LOCUS       NM_199346               1393 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens profilin family member 4 (PFN4), mRNA.
ACCESSION   NM_199346 XM_351423
VERSION     NM_199346.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Pandey,D.K. and Chaudhary,B.
  TITLE     Evolutionary expansion and structural functionalism of the ancient
            family of profilin proteins
  JOURNAL   Gene 626, 70-86 (2017)
   PUBMED   28501628
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Behnen,M., Murk,K., Kursula,P., Cappallo-Obermann,H., Rothkegel,M.,
            Kierszenbaum,A.L. and Kirchhoff,C.
  TITLE     Testis-expressed profilins 3 and 4 show distinct functional
            characteristics and localize in the acroplaxome-manchette complex
            in spermatids
  JOURNAL   BMC Cell Biol 10, 34 (2009)
   PUBMED   19419568
  REMARK    GeneRIF: Porfilin 4 bound to selected phosphoinositides but not to
            poly-L-proline, proline-rich proteins, or actin.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292601.1 and AC008073.4.
            
            On May 17, 2019 this sequence version replaced NM_199346.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292601.1, SRR5189667.139031.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313213.5/ ENSP00000322170.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1144              AK292601.1         144-1287
            1145-1145           AC008073.4         67138-67138         c
            1146-1393           AK292601.1         1289-1536
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1393
                     /gene="PFN4"
                     /note="profilin family member 4"
                     /db_xref="GeneID:375189"
                     /db_xref="HGNC:HGNC:31103"
                     /db_xref="MIM:620046"
     exon            1..217
                     /gene="PFN4"
                     /inference="alignment:Splign:2.1.0"
     exon            218..346
                     /gene="PFN4"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..619
                     /gene="PFN4"
                     /note="profilin IV"
                     /codon_start=1
                     /product="profilin-4"
                     /protein_id="NP_955378.1"
                     /db_xref="CCDS:CCDS1709.1"
                     /db_xref="GeneID:375189"
                     /db_xref="HGNC:HGNC:31103"
                     /db_xref="MIM:620046"
                     /translation="MSHLQSLLLDTLLGTKHVDSAALIKIQERSLCVASPGFNVTPSD
                     VRTLVNGFAKNPLQARREGLYFKGKDYRCVRADEYSLYAKNENTGVVVVKTHLYLLVA
                     TYTEGMYPSICVEATESLGDYLRKKGS"
     exon            347..484
                     /gene="PFN4"
                     /inference="alignment:Splign:2.1.0"
     exon            485..590
                     /gene="PFN4"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1393
                     /gene="PFN4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      721..726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFN4"
                     /note="hexamer: ACTAAA"
     polyA_site      739
                     /gene="PFN4"
                     /note="major polyA site"
     regulatory      811..816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFN4"
                     /note="hexamer: AATAAG"
     polyA_site      836
                     /gene="PFN4"
                     /note="major polyA site"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFN4"
                     /note="hexamer: AATACA"
     polyA_site      1120
                     /gene="PFN4"
                     /note="major polyA site"
     polyA_site      1292
                     /gene="PFN4"
ORIGIN      
        1 aatcctgccg ccgccaccca cccgcaaccg cgtccgttga cggtcgggtc cttggtcgcc
       61 gggtccttgc gggcaccaca gagcggggtg gcgtccgctc cctcgagtcc tcggtgccag
      121 ggaattcacc gctcaccacc ccctgccccg ccttgggtcc tgctcgggga ccaaaccact
      181 ggaaggcagt ggcgggaaac gggcgcctgt gccggagagt tgagggaaca tgagccattt
      241 gcagagctta ttgttagaca ccctcttggg aaccaagcat gtggacagtg cagccctcat
      301 caaaatccag gagcggagct tgtgtgtagc atcaccaggt ttcaatgtaa cgcccagtga
      361 tgtccgaaca ctggtgaatg gatttgccaa gaaccctttg caagcccgaa gagaaggact
      421 gtatttcaag ggaaaagatt acagatgtgt ccgggcagat gaatattctc tttatgccaa
      481 aaatgagaac actggtgtgg ttgtcgtgaa gacccatctg tatcttctgg tagcaactta
      541 cactgagggc atgtatccta gcatctgtgt ggaagccaca gagagcctgg gagactacct
      601 aagaaaaaaa ggaagttaag tcatcagagg cccatgaaag acaattttat tattttagaa
      661 gaaaattgaa gagcctaaag aaaaaatatt ttatggttga aaaaacacta gacagaaggc
      721 actaaaaaag aagaatgaat taagggagca atttttatta cttccagaga tcctcttctt
      781 tcactggaat tacttgatca actgtttttt aataagtgtt ggtcatcggc atggaatgag
      841 agagcactga tcatttcaca gagcatatct attgggaggc tcctttctgt gaggctcttg
      901 tactcctaca caccttgcta agtatgccaa gaatgcaagg ctctcaccac tctttatcca
      961 agacatttct cagggttagg ttgcagcaag caaccttgaa aaatgaaggg atgtctccca
     1021 tcaggacaga gagcaagctt gcttactgtt tgctataaaa gcagtggagt ccctgagctc
     1081 agtgttaccc ctcctgtaat acaactccct gcatgtgtga catctgtctg gctcacatca
     1141 ccccggtgag acttgggaga agggattgca aaggccattc aacaatggac cactagtcaa
     1201 ggtattcaat ggacatttca cactcccatt tgcaggtatc tggtatcatt ttgaacattg
     1261 gaaaggcctt ctcaaaaatc aactcaaaaa gatttctgac tctaacccta actctcactg
     1321 cacaccttag taaggcagta tggtcactaa atgcaccctt ccccagaaag agttcatctc
     1381 ctcttggtct cct
//
