LOCUS       XM_024450804            5567 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens phosphoribosylformylglycinamidine synthase
            (PFAS), transcript variant X1, mRNA.
ACCESSION   XM_024450804
VERSION     XM_024450804.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024450804.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..5567
                     /gene="PFAS"
                     /gene_synonym="FGAMS; FGAR-AT; FGARAT; GATD8; PURL"
                     /note="phosphoribosylformylglycinamidine synthase; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 24 ESTs, 1245 long SRA reads, 8 Proteins, and
                     97% coverage of the annotated genomic feature by RNAseq
                     alignments, including 14 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:5198"
                     /db_xref="HGNC:HGNC:8863"
                     /db_xref="MIM:602133"
     CDS             329..4345
                     /gene="PFAS"
                     /gene_synonym="FGAMS; FGAR-AT; FGARAT; GATD8; PURL"
                     /codon_start=1
                     /product="phosphoribosylformylglycinamidine synthase
                     isoform X1"
                     /protein_id="XP_024306572.1"
                     /db_xref="GeneID:5198"
                     /db_xref="HGNC:HGNC:8863"
                     /db_xref="MIM:602133"
                     /translation="MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNV
                     NWTAEALPSAEETKKLMWLFGCPLLLDDVARESWLLPGSNDLLLEVGPRLNFSTPTST
                     NIVSVCRATGLGPVDRVETTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQS
                     FSPESMPEPLNGPINILGEGRLALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVE
                     AFDLAQSNSEHSRHWFFKGQLHVDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAI
                     QGKEVRFLRPEDPTRPSRFQQQQGLRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDV
                     QCTGRGAHVVAGTAGYCFGNLHIPGYNLPWEDPSFQYPGNFARPLEVAIEASNGASDY
                     GNKFGEPVLAGFARSLGLQLPDGQRREWIKPIMFSGGIGSMEADHISKEAPEPGMEVV
                     KVGGPVYRIGVGGGAASSVQVQGDNTSDLDFGAVQRGDPEMEQKMNRVIRACVEAPKG
                     NPICSLHDQGAGGNGNVLKELSDPAGAIIYTSRFQLGDPTLNALEIWGAEYQESNALL
                     LRSPNRDFLTHVSARERCPACFVGTITGDRRIVLVDDRECPVRRNGQGDAPPTPLPTP
                     VDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLSVHQALERVLRLPAVASKRYLTN
                     KVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIGAATALGEQPVKSLLDPKVAA
                     RLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAALADACEAMVAVMAALGVA
                     VDGGKDSLSMAARVGTETVRAPGSLVISAYAVCPDITATVTPDLKHPEGRGHLLYVAL
                     SPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLKDRLLCSGHDVSDGG
                     LVTCLLEMAFAGNCGLQVDVPVPRVDVLSVLFAEEPGLVLEVQEPDLAQVLKRYRDAG
                     LHCLELGHTGEAGPHAMVRVSVNGAVVLEEPVGELRALWEETSFQLDRLQAEPRCVAE
                     EERGLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMADAFHLAGF
                     EVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAGAELRRF
                     RKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSGRYES
                     RWASVRVGPGPALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWADD
                     DGNPTEQYPLNPNGSPGGVAGICSCDGRHLAVMPHPERAVRPWQWAWRPPPFDTLTTS
                     PWLQLFINARNWTLEGSC"
ORIGIN      
        1 ccctttcggc gctttttgcc ttctacacgc acttcgggtc tcagacgctt ttacttatta
