LOCUS       NP_001364204            1210 aa            linear   PRI 24-OCT-2024
DEFINITION  period circadian protein homolog 3 isoform 1 [Homo sapiens].
ACCESSION   NP_001364204 XP_024306353
VERSION     NP_001364204.1
DBSOURCE    REFSEQ: accession NM_001377275.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1210)
  AUTHORS   Li,Y., Li,W., Deng,J. and Yin,M.
  TITLE     PER3 promoter hypermethylation correlates to the progression of
            pan-cancer
  JOURNAL   Clin Epigenetics 16 (1), 140 (2024)
   PUBMED   39402618
  REMARK    GeneRIF: PER3 promoter hypermethylation correlates to the
            progression of pan-cancer.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1210)
  AUTHORS   Li,T., Chen,Y., Xie,Y., Tao,S., Zou,L., Yang,Y., Tao,F. and Wu,X.
  TITLE     Moderating effects of PER3 gene DNA methylation on the association
            between problematic mobile phone use and chronotype among Chinese
            young adults: Focus on gender differences
  JOURNAL   J Behav Addict 13 (2), 554-564 (2024)
   PUBMED   38829707
  REMARK    GeneRIF: Moderating effects of PER3 gene DNA methylation on the
            association between problematic mobile phone use and chronotype
            among Chinese young adults: Focus on gender differences.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1210)
  AUTHORS   Plavc,L., Skubic,C., Dolenc Groselj,L. and Rozman,D.
  TITLE     Variants in the circadian clock genes PER2 and PER3 associate with
            familial sleep phase disorders
  JOURNAL   Chronobiol Int 41 (5), 757-766 (2024)
   PUBMED   38695651
  REMARK    GeneRIF: Variants in the circadian clock genes PER2 and PER3
            associate with familial sleep phase disorders.
REFERENCE   4  (residues 1 to 1210)
  AUTHORS   Wang,Q., Liu,H., Wang,Z., Chen,Y., Zhou,S., Hu,X., Xu,Y., Zhang,X.,
            Wang,Y., Gao,Y. and Li,S.
  TITLE     Circadian gene Per3 promotes astroblastoma progression through the
            P53/BCL2/BAX signalling pathway
  JOURNAL   Gene 895, 147978 (2024)
   PUBMED   37951372
  REMARK    GeneRIF: Circadian gene Per3 promotes astroblastoma progression
            through the P53/BCL2/BAX signalling pathway.
REFERENCE   5  (residues 1 to 1210)
  AUTHORS   Yigit,S., Nursal,A.F., Ozsoy,F., Duman,E. and Ustaoglu,M.S.
  TITLE     Lack of association between VNTR variant of the circadian gene
            (PER3) and major depressive disorder in a sample of a Turkish
            population
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (6), 530-539 (2024)
   PUBMED   38006223
  REMARK    GeneRIF: Lack of association between VNTR variant of the circadian
            gene (PER3) and major depressive disorder in a sample of a Turkish
            population.
REFERENCE   6  (residues 1 to 1210)
  AUTHORS   Takano,A., Shimizu,K., Kani,S., Buijs,R.M., Okada,M. and Nagai,K.
  TITLE     Cloning and characterization of rat casein kinase 1epsilon
  JOURNAL   FEBS Lett 477 (1-2), 106-112 (2000)
   PUBMED   10899319
REFERENCE   7  (residues 1 to 1210)
  AUTHORS   Yagita,K., Yamaguchi,S., Tamanini,F., van Der Horst,G.T.,
            Hoeijmakers,J.H., Yasui,A., Loros,J.J., Dunlap,J.C. and Okamura,H.
  TITLE     Dimerization and nuclear entry of mPER proteins in mammalian cells
  JOURNAL   Genes Dev 14 (11), 1353-1363 (2000)
   PUBMED   10837028
REFERENCE   8  (residues 1 to 1210)
  AUTHORS   Kume,K., Zylka,M.J., Sriram,S., Shearman,L.P., Weaver,D.R., Jin,X.,
            Maywood,E.S., Hastings,M.H. and Reppert,S.M.
  TITLE     mCRY1 and mCRY2 are essential components of the negative limb of
            the circadian clock feedback loop
  JOURNAL   Cell 98 (2), 193-205 (1999)
   PUBMED   10428031
REFERENCE   9  (residues 1 to 1210)
  AUTHORS   Shearman,L.P., Zylka,M.J., Weaver,D.R., Kolakowski,L.F. Jr. and
            Reppert,S.M.
  TITLE     Two period homologs: circadian expression and photic regulation in
            the suprachiasmatic nuclei
  JOURNAL   Neuron 19 (6), 1261-1269 (1997)
   PUBMED   9427249
REFERENCE   10 (residues 1 to 1210)
  AUTHORS   Ferrari,N., Desmarais,D. and Royal,A.
