LOCUS       NM_003847               2708 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens peroxisomal biogenesis factor 11 alpha (PEX11A),
            transcript variant 1, mRNA.
ACCESSION   NM_003847
VERSION     NM_003847.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Opalinski,L., Veenhuis,M. and van der Klei,I.J.
  TITLE     Peroxisomes: membrane events accompanying peroxisome proliferation
  JOURNAL   Int J Biochem Cell Biol 43 (6), 847-851 (2011)
   PUBMED   21419861
  REMARK    Review article
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Koch,J., Pranjic,K., Huber,A., Ellinger,A., Hartig,A., Kragler,F.
            and Brocard,C.
  TITLE     PEX11 family members are membrane elongation factors that
            coordinate peroxisome proliferation and maintenance
  JOURNAL   J Cell Sci 123 (Pt 19), 3389-3400 (2010)
   PUBMED   20826455
  REMARK    GeneRIF: coordinates peroxisome membrane proliferation and
            maintenance
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   Matsuzaki,T. and Fujiki,Y.
  TITLE     The peroxisomal membrane protein import receptor Pex3p is directly
            transported to peroxisomes by a novel Pex19p- and Pex16p-dependent
            pathway
  JOURNAL   J Cell Biol 183 (7), 1275-1286 (2008)
   PUBMED   19114594
REFERENCE   4  (bases 1 to 2708)
  AUTHORS   Delille,H.K. and Schrader,M.
  TITLE     Targeting of hFis1 to peroxisomes is mediated by Pex19p
  JOURNAL   J Biol Chem 283 (45), 31107-31115 (2008)
   PUBMED   18782765
REFERENCE   5  (bases 1 to 2708)
  AUTHORS   Shimizu,M., Akter,M.H., Emi,Y., Sato,R., Yamaguchi,T., Hirose,F.
            and Osumi,T.
  TITLE     Peroxisome proliferator-activated receptor subtypes differentially
            cooperate with other transcription factors in selective
            transactivation of the perilipin/PEX11 alpha gene pair
  JOURNAL   J Biochem 139 (3), 563-573 (2006)
   PUBMED   16567422
  REMARK    GeneRIF: Cooperation with other transcription factors may be
            differentially involved in selective transactivation of the
            PEX11alpha gene by different peroxisome proliferator-activated
            receptor subtypes.
REFERENCE   6  (bases 1 to 2708)
  AUTHORS   Li,X. and Gould,S.J.
  TITLE     PEX11 promotes peroxisome division independently of peroxisome
            metabolism
  JOURNAL   J Cell Biol 156 (4), 643-651 (2002)
   PUBMED   11839773
REFERENCE   7  (bases 1 to 2708)
  AUTHORS   Sacksteder,K.A., Jones,J.M., South,S.T., Li,X., Liu,Y. and
            Gould,S.J.
  TITLE     PEX19 binds multiple peroxisomal membrane proteins, is
            predominantly cytoplasmic, and is required for peroxisome membrane
            synthesis
  JOURNAL   J Cell Biol 148 (5), 931-944 (2000)
   PUBMED   10704444
REFERENCE   8  (bases 1 to 2708)
  AUTHORS   South,S.T. and Gould,S.J.
  TITLE     Peroxisome synthesis in the absence of preexisting peroxisomes
  JOURNAL   J Cell Biol 144 (2), 255-266 (1999)
   PUBMED   9922452
REFERENCE   9  (bases 1 to 2708)
  AUTHORS   Schrader,M., Reuber,B.E., Morrell,J.C., Jimenez-Sanchez,G.,
            Obie,C., Stroh,T.A., Valle,D., Schroer,T.A. and Gould,S.J.
  TITLE     Expression of PEX11beta mediates peroxisome proliferation in the
            absence of extracellular stimuli
  JOURNAL   J Biol Chem 273 (45), 29607-29614 (1998)
   PUBMED   9792670
REFERENCE   10 (bases 1 to 2708)
  AUTHORS   Abe,I., Okumoto,K., Tamura,S. and Fujiki,Y.
