LOCUS       NM_002622               1336 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens prefoldin subunit 1 (PFDN1), mRNA.
ACCESSION   NM_002622
VERSION     NM_002622.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Zhao,H., Chen,C., Yang,C., Mo,S., Zhao,H. and Tian,Y.
  TITLE     Prefoldin and prefoldin-like complex subunits as predictive
            biomarkers for hepatocellular carcinoma immunotherapy
  JOURNAL   Pathol Res Pract 232, 153808 (2022)
   PUBMED   35217267
  REMARK    GeneRIF: Prefoldin and prefoldin-like complex subunits as
            predictive biomarkers for hepatocellular carcinoma immunotherapy.
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Liang,J., Xia,L., Oyang,L., Lin,J., Tan,S., Yi,P., Han,Y., Luo,X.,
            Wang,H., Tang,L., Pan,Q., Tian,Y., Rao,S., Su,M., Shi,Y., Cao,D.,
            Zhou,Y. and Liao,Q.
  TITLE     The functions and mechanisms of prefoldin complex and
            prefoldin-subunits
  JOURNAL   Cell Biosci 10, 87 (2020)
   PUBMED   32699605
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Gestaut,D., Roh,S.H., Ma,B., Pintilie,G., Joachimiak,L.A.,
            Leitner,A., Walzthoeni,T., Aebersold,R., Chiu,W. and Frydman,J.
  TITLE     The Chaperonin TRiC/CCT Associates with Prefoldin through a
            Conserved Electrostatic Interface Essential for Cellular
            Proteostasis
  JOURNAL   Cell 177 (3), 751-765 (2019)
   PUBMED   30955883
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Cowan,N.J. and Lewis,S.A.
  TITLE     A chaperone with a hydrophilic surface
  JOURNAL   Nat Struct Biol 6 (11), 990-991 (1999)
   PUBMED   10542082
REFERENCE   7  (bases 1 to 1336)
  AUTHORS   Hansen,W.J., Cowan,N.J. and Welch,W.J.
  TITLE     Prefoldin-nascent chain complexes in the folding of cytoskeletal
            proteins
  JOURNAL   J Cell Biol 145 (2), 265-277 (1999)
   PUBMED   10209023
REFERENCE   8  (bases 1 to 1336)
  AUTHORS   Horrigan,S.K., Bartoloni,L., Speer,M.C., Fulton,N., Kravarusic,J.,
            Ramesar,R., Vance,J.M., Yamaoka,L.H. and Westbrook,C.A.
  TITLE     A radiation hybrid breakpoint map of the acute myeloid leukemia
            (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of
            chromosome 5q31 localizing 122 expressed sequences
  JOURNAL   Genomics 57 (1), 24-35 (1999)
   PUBMED   10191080
REFERENCE   9  (bases 1 to 1336)
  AUTHORS   Vainberg,I.E., Lewis,S.A., Rommelaere,H., Ampe,C.,
            Vandekerckhove,J., Klein,H.L. and Cowan,N.J.
  TITLE     Prefoldin, a chaperone that delivers unfolded proteins to cytosolic
            chaperonin
  JOURNAL   Cell 93 (5), 863-873 (1998)
   PUBMED   9630229
REFERENCE   10 (bases 1 to 1336)
  AUTHORS   Iijima,M., Kano,Y., Nohno,T. and Namba,M.
  TITLE     Cloning of cDNA with possible transcription factor activity at the
            G1-S phase transition in human fibroblast cell lines
  JOURNAL   Acta Med Okayama 50 (2), 73-77 (1996)
   PUBMED   8744932
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG707314.1, AC011380.6 and
            AA910992.1.
            
            On May 17, 2019 this sequence version replaced NM_002622.4.
            
            Summary: This gene encodes a member of the prefoldin beta subunit
            family. The encoded protein is one of six subunits of prefoldin, a
            molecular chaperone complex that binds and stabilizes newly
            synthesized polypeptides, thereby allowing them to fold correctly.