  TITLE     Transcriptional activation of the neuronal peripherin-encoding gene
            depends on a G + C-rich element that binds Sp1 in vitro and in vivo
  JOURNAL   Gene 159 (2), 159-165 (1995)
   PUBMED   7622044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98884.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 20, 2019 this sequence version replaced XP_024306353.1.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            CLOCK/ARNTL heterodimers but then represses this upregulation in a
            feedback loop using PER/CRY heterodimers to interact with
            CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep
            disorders. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1651917.1,
                                           SRR14038192.1969434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377532.8/ ENSP00000366755.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.23"
     Protein         1..1210
                     /product="period circadian protein homolog 3 isoform 1"
                     /note="period circadian protein 3; period circadian
                     protein homolog 3; circadian clock protein PERIOD 3; cell
                     growth-inhibiting gene 13 protein; period circadian clock
                     3"
                     /calculated_mol_wt=132529
     Region          1..50
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Region          55..64
                     /region_name="Nuclear export signal 1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Region          285..377
                     /region_name="PAS"
                     /note="PAS domain; PAS motifs appear in archaea,
                     eubacteria and eukarya. Probably the most surprising
                     identification of a PAS domain was that in EAG-like
                     K+-channels. PAS domains have been found to bind ligands,
                     and to act as sensors for light and oxygen in...; cd00130"
                     /db_xref="CDD:238075"
     Site            order(288,292,298,311..314,343,348)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(308,312,320,323..324,355,357)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          404..413
                     /region_name="Nuclear export signal 3.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Region          563..768
                     /region_name="CSNK1E binding domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Region          725..796
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Region          737..753
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Region          752..>1063
                     /region_name="Atrophin-1"
                     /note="Atrophin-1 family; pfam03154"
                     /db_xref="CDD:460830"
     Region          889..931
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Site            927
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P56645.4)"
     Region          933..940
                     /region_name="Nuclear export signal 2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Region          974..1063
                     /region_name="5 X 18 AA tandem repeats of
                     S-[HP]-[AP]-T-[AT]-[GST]-[ATV]-L-S-[MT]-G-[LS]-P-P-[MRS]-
                     [EKR]-[NST]-P"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     Site            1003
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P56645.4)"
     Site            1062
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P56645.4)"
     Region          <1083..1185
                     /region_name="Period_C"
                     /note="Period protein 2/3C-terminal region; pfam12114"
                     /db_xref="CDD:463464"
     Region          1132..1210
                     /region_name="CRY binding domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56645.4)"
     CDS             1..1210
                     /gene="PER3"
                     /gene_synonym="FASPS3; GIG13"
                     /coded_by="NM_001377275.1:311..3943"
                     /note="isoform 1 is encoded by transcript variant 7"
                     /db_xref="CCDS:CCDS72695.1"
                     /db_xref="GeneID:8863"
                     /db_xref="HGNC:HGNC:8847"
                     /db_xref="MIM:603427"
ORIGIN      
        1 mprgeapgpg rrgakdealg eesgerwspe fhlqrklads shseqqdrnr vseelimvvq
       61 emkkyfpser rnkpstldal nyalrcvhsv qanseffqil sqngapqadv smysleelat
      121 iasehtsknt dtfvavfsfl sgrlvhiseq aalilnrkkd vlasshfvdl lapqdmrvfy
      181 ahtaraqlpf wnnwtqraaa ryecapvkpf fcrirggedr kqekchspfr iipylihvhh
      241 paqpelesep ccltvvekih sgyeapripv nkriftttht pgcvflevde kavpllgylp
      301 qdligtsils ylhpedrslm vaihqkvlky aghppfehsp irfctqngdy iildsswssf
      361 vnpwsrkisf iigrhkvrts plnedvfatk ikkmndndkd itelqeqiyk lllqpvhvsv
      421 ssgygslgss gsqeqlvsia ssseasghrv eetkaeqmtl qqvyasvnki knlgqqlyie
      481 smtkssfkpv tgtrtepngg gesangggec ktftsfhqtl knnsvytepc edlrndehsp
      541 syqqincids virylksyni palkrkcisc tnttssssee dkqnhkaddv qalqaglqip
      601 aipksemptn grsidtggga pqilstamls lgsgisqcgy sstivhvppp etardatlfc
      661 epwtlnmqpa pltseefkhv gltaavlsah tqkeeqnyvd kfrekilssp yssylqqesr
      721 skakysyfqg dstskqtrsa gcrkgkhkrk klpeppdsss sntgsgprrg ahqnaqpccp
      781 saassphtss ptfppaamvp sqapylvpaf plpaatspgr eyaapgtape glhglplseg
      841 lqpypafpfp yldtfmtvfl pdppvcplls psflpcpflg atassaisps mssamsptld
      901 pppsvtsqrr eeekweaqse ghpfitsrss splqlnllqe emprpsespd qmrrntcpqt
      961 eyqcvtgnng sesspattga lstgsppren pshptasals tgsppmknps hptasalstg
     1021 sppmknpshp tastlsmglp psrtpshpta tvlstgspps espsrtgsaa sgssdssiyl
     1081 tssvysskis qngqqsqdvq kketfpnvae epiwrmirqt perilmtyqv pervkevvlk
     1141 edleklesmr qqqpqfshgq keelakvynw iqsqtvtqei diqacvtcen edsadgaats
     1201 cgqvlvedsc
//
