LOCUS       NM_080662               1078 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens peroxisomal biogenesis factor 11 gamma (PEX11G),
            transcript variant 1, mRNA.
ACCESSION   NM_080662
VERSION     NM_080662.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1078)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1078)
  AUTHORS   Koch,J., Pranjic,K., Huber,A., Ellinger,A., Hartig,A., Kragler,F.
            and Brocard,C.
  TITLE     PEX11 family members are membrane elongation factors that
            coordinate peroxisome proliferation and maintenance
  JOURNAL   J Cell Sci 123 (Pt 19), 3389-3400 (2010)
   PUBMED   20826455
  REMARK    GeneRIF: coordinates peroxisome membrane proliferation and
            maintenance
REFERENCE   3  (bases 1 to 1078)
  AUTHORS   Tanaka,A., Okumoto,K. and Fujiki,Y.
  TITLE     cDNA cloning and characterization of the third isoform of human
            peroxin Pex11p
  JOURNAL   Biochem Biophys Res Commun 300 (4), 819-823 (2003)
   PUBMED   12559946
  REMARK    GeneRIF: Data show that Pex11pgamma is a peroxisomal membrane
            protein, with both the N- and C-termini exposed to the cytosol.
REFERENCE   4  (bases 1 to 1078)
  AUTHORS   Li,X., Baumgart,E., Dong,G.X., Morrell,J.C., Jimenez-Sanchez,G.,
            Valle,D., Smith,K.D. and Gould,S.J.
  TITLE     PEX11alpha is required for peroxisome proliferation in response to
            4-phenylbutyrate but is dispensable for peroxisome
            proliferator-activated receptor alpha-mediated peroxisome
            proliferation
  JOURNAL   Mol Cell Biol 22 (23), 8226-8240 (2002)
   PUBMED   12417726
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY002496.1 and BC008780.2.
            
            On Nov 23, 2018 this sequence version replaced NM_080662.3.
            
            Summary: The protein encoded by this gene is a member of the PEX11
            family. This family is reported to regulate the number and size of
            peroxisomes in evolutionarily distant organisms. The protein
            encoded by this gene may induce clustering of peroxisomes.
            Alternative splicing results in multiple transcript variants that
            encode different protein isoforms. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008780.2, SRR1163658.417375.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221480.6/ ENSP00000221480.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                HY002496.1         5-20
            17-1078             BC008780.2         1-1062
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1078
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /note="peroxisomal biogenesis factor 11 gamma"
                     /db_xref="GeneID:92960"
                     /db_xref="HGNC:HGNC:20208"
                     /db_xref="MIM:607583"
     exon            1..85
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..751
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxin Pex11p gamma; peroxisomal biogenesis factor 11G;
                     peroxisomal membrane protein 11C; PEX11-gamma;
                     peroxin-11C; protein PEX11 homolog gamma; peroxisomal
                     biogenesis factor 11C; Pex11pgamma; Peroxisomal membrane
                     protein 11G"
                     /codon_start=1
                     /product="peroxisomal membrane protein 11C isoform 1"
                     /protein_id="NP_542393.1"
                     /db_xref="CCDS:CCDS12178.1"
                     /db_xref="GeneID:92960"
                     /db_xref="HGNC:HGNC:20208"
                     /db_xref="MIM:607583"
                     /translation="MASLSGLASALESYRGRDRLIRVLGYCCQLVGGVLVEQCPARSE
                     VGTRLLVVSTQLSHCRTILRLFDDLAMFVYTKQYGLGAQEEDAFVRCVSVLGNLADQL
                     YYPCEHVAWAADARVLHVDSSRWWTLSTTLWALSLLLGVARSLWMLLKLRQRLRSPTA
                     PFTSPLPRGKRRAMEAQMQSEALSLLSNLADLANAVHWLPRGVLWAGRFPPWLVGLMG
                     TISSILSMYQAARAGGQAEATTP"
     exon            86..274
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            275..453
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            454..516
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1078
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1058..1063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /note="hexamer: ATTAAA"
     polyA_site      1078
                     /gene="PEX11G"
                     /gene_synonym="PEX11gamma"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcggtga cgtcacggag ttgccatggc gtcgctgagc ggcctggcgt cggcgctgga
       61 gtcgtacagg ggccgggacc gcctgatccg agtgctgggg tactgctgcc agctggttgg
      121 tggagttctg gttgaacagt gtcccgccag gtccgaagtg gggacacgtc tgttggtggt
      181 gtccacccaa ctcagccact gcaggaccat cttgcgactc tttgatgacc tggccatgtt
      241 tgtctacact aagcaatatg gcctgggggc acaggaggag gacgcctttg tccgctgtgt
      301 ctccgtccta gggaacctgg ctgaccagct ctactacccc tgtgagcacg tggcctgggc
      361 ggctgatgcc cgggtcctcc acgtggactc ttctcggtgg tggacgctga gtacaaccct
      421 gtgggccctc tctctgctcc tgggggttgc caggtccctg tggatgctgc tgaaactgag
      481 acagaggctg cggagcccca cggcgccctt caccagcccg ctgccccggg gcaagcggag
      541 ggccatggag gcgcagatgc agtcggaggc gctgtcactt ctcagcaacc tggccgacct
      601 ggccaacgcc gtgcactggc tgccccgggg cgtgctgtgg gccggccgct tcccgccgtg
      661 gctagtgggc ctcatgggca ccatctcctc aatcctcagc atgtaccagg cggcccgggc
      721 cggcggccag gccgaggcca ctaccccctg acactgccgg aagagcacag ggacacagcc
      781 agagcccacg gagggccctt cccgcaaagc agaagccgcc agggcagggg ccggggctct
      841 catggagctg cctgtggtga aacccatggg cagggtgggt ggagggactg atgcgaggtc
      901 ccccaggcct cagcctggag ctcctgagcc gtgacagttt tcaggggccg tgcagggctt
      961 cagcagcacc tcctgcctgc cagctggcgt cttgtatcca aatcaagatg aggaagaggg
     1021 ggcctgtcgt gccttgagaa agctggaacg ggaatcaatt aaacattgtg gtgctggc
//
