LOCUS       NM_003846               1620 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens peroxisomal biogenesis factor 11 beta (PEX11B),
            transcript variant 1, mRNA.
ACCESSION   NM_003846
VERSION     NM_003846.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Esmaeili,M., Nasr-Esfahani,M.H., Shoaraye Nejati,A.,
            Safaeinejad,Z., Atefi,A., L Megraw,T. and Ghaedi,K.
  TITLE     PPARgamma dependent PEX11beta counteracts the suppressive role of
            SIRT1 on neural differentiation of HESCs
  JOURNAL   PLoS One 19 (5), e0298274 (2024)
   PUBMED   38753762
  REMARK    GeneRIF: PPARgamma dependent PEX11beta counteracts the suppressive
            role of SIRT1 on neural differentiation of HESCs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Khoddam,S., Kamal,N., Shiri,A., Jafari Khamirani,H.,
            Manoochehri,J., Dianatpour,M., Tabei,S.M.B. and Dastgheib,S.A.
  TITLE     Two siblings with PEX11B-related peroxisome biogenesis disorder
  JOURNAL   Eur J Med Genet 68, 104928 (2024)
   PUBMED   38423277
  REMARK    GeneRIF: Two siblings with PEX11B-related peroxisome biogenesis
            disorder.
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Abe,Y., Wanders,R.J.A., Waterham,H.R., Mandel,H.,
            Falik-Zaccai,T.C., Ishihara,N. and Fujiki,Y.
  TITLE     Genetic defects in peroxisome morphogenesis (Pex11beta,
            dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect
            docosahexaenoic acid-phospholipid metabolism
  JOURNAL   J Inherit Metab Dis 46 (2), 273-285 (2023)
   PUBMED   36522796
  REMARK    GeneRIF: Genetic defects in peroxisome morphogenesis (Pex11beta,
            dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect
            docosahexaenoic acid-phospholipid metabolism.
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Schrader,T.A., Carmichael,R.E., Islinger,M., Costello,J.L.,
            Hacker,C., Bonekamp,N.A., Weishaupt,J.H., Andersen,P.M. and
            Schrader,M.
  TITLE     PEX11beta and FIS1 cooperate in peroxisome division independently
            of mitochondrial fission factor
  JOURNAL   J Cell Sci 135 (13) (2022)
   PUBMED   35678336
  REMARK    GeneRIF: PEX11beta and FIS1 cooperate in peroxisome division
            independently of mitochondrial fission factor.
REFERENCE   6  (bases 1 to 1620)
  AUTHORS   Sacksteder,K.A., Jones,J.M., South,S.T., Li,X., Liu,Y. and
            Gould,S.J.
  TITLE     PEX19 binds multiple peroxisomal membrane proteins, is
            predominantly cytoplasmic, and is required for peroxisome membrane
            synthesis
  JOURNAL   J Cell Biol 148 (5), 931-944 (2000)
   PUBMED   10704444
REFERENCE   7  (bases 1 to 1620)
  AUTHORS   South,S.T. and Gould,S.J.
  TITLE     Peroxisome synthesis in the absence of preexisting peroxisomes
  JOURNAL   J Cell Biol 144 (2), 255-266 (1999)
   PUBMED   9922452
REFERENCE   8  (bases 1 to 1620)
  AUTHORS   Abe,I. and Fujiki,Y.
  TITLE     cDNA cloning and characterization of a constitutively expressed
            isoform of the human peroxin Pex11p
  JOURNAL   Biochem Biophys Res Commun 252 (2), 529-533 (1998)
   PUBMED   9826565
REFERENCE   9  (bases 1 to 1620)
  AUTHORS   Schrader,M., Reuber,B.E., Morrell,J.C., Jimenez-Sanchez,G.,
            Obie,C., Stroh,T.A., Valle,D., Schroer,T.A. and Gould,S.J.
  TITLE     Expression of PEX11beta mediates peroxisome proliferation in the
            absence of extracellular stimuli
  JOURNAL   J Biol Chem 273 (45), 29607-29614 (1998)
   PUBMED   9792670
REFERENCE   10 (bases 1 to 1620)
  AUTHORS   Steinberg,S.J., Raymond,G.V., Braverman,N.E. and Moser,A.B.
  TITLE     Zellweger Spectrum Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB054933.1, AK023991.1,
            BG435901.1 and AW162134.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003846.2.
