LOCUS       NM_000466               4369 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens peroxisomal biogenesis factor 1 (PEX1), transcript
            variant 1, mRNA.
ACCESSION   NM_000466
VERSION     NM_000466.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4369)
  AUTHORS   Karuntu,J.S., Klouwer,F.C.C., Engelen,M. and Boon,C.J.F.
  TITLE     Systematic study of ophthalmological findings in 10 patients with
            PEX1-mediated Zellweger spectrum disorder
  JOURNAL   Ophthalmic Genet 45 (4), 351-362 (2024)
   PUBMED   38664000
  REMARK    GeneRIF: Systematic study of ophthalmological findings in 10
            patients with PEX1-mediated Zellweger spectrum disorder.
REFERENCE   2  (bases 1 to 4369)
  AUTHORS   Miranda,V., Cortez,L., Rosmaninho-Salgado,J., Ramos,F. and Paiva,C.
  TITLE     Ophthalmic Manifestations of Heimler Syndrome in Two Siblings With
            PEX1 Variants
  JOURNAL   J Pediatr Ophthalmol Strabismus 61 (1), 59-66 (2024)
   PUBMED   37092661
  REMARK    GeneRIF: Ophthalmic Manifestations of Heimler Syndrome in Two
            Siblings With PEX1 Variants.
            Review article
REFERENCE   3  (bases 1 to 4369)
  AUTHORS   Liang,J.S., Hung,K.L., Lin,L.J., Ong,W.P., Keng,W.T. and Lu,J.F.
  TITLE     Novel PEX1 mutations in fibroblasts from children with Zellweger
            spectrum disorders exhibit temperature sensitive characteristics
  JOURNAL   Epilepsy Behav 145, 109266 (2023)
   PUBMED   37385119
  REMARK    GeneRIF: Novel PEX1 mutations in fibroblasts from children with
            Zellweger spectrum disorders exhibit temperature sensitive
            characteristics.
REFERENCE   4  (bases 1 to 4369)
  AUTHORS   Ott,J., Sehr,J., Schmidt,N., Schliebs,W. and Erdmann,R.
  TITLE     Comparison of human PEX knockout cell lines suggests a dual role of
            PEX1 in peroxisome biogenesis
  JOURNAL   Biol Chem 404 (2-3), 209-219 (2022)
   PUBMED   36534601
  REMARK    GeneRIF: Comparison of human PEX knockout cell lines suggests a
            dual role of PEX1 in peroxisome biogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4369)
  AUTHORS   Faber,K.N., Heyman,J.A. and Subramani,S.
  TITLE     Two AAA family peroxins, PpPex1p and PpPex6p, interact with each
            other in an ATP-dependent manner and are associated with different
            subcellular membranous structures distinct from peroxisomes
  JOURNAL   Mol Cell Biol 18 (2), 936-943 (1998)
   PUBMED   9447990
REFERENCE   6  (bases 1 to 4369)
  AUTHORS   Portsteffen,H., Beyer,A., Becker,E., Epplen,C., Pawlak,A.,
            Kunau,W.H. and Dodt,G.
  TITLE     Human PEX1 is mutated in complementation group 1 of the peroxisome
            biogenesis disorders
  JOURNAL   Nat Genet 17 (4), 449-452 (1997)
   PUBMED   9398848
REFERENCE   7  (bases 1 to 4369)
  AUTHORS   Reuber,B.E., Germain-Lee,E., Collins,C.S., Morrell,J.C.,
            Ameritunga,R., Moser,H.W., Valle,D. and Gould,S.J.
  TITLE     Mutations in PEX1 are the most common cause of peroxisome
            biogenesis disorders
  JOURNAL   Nat Genet 17 (4), 445-448 (1997)
   PUBMED   9398847
REFERENCE   8  (bases 1 to 4369)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   9  (bases 1 to 4369)
  AUTHORS   Steinberg,S.J., Raymond,G.V., Braverman,N.E. and Moser,A.B.