  TITLE     Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein
            is encoded by PEX11
  JOURNAL   FEBS Lett 431 (3), 468-472 (1998)
   PUBMED   9714566
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013787.15, AK001415.1,
            AL360141.1 and AI494060.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003847.2.
            
            Summary: This gene is a member of the PEX11 family, which is
            composed of membrane elongation factors involved in regulation of
            peroxisome maintenance and proliferation. This gene product
            interacts with peroxisomal membrane protein 19 and may respond to
            outside stimuli to increase peroxisome abundance. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA497604.1, SRR1660805.101562.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300056.8/ ENSP00000300056.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC013787.15        167822-167838       c
            18-1185             AK001415.1         41-1208
            1186-2704           AL360141.1         330-1848
            2705-2708           AI494060.1         9-12                c
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..2708
                     /gene="PEX11A"
                     /gene_synonym="hsPEX11p; PEX11-ALPHA; PEX11alpha; PMP28"
                     /note="peroxisomal biogenesis factor 11 alpha"
                     /db_xref="GeneID:8800"
                     /db_xref="HGNC:HGNC:8852"
                     /db_xref="MIM:603866"
     exon            1..178
                     /gene="PEX11A"
                     /gene_synonym="hsPEX11p; PEX11-ALPHA; PEX11alpha; PMP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..866
                     /gene="PEX11A"
                     /gene_synonym="hsPEX11p; PEX11-ALPHA; PEX11alpha; PMP28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal biogenesis factor 11A; peroxisomal membrane
                     protein 11A; peroxin-11A; protein PEX11 homolog alpha; 28
                     kDa peroxisomal integral membrane protein; peroxisomal
                     integral membrane protein 28-kDa"
                     /codon_start=1
                     /product="peroxisomal membrane protein 11A isoform 1"
                     /protein_id="NP_003838.1"
                     /db_xref="CCDS:CCDS10354.1"
                     /db_xref="GeneID:8800"
                     /db_xref="HGNC:HGNC:8852"
                     /db_xref="MIM:603866"
                     /translation="MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMK
                     LKKLESSVSTGRKWFRLGNVVHAIQATEQSIHATDLVPRLCLTLANLNRVIYFICDTI
                     LWVRSVGLTSGINKEKWRTRAAHHYYYSLLLSLVRDLYEISLQMKRVTCDRAKKEKSA
                     SQDPLWFSVAEEETEWLQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSN
                     PGIIGLGGLVSSIAGMITVAYPQMKLKTR"
     exon            179..294
                     /gene="PEX11A"
                     /gene_synonym="hsPEX11p; PEX11-ALPHA; PEX11alpha; PMP28"
                     /inference="alignment:Splign:2.1.0"
     exon            295..2708
                     /gene="PEX11A"
                     /gene_synonym="hsPEX11p; PEX11-ALPHA; PEX11alpha; PMP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2690..2695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEX11A"
                     /gene_synonym="hsPEX11p; PEX11-ALPHA; PEX11alpha; PMP28"
                     /note="hexamer: AATAAA"
     polyA_site      2708
                     /gene="PEX11A"
