LOCUS       NM_001377275            6365 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens period circadian regulator 3 (PER3), transcript
            variant 7, mRNA.
ACCESSION   NM_001377275 XM_024450585
VERSION     NM_001377275.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6365)
  AUTHORS   Li,Y., Li,W., Deng,J. and Yin,M.
  TITLE     PER3 promoter hypermethylation correlates to the progression of
            pan-cancer
  JOURNAL   Clin Epigenetics 16 (1), 140 (2024)
   PUBMED   39402618
  REMARK    GeneRIF: PER3 promoter hypermethylation correlates to the
            progression of pan-cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6365)
  AUTHORS   Li,T., Chen,Y., Xie,Y., Tao,S., Zou,L., Yang,Y., Tao,F. and Wu,X.
  TITLE     Moderating effects of PER3 gene DNA methylation on the association
            between problematic mobile phone use and chronotype among Chinese
            young adults: Focus on gender differences
  JOURNAL   J Behav Addict 13 (2), 554-564 (2024)
   PUBMED   38829707
  REMARK    GeneRIF: Moderating effects of PER3 gene DNA methylation on the
            association between problematic mobile phone use and chronotype
            among Chinese young adults: Focus on gender differences.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6365)
  AUTHORS   Plavc,L., Skubic,C., Dolenc Groselj,L. and Rozman,D.
  TITLE     Variants in the circadian clock genes PER2 and PER3 associate with
            familial sleep phase disorders
  JOURNAL   Chronobiol Int 41 (5), 757-766 (2024)
   PUBMED   38695651
  REMARK    GeneRIF: Variants in the circadian clock genes PER2 and PER3
            associate with familial sleep phase disorders.
REFERENCE   4  (bases 1 to 6365)
  AUTHORS   Wang,Q., Liu,H., Wang,Z., Chen,Y., Zhou,S., Hu,X., Xu,Y., Zhang,X.,
            Wang,Y., Gao,Y. and Li,S.
  TITLE     Circadian gene Per3 promotes astroblastoma progression through the
            P53/BCL2/BAX signalling pathway
  JOURNAL   Gene 895, 147978 (2024)
   PUBMED   37951372
  REMARK    GeneRIF: Circadian gene Per3 promotes astroblastoma progression
            through the P53/BCL2/BAX signalling pathway.
REFERENCE   5  (bases 1 to 6365)
  AUTHORS   Yigit,S., Nursal,A.F., Ozsoy,F., Duman,E. and Ustaoglu,M.S.
  TITLE     Lack of association between VNTR variant of the circadian gene
            (PER3) and major depressive disorder in a sample of a Turkish
            population
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (6), 530-539 (2024)
   PUBMED   38006223
  REMARK    GeneRIF: Lack of association between VNTR variant of the circadian
            gene (PER3) and major depressive disorder in a sample of a Turkish
            population.
REFERENCE   6  (bases 1 to 6365)
  AUTHORS   Takano,A., Shimizu,K., Kani,S., Buijs,R.M., Okada,M. and Nagai,K.
  TITLE     Cloning and characterization of rat casein kinase 1epsilon
  JOURNAL   FEBS Lett 477 (1-2), 106-112 (2000)
   PUBMED   10899319
REFERENCE   7  (bases 1 to 6365)
  AUTHORS   Yagita,K., Yamaguchi,S., Tamanini,F., van Der Horst,G.T.,
            Hoeijmakers,J.H., Yasui,A., Loros,J.J., Dunlap,J.C. and Okamura,H.
  TITLE     Dimerization and nuclear entry of mPER proteins in mammalian cells
  JOURNAL   Genes Dev 14 (11), 1353-1363 (2000)
   PUBMED   10837028
REFERENCE   8  (bases 1 to 6365)
  AUTHORS   Kume,K., Zylka,M.J., Sriram,S., Shearman,L.P., Weaver,D.R., Jin,X.,
            Maywood,E.S., Hastings,M.H. and Reppert,S.M.
  TITLE     mCRY1 and mCRY2 are essential components of the negative limb of
            the circadian clock feedback loop
  JOURNAL   Cell 98 (2), 193-205 (1999)
   PUBMED   10428031
REFERENCE   9  (bases 1 to 6365)
  AUTHORS   Shearman,L.P., Zylka,M.J., Weaver,D.R., Kolakowski,L.F. Jr. and
            Reppert,S.M.