  TITLE     Zellweger Spectrum Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301621
REFERENCE   10 (bases 1 to 4369)
  AUTHORS   Naritomi,K., Izumikawa,Y., Ohshiro,S., Yoshida,K., Shimozawa,N.,
            Suzuki,Y., Orii,T. and Hirayama,K.
  TITLE     Gene assignment of Zellweger syndrome to 7q11.23: report of the
            second case associated with a pericentric inversion of chromosome 7
  JOURNAL   Hum Genet 84 (1), 79-80 (1989)
   PUBMED   2606480
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA313282.1, BC035575.1,
            DB461678.1, AF026086.1 and AI377121.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000466.2.
            
            Summary: This gene encodes a member of the AAA ATPase family, a
            large group of ATPases associated with diverse cellular activities.
            This protein is cytoplasmic but is often anchored to a peroxisomal
            membrane where it forms a heteromeric complex and plays a role in
            the import of proteins into peroxisomes and peroxisome biogenesis.
            Mutations in this gene have been associated with complementation
            group 1 peroxisomal disorders such as neonatal
            adrenoleukodystrophy, infantile Refsum disease, and Zellweger
            syndrome. Alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035575.1, SRR1660805.204223.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248633.9/ ENSP00000248633.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DA313282.1         12-81
            71-2415             BC035575.1         24-2368
            2416-2787           DB461678.1         101-472
            2788-4368           AF026086.1         2763-4343
            4369-4369           AI377121.1         13-13               c
FEATURES             Location/Qualifiers
     source          1..4369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..4369
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /note="peroxisomal biogenesis factor 1"
                     /db_xref="GeneID:5189"
                     /db_xref="HGNC:HGNC:8850"
                     /db_xref="MIM:602136"
     exon            1..214
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3937
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisome biogenesis disorder protein 1; peroxin-1;
                     Zellweger syndrome; peroxisomal ATPase PEX1"
                     /codon_start=1
                     /product="peroxisomal ATPase PEX1 isoform 1"
                     /protein_id="NP_000457.1"
                     /db_xref="CCDS:CCDS5627.1"
                     /db_xref="GeneID:5189"
                     /db_xref="HGNC:HGNC:8850"
                     /db_xref="MIM:602136"
                     /translation="MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQN
                     QAIEVVWSHQPAFLSWVEGRHFSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVS
                     CQQVEVEPLSADDWEILELHAVSLEQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVAL
                     IPAASYGRLETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGRDQKGMMKELQTKQL
                     QSNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQSEKKQETSWGLTEINAFKNM
                     QSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGK
                     LVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNGLE
                     ELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPR
                     ENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWE
                     KEKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSS
                     LEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHV
                     ERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDA
                     VQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPP
                     NQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSR
