LOCUS       NM_001323071            2742 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens phosphofructokinase, platelet (PFKP), transcript
            variant 7, mRNA.
ACCESSION   NM_001323071
VERSION     NM_001323071.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2742)
  AUTHORS   Liu,W., Ding,Z., Tao,Y., Liu,S., Jiang,M., Yi,F., Wang,Z., Han,Y.,
            Zong,H., Li,D., Zhu,Y., Xie,Z., Sang,S., Chen,X., Miao,M., Chen,X.,
            Lin,W., Zhao,Y., Zheng,G., Zafereo,M., Li,G., Wu,J., Zha,X. and
            Liu,Y.
  TITLE     A positive feedback loop between PFKP and c-Myc drives head and
            neck squamous cell carcinoma progression
  JOURNAL   Mol Cancer 23 (1), 141 (2024)
   PUBMED   38982480
  REMARK    GeneRIF: A positive feedback loop between PFKP and c-Myc drives
            head and neck squamous cell carcinoma progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2742)
  AUTHORS   Peng,Z.M., Han,X.J., Wang,T., Li,J.J., Yang,C.X., Tou,F.F. and
            Zhang,Z.
  TITLE     PFKP deubiquitination and stabilization by USP5 activate aerobic
            glycolysis to promote triple-negative breast cancer progression
  JOURNAL   Breast Cancer Res 26 (1), 10 (2024)
   PUBMED   38217030
  REMARK    GeneRIF: PFKP deubiquitination and stabilization by USP5 activate
            aerobic glycolysis to promote triple-negative breast cancer
            progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2742)
  AUTHORS   Yang,S., Wu,H., Li,Y., Li,L., Xiang,J., Kang,L., Yang,G. and
            Liang,Z.
  TITLE     Inhibition of PFKP in renal tubular epithelial cell restrains
            TGF-beta induced glycolysis and renal fibrosis
  JOURNAL   Cell Death Dis 14 (12), 816 (2023)
   PUBMED   38086793
  REMARK    GeneRIF: Inhibition of PFKP in renal tubular epithelial cell
            restrains TGF-beta induced glycolysis and renal fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2742)
  AUTHORS   Huang,Y., Xiong,C., Wang,C., Deng,J., Zuo,Z., Wu,H., Xiong,J.,
            Wu,X., Lu,H., Hao,Q. and Zhou,X.
  TITLE     p53-responsive CMBL reprograms glucose metabolism and suppresses
            cancer development by destabilizing phosphofructokinase PFKP
  JOURNAL   Cell Rep 42 (11), 113426 (2023)
   PUBMED   37967006
  REMARK    GeneRIF: p53-responsive CMBL reprograms glucose metabolism and
            suppresses cancer development by destabilizing phosphofructokinase
            PFKP.
REFERENCE   5  (bases 1 to 2742)
  AUTHORS   Webb,B.A., Forouhar,F., Szu,F.E., Seetharaman,J., Tong,L. and
            Barber,D.L.
  TITLE     Structures of human phosphofructokinase-1 and atomic basis of
            cancer-associated mutations
  JOURNAL   Nature 523 (7558), 111-114 (2015)
   PUBMED   25985179
REFERENCE   6  (bases 1 to 2742)
  AUTHORS   Moon,J.S., Kim,H.E., Koh,E., Park,S.H., Jin,W.J., Park,B.W.,
            Park,S.W. and Kim,K.S.
  TITLE     Kruppel-like factor 4 (KLF4) activates the transcription of the
            gene for the platelet isoform of phosphofructokinase (PFKP) in
            breast cancer
  JOURNAL   J Biol Chem 286 (27), 23808-23816 (2011)
   PUBMED   21586797
  REMARK    GeneRIF: KLF4 plays a role in maintenance of high glycolytic
            metabolism by transcriptional activation of the PFKP gene in breast
            cancer cells.
REFERENCE   7  (bases 1 to 2742)
  AUTHORS   Morrison,N., Simpson,C., Fothergill-Gilmore,L., Boyd,E. and
            Connor,J.M.
  TITLE     Regional chromosomal assignment of the human platelet
            phosphofructokinase gene to 10p15
  JOURNAL   Hum Genet 89 (1), 105-106 (1992)
   PUBMED   1533608
REFERENCE   8  (bases 1 to 2742)
  AUTHORS   Simpson,C.J. and Fothergill-Gilmore,L.A.
  TITLE     Isolation and sequence of a cDNA encoding human platelet
            phosphofructokinase
  JOURNAL   Biochem Biophys Res Commun 180 (1), 197-203 (1991)
   PUBMED   1834056
REFERENCE   9  (bases 1 to 2742)
  AUTHORS   Meienhofer,M.C., Lagrange,J.L., Cottreau,D., Lenoir,G.,
            Dreyfus,J.C. and Kahn,A.
