LOCUS       NM_001079807            1613 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens pepsinogen A3 (PGA3), mRNA.
ACCESSION   NM_001079807 XM_001129376 XM_001129398 XM_927605
VERSION     NM_001079807.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1613)
  AUTHORS   Li,M., Zheng,G., Yu,L., Tan,L.L., Li,X., Li,M.J., Li,C., Li,S.,
            Liang,J., Zhong,Z. and Li,Z.M.
  TITLE     Diagnostic value of MRI-DWI signal intensity value combined with
            serum PGI, PGII and CA199 in early gastric cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (2), 95-100 (2021)
   PUBMED   34817333
  REMARK    GeneRIF: Diagnostic value of MRI-DWI signal intensity value
            combined with serum PGI, PGII and CA199 in early gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1613)
  AUTHORS   Dong,Z., Zhang,X., Chen,X. and Zhang,J.
  TITLE     Significance of Serological Gastric Biopsy in Different Gastric
            Mucosal Lesions: an Observational Study
  JOURNAL   Clin Lab 65 (12) (2019)
   PUBMED   31414587
  REMARK    GeneRIF: Serum pepsinogen (PG), gastrin, and Helicobacter pylori
            (H. pylori) IgG antibodies have become indicators for 'serological
            biopsy' of the gastric mucosa lesion.
REFERENCE   3  (bases 1 to 1613)
  AUTHORS   Terasawa,T., Nishida,H., Kato,K., Miyashiro,I., Yoshikawa,T.,
            Takaku,R. and Hamashima,C.
  TITLE     Prediction of gastric cancer development by serum pepsinogen test
            and Helicobacter pylori seropositivity in Eastern Asians: a
            systematic review and meta-analysis
  JOURNAL   PLoS One 9 (10), e109783 (2014)
   PUBMED   25314140
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1613)
  AUTHORS   Mansour-Ghanaei,F., Joukar,F., Rajpout,Y. and Hasandokht,T.
  TITLE     Screening of precancerous gastric lesions by serum pepsinogen,
            gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in
            dyspeptic patients over 50 years old in Guilan Province, north of
            Iran
  JOURNAL   Asian Pac J Cancer Prev 15 (18), 7635-7638 (2014)
   PUBMED   25292040
  REMARK    GeneRIF: Low Pepsinogen I is associated with precancerous gastric
            lesions.
REFERENCE   5  (bases 1 to 1613)
  AUTHORS   Kageyama,T.
  TITLE     Pepsinogens, progastricsins, and prochymosins: structure, function,
            evolution, and development
  JOURNAL   Cell Mol Life Sci 59 (2), 288-306 (2002)
   PUBMED   11915945
  REMARK    Review article
REFERENCE   6  (bases 1 to 1613)
  AUTHORS   Takahashi,K.
  TITLE     Gene structures of pepsinogens A and C
  JOURNAL   Scand J Clin Lab Invest Suppl 210, 97-110 (1992)
   PUBMED   1455184
  REMARK    Review article
REFERENCE   7  (bases 1 to 1613)
  AUTHORS   ten Dam,M.A., van Kamp,G.J., Kok,A., Meuwissen,S.G., Donker,A.J.
            and ten Kate,R.W.
  TITLE     The effect of acute and chronic protein loading on urinary
            pepsinogen A excretion
  JOURNAL   Nephron 59 (2), 239-243 (1991)
   PUBMED   1956484
REFERENCE   8  (bases 1 to 1613)
  AUTHORS   Meijerink,P.H., Bebelman,J.P., Pals,G., Arwert,F., Planta,R.J.,
            Eriksson,A.W. and Mager,W.H.
  TITLE     Analysis of the promoter of a human pepsinogen A gene
  JOURNAL   Adv Exp Med Biol 306, 87-90 (1991)
   PUBMED   1812762
REFERENCE   9  (bases 1 to 1613)
  AUTHORS   Boudi,F.H., Lothe,R.A. and Taggart,R.T.
  TITLE     Human pepsinogen A (PGA): an informative gene complex located at
            11q13
  JOURNAL   Hum Genet 84 (3), 293-295 (1990)
   PUBMED   1968039
REFERENCE   10 (bases 1 to 1613)
  AUTHORS   Sogawa,K., Fujii-Kuriyama,Y., Mizukami,Y., Ichihara,Y. and
            Takahashi,K.
  TITLE     Primary structure of human pepsinogen gene
  JOURNAL   J Biol Chem 258 (8), 5306-5311 (1983)
   PUBMED   6300126
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312941.1, AP000437.5 and
            AK225679.1.
            
            On May 17, 2019 this sequence version replaced NM_001079807.3.
