LOCUS       NM_001394713            3520 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens PPARGC1 and ESRR induced regulator, muscle 1 (PERM1),
            transcript variant 5, mRNA.
ACCESSION   NM_001394713 XM_017002583
VERSION     NM_001394713.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Oka,S.I., Sabry,A.D., Horiuchi,A.K., Cawley,K.M., O'Very,S.A.,
            Zaitsev,M.A., Shankar,T.S., Byun,J., Mukai,R., Xu,X., Torres,N.S.,
            Kumar,A., Yazawa,M., Ling,J., Taleb,I., Saijoh,Y., Drakos,S.G.,
            Sadoshima,J. and Warren,J.S.
  TITLE     Perm1 regulates cardiac energetics as a downstream target of the
            histone methyltransferase Smyd1
  JOURNAL   PLoS One 15 (6), e0234913 (2020)
   PUBMED   32574189
  REMARK    GeneRIF: Perm1 regulates cardiac energetics as a downstream target
            of the histone methyltransferase Smyd1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Cho,Y., Tachibana,S., Hazen,B.C., Moresco,J.J., Yates,J.R. 3rd,
            Kok,B., Saez,E., Ross,R.S., Russell,A.P. and Kralli,A.
  TITLE     Perm1 regulates CaMKII activation and shapes skeletal muscle
            responses to endurance exercise training
  JOURNAL   Mol Metab 23, 88-97 (2019)
   PUBMED   30862473
  REMARK    GeneRIF: These findings identify Perm1 as a muscle-specific
            regulator of exercise-induced signaling and Perm1 levels as tuners
            of the skeletal muscle response to exercise.
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Kim,M.S., Pinto,S.M., Getnet,D., Nirujogi,R.S., Manda,S.S.,
            Chaerkady,R., Madugundu,A.K., Kelkar,D.S., Isserlin,R., Jain,S.,
            Thomas,J.K., Muthusamy,B., Leal-Rojas,P., Kumar,P.,
            Sahasrabuddhe,N.A., Balakrishnan,L., Advani,J., George,B.,
            Renuse,S., Selvan,L.D., Patil,A.H., Nanjappa,V., Radhakrishnan,A.,
            Prasad,S., Subbannayya,T., Raju,R., Kumar,M.,
            Sreenivasamurthy,S.K., Marimuthu,A., Sathe,G.J., Chavan,S.,
            Datta,K.K., Subbannayya,Y., Sahu,A., Yelamanchi,S.D., Jayaram,S.,
            Rajagopalan,P., Sharma,J., Murthy,K.R., Syed,N., Goel,R.,
            Khan,A.A., Ahmad,S., Dey,G., Mudgal,K., Chatterjee,A., Huang,T.C.,
            Zhong,J., Wu,X., Shaw,P.G., Freed,D., Zahari,M.S., Mukherjee,K.K.,
            Shankar,S., Mahadevan,A., Lam,H., Mitchell,C.J., Shankar,S.K.,
            Satishchandra,P., Schroeder,J.T., Sirdeshmukh,R., Maitra,A.,
            Leach,S.D., Drake,C.G., Halushka,M.K., Prasad,T.S., Hruban,R.H.,
            Kerr,C.L., Bader,G.D., Iacobuzio-Donahue,C.A., Gowda,H. and
            Pandey,A.
  TITLE     A draft map of the human proteome
  JOURNAL   Nature 509 (7502), 575-581 (2014)
   PUBMED   24870542
  REMARK    GeneRIF: Proteomics evidence was identified for the PERM1 gene
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Cho,Y., Hazen,B.C., Russell,A.P. and Kralli,A.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1
            (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in
            muscle 1 (Perm1) is a tissue-specific regulator of oxidative
            capacity in skeletal muscle cells
  JOURNAL   J Biol Chem 288 (35), 25207-25218 (2013)
   PUBMED   23836911
REFERENCE   5  (bases 1 to 3520)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645608.30.