       61 tggttgccct tttcccctac agctccgtca agggtcttct ccaggaaccc acagccccat
      121 agttccccca ttaacctgct cctggtttcc caccaggatt aaaccctaga gagtgaacgg
      181 agaccagttt aaggctcaca gcgggcgccg cgtgaatgag ggaataaaca ttcgcagaac
      241 cagtaagagg aacctaattc atctctccag caaaggacac atctctccag caaaggacac
      301 ctctctccag caaaggacac ctgcagagat gtccccagtc cttcacttct atgttcgtcc
      361 ctctggccat gagggggcag cccctggaca cactcggagg aaactgcaag ggaaactgcc
      421 agagctgcag ggcgtcgaga ctgaactgtg ctacaacgtg aactggacag ctgaggccct
      481 ccccagtgct gaggagacaa agaagctgat gtggctgttt ggttgcccct tactgctgga
      541 tgatgttgct cgggagtcct ggctccttcc tggctccaat gacctgctgc tggaggtcgg
      601 gcccaggctg aacttctcca ccccaacatc caccaacatc gtgtcagtgt gccgcgccac
      661 tgggctgggg cctgtggatc gtgtggagac cacccggcgc taccggctct cgtttgccca
      721 ccccccgtca gctgaggtgg aagccattgc tctggctacc ctgcacgacc ggatgacaga
      781 gcagcacttc ccccatccca tccagagttt ctcccctgag agcatgccgg aacccctcaa
      841 tggccctatc aatatactgg gtgagggccg gcttgcgctg gagaaggcca accaggagct
      901 tggtctggct ttagactctt gggacctaga cttctacacc aagcgcttcc aggagctaca
      961 gcggaacccg agcactgtgg aggcctttga cttggcgcag tccaatagcg agcacagccg
     1021 acactggttc ttcaagggcc agctccacgt ggatgggcag aagctggtgc actcactgtt
     1081 tgagtccatc atgagcaccc aggaatcctc gaaccccaac aacgtcctca aattctgtga
     1141 taacagcagt gcaatccagg gaaaggaagt ccgattccta cggcctgagg accccacacg
     1201 gccaagccgc ttccagcaac agcaagggct gagacatgtt gtcttcacag cagagactca
     1261 caactttccc acaggagtat gcccctttag tggtgcaacc actggcacag ggggccggat
     1321 tcgagatgtc cagtgcacag gccgcggggc ccacgtggtg gctggcactg ccggctattg
     1381 ctttggaaat ctgcatattc caggttacaa tctgccctgg gaggatccaa gcttccagta
     1441 tcctgggaat tttgcccggc ccctggaggt tgccattgaa gccagtaatg gagcttctga
     1501 ctatggcaac aagtttgggg aaccagtgct ggctggcttc gcccgctcct tgggcctcca
     1561 gctcccagac ggccagcggc gtgagtggat caagcccatc atgtttagtg ggggcattgg
     1621 gtccatggaa gctgaccaca taagcaagga ggccccagag ccaggcatgg aagttgtaaa
     1681 ggttggaggt cccgtctaca ggattggagt tggaggtgga gctgcttcat ctgtgcaggt
     1741 gcagggagat aacaccagtg acctggactt tggggctgtg cagcgaggag acccggagat
     1801 ggaacagaag atgaaccgtg tgatcagggc ttgtgtggag gcccccaagg gaaaccccat
     1861 ctgcagcctt catgatcagg gcgctggtgg caatggcaat gtcctaaaag agctgagtga
     1921 cccagctgga gccatcattt acaccagccg cttccagctt ggggacccaa ccctgaatgc
     1981 cctggaaatc tggggggctg agtaccagga atcaaatgct cttctgctga ggtcccccaa
     2041 ccgggacttc ctgactcatg tcagtgcccg tgaacgttgc ccggcttgct tcgtgggcac
     2101 catcactgga gaccggagaa tagtgctggt ggacgatcgg gagtgtcctg tcagaagaaa
     2161 tggccagggg gatgcccccc cgacacccct gccaacccct gtggacctgg agctcgaatg
     2221 ggtgctgggc aagatgcctc ggaaggagtt cttcctgcag aggaagcccc ccatgctgca
     2281 gcctctggcc ttgcccccag ggctgagcgt gcaccaggct ctggagaggg ttctgaggct
     2341 gcccgccgtg gccagcaagc gctacctcac caataaggtg gaccgctctg tgggaggcct
     2401 ggtggcccag cagcagtgcg tggggcccct gcaaactcct ctggcagatg tagcggttgt
     2461 ggcactgagc catgaggagc tcataggggc tgccacagcc ttgggagaac agccagtcaa
     2521 gagcctgctg gacccaaaag tcgccgcccg gctggccgtg gccgaagccc tcaccaacct
     2581 ggtgtttgct ctggtcactg acctccggga tgtgaagtgt agcgggaact ggatgtgggc
     2641 agccaagctc ccaggggagg gcgcagcttt ggcggatgcc tgtgaggcta tggtggcagt
     2701 gatggcagcc ctgggtgtgg cagtggatgg tggcaaggac tccctcagca tggctgctcg
     2761 ggttggcact gagaccgtgc gggctcctgg gtcactggtc atctcagcct atgccgtctg
