LOCUS       XM_047436297            3395 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens phosphoribosylformylglycinamidine synthase
            (PFAS), transcript variant X4, mRNA.
ACCESSION   XM_047436297
VERSION     XM_047436297.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..3395
                     /gene="PFAS"
                     /gene_synonym="FGAMS; FGAR-AT; FGARAT; GATD8; PURL"
                     /note="phosphoribosylformylglycinamidine synthase; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 17 ESTs, 34 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     13 samples with support for all annotated introns"
                     /db_xref="GeneID:5198"
                     /db_xref="HGNC:HGNC:8863"
                     /db_xref="MIM:602133"
     CDS             329..3172
                     /gene="PFAS"
                     /gene_synonym="FGAMS; FGAR-AT; FGARAT; GATD8; PURL"
                     /codon_start=1
                     /product="phosphoribosylformylglycinamidine synthase
                     isoform X4"
                     /protein_id="XP_047292253.1"
                     /db_xref="GeneID:5198"
                     /db_xref="HGNC:HGNC:8863"
                     /db_xref="MIM:602133"
                     /translation="MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNV
                     NWTAEALPSAEETKKLMWLFGCPLLLDDVARESWLLPGSNDLLLEVGPRLNFSTPTST
                     NIVSVCRATGLGPVDRVETTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQS
                     FSPESMPEPLNGPINILGEGRLALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVE
                     AFDLAQSNSEHSRHWFFKGQLHVDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAI
                     QGKEVRFLRPEDPTRPSRFQQQQGLRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDV
                     QCTGRGAHVVAGTAGYCFGNLHIPGYNLPWEDPSFQYPGNFARPLEVAIEASNGASDY
                     GNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEADHISKEAPEPGMEVV
                     KVGGPVYRIGVGGGAASSVQVQGDNTSDLDFGAVQRGDPEMEQKMNRVIRACVEAPKG
                     NPICSLHDQGAGGNGNVLKELSDPAGAIIYTSRFQLGDPTLNALEIWGAEYQESNALL
                     LRSPNRDFLTHVSARERCPACFVGTITGDRRIVLVDDRECPVRRNGQGDAPPTPLPTP
                     VDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLSVHQALERVLRLPAVASKRYLTN
                     KVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIGAATALGEQPVKSLLDPKVAA
                     RLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVA
                     VDGGKDSLSMAARVGTETVRAPGSLVISAYAVCPDITATVTPDLKHPEGRGHLLYVAL
                     SPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLKDRLLCSGHDVSDGG
                     LVTCLLEMAFAGNCGLQVDVPVPRVDAELDGTG"
ORIGIN      
        1 ccctttcggc gctttttgcc ttctacacgc acttcgggtc tcagacgctt ttacttatta
       61 tggttgccct tttcccctac agctccgtca agggtcttct ccaggaaccc acagccccat
      121 agttccccca ttaacctgct cctggtttcc caccaggatt aaaccctaga gagtgaacgg
      181 agaccagttt aaggctcaca gcgggcgccg cgtgaatgag ggaataaaca ttcgcagaac
      241 cagtaagagg aacctaattc atctctccag caaaggacac atctctccag caaaggacac
      301 ctctctccag caaaggacac ctgcagagat gtccccagtc cttcacttct atgttcgtcc
      361 ctctggccat gagggggcag cccctggaca cactcggagg aaactgcaag ggaaactgcc
      421 agagctgcag ggcgtcgaga ctgaactgtg ctacaacgtg aactggacag ctgaggccct
      481 ccccagtgct gaggagacaa agaagctgat gtggctgttt ggttgcccct tactgctgga
      541 tgatgttgct cgggagtcct ggctccttcc tggctccaat gacctgctgc tggaggtcgg