            
            On May 3, 2021 this sequence version replaced XM_017002583.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038194.1536214.1,
                                    SRR14038195.1999130.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA2142680,
                                    SAMEA2145893 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433179.4/ ENSP00000414022.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL645608.30        105915-105943       c
            30-2322             AL645608.30        102731-105023       c
            2323-2448           AL645608.30        100349-100474       c
            2449-3520           AL645608.30        99048-100119        c
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..3520
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /note="PPARGC1 and ESRR induced regulator, muscle 1"
                     /db_xref="GeneID:84808"
                     /db_xref="HGNC:HGNC:28208"
                     /db_xref="MIM:615921"
     exon            1..29
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /inference="alignment:Splign:2.1.0"
     exon            30..2322
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2546
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /note="isoform 1 is encoded by transcript variant 5; PGC-1
                     and ERR-induced regulator in muscle 1; PPARGC1 and
                     ESRR-induced regulator in muscle 1; peroxisome
                     proliferator-activated receptor gamma coactivator 1 and
                     estrogen-related receptor-induced regulator in muscle 1;
                     pGC-1 and ERR-induced regulator in muscle protein 1"
                     /codon_start=1
                     /product="PGC-1 and ERR-induced regulator in muscle
                     protein 1 isoform 1"
                     /protein_id="NP_001381642.1"
                     /db_xref="CCDS:CCDS76083.1"
                     /db_xref="GeneID:84808"
                     /db_xref="HGNC:HGNC:28208"
                     /db_xref="MIM:615921"
                     /translation="MENFQYSVQLSDQDWAEFSATADECGLLQAGLASGDELLSSDID
                     QGDSSGSSPPRAPPLPTGQLAAGGRSRRGCEEEDVATQQPVSRSQGEPVLALGTGQQT
                     PSTSARAEAPPSLGPGASPPSQFSSCPGPASSGDQMQRLLQGPAPRPPGEPPGSPKSP
                     GHSTGSQRPPDSPGAPPRSPSRKKRRAVGAKGGGHTGASASAQTGSPLLPAASPETAK
                     LMAKAGQEELGPGPAGAPEPGPRSPVQEDRPGPGLGLSTPVPVTEQGTDQIRTPRRAK
                     LHTVSTTVWEALPDVSRAKSDMAVSTPASEPQPDRDMAVSTPASEPQSDRDMAVSTPA
                     SEPQPDTDMAVSTPASEPQPDRDMAVSIPASKPQSDTAVSTPASEPQSSVALSTPISK
                     PQLDTDVAVSTPASKHGLDVALPTAGPVAKLEVASSPPVSEAVPRMTESSGLVSTPVP
                     RADAAGLAWPPTRRAGPDVVEMEAVVSEPSAGAPGCCSGAPALGLTQVPRKKKVRFSV
                     AGPSPNKPGSGQASARPSAPQTATGAHGGPGAWEAVAVGPRPHQPRILKHLPRPPPSA
                     VTRVGPGSSFAVTLPEAYEFFFCDTIEENEEAEAAAAGQDPAGVQWPDMCEFFFPDVG
                     AQRSRRRGSPEPLPRADPVPAPIPGDPVPISIPEVYEHFFFGEDRLEGVLGPAVPLPL
                     QALEPPRSASEGAGPGTPLKPAVVERLHLALRRAGELRGPVPSFAFSQNDMCLVFVAF
                     ATWAVRTSDPHTPDAWKTALLANVGTISAIRYFRRQVGQGRRSHSPSPSS"
     exon            2323..2448
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..3520
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2896
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /note="major polyA site"
     polyA_site      2901
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /note="major polyA site"
     regulatory      3496..3501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /note="hexamer: AATAAA"
     polyA_site      3520
                     /gene="PERM1"
                     /gene_synonym="C1orf170"
                     /note="major polyA site"
ORIGIN      
        1 agacgcccag ctcggccgcc gggacccagg gcatggatgg agccccgagg cggtgggagc
       61 tcccaggtct cgtggggcag gggcggcatg tgcagggtgg tgcccggggc ctgaacccat
      121 gaagacccca ccggacccat tctgctaccc tccagtgcct ctgctgactc cacatggaaa
      181 atttccagta cagcgtccag ctgagtgacc aggactgggc cgagttctca gccaccgccg
