LOCUS       NP_002620                254 aa            linear   PRI 28-APR-2025
DEFINITION  phosphoglycerate mutase 1 isoform 1 [Homo sapiens].
ACCESSION   NP_002620 XP_012219
VERSION     NP_002620.1
DBSOURCE    REFSEQ: accession NM_002629.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 254)
  AUTHORS   Zhang,D., Wang,M., Ma,S., Liu,M., Yu,W., Zhang,X., Liu,T., Liu,S.,
            Ren,X. and Sun,Q.
  TITLE     Phosphoglycerate mutase 1 promotes breast cancer progression
            through inducing immunosuppressive M2 macrophages
  JOURNAL   Cancer Gene Ther 31 (7), 1018-1033 (2024)
   PUBMED   38750301
  REMARK    GeneRIF: Phosphoglycerate mutase 1 promotes breast cancer
            progression through inducing immunosuppressive M2 macrophages.
REFERENCE   2  (residues 1 to 254)
  AUTHORS   Qiu,Z., Wang,C., Huang,P., Yuan,Y., Shi,Y., Lin,Z., Huang,Z.,
            Zuo,D., Qiu,J., He,W., Shen,J., Niu,Y., Yuan,Y. and Li,B.
  TITLE     RFX6 facilitates aerobic glycolysis-mediated growth and metastasis
            of hepatocellular carcinoma through targeting PGAM1
  JOURNAL   Clin Transl Med 13 (12), e1511 (2023)
   PUBMED   38093528
  REMARK    GeneRIF: RFX6 facilitates aerobic glycolysis-mediated growth and
            metastasis of hepatocellular carcinoma through targeting PGAM1.
REFERENCE   3  (residues 1 to 254)
  AUTHORS   Zheng,Y., Wang,Y., Lu,Z., Wan,J., Jiang,L., Song,D., Wei,C.,
            Gao,C., Shi,G., Zhou,J., Fan,J., Ke,A., Zhou,L. and Cai,J.
  TITLE     PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with
            Anti-PD-1 Immunotherapy
  JOURNAL   Adv Sci (Weinh) 10 (29), e2301928 (2023)
   PUBMED   37705495
  REMARK    GeneRIF: PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes
            with Anti-PD-1 Immunotherapy.
REFERENCE   4  (residues 1 to 254)
  AUTHORS   Luo,J.Q., Yang,T.W., Wu,J., Lai,H.H., Zou,L.B., Chen,W.B.,
            Zhou,X.M., Lv,D.J., Cen,S.R., Long,Z.N., Mao,Y.Y., Zheng,P.X.,
            Su,X.H., Xian,Z.Y., Shu,F.P. and Mao,X.M.
  TITLE     Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis
            by interacting with ACTG1
  JOURNAL   Cell Death Dis 14 (8), 502 (2023)
   PUBMED   37542027
  REMARK    GeneRIF: Exosomal PGAM1 promotes prostate cancer angiogenesis and
            metastasis by interacting with ACTG1.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 254)
  AUTHORS   Weng,Y., Duan,W., Yu,X., Wu,F., Yang,D., Jiang,Y., Wu,J., Wang,M.,
            Wang,X., Shen,Y., Zhang,Y. and Xu,H.
  TITLE     MicroRNA-324-3p inhibits osteosarcoma progression by suppressing
            PGAM1-mediated aerobic glycolysis
  JOURNAL   Cancer Sci 114 (6), 2345-2359 (2023)
   PUBMED   36880587
  REMARK    GeneRIF: MicroRNA-324-3p inhibits osteosarcoma progression by
            suppressing PGAM1-mediated aerobic glycolysis.
REFERENCE   6  (residues 1 to 254)
  AUTHORS   Blouquit,Y., Calvin,M.C., Rosa,R., Prome,D., Prome,J.C.,
            Pratbernou,F., Cohen-Solal,M. and Rosa,J.