  TITLE     Two period homologs: circadian expression and photic regulation in
            the suprachiasmatic nuclei
  JOURNAL   Neuron 19 (6), 1261-1269 (1997)
   PUBMED   9427249
REFERENCE   10 (bases 1 to 6365)
  AUTHORS   Ferrari,N., Desmarais,D. and Royal,A.
  TITLE     Transcriptional activation of the neuronal peripherin-encoding gene
            depends on a G + C-rich element that binds Sp1 in vitro and in vivo
  JOURNAL   Gene 159 (2), 159-165 (1995)
   PUBMED   7622044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98884.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 20, 2019 this sequence version replaced XM_024450585.1.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            CLOCK/ARNTL heterodimers but then represses this upregulation in a
            feedback loop using PER/CRY heterodimers to interact with
            CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep
            disorders. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1651917.1,
                                           SRR14038192.1969434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377532.8/ ENSP00000366755.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                Z98884.11          61510-61595
            87-438              Z98884.11          61873-62224
            439-584             Z98884.11          62660-62805
            585-700             Z98884.11          63940-64055
            701-902             Z98884.11          65264-65465
            903-954             Z98884.11          71176-71227
            955-1103            Z98884.11          75744-75892
            1104-1182           Z98884.11          78332-78410
            1183-1289           Z98884.11          80266-80372
            1290-1446           Z98884.11          80911-81067
            1447-1552           Z98884.11          86112-86217
            1553-1681           Z98884.11          87112-87240
            1682-1832           Z98884.11          87657-87807
            1833-1968           Z98884.11          96504-96639
            1969-2093           Z98884.11          97334-97458
            2094-2267           Z98884.11          97686-97859
            2268-2498           Z98884.11          103699-103929
            2499-3196           Z98884.11          104337-105034
            3197-3524           Z98884.11          107053-107380
            3525-3708           Z98884.11          112981-113164
            3709-3859           Z98884.11          114218-114368
            3860-6365           Z98884.11          119891-122396
FEATURES             Location/Qualifiers
     source          1..6365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     gene            1..6365
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /note="period circadian regulator 3"
                     /db_xref="GeneID:8863"
                     /db_xref="HGNC:HGNC:8847"
                     /db_xref="MIM:603427"
     exon            1..86
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            87..438
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..3943
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /note="isoform 1 is encoded by transcript variant 7;
                     period circadian protein 3; period circadian protein
                     homolog 3; circadian clock protein PERIOD 3; cell
                     growth-inhibiting gene 13 protein; period circadian clock
                     3"
                     /codon_start=1
                     /product="period circadian protein homolog 3 isoform 1"
                     /protein_id="NP_001364204.1"
                     /db_xref="CCDS:CCDS72695.1"
                     /db_xref="GeneID:8863"
                     /db_xref="HGNC:HGNC:8847"