  TITLE     Phosphofructokinase in human blood cells
  JOURNAL   Blood 54 (2), 389-400 (1979)
   PUBMED   156568
REFERENCE   10 (bases 1 to 2742)
  AUTHORS   Kahn,A., Meienhofer,M.C., Cottreau,D., Lagrange,J.L. and
            Dreyfus,J.C.
  TITLE     Phosphofructokinase (PFK) isozymes in man. I. Studies of adult
            human tissues
  JOURNAL   Hum Genet 48 (1), 93-108 (1979)
   PUBMED   156693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731533.8, KF455188.1 and
            AL451164.13.
            
            On May 31, 2019 this sequence version replaced NM_001323071.1.
            
            Summary: This gene encodes a member of the phosphofructokinase A
            protein family. The encoded enzyme is the platelet-specific isoform
            of phosphofructokinase and plays a key role in glycolysis
            regulation. This gene may play a role in metabolic reprogramming in
            some cancers, including clear cell renal cell carcinomas, and
            cancer of the bladder, breast, and lung. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2016].
            
            Transcript Variant: This variant (7) and variants 8 and 11 all
            encode isoform 7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.132943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL731533.8         64203-64362
            161-276             AL731533.8         65929-66044
            277-350             AL731533.8         79043-79116
            351-428             AL731533.8         95930-96007
            429-618             KF455188.1         83-272
            619-784             AL451164.13        4036-4201
            785-829             AL451164.13        5372-5416
            830-938             AL451164.13        5650-5758
            939-1034            AL451164.13        7471-7566
            1035-1127           AL451164.13        8958-9050
            1128-1253           AL451164.13        9612-9737
            1254-1318           AL451164.13        12479-12543
            1319-1388           AL451164.13        13376-13445
            1389-1535           AL451164.13        13629-13775
            1536-1606           AL451164.13        17033-17103
            1607-1694           AL451164.13        19039-19126
            1695-1847           AL451164.13        20149-20301
            1848-2012           AL451164.13        30076-30240
            2013-2074           AL451164.13        32637-32698
            2075-2186           AL451164.13        33460-33571
            2187-2286           AL451164.13        34740-34839
            2287-2389           AL451164.13        35993-36095
            2390-2742           AL451164.13        36707-37059
FEATURES             Location/Qualifiers
     source          1..2742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.2"
     gene            1..2742
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /note="phosphofructokinase, platelet"
                     /db_xref="GeneID:5214"
                     /db_xref="HGNC:HGNC:8878"
                     /db_xref="MIM:171840"
     exon            1..160
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            161..276
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            277..350
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2519
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /EC_number="2.7.1.11"
                     /note="isoform 7 is encoded by transcript variant 7;
                     6-phosphofructokinase type C; phosphohexokinase;
                     phosphofructokinase 1; phosphofructo-1-kinase isozyme C;
                     6-phosphofructokinase, platelet type; ATP-dependent
                     6-phosphofructokinase, platelet type"
                     /codon_start=1
                     /product="ATP-dependent 6-phosphofructokinase, platelet
                     type isoform 7"
                     /protein_id="NP_001310000.1"
                     /db_xref="CCDS:CCDS91203.1"
                     /db_xref="GeneID:5214"
                     /db_xref="HGNC:HGNC:8878"
                     /db_xref="MIM:171840"
                     /translation="MNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESV
                     SSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKE
                     WSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV
                     DAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKL
                     SENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTP
                     SAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMD
                     ERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAPAAGMNAAVR
                     SAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYL
                     EEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGS
                     DFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAY
                     IFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGVF
                     DCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL
                     GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEH
                     VQPWSV"
     exon            351..428
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            429..618
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            619..784
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            785..829
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            830..938
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1034
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1127
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1253
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1318
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1388
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1535
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1606
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1694
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1847
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2012
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2074
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2186
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2286
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2389
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2742
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /note="hexamer: ATTAAA"
     polyA_site      2742
                     /gene="PFKP"
                     /gene_synonym="ATP-PFK; PFK-C; PFK-P; PFKF"
                     /note="major polyA site"
ORIGIN      
        1 attgcctgct gcgcacccgg acgtgcggct cccctcggcc tcctcgccat ggacgcggac
       61 gactcccggg cccccaaggg ctccttgcgg aagttcctgg agcacctctc cggggccggc
      121 aaggccatcg gcgtgctgac cagcggcggg gatgctcaag ggctgggttc tcagagaaag
      181 aaaacgtgat gcagcagagg atgggattga agaaacagga gagtgaagtg gaaatagcct
      241 ggcccgcgtg acttaaaccg gcccggagat gtgcgggtat gaacgctgcc gtccgtgccg
      301 tggtgcgcat gggtatctac gtgggggcca aggtgtactt catctacgag ggctaccagg
      361 gcatggtgga cggaggctca aacatcgcag aggccgactg ggagagtgtc tccagcatcc
      421 tgcaagtggg cgggacgatc attggcagtg cgcggtgcca ggccttccgc acgcgggaag
      481 gccgcctgaa ggctgcttgc aacctgctgc agcgcggcat caccaacctg tgtgtgatcg
      541 gcggggacgg gagcctcacc ggggccaacc tcttccggaa ggagtggagt gggctgctgg
      601 aggagctggc caggaacggc cagatcgata aggaggccgt gcagaagtac gcctacctca
      661 acgtggtggg catggtgggc tccatcgaca atgatttctg cggcaccgac atgaccatcg
      721 gcacggactc cgccctgcac aggatcatcg aggtcgtcga cgccatcatg accacggccc
      781 agagccacca gaggaccttc gttctggagg tgatgggacg acactgtggg tacctggccc
      841 tggtgagtgc cttggcctgc ggtgcggact gggtgttcct tccagaatct ccaccagagg
      901 aaggctggga ggagcagatg tgtgtcaaac tctcggagaa ccgtgcccgg aaaaaaaggc
      961 tgaatattat tattgtggct gaaggagcaa ttgataccca aaataaaccc atcacctctg
     1021 agaaaatcaa agagcttgtc gtcacgcagc tgggctatga cacacgtgtg accatcctcg
     1081 ggcacgtgca gagaggaggg accccttcgg cattcgacag gatcttggcc agccgcatgg
     1141 gagtggaggc agtcatcgcc ttgctagagg ccaccccgga caccccagct tgcgtcgtgt
     1201 cactgaacgg gaaccacgcc gtgcgcctgc cgctgatgga gtgcgtgcag atgactcagg
     1261 atgtgcagaa ggcgatggac gagaggagat ttcaagatgc ggttcgactc cgagggagga
     1321 gctttgcggg caacctgaac acctacaagc gacttgccat caagctgccg gatgatcaga
     1381 tcccaaagac caattgcaac gtagctgtca tcaacgtggg ggcacccgcg gctgggatga
     1441 acgcagccgt acgctcagct gtgcgcgtgg gcattgccga cggccacagg atgctcgcca
     1501 tctatgatgg ctttgacggc ttcgccaagg gccagatcaa agaaatcggc tggacagatg
     1561 tcgggggctg gaccggccaa ggaggctcca ttcttgggac aaaacgcgtt ctcccgggga
     1621 agtacttgga agagatcgcc acacagatgc gcacgcacag catcaacgcg ctgctgatca
     1681 tcggtggatt cgaggcctac ctgggactcc tggagctgtc agccgcccgg gagaagcacg
     1741 aggagttctg tgtccccatg gtcatggttc ccgctactgt gtccaacaat gtgccgggtt
     1801 ccgatttcag catcggggca gacaccgccc tgaacactat caccgacacc tgcgaccgca
     1861 tcaagcagtc cgccagcgga accaagcggc gcgtgttcat catcgagacc atgggcggct
     1921 actgtggcta cctggccaac atgggggggc tcgcggccgg agctgatgcc gcatacattt
     1981 tcgaagagcc cttcgacatc agggatctgc agtccaacgt ggagcacctg acggagaaaa
     2041 tgaagaccac catccagaga ggccttgtgc tcagaaatga gagctgcagt gaaaactaca
     2101 ccaccgactt catttaccag ctgtattcag aagagggcaa aggcgtgttt gactgcagga
     2161 agaacgtgct gggtcacatg cagcagggtg gggcaccctc tccatttgat agaaactttg
     2221 gaaccaaaat ctctgccaga gctatggagt ggatcactgc aaaactcaag gaggcccggg
     2281 gcagaggaaa aaaatttacc accgatgatt ccatttgtgt gctgggaata agcaaaagaa
     2341 acgttatttt tcaacctgtg gcagagctga agaagcaaac ggattttgag cacaggattc
     2401 ccaaagaaca gtggtggctc aagctacggc ccctcatgaa aatcctggcc aagtacaagg
     2461 ccagctatga cgtgtcggac tcaggccagc tggaacatgt gcagccctgg agtgtctgac
     2521 ccagtcccgc ctgcatgtgc ctgcagccac cgtggactgt ctgtttttgt aacacttaag
     2581 ttattttatc agcactttat gcacgtatta ttgacattaa tacctaatcg gcgagtgccc
     2641 atctgcccca cctgctccag tgcgtgctgt ctgtggagtg tgtctcatgc tttcagatgt
     2701 gcatatgagc agaattaatt aaacatttgc ctatgactcc aa
//
