LOCUS       XM_047436296            3320 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens phosphoribosylformylglycinamidine synthase
            (PFAS), transcript variant X3, mRNA.
ACCESSION   XM_047436296
VERSION     XM_047436296.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..3320
                     /gene="PFAS"
                     /gene_synonym="FGAMS; FGAR-AT; FGARAT; GATD8; PURL"
                     /note="phosphoribosylformylglycinamidine synthase; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 20 ESTs, 76 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     113 samples with support for all annotated introns"
                     /db_xref="GeneID:5198"
                     /db_xref="HGNC:HGNC:8863"
                     /db_xref="MIM:602133"
     CDS             131..3109
                     /gene="PFAS"
                     /gene_synonym="FGAMS; FGAR-AT; FGARAT; GATD8; PURL"
                     /codon_start=1
                     /product="phosphoribosylformylglycinamidine synthase
                     isoform X3"
                     /protein_id="XP_047292252.1"
                     /db_xref="GeneID:5198"
                     /db_xref="HGNC:HGNC:8863"
                     /db_xref="MIM:602133"
                     /translation="MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNV
                     NWTAEALPSAEETKKLMWLFGCPLLLDDVARESWLLPGSNDLLLEVGPRLNFSTPTST
                     NIVSVCRATGLGPVDRVETTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQS
                     FSPESMPEPLNGPINILGEGRLALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVE
                     AFDLAQSNSEHSRHWFFKGQLHVDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAI
                     QGKEVRFLRPEDPTRPSRFQQQQGLRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDV
                     QCTGRGAHVVAGTAGYCFGNLHIPGYNLPWEDPSFQYPGNFARPLEVAIEASNGASDY
                     GNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEADHISKEAPEPGMEVV
                     KVGGPVYRIGVGGGAASSVQVQGDNTSDLDFGAVQRGDPEMEQKMNRVIRACVEAPKG
                     NPICSLHDQGAGGNGNVLKELSDPAGAIIYTSRFQLGDPTLNALEIWGAEYQESNALL
                     LRSPNRDFLTHVSARERCPACFVGTITGDRRIVLVDDRECPVRRNGQGDAPPTPLPTP
                     VDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLSVHQALERVLRLPAVASKRYLTN
                     KVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIGAATALGEQPVKSLLDPKVAA
                     RLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVA
                     VDGGKDSLSMAARVGTETVRAPGSLVISAYAVCPDITATVTPDLKHPEGRGHLLYVAL
                     SPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLKDRLLCSGHDVSDGG
                     LVTCLLEMAFAGNCGLQVDVPVPRVDVLSVLFAEEPGLVLEVQEPDLAQVLKRYRDAG
                     LHCLELGHTGEAGPHAMVRK"
ORIGIN      
        1 aaacgcgcgc gacgattcga ggtgctctgt ggccgcgagt gcatcttcca cgaacctaat
       61 tcatctctcc agcaaaggac acatctctcc agcaaaggac acctctctcc agcaaaggac
      121 acctgcagag atgtccccag tccttcactt ctatgttcgt ccctctggcc atgagggggc
      181 agcccctgga cacactcgga ggaaactgca agggaaactg ccagagctgc agggcgtcga
      241 gactgaactg tgctacaacg tgaactggac agctgaggcc ctccccagtg ctgaggagac
      301 aaagaagctg atgtggctgt ttggttgccc cttactgctg gatgatgttg ctcgggagtc
      361 ctggctcctt cctggctcca atgacctgct gctggaggtc gggcccaggc tgaacttctc
      421 caccccaaca tccaccaaca tcgtgtcagt gtgccgcgcc actgggctgg ggcctgtgga
      481 tcgtgtggag accacccggc gctaccggct ctcgtttgcc caccccccgt cagctgaggt