                     /db_xref="MIM:603427"
                     /translation="MPRGEAPGPGRRGAKDEALGEESGERWSPEFHLQRKLADSSHSE
                     QQDRNRVSEELIMVVQEMKKYFPSERRNKPSTLDALNYALRCVHSVQANSEFFQILSQ
                     NGAPQADVSMYSLEELATIASEHTSKNTDTFVAVFSFLSGRLVHISEQAALILNRKKD
                     VLASSHFVDLLAPQDMRVFYAHTARAQLPFWNNWTQRAAARYECAPVKPFFCRIRGGE
                     DRKQEKCHSPFRIIPYLIHVHHPAQPELESEPCCLTVVEKIHSGYEAPRIPVNKRIFT
                     TTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHP
                     PFEHSPIRFCTQNGDYIILDSSWSSFVNPWSRKISFIIGRHKVRTSPLNEDVFATKIK
                     KMNDNDKDITELQEQIYKLLLQPVHVSVSSGYGSLGSSGSQEQLVSIASSSEASGHRV
                     EETKAEQMTLQQVYASVNKIKNLGQQLYIESMTKSSFKPVTGTRTEPNGGGESANGGG
                     ECKTFTSFHQTLKNNSVYTEPCEDLRNDEHSPSYQQINCIDSVIRYLKSYNIPALKRK
                     CISCTNTTSSSSEEDKQNHKADDVQALQAGLQIPAIPKSEMPTNGRSIDTGGGAPQIL
                     STAMLSLGSGISQCGYSSTIVHVPPPETARDATLFCEPWTLNMQPAPLTSEEFKHVGL
                     TAAVLSAHTQKEEQNYVDKFREKILSSPYSSYLQQESRSKAKYSYFQGDSTSKQTRSA
                     GCRKGKHKRKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAM
                     VPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFPFPYLDTFM
                     TVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTSQRREEEK
                     WEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYQCVTGNNGSE
                     SSPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHP
                     TASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSRTGSAASGSSDSSIYLTSSVYSSK
                     ISQNGQQSQDVQKKETFPNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKL
                     ESMRQQQPQFSHGQKEELAKVYNWIQSQTVTQEIDIQACVTCENEDSADGAATSCGQV
                     LVEDSC"
     exon            439..584
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            585..700
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            701..902
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            903..954
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1103
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1182
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1289
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1446
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1552
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1681
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1832
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1968
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2093
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2267
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2498
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..3196
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3524
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            3525..3708
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3859
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..6365
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6339..6344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /note="hexamer: AATAAA"
     polyA_site      6365
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /note="major polyA site"
ORIGIN      
        1 gaccggcacg cggcgagcct cgagactgcg cgagggcggc cccgggggcg agcggctgtg
       61 cgcggggcca agggcggggg cagcaggccg gagtcctgaa agtcgagcga gctccgggtt
      121 ttgaaaatgt tggagggaaa agctcctcgg agatgagcgt gaccccctgg ctcgtggtgg
      181 ccgcctgttc tcactaacgc catggcgggg accggagtga gaaaccggtg tctgtcactg
      241 actgcaaagt gagcgagaag caggctgcgg gccgtcccag cacgacgtgg agccccgcgg
      301 agacctcgag atgccccgcg gggaagctcc tggccccggg agacgggggg ctaaggacga
      361 ggccctgggc gaagaatcgg gggagcggtg gagccccgag ttccatctgc agaggaaatt