                     QSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTI
                     QLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKY
                     IGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVE
                     GLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDV
                     DLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLN
                     HSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDL
                     SSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADISIIK
                     GRYRSQSGEDESMNQPGPIKTRLAISQSHLMTALGHTRPSISEDDWKNFAELYESFQN
                     PKRRKNQSGTMFRPGQKVTLA"
     exon            215..358
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..442
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..557
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..1324
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1444
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1568
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1672
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1755
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1888
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1985
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2156
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2311
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2501
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2668
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2803
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2868
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3011
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3115
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3292
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3523
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3721
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3852
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..4369
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4345..4350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /note="hexamer: AATAAA"
     polyA_site      4369
                     /gene="PEX1"
                     /gene_synonym="HMLR1; PBD1A; PBD1B; ZWS; ZWS1"
                     /note="major polyA site"
ORIGIN      
        1 ctccggctcc gacgtcctcg gcctgccggg tcccgggtcc tttgcggcgc tagggtgggc
       61 gaacccagag cgacgctccg ggacgatgtg gggcagcgat cgcctggcgg gtgctggggg
      121 aggcggggcg gcagtgactg tggccttcac caacgctcgc gactgcttcc tccacctgcc
      181 gcggcgtctc gtggcccagc tgcatctgct gcagaatcaa gctatagaag tggtctggag
      241 tcaccagcct gcattcttga gctgggtgga aggcaggcat tttagtgatc aaggtgaaaa
      301 tgtggctgaa attaacagac aagttggtca aaaacttgga ctctcaaatg ggggacaggt
      361 atttctcaag ccatgttccc atgtggtatc ttgtcaacaa gttgaggtgg aacccctctc
      421 agcagatgat tgggagatac tggagctgca tgctgtttcc cttgaacaac atcttctaga
      481 tcaaattcga atagtttttc caaaagccat ttttcctgtt tgggttgatc aacaaacgta
      541 catatttatc caaattgttg cactaatacc agctgcctct tatggaaggc tggaaactga
      601 caccaaactc cttattcagc caaagacacg ccgagccaaa gagaatacat tttcaaaagc
      661 tgatgctgaa tataaaaaac ttcatagtta tggaagagac cagaaaggaa tgatgaaaga
      721 acttcaaacc aagcaacttc agtcaaatac tgtgggaatc actgaatcta atgaaaacga
      781 gtcagagatt ccagttgact catcatcagt agcaagttta tggactatga taggaagcat
      841 tttttccttt caatctgaga agaaacaaga gacatcttgg ggtttaactg aaatcaatgc
      901 attcaaaaat atgcagtcaa aggttgttcc tctagacaat attttcagag tatgcaaatc
      961 tcaacctcct agtatatata acgcgtcagc aacctctgtt tttcataaac actgtgccat
     1021 tcatgtattt ccatgggacc aggaatattt tgatgtagag cccagcttta ctgtgacata
     1081 tggaaagcta gttaagctac tttctccaaa gcaacagcaa agtaaaacaa aacaaaatgt
     1141 gttatcacct gaaaaagaga agcagatgtc agagccacta gatcaaaaaa aaattaggtc
     1201 agatcataat gaagaagatg agaaggcctg tgtgctacaa gtagtctgga atggacttga
