LOCUS       NM_053024               2047 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens profilin 2 (PFN2), transcript variant 1, mRNA.
ACCESSION   NM_053024
VERSION     NM_053024.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Jin,M., Yuan,T., Tian,K., Li,J., Huang,Q., Chi,Y. and Huang,G.
  TITLE     Oncogenic circ-SLC16A1 promotes progression of non-small cell lung
            cancer via regulation of the miR-1287-5p/profilin 2 axis
  JOURNAL   Cell Mol Biol Lett 29 (1), 43 (2024)
   PUBMED   38539084
  REMARK    GeneRIF: Oncogenic circ-SLC16A1 promotes progression of non-small
            cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Li,S., Lv,J., Zhang,X., Zhang,Q., Li,Z., Lu,J., Huo,X., Guo,M.,
            Liu,X., Gao,R., Gong,J., Li,C., Li,W., Zhang,T., Wang,J., Chen,Z.
            and Du,X.
  TITLE     ELAVL4 promotes the tumorigenesis of small cell lung cancer by
            stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation
  JOURNAL   FASEB J 37 (10), e23170 (2023)
   PUBMED   37676718
  REMARK    GeneRIF: ELAVL4 promotes the tumorigenesis of small cell lung
            cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2
            activation.
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Liu,H. and Wang,X.
  TITLE     MiR-200b-3p is upregulated in the placental tissues from patients
            with preeclampsia and promotes the development of preeclampsia via
            targeting profilin 2
  JOURNAL   Cell Cycle 21 (18), 1945-1957 (2022)
   PUBMED   35613309
  REMARK    GeneRIF: MiR-200b-3p is upregulated in the placental tissues from
            patients with preeclampsia and promotes the development of
            preeclampsia via targeting profilin 2.
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Obinata,D., Funakoshi,D., Takayama,K., Hara,M., Niranjan,B.,
            Teng,L., Lawrence,M.G., Taylor,R.A., Risbridger,G.P., Suzuki,Y.,
            Takahashi,S. and Inoue,S.
  TITLE     OCT1-target neural gene PFN2 promotes tumor growth in androgen
            receptor-negative prostate cancer
  JOURNAL   Sci Rep 12 (1), 6094 (2022)
   PUBMED   35413990
  REMARK    GeneRIF: OCT1-target neural gene PFN2 promotes tumor growth in
            androgen receptor-negative prostate cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Hu,S. and Shi,L.
  TITLE     [Profilin 2 is highly expressed in gastric cancer and promotes
            tumor cell proliferation and migration]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (2), 215-222 (2022)
   PUBMED   35365445
  REMARK    GeneRIF: [Profilin 2 is highly expressed in gastric cancer and
            promotes tumor cell proliferation and migration].
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   Gieselmann,R., Kwiatkowski,D.J., Janmey,P.A. and Witke,W.
  TITLE     Distinct biochemical characteristics of the two human profilin
            isoforms
  JOURNAL   Eur J Biochem 229 (3), 621-628 (1995)
   PUBMED   7758455
REFERENCE   7  (bases 1 to 2047)
  AUTHORS   Reinhard,M., Giehl,K., Abel,K., Haffner,C., Jarchau,T., Hoppe,V.,
            Jockusch,B.M. and Walter,U.
  TITLE     The proline-rich focal adhesion and microfilament protein VASP is a
            ligand for profilins
  JOURNAL   EMBO J 14 (8), 1583-1589 (1995)
   PUBMED   7737110
REFERENCE   8  (bases 1 to 2047)
  AUTHORS   Honore,B., Madsen,P., Andersen,A.H. and Leffers,H.
  TITLE     Cloning and expression of a novel human profilin variant, profilin
            II
  JOURNAL   FEBS Lett 330 (2), 151-155 (1993)
   PUBMED   8365484
REFERENCE   9  (bases 1 to 2047)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   10 (bases 1 to 2047)
  AUTHORS   Kwiatkowski,D.J. and Bruns,G.A.
  TITLE     Human profilin. Molecular cloning, sequence comparison, and
            chromosomal analysis
  JOURNAL   J Biol Chem 263 (12), 5910-5915 (1988)
   PUBMED   3356709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC043646.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_053024.3.