      601 gcccaggctg aacttctcca ccccaacatc caccaacatc gtgtcagtgt gccgcgccac
      661 tgggctgggg cctgtggatc gtgtggagac cacccggcgc taccggctct cgtttgccca
      721 ccccccgtca gctgaggtgg aagccattgc tctggctacc ctgcacgacc ggatgacaga
      781 gcagcacttc ccccatccca tccagagttt ctcccctgag agcatgccgg aacccctcaa
      841 tggccctatc aatatactgg gtgagggccg gcttgcgctg gagaaggcca accaggagct
      901 tggtctggct ttagactctt gggacctaga cttctacacc aagcgcttcc aggagctaca
      961 gcggaacccg agcactgtgg aggcctttga cttggcgcag tccaatagcg agcacagccg
     1021 acactggttc ttcaagggcc agctccacgt ggatgggcag aagctggtgc actcactgtt
     1081 tgagtccatc atgagcaccc aggaatcctc gaaccccaac aacgtcctca aattctgtga
     1141 taacagcagt gcaatccagg gaaaggaagt ccgattccta cggcctgagg accccacacg
     1201 gccaagccgc ttccagcaac agcaagggct gagacatgtt gtcttcacag cagagactca
     1261 caactttccc acaggagtat gcccctttag tggtgcaacc actggcacag ggggccggat
     1321 tcgagatgtc cagtgcacag gccgcggggc ccacgtggtg gctggcactg ccggctattg
     1381 ctttggaaat ctgcatattc caggttacaa tctgccctgg gaggatccaa gcttccagta
     1441 tcctgggaat tttgcccggc ccctggaggt tgccattgaa gccagtaatg gagcttctga
     1501 ctatggcaac aagtttgggg aaccagtgct ggctggcttc gcccgctcct tgggcctcca
     1561 gctcccagac ggccagcggc gtgagtggat caagcccatc atgtttagtg ggggcattgg
     1621 gtccatggaa gctgaccaca taagcaagga ggccccagag ccaggcatgg aagttgtaaa
     1681 ggttggaggt cccgtctaca ggattggagt tggaggtgga gctgcttcat ctgtgcaggt
     1741 gcagggagat aacaccagtg acctggactt tggggctgtg cagcgaggag acccggagat
     1801 ggaacagaag atgaaccgtg tgatcagggc ttgtgtggag gcccccaagg gaaaccccat
     1861 ctgcagcctt catgatcagg gcgctggtgg caatggcaat gtcctaaaag agctgagtga
     1921 cccagctgga gccatcattt acaccagccg cttccagctt ggggacccaa ccctgaatgc
     1981 cctggaaatc tggggggctg agtaccagga atcaaatgct cttctgctga ggtcccccaa
     2041 ccgggacttc ctgactcatg tcagtgcccg tgaacgttgc ccggcttgct tcgtgggcac
     2101 catcactgga gaccggagaa tagtgctggt ggacgatcgg gagtgtcctg tcagaagaaa
     2161 tggccagggg gatgcccccc cgacacccct gccaacccct gtggacctgg agctcgaatg
     2221 ggtgctgggc aagatgcctc ggaaggagtt cttcctgcag aggaagcccc ccatgctgca
     2281 gcctctggcc ttgcccccag ggctgagcgt gcaccaggct ctggagaggg ttctgaggct
     2341 gcccgccgtg gccagcaagc gctacctcac caataaggtg gaccgctctg tgggaggcct
     2401 ggtggcccag cagcagtgcg tggggcccct gcaaactcct ctggcagatg tagcggttgt
     2461 ggcactgagc catgaggagc tcataggggc tgccacagcc ttgggagaac agccagtcaa
     2521 gagcctgctg gacccaaaag tcgccgcccg gctggccgtg gccgaagccc tcaccaacct
     2581 ggtgtttgct ctggtcactg acctccggga tgtgaagtgt agcgggaact ggatgtgggc
     2641 agccaagctc ccaggggagg gcgcagcttt ggcggatgcc tgtgaggcta tggtggcagt
     2701 gatggcagcc ctgggtgtgg cagtggatgg tggcaaggac tccctcagca tggctgctcg
     2761 ggttggcact gagaccgtgc gggctcctgg gtcactggtc atctcagcct atgccgtctg
     2821 cccagacatc acagccactg tgaccccaga cctcaagcat cctgaaggga gaggccatct
     2881 gctctatgtg gctctgagcc ctgggcagca ccggctcggg ggcacagctc tggcccagtg
     2941 cttctcccag cttggggaac accctccaga cctggacctt cctgagaact tggtgcgggc
     3001 cttcagcatc actcaggggc tgctgaaaga ccgcctcctc tgctcaggcc acgatgtcag
     3061 tgacggaggc ctcgtcacat gcctgctgga gatggccttt gctggaaatt gcgggctaca
     3121 ggtggatgtg cctgtcccca gggttgatgc tgaactggat ggaactggct gacacccacc
     3181 atgttcctga ctgcacccct ctgagacttc ccatccctga gatgtccatg atgaaacatc
     3241 ctcagtcctg ccgtcctagc cctcatcctc cctgatccct accctactct ctggctgcat
     3301 ccctctgacc ctcaccctgg cccttcctgc atttccctga tcccgcccca actcccttgg
     3361 cccttcttgc atccccctga ctccccacat tgctc
//