     1261 agaattgaac aatgccatca aatataccaa aaatgtagaa gttctccatc ttgggaaagt
     1321 ctggattcca gatgacctga ggaagagact aaatatagaa atgcatgccg tagtcaggat
     1381 aactccagtg gaagttaccc ctaaaattcc aagatctcta aagttacaac ctagagagaa
     1441 tttacctaaa gacataagtg aagaagacat aaaaactgta ttttattcat ggctacagca
     1501 gtctactacc accatgcttc ctttggtaat atcagaggaa gaatttatta agctggaaac
     1561 taaagatgga ctgaaggaat tttctctgag tatagttcat tcttgggaaa aagaaaaaga
     1621 taaaaatatt tttctgttga gtcccaattt gctgcagaag actacaatac aagtccttct
     1681 agatcctatg gtaaaagaag aaaacagtga ggaaattgac tttattcttc cttttttaaa
     1741 gctgagctct ttgggaggag tgaattcctt aggcgtatcc tccttggagc acatcactca
     1801 cagcctcctg ggacgccctt tgtctcggca gctgatgtct cttgttgcag gacttaggaa
     1861 tggagctctt ttactcacag gaggaaaggg aagtggaaaa tcaactttag ccaaagcaat
     1921 ctgtaaagaa gcatttgaca aactggatgc ccatgtggag agagttgact gtaaagcttt
     1981 acgaggaaaa aggcttgaaa acatacaaaa aaccctagag gtggctttct cagaggcagt
     2041 gtggatgcag ccatctgttg tcctgctgga tgaccttgac ctcattgctg gactgcctgc
     2101 tgtcccggaa catgagcaca gtcctgatgc ggtgcagagc cagcggcttg ctcatgcttt
     2161 gaatgatatg ataaaagagt ttatctccat gggaagtttg gttgcactga ttgccacaag
     2221 tcagtctcag caatctctac atcctttact tgtttctgct caaggagttc acatatttca
     2281 gtgcgtccaa cacattcagc ctcctaatca ggaacaaaga tgtgaaattc tgtgtaatgt
     2341 aataaaaaat aaattggact gtgatataaa caagttcacc gatcttgacc tgcagcatgt
     2401 agctaaagaa actggcgggt ttgtggctag agattttaca gtacttgtgg atcgagccat
     2461 acattctcga ctctctcgtc agagtatatc caccagagaa aaattagttt taacaacatt
     2521 ggacttccaa aaggctctcc gcggatttct tcctgcgtct ttgcgaagtg tcaacctgca
     2581 taaacctaga gacctgggtt gggacaagat tggtgggtta catgaagtta ggcagatact
     2641 catggatact atccagttac ctgccaagta tccagaatta tttgcaaact tgcccatacg
     2701 acaaagaaca ggaatactgt tgtatggtcc gcctggaaca ggaaaaacct tactagctgg
     2761 ggtaattgca cgagagagta gaatgaattt tataagtgtc aaggggccag agttactcag
     2821 caaatacatt ggagcaagtg aacaagctgt tcgggatatt tttattagag cacaggctgc
     2881 aaagccctgc attcttttct ttgatgaatt tgaatccatt gctcctcggc ggggtcatga
     2941 taatacagga gttacagacc gagtagttaa ccagttgctg actcagttgg atggagtaga
     3001 aggcttacag ggtgtttatg tattggctgc tactagtcgc cctgacttga ttgaccctgc
     3061 cctgcttagg cctggtcgac tagataaatg tgtatactgt cctcctcctg atcaggtgtc
     3121 acgtcttgaa attttaaatg tcctcagtga ctctctacct ctggcagatg atgttgacct
     3181 tcagcatgta gcatcagtaa ctgactcctt tactggagct gatctgaaag ctttacttta
     3241 caatgcccaa ttggaggcct tacatggaat gctgctctcg agtggactcc aggatggaag
     3301 ttccagctct gatagtgacc taagtctgtc ttcaatggtc tttcttaacc atagcagtgg
     3361 ctctgacgat tcagctggag atggagaatg tggcttagat cagtcccttg tttctttaga
     3421 gatgtccgag atccttccag atgaatcaaa attcaatatg taccggctct actttggaag
     3481 ctcttatgaa tcagaacttg gaaatggaac ctcttctgat ttgagctcac aatgtctctc
     3541 tgcaccaagc tccatgactc aggatttgcc tggagttcct gggaaagacc agttgttttc
     3601 acagcctcca gtgttaagga cagcttcaca agagggttgc caagaactta cacaagaaca
     3661 aagagatcaa ctgagggcag atatcagtat tatcaaaggc agataccgga gccaaagtgg
     3721 agaggacgaa tccatgaacc aaccaggacc aatcaaaacc agactggcta ttagtcagtc
     3781 acatttaatg actgcacttg gtcacacaag accatccatt agtgaagatg actggaagaa
     3841 ttttgctgag ctatatgaaa gctttcaaaa tccaaagagg agaaaaaatc aaagtggaac
     3901 aatgtttcga cctggacaga aagtaacttt agcataaaat atacttcttt ttgatttggt
     3961 tctgttaagt tttttgatgg cttttccata tgttgtaaca ggaaaaaaat ggtgtctatg
     4021 aatttcttct taatttaaca aatttggtta atttataaaa tcacagattg gtaaatgcta
     4081 taattatgta atgatcagga ttgagattaa tactgtagta taaattggga cattataaca
     4141 gattccatat tttatttcct aaaatctaaa ttcagtcttt aatgaaataa tattagccaa
     4201 atggtggaac taatttattt cttttgagga aaagataata aagaatgtaa ttaaatttaa
     4261 atttcttgga attcccagtt gtatattcat cacctttgta gcatttgaca aattttatgc
     4321 ttagcagctt cttcactgtt ttgaaataaa atatcctatt acctactga
//
