggagtga tgtgcaatag
     1801 ct
//