            The complex, consisting of two alpha and four beta subunits, forms
            a double beta barrel assembly with six protruding coiled-coils.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.252249.1,
                                           SRR3476690.14593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMN03267763
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261813.9/ ENSP00000261813.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BG707314.1         18-46
            30-61               AC011380.6         133490-133521       c
            62-228              AC011380.6         130865-131031       c
            229-313             AC011380.6         111898-111982       c
            314-1293            AC011380.6         75527-76506         c
            1294-1321           AA910992.1         31-58               c
            1322-1336           AC011380.6         75484-75498         c
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1336
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /note="prefoldin subunit 1"
                     /db_xref="GeneID:5201"
                     /db_xref="HGNC:HGNC:8866"
                     /db_xref="MIM:604897"
     exon            1..61
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..397
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /note="prefoldin 1"
                     /codon_start=1
                     /product="prefoldin subunit 1"
                     /protein_id="NP_002613.2"
                     /db_xref="CCDS:CCDS4222.1"
                     /db_xref="GeneID:5201"
                     /db_xref="HGNC:HGNC:8866"
                     /db_xref="MIM:604897"
                     /translation="MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHA
                     HLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLE
                     RSVKEAEDNIREMLMARRAQ"
     exon            62..228
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..313
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1336
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1279..1284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /note="hexamer: AATAAA"
     polyA_site      1304
                     /gene="PFDN1"
                     /gene_synonym="PDF; PFD1"
                     /note="major polyA site"
ORIGIN      
        1 actgcgcagg cgcttacagt gcaccaagat ggccgccccc gtggatctag agctgaagaa
       61 ggccttcaca gagcttcaag ccaaagttat tgacactcaa cagaaggtga agctcgcaga
      121 catacagatt gaacagctaa acagaacgaa aaagcatgca catcttacag atacagagat
      181 catgactttg gtagatgaga ctaacatgta tgaaggtgta ggaagaatgt ttattcttca
      241 gtccaaggaa gcaattcaca gtcagctgtt agagaagcag aaaatagcag aagaaaaaat
      301 taaagaacta gaacagaaaa agtcctacct ggagcgaagc gttaaggaag ctgaggacaa
      361 catccgggag atgctgatgg cacgaagggc ccagtaggga gcctctctgg gaagctcttc
      421 ctcctgcccc tcccattcct ggtgggggca gaggagtgtc tgcagggaaa cagcttctcc
      481 tctgccccga tggatgcttt atttggatgg cctggcaaca tcacattttc tgcatcaccc
      541 tgagccccat ttgcttccca gccctggagt ttttacccgg ctttgcctgc cacctctgcc
      601 caggacactc ttccctctcg ggatgtgtga tgaactccca ggagagggaa gatgggagcc
      661 agggcaagat aggaagctct gcctgagctt tccactaggc acgccagcca gaccaataaa
      721 aagcgtctgt cccactctgc taagcctggt tttcttgagc agagggatgg aacagagggt
      781 gagagaggca gtggccgtct ccacctcagc tcctgctccc tctgcatcag agcccttcct
      841 ttcttggggg atgggccttg ccctcttctc ttttcccttc ctgtaccttt gactaacgct
      901 cagcttccgg gcctgcatgc agtagacaga agaggaagaa agaacagatg ttcacagctg
      961 aatctcagtg aacagaatag cagtccctgg atggcagtct gcctaaagat tcctttccct
     1021 gccttctccc atacattcca aaaggaagtt caacagtaag cagcacctcc aagactgtct
     1081 ccttttggcc aatatcataa gatggacgcc ataatcctga ggcctcctag aggctgaggg
     1141 ggcaacggtg tgatccagct ggctcatccc agcccaggtg ggccaattat tcaattttca
     1201 agaattttgt tgcaagccag ttgtcaaaca cagccattat aattatgtaa atttgcaaat
     1261 tatgttaaaa acaaggacaa taaatattca aaatgcatcc ctaattacta catttgacca
     1321 cgatctgtgc tctatc
//