      421 ggcggacagc agccacagtg aacagcaaga tcgaaacaga gtttctgaag aacttatcat
      481 ggttgtccaa gaaatgaaaa aatacttccc ctcggagaga cgcaataaac caagcactct
      541 agatgccctc aactatgctc tccgctgtgt ccacagcgtt caagcaaaca gtgagttttt
      601 ccagattctc agtcagaatg gagcacctca ggcagatgtg agcatgtaca gtcttgagga
      661 gctggccact atcgcttcag aacacacttc caaaaacaca gatacctttg tggcagtatt
      721 ttcatttctg tctggaaggt tagtgcacat ttctgaacag gctgctttga tcctgaatcg
      781 taagaaagat gtcctggcgt cttctcactt tgttgacctg cttgcacctc aagacatgag
      841 ggtattctac gcgcacactg ccagagctca gcttcctttc tggaacaact ggacccaaag
      901 agcagctgca cggtatgaat gtgctccggt gaaacctttt ttctgcagga tccgtggagg
      961 tgaagacaga aagcaagaga agtgtcactc cccattccgg atcatcccct atctgattca
     1021 tgtacatcac cctgcccagc cagaattgga atcggaacct tgctgtctca ctgtggttga
     1081 aaagattcac tctggttatg aagctcctcg gatcccagtg aataaaagaa tcttcaccac
     1141 cacacacacc ccagggtgtg tttttcttga agtagatgaa aaagcagtgc ctttgctggg
     1201 ttacctacct caggacctga ttggaacatc gatcctaagc tacctgcacc ctgaagatcg
     1261 ttctctgatg gttgccatac accaaaaagt tttgaagtat gcagggcatc ctccctttga
     1321 acattctccc attcgatttt gtactcaaaa cggagactac atcatactgg attccagttg
     1381 gtccagcttt gtgaatccct ggagccggaa gatttctttc atcattggtc ggcataaagt
     1441 tcgaacgagc ccactaaatg aggatgtttt tgctaccaaa attaaaaaga tgaacgataa
     1501 tgacaaagac ataacagaat tacaagaaca aatttacaaa cttctcttac agccagttca
     1561 cgtgagcgtg tccagcggct acgggagcct ggggagcagc gggtcgcagg agcagcttgt
     1621 cagcatcgcc tcctccagtg aggccagtgg gcaccgtgtg gaggagacga aggcggagca
     1681 gatgaccttg cagcaggtct atgccagtgt gaacaaaatt aaaaatctgg gtcagcagct
     1741 ctacattgag tcaatgacca aatcatcatt caagccagtg acggggacac gcacagaacc
     1801 gaatggtggt ggtgagtcag cgaatggtgg tggtgaatgt aagaccttta cttccttcca
     1861 ccaaacactg aaaaacaata gtgtgtacac tgagccctgt gaggatttga ggaacgatga
     1921 gcacagccca tcctatcaac agatcaactg tatcgacagt gtcatcagat acctgaagag
     1981 ctacaacatt ccagctttga aaagaaagtg tatctcctgt acaaatacaa cttcttcctc
     2041 ctcagaagaa gacaaacaga accacaaggc agatgatgtc caagccttac aagctggttt
     2101 gcaaatccca gccataccta aatcagaaat gccaacaaat ggacggtcca tagacacagg
     2161 aggaggagct ccacagatcc tgtccacggc gatgctgagc ttggggtcgg gcataagcca
     2221 atgcggttac agcagcacca ttgtccatgt cccaccccca gagacagcca gggatgctac
     2281 cctcttctgt gagccctgga ccctgaacat gcagccagcc cctttgacct cggaagaatt
     2341 taaacacgtg gggctcacag cggctgttct gtcagcgcac acccagaagg aagagcagaa
     2401 ttatgttgat aaattccgag aaaagatcct gtcatcaccc tacagctcct atcttcagca
     2461 agaaagcagg agcaaagcta aatattcata ttttcaagga gattctactt ccaagcagac
     2521 gcggtcggcc ggctgcagga aagggaagca caagcggaag aagctgccgg agccgccaga
     2581 cagcagcagc tcgaacaccg gctctggtcc ccgcagggga gcgcatcaga acgcacagcc
     2641 ctgctgcccc tccgcggcct cctctccgca cacctcgagc ccgaccttcc cacctgccgc
     2701 catggtgccc agccaggccc cttacctcgt cccagctttt cccctcccag ccgcgacctc
     2761 acccggaaga gaatacgcag cccccggaac tgcaccggaa ggcctgcatg ggctgccctt
     2821 gtccgagggc ttgcagcctt acccagcttt cccttttcct tacttggata cttttatgac
     2881 cgttttcctg cctgaccccc ctgtctgtcc tctgttgtcg ccatcgtttt tgccatgtcc
     2941 attcctgggg gcgacagcct cttctgcgat atcaccctca atgtcgtcag caatgagtcc
     3001 aactctggac ccaccccctt cagtcaccag ccaaaggaga gaggaggaaa agtgggaggc
     3061 acaaagcgag gggcacccgt tcattacttc gagaagcagc tcacccttgc agttaaactt
     3121 acttcaggaa gagatgccca gaccctctga atctccagat cagatgagaa ggaacacgtg
     3181 cccacaaact gagtatcagt gtgttacagg caacaatggc agtgagagca gtcctgctac
     3241 taccggtgca ctgtccacgg ggtcacctcc cagggagaat ccatcccatc ctactgccag
     3301 cgctctgtcc acaggatcgc ctcccatgaa gaatccatcc catcctactg ccagcgctct
