LOCUS       NM_002623               1230 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens prefoldin subunit 4 (PFDN4), mRNA.
ACCESSION   NM_002623
VERSION     NM_002623.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1230)
  AUTHORS   Wang,S.H., Yeh,C.H., Wu,C.W., Hsu,C.Y., Tsai,E.M., Hung,C.M.,
            Wang,Y.W. and Hsieh,T.H.
  TITLE     PFDN4 as a Prognostic Marker Was Associated with Chemotherapy
            Resistance through CREBP1/AURKA Pathway in Triple-Negative Breast
            Cancer
  JOURNAL   Int J Mol Sci 25 (7), 3906 (2024)
   PUBMED   38612711
  REMARK    GeneRIF: PFDN4 as a Prognostic Marker Was Associated with
            Chemotherapy Resistance through CREBP1/AURKA Pathway in
            Triple-Negative Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1230)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1230)
  AUTHORS   Sadeghi,H., Nazemalhosseini-Mojarad,E., Sahebi,U., Fazeli,E.,
            Azizi-Tabesh,G., Yassaee,V.R., Savabkar,S., Asadzadeh Aghdaei,H.,
            Zali,M.R. and Mirfakhraie,R.
  TITLE     Novel long noncoding RNAs upregulation may have synergistic effects
            on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer
  JOURNAL   J Cell Physiol 236 (3), 2051-2057 (2021)
   PUBMED   32743796
  REMARK    GeneRIF: Novel long noncoding RNAs upregulation may have
            synergistic effects on the CYP24A1 and PFDN4 biomarker role in
            human colorectal cancer.
REFERENCE   4  (bases 1 to 1230)
  AUTHORS   Liang,J., Xia,L., Oyang,L., Lin,J., Tan,S., Yi,P., Han,Y., Luo,X.,
            Wang,H., Tang,L., Pan,Q., Tian,Y., Rao,S., Su,M., Shi,Y., Cao,D.,
            Zhou,Y. and Liao,Q.
  TITLE     The functions and mechanisms of prefoldin complex and
            prefoldin-subunits
  JOURNAL   Cell Biosci 10, 87 (2020)
   PUBMED   32699605
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1230)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1230)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 1230)
  AUTHORS   Cowan,N.J. and Lewis,S.A.
  TITLE     A chaperone with a hydrophilic surface
  JOURNAL   Nat Struct Biol 6 (11), 990-991 (1999)
   PUBMED   10542082
REFERENCE   8  (bases 1 to 1230)
  AUTHORS   Hansen,W.J., Cowan,N.J. and Welch,W.J.
  TITLE     Prefoldin-nascent chain complexes in the folding of cytoskeletal
            proteins
  JOURNAL   J Cell Biol 145 (2), 265-277 (1999)
   PUBMED   10209023
REFERENCE   9  (bases 1 to 1230)
  AUTHORS   Vainberg,I.E., Lewis,S.A., Rommelaere,H., Ampe,C.,
            Vandekerckhove,J., Klein,H.L. and Cowan,N.J.
  TITLE     Prefoldin, a chaperone that delivers unfolded proteins to cytosolic
            chaperonin
  JOURNAL   Cell 93 (5), 863-873 (1998)
   PUBMED   9630229
REFERENCE   10 (bases 1 to 1230)
  AUTHORS   Iijima,M., Kano,Y., Nohno,T. and Namba,M.
  TITLE     Cloning of cDNA with possible transcription factor activity at the
            G1-S phase transition in human fibroblast cell lines
  JOURNAL   Acta Med Okayama 50 (2), 73-77 (1996)
   PUBMED   8744932
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010953.1, U41816.1 and
            AL133335.29.
            
            On Nov 22, 2018 this sequence version replaced NM_002623.3.
            
            Summary: This gene encodes a member of the prefoldin beta subunit
            family. The encoded protein is one of six subunits of prefoldin, a
            molecular chaperone complex that binds and stabilizes newly
            synthesized polypeptides, thereby allowing them to fold correctly.