      541 ggaagccatt gctctggcta ccctgcacga ccggatgaca gagcagcact tcccccatcc
      601 catccagagt ttctcccctg agagcatgcc ggaacccctc aatggcccta tcaatatact
      661 gggtgagggc cggcttgcgc tggagaaggc caaccaggag cttggtctgg ctttagactc
      721 ttgggaccta gacttctaca ccaagcgctt ccaggagcta cagcggaacc cgagcactgt
      781 ggaggccttt gacttggcgc agtccaatag cgagcacagc cgacactggt tcttcaaggg
      841 ccagctccac gtggatgggc agaagctggt gcactcactg tttgagtcca tcatgagcac
      901 ccaggaatcc tcgaacccca acaacgtcct caaattctgt gataacagca gtgcaatcca
      961 gggaaaggaa gtccgattcc tacggcctga ggaccccaca cggccaagcc gcttccagca
     1021 acagcaaggg ctgagacatg ttgtcttcac agcagagact cacaactttc ccacaggagt
     1081 atgccccttt agtggtgcaa ccactggcac agggggccgg attcgagatg tccagtgcac
     1141 aggccgcggg gcccacgtgg tggctggcac tgccggctat tgctttggaa atctgcatat
     1201 tccaggttac aatctgccct gggaggatcc aagcttccag tatcctggga attttgcccg
     1261 gcccctggag gttgccattg aagccagtaa tggagcttct gactatggca acaagtttgg
     1321 ggaaccagtg ctggctggct tcgcccgctc cttgggcctc cagctcccag acggccagcg
     1381 gcgtgagtgg atcaagccca tcatgtttag tgggggcatt gggtccatgg aagctgacca
     1441 cataagcaag gaggccccag agccaggcat ggaagttgta aaggttggag gtcccgtcta
     1501 caggattgga gttggaggtg gagctgcttc atctgtgcag gtgcagggag ataacaccag
     1561 tgacctggac tttggggctg tgcagcgagg agacccggag atggaacaga agatgaaccg
     1621 tgtgatcagg gcttgtgtgg aggcccccaa gggaaacccc atctgcagcc ttcatgatca
     1681 gggcgctggt ggcaatggca atgtcctaaa agagctgagt gacccagctg gagccatcat
     1741 ttacaccagc cgcttccagc ttggggaccc aaccctgaat gccctggaaa tctggggggc
     1801 tgagtaccag gaatcaaatg ctcttctgct gaggtccccc aaccgggact tcctgactca
     1861 tgtcagtgcc cgtgaacgtt gcccggcttg cttcgtgggc accatcactg gagaccggag
     1921 aatagtgctg gtggacgatc gggagtgtcc tgtcagaaga aatggccagg gggatgcccc
     1981 cccgacaccc ctgccaaccc ctgtggacct ggagctcgaa tgggtgctgg gcaagatgcc
     2041 tcggaaggag ttcttcctgc agaggaagcc ccccatgctg cagcctctgg ccttgccccc
     2101 agggctgagc gtgcaccagg ctctggagag ggttctgagg ctgcccgccg tggccagcaa
     2161 gcgctacctc accaataagg tggaccgctc tgtgggaggc ctggtggccc agcagcagtg
     2221 cgtggggccc ctgcaaactc ctctggcaga tgtagcggtt gtggcactga gccatgagga
     2281 gctcataggg gctgccacag ccttgggaga acagccagtc aagagcctgc tggacccaaa
     2341 agtcgccgcc cggctggccg tggccgaagc cctcaccaac ctggtgtttg ctctggtcac
     2401 tgacctccgg gatgtgaagt gtagcgggaa ctggatgtgg gcagccaagc tcccagggga
     2461 gggcgcagct ttggcggatg cctgtgaggc tatggtggca gtgatggcag ccctgggtgt
     2521 ggcagtggat ggtggcaagg actccctcag catggctgct cgggttggca ctgagaccgt
     2581 gcgggctcct gggtcactgg tcatctcagc ctatgccgtc tgcccagaca tcacagccac
     2641 tgtgacccca gacctcaagc atcctgaagg gagaggccat ctgctctatg tggctctgag
     2701 ccctgggcag caccggctcg ggggcacagc tctggcccag tgcttctccc agcttgggga
     2761 acaccctcca gacctggacc ttcctgagaa cttggtgcgg gccttcagca tcactcaggg
     2821 gctgctgaaa gaccgcctcc tctgctcagg ccacgatgtc agtgacggag gcctcgtcac
     2881 atgcctgctg gagatggcct ttgctggaaa ttgcgggcta caggtggatg tgcctgtccc
     2941 cagggttgat gtcctgtctg tgctgttcgc tgaggagcca ggcctcgtgc tggaggtgca
     3001 ggagccagac ctggcccagg tgctgaagcg ttaccgggat gctggcctcc attgcctgga
     3061 gctgggccac acaggcgagg ccgggcccca cgccatggtg aggaagtgag ggagagagcg
     3121 gtgtgcagtg ggcagtcaga gtggggtggc cgcggtccat ccctctccca ctgtggaggg
     3181 ggccatcctt tctcctagcc cgtgggagat ttgttcctct tcctaggtcc gggtgtcagt
     3241 gaacggggct gtggttctgg aggagcctgt tggggagctg cgagccctct gggaggagac
     3301 gagtttccag ctggaccggc
//
