LOCUS       NM_001029886             553 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens profilin 3 (PFN3), mRNA.
ACCESSION   NM_001029886 XM_293821
VERSION     NM_001029886.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 553)
  AUTHORS   Gul,S.I., Ayoub,A., Ali,S.A., Hanook,S. and Baig,D.N.
  TITLE     Profilin 3 genetic architecture in glioma formalin fixed paraffin
            embedded (FFPE) archive
  JOURNAL   Gene 787, 145614 (2021)
   PUBMED   33775850
  REMARK    GeneRIF: Profilin 3 genetic architecture in glioma formalin fixed
            paraffin embedded (FFPE) archive.
REFERENCE   2  (bases 1 to 553)
  AUTHORS   Pandey,D.K. and Chaudhary,B.
  TITLE     Evolutionary expansion and structural functionalism of the ancient
            family of profilin proteins
  JOURNAL   Gene 626, 70-86 (2017)
   PUBMED   28501628
REFERENCE   3  (bases 1 to 553)
  AUTHORS   Piatek,M.J., Henderson,V., Zynad,H.S. and Werner,A.
  TITLE     Natural antisense transcription from a comparative perspective
  JOURNAL   Genomics 108 (2), 56-63 (2016)
   PUBMED   27241791
REFERENCE   4  (bases 1 to 553)
  AUTHORS   Inouye,M., Ripatti,S., Kettunen,J., Lyytikainen,L.P., Oksala,N.,
            Laurila,P.P., Kangas,A.J., Soininen,P., Savolainen,M.J.,
            Viikari,J., Kahonen,M., Perola,M., Salomaa,V., Raitakari,O.,
            Lehtimaki,T., Taskinen,M.R., Jarvelin,M.R., Ala-Korpela,M.,
            Palotie,A. and de Bakker,P.I.
  TITLE     Novel Loci for metabolic networks and multi-tissue expression
            studies reveal genes for atherosclerosis
  JOURNAL   PLoS Genet 8 (8), e1002907 (2012)
   PUBMED   22916037
REFERENCE   5  (bases 1 to 553)
  AUTHORS   Urabe,Y., Tanikawa,C., Takahashi,A., Okada,Y., Morizono,T.,
            Tsunoda,T., Kamatani,N., Kohri,K., Chayama,K., Kubo,M., Nakamura,Y.
            and Matsuda,K.
  TITLE     A genome-wide association study of nephrolithiasis in the Japanese
            population identifies novel susceptible Loci at 5q35.3, 7p14.3, and
            13q14.1
  JOURNAL   PLoS Genet 8 (3), e1002541 (2012)
   PUBMED   22396660
REFERENCE   6  (bases 1 to 553)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   7  (bases 1 to 553)
  AUTHORS   Behnen,M., Murk,K., Kursula,P., Cappallo-Obermann,H., Rothkegel,M.,
            Kierszenbaum,A.L. and Kirchhoff,C.
  TITLE     Testis-expressed profilins 3 and 4 show distinct functional
            characteristics and localize in the acroplaxome-manchette complex
            in spermatids
  JOURNAL   BMC Cell Biol 10, 34 (2009)
   PUBMED   19419568
  REMARK    GeneRIF: Porfilin 3 has the actin-binding site conserved, but
            retains only approximately half of the common poly-L-proline
            binding site.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 553)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
REFERENCE   9  (bases 1 to 553)
  AUTHORS   Braun,A., Aszodi,A., Hellebrand,H., Berna,A., Fassler,R. and
            Brandau,O.
  TITLE     Genomic organization of profilin-III and evidence for a transcript
            expressed exclusively in testis
  JOURNAL   Gene 283 (1-2), 219-225 (2002)
   PUBMED   11867228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145098.2, BC132952.1 and
            AA909745.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001029886.2.
            
            Summary: The product of this gene belongs to the profilin family of
            proteins. This protein binds to actin and affects the structure of
            the cytoskeleton. It also may be involved in spermatogenesis. It is
            a single exon gene. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC132954.1, HY027629.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358571.3/ ENSP00000351379.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC145098.2         37817-37841         c
            26-542              BC132952.1         1-517
            543-553             AA909745.1         21-31               c
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..553
                     /gene="PFN3"
                     /gene_synonym="profilin-3"
                     /note="profilin 3"
                     /db_xref="GeneID:345456"
                     /db_xref="HGNC:HGNC:18627"
                     /db_xref="MIM:612812"
     exon            1..553
                     /gene="PFN3"
                     /gene_synonym="profilin-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..499
                     /gene="PFN3"
                     /gene_synonym="profilin-3"
                     /note="profilin III"
                     /codon_start=1
                     /product="profilin-3"
                     /protein_id="NP_001025057.1"
                     /db_xref="CCDS:CCDS34301.1"
                     /db_xref="GeneID:345456"
                     /db_xref="HGNC:HGNC:18627"
                     /db_xref="MIM:612812"
                     /translation="MGDWKVYISAVLRDQRIDDVAIVGHADNSCVWASRPGGLLAAIS
                     PQEVGVLTGPDRHTFLQAGLSVGGRRCCVIRDHLLAEGDGVLDARTKGLDARAVCVGR
                     APRALLVLMGRRGVHGGILNKTVHELIRGLRMQGA"
     regulatory      536..541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFN3"
                     /gene_synonym="profilin-3"
                     /note="hexamer: AATAAA"
     polyA_site      553
                     /gene="PFN3"
                     /gene_synonym="profilin-3"
                     /note="major polyA site"
ORIGIN      
        1 gcctcacagc gccgcaggcc ttccccgcgt ggcgcctcta tatttccccg agaggtgcga
       61 ggcggctggg cgcactcgga gcgcgatggg cgactggaag gtctacatca gtgcagtgct
      121 gcgggaccag cgcatcgacg acgtggccat cgtgggccat gcggacaaca gctgcgtgtg
      181 ggcttcgcgg cccgggggcc tgctggcggc catctcgccg caggaggtgg gcgtgctcac
      241 ggggccggac aggcacacct tcctgcaggc gggcctgagc gtggggggcc gccgctgctg
      301 cgtcatccgc gaccacctgc tggccgaggg tgacggcgtg ctggacgcac gcaccaaggg
      361 gctggacgcg cgcgccgtgt gcgtgggccg tgcgccgcgc gcgctcctgg tgctaatggg
      421 ccgacgcggc gtacatgggg gcatcctcaa caagacggtg cacgaactca tacgcgggct
      481 gcgcatgcag ggcgcctagc cggccagcca ggccgcccac tggtagcgcg ggccaaataa
      541 actgtgacct ggg
//