                     /gene_synonym="hsPEX11p; PEX11-ALPHA; PEX11alpha; PMP28"
                     /note="major polyA site"
ORIGIN      
        1 gagagactca gcccctcccc ctcagcggat aacctgggac tgaccgttcc ctggggatcc
       61 gacgggcccc agaggaccca cgcctgagcc ccgtgcgact cgtggccttt gggctagaag
      121 ccatggacgc cttcacccgc ttcaccaacc agacccaggg ccgggaccga ctcttcagag
      181 ccactcagta cacatgcatg ttgcttagat atttgttaga gcccaaagct ggcaaagaga
      241 aggtggtaat gaagctcaag aaactggagt ccagtgtgag cactggtcgt aaatggttca
      301 gactaggcaa tgtggtacat gctatacagg caactgagca gagcattcat gccactgacc
      361 tggtacctcg cttatgctta acattagcca acctgaaccg tgtgatttat ttcatctgtg
      421 acaccatcct ctgggtgagg agcgtaggtc tcacctctgg catcaacaaa gagaaatggc
      481 gaacgagggc tgctcaccac tactactatt ctcttctgct gagcctggtc agggatctgt
      541 atgaaatctc cctgcagatg aaacgagtta catgtgacag ggcaaagaaa gagaaatcag
      601 catcccagga tcctctttgg ttcagcgtgg ctgaggagga aacagaatgg ctccaatcct
      661 ttctacttct tttattccga tctctgaagc agcatcctcc cttgctcctg gacacagtga
      721 agaacctttg tgatatcctg aaccctttgg accagctggg gatctataaa tccaatcctg
      781 gcatcattgg acttggaggt cttgtgtcct ctatagcagg catgatcact gtggcatatc
      841 ctcagatgaa gctgaagacc cgttagggtg tttttaggct tggaactagt acctacttta
      901 aaagatggcc tcttggtggg acagacattt gtataagtca caggccatgt catactgtgc
      961 ttaagttctt gttcatgtga gcatttaaca acctgtgatg tgggcagaga tgaggccaag
     1021 aacggagaag ggaggagcat gaagagttgt atgtttttgg agtgctggag tgacttgtga
     1081 atttctgaat attttccctt catctaacat tgattgaaca tctcttatgt gcatagtggg
     1141 agcttagtat ttgctgaatg aataaaaatt gaaaggaaaa aatttaaaaa gacccaatcg
     1201 cactgatcat tgaacaccag tatacaataa ctttagggtc atatggatca ttggtttcac
     1261 gattacagta ggtctggtgc atggcactct cagatctagt agaggctctg atgtcagtag
     1321 caggatggag gagagctggg cttacagcct ctcaacttgt tggcccttat accatcactg
     1381 cactcatgtc cttgctctgt gcagaagtag aatcagaaaa gcatcaggca ccttcatggt
     1441 ataaattgtg tctatgggtg cagtgaataa gcaaaaatca gaagcagacc ggagggactt
     1501 ataaaaatag gtacagggtc acaatgggtg cctatatgta gcctgtgaca gataagaagc
     1561 tgacagtgag acaaacaaaa aactgaggct agagcctcat tcctctgact cctaatccag
     1621 tgttctctcc atgctctccc actgtcttca gaattgagta gaaatgtgat cccctcctga
     1681 atcctgtttt ttgcctctta ctctcccata atttggaaat ttccttgtcc agtggtttat
     1741 attcttttct agaaaaacta aaactgggtg gagtgtggtg gctcacacct ataatcccag
     1801 cactttggga ggctgaagcg gaaggattgc ttgaggccag gagttcaaga ccagcctggg
     1861 caatgtagtg agactccttc tctacaacaa agtgttaaaa aattagccag gcatggtgga
     1921 gtatgcctgt agtcccagat actctggagg ctgaagcagg aggatcactt gagcccagga
     1981 gttcaaggct gcagtgagct tccaccgcac tccagcccgg gtgatagagc aagaccctgt
     2041 gtcttaaaaa aaaattaaga cagtatttag acttatcagt tagattgttt tatttaaatc
     2101 cttctaacaa tttaggcaat tctacattaa ttttcatcaa aatttatcca gtcaaaaaaa
     2161 tttcatgaat actccagatg taagagagtc acaattttct acgataaatc agacatctta
     2221 tttctagggt gattgaggga ggtggaaagc gcaggaggaa gccagtgaag aggacaatgg
     2281 aatgctgagt caatgacatt gacttgtgtt cctatctgcc atcttgggtg tgggtcttta
     2341 tatgtggtta cagatccttt agtttgaggg aggtgaggta gagaaatagg atgccagcag
     2401 gtaggaggcc gatgtcagtc ctcccagcaa agctgtgtca tttatctgaa tggaaatgag
     2461 aaaataaata tgtactcaat aagtcacatt tcccagaaat gtgattgaga ttctcaaaaa
     2521 atagactcag attcttggct gtctgtttaa ccaatcacga tatgggattt gagaaataaa
     2581 atttagggaa ttttaagaga catgaaagct actaggtcag ggaaaataaa aagcttaaat
     2641 aactattttt attgtccaga tcctctactg taatagatta actatgttca ataaatttct
     2701 agacaaaa
//