  TITLE     Sequence of the human erythrocyte phosphoglycerate mutase by
            microsequencer and mass spectrometry
  JOURNAL   J Biol Chem 263 (32), 16906-16910 (1988)
   PUBMED   2846554
REFERENCE   7  (residues 1 to 254)
  AUTHORS   Sakoda,S., Shanske,S., DiMauro,S. and Schon,E.A.
  TITLE     Isolation of a cDNA encoding the B isozyme of human
            phosphoglycerate mutase (PGAM) and characterization of the PGAM
            gene family
  JOURNAL   J Biol Chem 263 (32), 16899-16905 (1988)
   PUBMED   2846553
REFERENCE   8  (residues 1 to 254)
  AUTHORS   Shanske,S., Sakoda,S., Hermodson,M.A., DiMauro,S. and Schon,E.A.
  TITLE     Isolation of a cDNA encoding the muscle-specific subunit of human
            phosphoglycerate mutase
  JOURNAL   J Biol Chem 262 (30), 14612-14617 (1987)
   PUBMED   2822696
REFERENCE   9  (residues 1 to 254)
  AUTHORS   Omenn,G.S. and Cheung,S.C.
  TITLE     Phosphoglycerate mutase isozyme marker for tissue differentiation
            in man
  JOURNAL   Am J Hum Genet 26 (3), 393-399 (1974)
   PUBMED   4827367
REFERENCE   10 (residues 1 to 254)
  AUTHORS   Chen,S.H., Anderson,J., Giblett,E.R. and Lewis,M.
  TITLE     Phosphoglyceric acid mutase: rare genetic variants and tissue
            distribution
  JOURNAL   Am J Hum Genet 26 (1), 73-77 (1974)
   PUBMED   4811757
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA270129.1, AK292216.1 and
            CA307301.1.
            
            On Jan 18, 2005 this sequence version replaced XP_012219.4.
            
            Summary: The protein encoded by this gene is a mutase that
            catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to
            2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.137605.1,
                                           SRR3476690.775878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334828.6/ ENSP00000359991.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     Protein         1..254
                     /product="phosphoglycerate mutase 1 isoform 1"
                     /EC_number="5.4.2.4"
                     /EC_number="5.4.2.11"
                     /note="BPG-dependent PGAM 1; phosphoglycerate mutase A,
                     nonmuscle form; phosphoglycerate mutase isozyme B;
                     epididymis secretory protein Li 35; phosphoglycerate
                     mutase 1 (brain)"
                     /calculated_mol_wt=28673
     Region          4..253
                     /region_name="gpmA"
                     /note="2,3-diphosphoglycerate-dependent phosphoglycerate
                     mutase; PRK14115"
                     /db_xref="CDD:184516"
     Site            order(10..11,62,186..187)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (P18669.2)"
     Site            23
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:23653202; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            31
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            106
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9DBJ1; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9DBJ1; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            186
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P00950; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            251
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:22157007; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            253
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:22157007; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     Site            254
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:22157007; propagated from
                     UniProtKB/Swiss-Prot (P18669.2)"
     CDS             1..254
                     /gene="PGAM1"
                     /gene_synonym="HEL-S-35; PGAM-B; PGAMA"
                     /coded_by="NM_002629.4:118..882"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS7458.1"
                     /db_xref="GeneID:5223"
                     /db_xref="HGNC:HGNC:8888"
                     /db_xref="MIM:172250"
ORIGIN      
        1 maayklvlir hgesawnlen rfsgwydadl spagheeakr ggqalrdagy efdicftsvq
       61 krairtlwtv ldaidqmwlp vvrtwrlner hyggltglnk aetaakhgea qvkiwrrsyd
      121 vppppmepdh pfysniskdr ryadltedql psceslkdti aralpfwnee ivpqikegkr
      181 vliaahgnsl rgivkhlegl seeaimelnl ptgipivyel dknlkpikpm qflgdeetvr
      241 kameavaaqg kakk
//