            The complex, consisting of two alpha and four beta subunits, forms
            a double beta barrel assembly with six protruding coiled-coils.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.312312.1,
                                           SRR1660805.375126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371419.7/ ENSP00000360473.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               BC010953.1         5-470
            467-481             U41816.1           452-466
            482-1205            AL133335.29        41883-42606
            1206-1222           U41816.1           1188-1204
            1223-1230           AL133335.29        42624-42631
FEATURES             Location/Qualifiers
     source          1..1230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.2"
     gene            1..1230
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="prefoldin subunit 4"
                     /db_xref="GeneID:5203"
                     /db_xref="HGNC:HGNC:8868"
                     /db_xref="MIM:604898"
     exon            1..38
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..419
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="prefoldin 4; protein C-1"
                     /codon_start=1
                     /product="prefoldin subunit 4"
                     /protein_id="NP_002614.2"
                     /db_xref="CCDS:CCDS13445.1"
                     /db_xref="GeneID:5203"
                     /db_xref="HGNC:HGNC:8868"
                     /db_xref="MIM:604898"
                     /translation="MAATMKKAAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKK
                     KQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALE
                     SRVESIQRVLADLKVQLYAKFGSNINLEADES"
     exon            39..146
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /inference="alignment:Splign:2.1.0"
     exon            147..287
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /inference="alignment:Splign:2.1.0"
     exon            288..1230
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      449..454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="hexamer: AATAAA"
     polyA_site      472
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="major polyA site"
     regulatory      661..666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="hexamer: ATTAAA"
     polyA_site      681
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
     regulatory      731..736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="hexamer: AAGAAA"
     polyA_site      753
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="hexamer: ACTAAA"
     polyA_site      869
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
     regulatory      893..898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="hexamer: AATATA"
     polyA_site      918
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
     regulatory      1200..1205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
                     /note="hexamer: AATAAA"
     polyA_site      1230
                     /gene="PFDN4"
                     /gene_synonym="C1; PFD4"
ORIGIN      
        1 agtccagtcc caagatggcg gccaccatga agaaggcggc tgcagaagat gtcaatgtta
       61 ctttcgaaga tcaacaaaag ataaacaaat ttgcacggaa tacaagtaga atcacagagc
      121 tgaaggaaga aatagaagta aaaaagaaac aactccaaaa cctagaagat gcttgtgatg
      181 acatcatgct tgcagatgat gattgcttaa tgatacctta tcaaattggt gatgtcttca
      241 ttagccattc tcaagaagaa acgcaagaaa tgttagaaga agcaaagaaa aatttgcaag
      301 aagaaattga cgccttagaa tccagagtgg aatcaattca gcgagtgtta gcagatttga
      361 aagttcagtt gtatgcaaaa ttcgggagca acataaacct tgaagctgat gaaagttaaa
      421 cattttataa tacttttttt atttgtttaa taaacttgaa tattgtttaa aatgataatt
      481 ttccttcttc aaatgacatg gaaagcaaaa ctttcttttt taaaaatttt catttattta
      541 atggaaactt gcccattttc acatgtctgc ttatttattt tatattttta aaagaagaca
      601 gtattcacct atgtattttg cataacgatt atatcaagtc taggggcttc atgtcatgtt
      661 attaaaatca gttaagcaat cttttatgtt tctatattat ttagaatatt tgttgttgca
      721 attttcacat aagaaaattt aacagttgtg tcatgttgtt tctgtctgat tttaattgct
      781 gtctaatgac ggggaaagca cgatgaaaag atgtacaatc ctgcatcctt gcttatttca
      841 caactaaagc tttgtcatag acttcaaaat atatatgtat atattttatt taaatatatg
      901 ttacatatta tatttaaaca tacatattta acatttttta catatctatc aatatcagag
      961 atttgggtaa aagaatgggt aatgtttaaa catgtggagg catgtggagc tttatacaaa
     1021 cagggcagaa ccacagaaga acgttttaga aaccaagaga tgtgcagaaa gaaatgttta
     1081 gtgttttttc gttttaaatt ttagatttta ttttagtgct ttgtaattaa ttggggttta
     1141 tattgataaa gatgtggaag ttaaacagct atgtatgtaa aagtaaggct tatttcttaa
     1201 ataaaggatg catttcttcc cactccccca
//