            
            Summary: This gene encodes a protein precursor of the digestive
            enzyme pepsin, a member of the peptidase A1 family of
            endopeptidases. The encoded precursor is secreted by gastric chief
            cells and undergoes autocatalytic cleavage in acidic conditions to
            form the active enzyme, which functions in the digestion of dietary
            proteins. This gene is found in a cluster of related genes on
            chromosome 11, each of which encodes one of multiple pepsinogens.
            Pepsinogen levels in serum may serve as a biomarker for atrophic
            gastritis and gastric cancer. [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225679.1, AK225669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325558.11/ ENSP00000322192.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AK312941.1         3-321
            320-324             AP000437.5         129613-129617
            325-1207            AK312941.1         327-1209
            1208-1384           AK225679.1         1208-1384
            1385-1613           AP000437.5         135923-136151
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..1613
                     /gene="PGA3"
                     /note="pepsinogen A3"
                     /db_xref="GeneID:643834"
                     /db_xref="HGNC:HGNC:8885"
                     /db_xref="MIM:169710"
     exon            1..106
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1217
                     /gene="PGA3"
                     /EC_number="3.4.23.1"
                     /note="pepsinogen-3; pepsin A-3; pepsinogen 3, group I
                     (pepsinogen A)"
                     /codon_start=1
                     /product="pepsin A-3 preproprotein"
                     /protein_id="NP_001073275.1"
                     /db_xref="CCDS:CCDS31574.1"
                     /db_xref="GeneID:643834"
                     /db_xref="HGNC:HGNC:8885"
                     /db_xref="MIM:169710"
                     /translation="MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKK
                     HNLNPARKYFPQWKAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWV
                     PSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTN
                     QIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLS
                     ADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIV
                     DTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPS
                     AYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA"
     exon            107..269
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            270..387
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..506
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            507..706
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..823
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..968
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1067
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1613
                     /gene="PGA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PGA3"
                     /note="hexamer: AATAAA"
     polyA_site      1380
                     /gene="PGA3"
                     /note="major polyA site"
ORIGIN      
        1 accttcctcc cgtcttgcct tctccctcga gttgggaccc gggaagaacc atgaagtggc
       61 tgctgctgct gggtctggtg gcactctctg agtgcatcat gtacaaggtc cccctcatca
      121 gaaagaagtc cttgaggcgc accctgtccg agcgtggcct gctgaaggac ttcctgaaga
      181 agcacaacct caacccagcc agaaagtact tcccccagtg gaaggctccc accctggtag
      241 atgaacagcc cctggagaac tacctggata tggagtactt cggcactatc ggcatcggaa
      301 ctcctgccca ggatttcacc gtcgtctttg acaccggctc ctccaacctg tgggtgccct
      361 cagtctactg ctccagtctt gcctgcacca accacaaccg cttcaaccct gaggattctt
      421 ccacctacca gtccaccagc gagacagtct ccatcaccta cggcaccggc agcatgacag
      481 gcatcctcgg atacgacact gtccaggttg gaggcatctc tgacaccaat cagatcttcg
      541 gcctgagcga gacggaacct ggctccttcc tgtattatgc tcccttcgat ggcatcctgg
      601 ggctggccta ccccagcatt tcctcctccg gggccacacc cgtctttgac aacatctgga
      661 accagggcct ggtttctcag gacctcttct ctgtctacct cagcgccgat gaccagagtg
      721 gcagcgtggt gatctttggt ggcattgact cttcttacta cactggaagt ctgaactggg
      781 tgcctgttac cgtcgagggt tactggcaga tcaccgtgga cagcatcacc atgaacggag
      841 aggccatcgc ctgcgctgag ggctgccagg ccattgttga caccggcacc tctctgctga
      901 ccggcccaac cagccccatt gccaacatcc agagcgacat cggagccagc gagaactcag
      961 atggcgacat ggtggtcagc tgctcagcca tcagcagcct gcccgacatc gtcttcacca
     1021 tcaatggagt ccagtacccc gtgccaccca gtgcctacat cctgcagagc gaggggagct
     1081 gcatcagtgg cttccagggc atgaacctcc ccaccgaatc tggagagctt tggatcctgg
     1141 gtgatgtctt catccgccag tactttaccg tcttcgacag ggcaaacaac caggtcggcc
     1201 tggcccccgt ggcttaagcc taagtctctt cagccacctc ccaggaagat ctggcctctg
     1261 tcctgtgccc actttagatg tatctaattc tcctgactgt tcttcccagg ggagtgtgga
     1321 ggtcttggcc ctgttccctg tcctaccaat aacgtagaat aaaaacataa cccactgaaa
     1381 caggttttgt ggagctgctt ctctttgctg gtctttttcc ttcacattac tggggttaga
     1441 acaccagggc agggatgaaa atgaccacat ccatttggat ggcacccaac atagtgaccc
     1501 cagcagctga cacttcatga tggagccaag aagacagaga ggcttcgggg gttgtgctgg
     1561 aagcatcata aaaagacctg ggggtcaaaa tactgggcta attgtcttct cat
//