      241 atgagtgtgg cctcctgcag gccggcctgg cctctgggga cgagctcttg tccagtgaca
      301 ttgaccaagg ggacagcagt ggcagcagtc cccccagggc cccacctctc ccaactgggc
      361 agctagctgc aggagggcgg agccggcggg gctgcgagga ggaggacgtg gccacacagc
      421 agccggtcag caggtctcag ggtgagcctg tcttggccct ggggaccggt cagcagacac
      481 ccagcacgtc cgcacgggca gaagctccac cgtccctcgg ccccggcgcc agccctccca
      541 gccagttctc atcctgccct ggtccggcgt cttctggaga ccagatgcag aggcttctgc
      601 agggccctgc cccacggccc cctggtgagc cccctgggag tcccaagtcc cctggccaca
      661 gcactggctc ccagaggccc cccgatagcc ctggagcccc accacggagc cccagccgaa
      721 agaagaggcg agctgtgggt gccaaggggg gtgggcacac aggagcctct gcttctgccc
      781 agacgggctc cccgctgctc cctgcggcca gtcctgagac ggcaaagctg atggccaaag
      841 ccgggcagga ggagttgggg ccaggtcctg caggagctcc tgagcctggc cccaggtccc
      901 ctgtgcagga agacagacca gggccaggtt tgggcctgtc tacacctgtc cctgtgacag
      961 agcaaggcac agaccaaatc agaaccccgc gccgagccaa gctgcacaca gtgtccacga
     1021 ctgtctggga agccctccca gatgtctcaa gggctaagtc agacatggct gtgtctacac
     1081 ctgcctccga gccgcaacct gacagggaca tggctgtgtc tacacctgcc tccgagccgc
     1141 aatctgacag ggacatggct gtgtctacac ctgcctctga gccgcaacct gacacggaca
     1201 tggctgtgtc tacacctgcc tctgagccgc aacctgacag ggacatggct gtgtctatac
     1261 ctgcctccaa gccgcaatct gacacggctg tgtctacacc agcttctgag cctcagtcca
     1321 gtgtggctct gtctacaccc atctccaagc cacaattgga cacggacgtg gctgtgtcca
     1381 cacctgcctc caaacatggc ctggatgtgg ccttgcctac agcaggccca gtggctaagc
     1441 tagaggtggc ttcatctcca cctgtctcgg aggctgtgcc gaggatgacc gagtccagcg
     1501 ggcttgtgtc tacacctgtt cccagagccg acgccgctgg cctcgcctgg cctcccaccc
     1561 gcagagctgg gcctgatgtg gtggagatgg aggcggttgt gtctgagccc tcagcagggg
     1621 cccccggatg ctgctctggg gcacccgcac tgggtctcac ccaagtcccc aggaagaaga
     1681 aagtgcgctt ctccgtggct gggcccagcc ccaataagcc aggctcagga caggcctcag
     1741 cccggccctc agccccccag acagcaactg gggcccacgg ggggcccgga gcctgggagg
     1801 ctgtggctgt cgggccccgg ccccaccagc ctcggatcct caagcacctg cctcgccccc
     1861 ctccctctgc cgtgacgagg gtcgggcccg ggagcagctt tgccgtgacc ctcccggagg
     1921 cctacgagtt cttcttctgt gacaccatcg aggagaacga agaggctgag gcggcagcgg
     1981 ccggtcagga tccggcaggc gtccagtggc cggacatgtg cgagttcttc ttcccagacg
     2041 ttggagccca gaggtcgagg cggcgggggt ccccggagcc gctcccgaga gctgatcctg
     2101 tgccggcccc catacctgga gaccccgtgc ccatctccat ccctgaggtc tatgaacact
     2161 tcttcttcgg ggaggacagg cttgagggcg tgctggggcc ggctgtcccg ctcccactgc
     2221 aggccctgga gcctccccgg tcggcctccg agggggcggg gcctgggacc cccctcaagc
     2281 cagccgtggt agagcggctc cacctggctc ttagacgggc aggggagctc cgggggcctg
     2341 tcccatcatt tgccttcagc cagaatgaca tgtgcctggt gtttgtagct tttgccacct
     2401 gggctgtgag gacgtcagat ccgcataccc cagacgcctg gaaaacagcc ttgctggcca
     2461 acgtcggcac catctctgcc atccgctact tccgccggca ggtggggcaa gggcgccgca
     2521 gccacagccc cagccccagc tcctaggagc caggcccggg ccagggagat gcaggatgag
     2581 gagacgacca caggcgccca gggcaggacg aggtgccgcc ctcgcccggg ccctctgacc
     2641 cctctcttct accgcgtcca ggaggggggc gtgtcctggt gctgctccct ccgactcacc
     2701 tgaggatcca gccagtgacc acggccactc cccacgcctg ggagggaggt gctaaagtct
     2761 gggtgggtgg agggcaggca ggtggctggg taggagggtg gccagattca cagatgagaa
     2821 cacagggcat tcggttaatt tcagacaggc aatagtgggg aggtcatttt actaagaagt
     2881 tgttgtttat ctgaaatcaa atgcaaccgc accctgcgtt tcttctgggg tgcaggggga
     2941 gctgagtggc aggacaggac ttggacctcg gaggggtctg agcagcaaga cactccggct
     3001 ggagctctgg gcagaggcag gggagaggac acagggtggc ctcaaagagg ggatgggcag
     3061 cctcctcaca ggtgggctgg gctggcaagg gctccaaggc ccatcactct tgatcctcaa
     3121 aggactgtgg ccaaggcctc tgcgggctct ggcctgagac agcgaaggct ctgcctgccc
     3181 ctccccagtg cagcagcccc tgcagggtgg gggtctgtgg cagagccgcg agcccctccc
     3241 cgggagccct gggtgcaggt gcagagggag aattcggtgg cctcagatgg agggctgggc
     3301 tcctggggtt gtcccggggg ctcctgtggg gcagctgggg acccacagcc aagaggagtc
     3361 agagatgagg tgggaaggtc ggtgaggggc ccgaggtggc agaggaaggg ggctgcctgg
     3421 ctgggtgctg ggtgggggtc ctcaagactg tgggagaccc tggctgctga gcagagaaca
     3481 catggatgca gcaccaataa aattctatct tttctttttc
//
