LOCUS       NM_012394                598 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens prefoldin subunit 2 (PFDN2), mRNA.
ACCESSION   NM_012394
VERSION     NM_012394.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 598)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 598)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 598)
  AUTHORS   Liang,J., Xia,L., Oyang,L., Lin,J., Tan,S., Yi,P., Han,Y., Luo,X.,
            Wang,H., Tang,L., Pan,Q., Tian,Y., Rao,S., Su,M., Shi,Y., Cao,D.,
            Zhou,Y. and Liao,Q.
  TITLE     The functions and mechanisms of prefoldin complex and
            prefoldin-subunits
  JOURNAL   Cell Biosci 10, 87 (2020)
   PUBMED   32699605
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 598)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 598)
  AUTHORS   Cloutier,P., Poitras,C., Faubert,D., Bouchard,A., Blanchette,M.,
            Gauthier,M.S. and Coulombe,B.
  TITLE     Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of
            the PAQosome
  JOURNAL   J Proteome Res 19 (1), 18-27 (2020)
   PUBMED   31738558
REFERENCE   6  (bases 1 to 598)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   7  (bases 1 to 598)
  AUTHORS   Cowan,N.J. and Lewis,S.A.
  TITLE     A chaperone with a hydrophilic surface
  JOURNAL   Nat Struct Biol 6 (11), 990-991 (1999)
   PUBMED   10542082
REFERENCE   8  (bases 1 to 598)
  AUTHORS   Hansen,W.J., Cowan,N.J. and Welch,W.J.
  TITLE     Prefoldin-nascent chain complexes in the folding of cytoskeletal
            proteins
  JOURNAL   J Cell Biol 145 (2), 265-277 (1999)
   PUBMED   10209023
REFERENCE   9  (bases 1 to 598)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   10 (bases 1 to 598)
  AUTHORS   Vainberg,I.E., Lewis,S.A., Rommelaere,H., Ampe,C.,
            Vandekerckhove,J., Klein,H.L. and Cowan,N.J.
  TITLE     Prefoldin, a chaperone that delivers unfolded proteins to cytosolic
            chaperonin
  JOURNAL   Cell 93 (5), 863-873 (1998)
   PUBMED   9630229
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012464.1 and AF165883.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012394.3.
            
            Summary: This gene encodes a member of the prefoldin beta subunit
            family. The encoded protein is one of six subunits of prefoldin, a
            molecular chaperone complex that binds and stabilizes newly
            synthesized polypeptides, thereby allowing them to fold correctly.
            The complex, consisting of two alpha and four beta subunits, forms
            a double beta barrel assembly with six protruding coiled-coils.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ646466.1, BM719541.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368010.4/ ENSP00000356989.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-595               BC012464.1         9-603
            596-598             AF165883.1         608-610
FEATURES             Location/Qualifiers
     source          1..598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..598
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /note="prefoldin subunit 2"
                     /db_xref="GeneID:5202"
                     /db_xref="HGNC:HGNC:8867"
                     /db_xref="MIM:613466"
     exon            1..86
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..476
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /note="prefoldin 2"
                     /codon_start=1
                     /product="prefoldin subunit 2"
                     /protein_id="NP_036526.2"
                     /db_xref="CCDS:CCDS1217.1"
                     /db_xref="GeneID:5202"
                     /db_xref="HGNC:HGNC:8867"
                     /db_xref="MIM:613466"
                     /translation="MAENSGRAGKSSGSGAGKGAVSAEQVIAGFNRLRQEQRGLASKA
                     AELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALENNKEQIQKIIE
                     TLTQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS"
     exon            87..175
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            176..299
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..598
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      579..584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /note="hexamer: ATTAAA"
     polyA_site      598
                     /gene="PFDN2"
                     /gene_synonym="PFD2"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcgaa gatggcggag aacagcggtc gcgccggcaa gagcagcggg agcggcgcgg
       61 ggaagggggc ggtgtccgca gagcaggtga ttgctggctt caaccgcctt cggcaggaac
      121 agcgaggcct ggcatccaaa gcagctgagt tggagatgga gttgaatgag cacagcctag
      181 tgatcgatac actgaaggag gtagatgaaa ctcgtaagtg ctaccgcatg gttggaggag
      241 tgctggtgga gcgaactgtc aaagaggtgc tgcccgcttt ggagaacaac aaggagcaga
      301 tacagaagat cattgagaca ctgacacagc agcttcaggc aaagggaaaa gaactaaatg
      361 aattccggga aaagcacaac attcgtctca tgggagaaga tgagaagcca gcagccaagg
      421 aaaactcaga aggggctggg gctaaggcca gctcagctgg agtgttggtc tcctagggac
      481 caaggccttt gcattttttt ctaccctgac tcccacttct aatttctctt tattgttatt
      541 attattattt tctctgctat tgtaatattt ttttgttaat taaatgtttt ggtcagaa
//