     2821 cccagacatc acagccactg tgaccccaga cctcaagcat cctgaaggga gaggccatct
     2881 gctctatgtg gctctgagcc ctgggcagca ccggctcggg ggcacagctc tggcccagtg
     2941 cttctcccag cttggggaac accctccaga cctggacctt cctgagaact tggtgcgggc
     3001 cttcagcatc actcaggggc tgctgaaaga ccgcctcctc tgctcaggcc acgatgtcag
     3061 tgacggaggc ctcgtcacat gcctgctgga gatggccttt gctggaaatt gcgggctaca
     3121 ggtggatgtg cctgtcccca gggttgatgt cctgtctgtg ctgttcgctg aggagccagg
     3181 cctcgtgctg gaggtgcagg agccagacct ggcccaggtg ctgaagcgtt accgggatgc
     3241 tggcctccat tgcctggagc tgggccacac aggcgaggcc gggccccacg ccatggtccg
     3301 ggtgtcagtg aacggggctg tggttctgga ggagcctgtt ggggagctgc gagccctctg
     3361 ggaggagacg agtttccagc tggaccggct acaggcagag cctcgctgtg tggcagagga
     3421 ggaacggggc ctgagggagc ggatggggcc cagctattgc ctgcccccca cctttcccaa
     3481 agcctccgtg ccccgtgagc ctggtggtcc cagcccccga gtcgccatct tgcgagagga
     3541 gggcagtaat ggagaccggg agatggccga tgccttccac ttagctgggt ttgaggtatg
     3601 ggacgtgacc atgcaggacc tctgctctgg ggcaattggg ctggacactt tccgtggcgt
     3661 ggccttcgtg ggcggcttca gctatgcaga tgtcctgggc tctgccaaag ggtgggcagc
     3721 tgctgtgacc tttcatccca gggctggggc tgagctgagg cgcttccgga agcggccaga
     3781 caccttcagc ctgggcgtgt gtaatggctg tcaactgctg gctctgctcg gctgggtggg
     3841 aggcgacccc aatgaggatg ctgcagagat gggccctgac tcccagccag cccggccagg
     3901 ccttctgcta cgccacaacc tgtctgggcg ctacgagtct cgctgggcca gcgtgcgtgt
     3961 ggggcctggg ccagccctga tgctgcgagg gatggagggc gccgtgctgc ccgtgtggag
     4021 tgcgcacggg gaaggttacg tagcattttc ttctccggaa ctccaagctc agattgaggc
     4081 caggggcttg gctccactgc actgggctga tgatgacggg aaccccacag agcagtaccc
     4141 tctgaatccc aatgggtccc cagggggcgt ggctggcatc tgctcctgtg atggccgcca
     4201 cctggctgtc atgcctcacc ctgagcgggc cgttaggcct tggcagtggg catggcgacc
     4261 ccctccattt gatactctga ccacctcccc ctggctccag ctctttatca atgcccgaaa
     4321 ctggaccctg gaagggagct gctgactggc cacaggggct cacctgggcc ccatggcttt
     4381 tcacctaagt gggtcctgcc ccctccccca tgaccttcag gagcacccca tattatttcc
     4441 aaaaatatct tggacagaca aggaccaaaa tgccaaaatc tcagcggact cgataatctg
     4501 cctgctgatg ttccttctgt ggctgtgtct attttcagtt ctgctctaac atggcatgcc
     4561 ctttctcagc ccaggaaaca gcatgtggtt cagagaaaag agcgacaagg aaaagttagg
     4621 actcctgagg tccgaacagg ggcttctgtt gcccacttca caacacccag tgatcaccgg
     4681 tgtgcaattg cctccttggc tctgagggat gttttgcgct cccttttctc atcattgggg
     4741 ttagcgggtg cagacaaatt cagcaatagt atgcagatca gcccctcacc acctcattgt
     4801 tctcatctgg aactgaaact ttctggattt ctcttgaagt gctacactgc actgaatgta
     4861 aggaattgtt gcttgtggaa gtttctcagc gtttctggct gtcttagggc tggcctcaga
     4921 acccagcatt cctgttattt gcttctaaat tagcagctct cttttttttt ttttttttga
     4981 ggcagtctca ctctgtcacc caggctggag tacaatggcg tgatctcggc ccactgcaac
     5041 ctctgcctcc tgggttcaag caattttcct gcctcagcct cccgagtagc tgggagtaca
     5101 ggcacacacc accacaccca gctaattttt gtatttttag tagagatagg gtttcaccat
     5161 gtctcccagg ctggtctcaa actcctaacc tcaagtgatt cgcctgcctc ggcctcccaa
     5221 agtgctggga ttacaggtgg gagccactac agctggccca gcagctctgt ttctgataga
     5281 ggtggttggg gctctcatcc ctagatccta accctttagt atgctggaat tctactcttc
     5341 acttactgca ttgactgttg ttgattagtt attattgcaa agcactgtca ccggcctcag
     5401 ggagtttatg tgtaatagaa ttaaaaataa tagctgtgta taacacttag ctcaagccac
     5461 gcatgtgtga ggcatttggt atgtatctga attaattctc actaaaattc agcaaaggac
     5521 ttgatagccc ctccccgcct tttcaataaa ggatgaatga aggttga
//