            
            Summary: The protein encoded by this gene facilitates peroxisomal
            proliferation and interacts with PEX19. The encoded protein is
            found in the peroxisomal membrane. Several transcript variants,
            some protein-coding and some not protein-coding, have been found
            for this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.127647.1,
                                           SRR3476690.384250.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369306.8/ ENSP00000358312.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               DB054933.1         208-563
            357-922             AK023991.1         328-893
            923-1130            BG435901.1         85-292
            1131-1620           AW162134.1         10-499              c
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..1620
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /note="peroxisomal biogenesis factor 11 beta"
                     /db_xref="GeneID:8799"
                     /db_xref="HGNC:HGNC:8853"
                     /db_xref="MIM:603867"
     exon            1..85
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..809
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal biogenesis factor 11B; peroxisomal membrane
                     protein 11B; peroxin-11B; protein PEX11 homolog beta"
                     /codon_start=1
                     /product="peroxisomal membrane protein 11B isoform 1"
                     /protein_id="NP_003837.1"
                     /db_xref="CCDS:CCDS72871.1"
                     /db_xref="GeneID:8799"
                     /db_xref="HGNC:HGNC:8853"
                     /db_xref="MIM:603867"
                     /translation="MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQ
                     IRQLESHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNV
                     LWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGS
                     GGGVPGGSETGGLGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDL
                     FIPLDKLGLWRCGPGIVGLCGLVSSILSILTLIYPWLRLKP"
     exon            86..201
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /inference="alignment:Splign:2.1.0"
     exon            202..403
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /inference="alignment:Splign:2.1.0"
     exon            404..1620
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1597..1602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /note="hexamer: ATTAAA"
     polyA_site      1620
                     /gene="PEX11B"
                     /gene_synonym="PEX11-BETA; PEX11beta; PEX14B"
                     /note="major polyA site"
ORIGIN      
        1 agggccgcgg agcctgggct gcggctgtca tggacgcctg ggtccgcttc agtgctcaga
       61 gccaagcccg ggagcggctg tgtagggccg cccagtatgc ttgctctctt cttggccatg
      121 cgctgcagag gcatggagcc agtcctgagt tacagaaaca gattcgacaa ctggagagcc
      181 acctgagcct tggaagaaag cttctacgcc tgggtaactc agcagatgcc cttgagtcag
      241 ccaaaagagc tgttcaccta tcagatgttg tcctgagatt ctgcatcact gttagtcacc
      301 tcaatcgagc cttgtacttc gcctgtgaca atgtcctgtg ggctggaaag tctggactgg
      361 ctccccgtgt ggatcaggag aagtgggccc agcgttcatt caggtactat ttgttttccc
      421 tcatcatgaa tttgagccgt gatgcttatg agattcgcct actgatggag caagagtctt
      481 ctgcttgtag ccggcgactg aaaggttctg gaggaggagt cccaggagga agtgaaactg
      541 ggggacttgg gggaccaggg actccaggag gaggtctgcc ccaactggct ctgaaacttc
      601 ggctgcaagt cctgctcctg gctcgagtcc ttagaggtca tcccccactt ctgctagacg
      661 tggtcagaaa tgcctgtgat ctcttcattc ctctggacaa actaggcctc tggcgctgtg
      721 gccctgggat tgtggggctt tgtggcctcg tgtcctccat cctgtctatt ctcaccctaa
      781 tctatccctg gctacgactc aagccctgac cttccggtac aggataagga ggggacctga
      841 attggtgaga tggaatctta gatcgtcccc catgtgccag cctcattcga attctactct
      901 ttggttaaag ttagaaattc agagatttag gggtggagga agagctttgg ggaagatgag
      961 gtaaggaaag atgactcgtg aagttaatag gatgtctcta atttctagat gtgcctgagc
     1021 ttctgttctt ttcctctttc tttgtgtctc tcttgaatat atttactttg tgtctcttaa
     1081 ctctgtttaa ggttctgtgt ctatgcatct ctctctttct tttttcaacc ttctcattct
     1141 cctatccagg gatttaatca gcagaattac tttttgatag gggaggtata aggtttggcc
     1201 tgtaaggttc taactgcctt cttttttctc acagaggtgg cttatggcag atttttcctc
     1261 cttcaaactc caaacataat ttttaagact atgtgccagt ggactcttcc cttatatctc
     1321 tgcaccacaa gttgttggat gtttcctctt cctcccttat gtctacctca ccaacctcgc
     1381 tcatcatttg gcccttatcc ttccttgtac acctaccttc agatttctgc ttacactttg
     1441 atttcagagc tttattcccc agtctgttct tactcctttg tcgcttatcc agaatgatgc
     1501 tatgtgtagc atcttgctgt aaatcctgta caatgattct gtgtaaatag ctgtggccta
     1561 tgccaataat gaagagcaag cctttcaggt aagcaaatta aagttcagtt tgctcatcga
//