     3361 gtccacagga tcgcctccca tgaagaatcc atcccatcct actgccagca cactgtccat
     3421 gggattgcct cccagcagga ctccatccca tcctactgcc actgttctgt ccacggggtc
     3481 acctcccagc gaatccccat ccagaactgg ttcagcagca tcaggaagca gcgacagcag
     3541 tatatacctt actagtagtg tttattcttc taaaatctcc caaaatgggc agcaatctca
     3601 ggacgtacag aaaaaagaaa catttcctaa tgtcgccgaa gagcccatct ggagaatgat
     3661 acggcagaca cctgagcgca ttctcatgac ataccaggta cctgagaggg ttaaagaagt
     3721 tgtactaaaa gaagacctgg aaaagctaga aagtatgagg cagcagcagc cccagttttc
     3781 tcatgggcaa aaggaggagc tggctaaggt gtataattgg attcaaagcc agactgtcac
     3841 tcaagaaatc gacattcaag cctgtgtcac ttgtgaaaat gaagattcag ctgatggtgc
     3901 ggccacatcc tgtggtcagg ttctggtaga agacagctgt tgagtgactg tgaggatgaa
     3961 ccttcatacc ctttccaaga cgtgttacac agacagacct ttttaagtcc tggactttta
     4021 aatgaccatg aagttatcat tgaatgttaa gattttttct tcttgatttt ttaatacacg
     4081 taatcttttt gaagcagaca ttgtatacag aatcttactt ctctttgttc ctgatatatt
     4141 aaaatggcca gttaggctct ttttgtagtt gaattgtctt ctaaagagat tggatggcct
     4201 ctaaagaggt atgtgtatct ttatttcaga tgtcacccag agtaaattat aattagaagt
     4261 atagctagaa tgagccccaa accttagcct catttatttt gttctgttac ataagtcatt
     4321 ttccccttag agtgcttgaa gaaatgccac ctacaggttg tgtacttttc ataatggttt
     4381 ccatgaatgt agtacgttca tacaggcttc attcaacctg gcgttcccct ccataattaa
     4441 gatgaaacat tccggttttc tcacaacaca ttagcacata ctgtccatta gcatatctgg
     4501 gataaccagg ttttgggggt tgagttttgg ccttcatcct tgtagatccc tttcctattg
     4561 atttcccacc ttccagtgaa attctgaaag tcttatctta aaaatcgatc cgcttaccat
     4621 gggcctattc ttgtaagttt cagttagcat ttgcatgtgt aatattaaaa tgaaagagct
     4681 tcttacccag tgctgttgcc cttttgagta tttttgtttt taaaataatg attgtaaaat
     4741 gttttacaag taatgtaaaa gctagtatca ttcttacata cttctgtgtt taaattttca
     4801 ttcttaccaa aacagttaac tctttctttc caatcaattt atacaaaaga ggtcgctcca
     4861 gccctaccac aggtctgact ggcactgcct tttgtttgcc cttgaacagg gcagtgttgt
     4921 ggggactgca aaagagaaaa cgtccaggcg agcccagttg tcctcgccca cagggtcctg
     4981 caggctccat cagtcaccgc tttctatggc gtttgtagtt gtgtctttta agaagtgagt
     5041 gtgattgttt acttgataaa tcagctcact ctctggtgct ttttagagaa gtccctgatt
     5101 ccttcttaaa cttggaatga tagatgaaat tcacacccct gcagatcaga aaaaacaaat
     5161 agaagaaaat gagggttaca gtaacctgtt gtctttatat aacttgcaac aaactaattt
     5221 attttttttt cctttttttg tttttggttt tttatggttt tttaaggaaa atacttttct
     5281 cctttgaagt tttacagctt tttgtaaatg cgtcctgata atgattagga aaatcgacct
     5341 tttcatccat gatgaccatc ctcatagctc agatctcctt tcaaagtagt ggctttctgg
     5401 atggtaattc catcttaagg tgtcagaact attttcaaat gctgcctttg acagttcttg
     5461 gaattttctg atattaagca gttccatgca aatattcgtg ttttataaat agctctcata
     5521 gtctgctcca tcttgatagt taagtgattt ctgaagcgtt tgtgtgtgtg ttgatcaggt
     5581 tgtgtgatat ttttgcttga tagagaatca aatttgaaac aattaaccag ccagtagatt
     5641 gtctgtcagt gaccttctgt agtaataaag tttttgccac tgtaaataaa aacagtatcc
     5701 gtagctatca ggatcattgc gcactcatat atgctaagcc ttctgttctc taatagaagc
     5761 ctttcttttc cattgtttct ggatatttgt attatccaaa tgtgcttatt tctttgcctt
     5821 agcacacgtt ttatggagta cttgttatac taggtttgat ttgaaactgg tgcttgtcgc
     5881 agaactgtca gagcatgagg agcgctcctc ctgtgggtgg acgcattcac gcactcccag
     5941 gttgcacctg ctgctggcgg tgagcagggg gttcagcagc ttgaccgatg ccccccgagg
     6001 gggctctccc cagcttaaac tttgttgttt aaatttgtta actttttata ttaatgacta
     6061 ttgaaagtgg taataaaaat ttatattata ggcttcaatg ttttcatgaa tgttacccaa
     6121 aaagctgtgt tttctttggt cagaggtcaa aatttatgaa aaacaaaatg ctgtatgaat
     6181 ggaaatcatt ttgcaattga gtgacacttc attgtaattc acagtgtaaa tttaatccaa
     6241 actgaaattt tgtttcaact gaatttgtaa ttaactctga atttgttttt aatcattagt
     6301 aatatttcag ttgggtatct ttttaagtaa aaacaacaaa taaactctgt acatgtaaaa
     6361 cgtga
//