            
            Summary: The protein encoded by this gene is a ubiquitous actin
            monomer-binding protein belonging to the profilin family. It is
            thought to regulate actin polymerization in response to
            extracellular signals. There are two alternatively spliced
            transcript variants encoding different isoforms described for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002964.1, SRR5189655.109921.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1966682, SAMEA2144835
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239940.12/ ENSP00000239940.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1241              BC043646.1         217-1457
            1242-2047           BC043646.1         1460-2265
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..2047
                     /gene="PFN2"
                     /gene_synonym="D3S1319E; PFL"
                     /note="profilin 2"
                     /db_xref="GeneID:5217"
                     /db_xref="HGNC:HGNC:8882"
                     /db_xref="MIM:176590"
     exon            1..171
                     /gene="PFN2"
                     /gene_synonym="D3S1319E; PFL"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..462
                     /gene="PFN2"
                     /gene_synonym="D3S1319E; PFL"
                     /note="isoform a is encoded by transcript variant 1;
                     profilin II"
                     /codon_start=1
                     /product="profilin-2 isoform a"
                     /protein_id="NP_444252.1"
                     /db_xref="CCDS:CCDS3148.1"
                     /db_xref="GeneID:5217"
                     /db_xref="HGNC:HGNC:8882"
                     /db_xref="MIM:176590"
                     /translation="MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSIT
                     PIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVA
                     VGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF"
     exon            172..364
                     /gene="PFN2"
                     /gene_synonym="D3S1319E; PFL"
                     /inference="alignment:Splign:2.1.0"
     exon            365..2047
                     /gene="PFN2"
                     /gene_synonym="D3S1319E; PFL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFN2"
                     /gene_synonym="D3S1319E; PFL"
                     /note="hexamer: AATAAA"
     polyA_site      2047
                     /gene="PFN2"
                     /gene_synonym="D3S1319E; PFL"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcgcc gtccgcgctg cagtgcgaag ggctcgaaga tggccggttg gcagagctac
       61 gtggataacc tgatgtgcga tggctgctgc caggaggccg ccattgtcgg ctactgcgac
      121 gccaaatacg tctgggcagc cacggccggg ggcgtctttc agagcattac gccaatagaa
      181 atagatatga ttgtaggaaa agaccgggaa ggtttcttta ccaacggttt gactcttggc
      241 gcgaagaaat gctcagtgat cagagatagt ctatacgtcg atggtgactg cacaatggac
      301 atccggacaa agagtcaagg tggggagcca acatacaatg tggctgtcgg cagagctggt
      361 agagtcttgg tctttgtaat gggaaaagaa ggggtccatg gaggcggatt gaataagaag
      421 gcatactcaa tggcaaaata cttgagagac tctgggttct agctgctagg cagactgtta
      481 agtattaggg gaaaattgct cttaaacttt cctagctata agcttaagtc ttaattctgg
      541 aaattttatt agcaatgcag ggtgatgggg tatgaacctg tgtctccttt gtatccctct
      601 gttggtgggg aaaggtgtct ttctttctgc cctccccccc caaaataatt ctgttcactt
      661 ttgttttgtt tccttgtgta ctccagcatt ggttatagtc atgggaaagg aaggtgtcca
      721 cggaggcaca cttaacaaga aagcatatga actcgcttta tacctgagga ggtctgatgt
      781 gtaagcagcc tctccccatc tacctagcaa ctgtcttcat caacaaccct aattatggtc
      841 acaatgctac caaactgtag atggtagcta atttttcttt acctattttc taatgtcatg
      901 attcctgttt gcccaatgga tcatttgtat gttaaccact gtatgtaacc aacccttatc
      961 tggcaacata attgcagcac aataatgatt tgcatgatac cttgaaattg gggggagggg
     1021 gcatgccaag ttgggcatca ctttgtctta gcaattaatg ggatattgat tactaaaata
     1081 agttaatatt aagcaaggtg ccggttgtac aatctctgat cagtgtcttt tcagcacttt
     1141 gagcatttac ttggctcatt tagtcttcct tttgtagcgc atggttggga ggaaaaagtg
     1201 catgcatcat tccttcactc ttctcttttt cccgcccccc ctcccttcgc acataggcat
     1261 ttggtttgct tccatctttt tttatgcagt gcctgttttt ttttaaccaa ttaaaatccc
     1321 ttttgttgat gagctattga gagctgcagt agtttgcttt tagtattgtt gttgcacttg
     1381 agcagagaca aacctttatt catagtgtct acaggacata tgaagagtgc aatggcaaaa
     1441 caagagcaaa aagcacttcc tcccatgacc ttacagtaac catactgatt gaatccccag
     1501 ggacattcca tcattgcaat agctcagatt tttcttcctt tttctttgca caccagctct
     1561 actctttagt aaaattgtaa aaggctgcca ttatggacat taggtatccc aacataacca
     1621 tctggagtgt gtccagtttg ttcttcatag gaccaatttt tatttgcagc ttgagttttt
     1681 atatgaagtt gcattattgt ggacttggct gtcttgtgat gaattttttt catatgtatt
     1741 ctgtgccata ctattgttaa aatgaactgt tgctattgtg agatggattt taactgacct
     1801 attaagggtt tctttcgaat ggcactactt tagggacatt ctagtatttg cttctattgt
     1861 ttgggccttg tggataatgt acagatttaa aaacaaatct tgttgctgat ttgtccattt
     1921 ctttccctgc actttgttac atctgggata cagtctaact catctgattt aatatgcatt
     1981 taaaaaaatg ccataactat taaacacctt gtttacagac agatgaaata aatttattcc
     2041 aaccaaa
//
