LOCUS       NM_022817               6380 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens period circadian regulator 2 (PER2), mRNA.
ACCESSION   NM_022817 XR_017695
VERSION     NM_022817.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6380)
  AUTHORS   Otobe,Y., Jeong,E.M., Ito,S., Shinohara,Y., Kurabayashi,N.,
            Aiba,A., Fukada,Y., Kim,J.K. and Yoshitane,H.
  TITLE     Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for
            PER-dependent inhibition in circadian clock of mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (23), e2316858121 (2024)
   PUBMED   38805270
  REMARK    GeneRIF: Phosphorylation of DNA-binding domains of CLOCK-BMAL1
            complex for PER-dependent inhibition in circadian clock of
            mammalian cells.
REFERENCE   2  (bases 1 to 6380)
  AUTHORS   Francisco,J.C. and Virshup,D.M.
  TITLE     Hierarchical and scaffolded phosphorylation of two degrons controls
            PER2 stability
  JOURNAL   J Biol Chem 300 (6), 107391 (2024)
   PUBMED   38777144
  REMARK    GeneRIF: Hierarchical and scaffolded phosphorylation of two degrons
            controls PER2 stability.
REFERENCE   3  (bases 1 to 6380)
  AUTHORS   Plavc,L., Skubic,C., Dolenc Groselj,L. and Rozman,D.
  TITLE     Variants in the circadian clock genes PER2 and PER3 associate with
            familial sleep phase disorders
  JOURNAL   Chronobiol Int 41 (5), 757-766 (2024)
   PUBMED   38695651
  REMARK    GeneRIF: Variants in the circadian clock genes PER2 and PER3
            associate with familial sleep phase disorders.
REFERENCE   4  (bases 1 to 6380)
  AUTHORS   Bhaskara,M., Anjorin,O., Yoniles,A., Liu,J. and Wang,M.
  TITLE     Importance of Per2 in cardiac mitochondrial protection during
            stress
  JOURNAL   Sci Rep 14 (1), 1290 (2024)
   PUBMED   38221535
  REMARK    GeneRIF: Importance of Per2 in cardiac mitochondrial protection
            during stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6380)
  AUTHORS   Pavithra,S., Aich,A., Chanda,A., Zohra,I.F., Gawade,P. and Das,R.K.
  TITLE     PER2 gene and its association with sleep-related disorders: A
            review
  JOURNAL   Physiol Behav 273, 114411 (2024)
   PUBMED   37981094
  REMARK    GeneRIF: PER2 gene and its association with sleep-related
            disorders: A review.
            Review article
REFERENCE   6  (bases 1 to 6380)
  AUTHORS   Kume,K., Zylka,M.J., Sriram,S., Shearman,L.P., Weaver,D.R., Jin,X.,
            Maywood,E.S., Hastings,M.H. and Reppert,S.M.
  TITLE     mCRY1 and mCRY2 are essential components of the negative limb of
            the circadian clock feedback loop
  JOURNAL   Cell 98 (2), 193-205 (1999)
   PUBMED   10428031
REFERENCE   7  (bases 1 to 6380)
  AUTHORS   Sangoram,A.M., Saez,L., Antoch,M.P., Gekakis,N., Staknis,D.,
            Whiteley,A., Fruechte,E.M., Vitaterna,M.H., Shimomura,K.,
            King,D.P., Young,M.W., Weitz,C.J. and Takahashi,J.S.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
REFERENCE   8  (bases 1 to 6380)
  AUTHORS   Shearman,L.P., Zylka,M.J., Weaver,D.R., Kolakowski,L.F. Jr. and
            Reppert,S.M.
  TITLE     Two period homologs: circadian expression and photic regulation in
            the suprachiasmatic nuclei
  JOURNAL   Neuron 19 (6), 1261-1269 (1997)
   PUBMED   9427249
REFERENCE   9  (bases 1 to 6380)
  AUTHORS   Knippschild,U., Milne,D.M., Campbell,L.E., DeMaggio,A.J.,
            Christenson,E., Hoekstra,M.F. and Meek,D.W.
  TITLE     p53 is phosphorylated in vitro and in vivo by the delta and epsilon
            isoforms of casein kinase 1 and enhances the level of casein kinase
            1 delta in response to topoisomerase-directed drugs
  JOURNAL   Oncogene 15 (14), 1727-1736 (1997)
   PUBMED   9349507
REFERENCE   10 (bases 1 to 6380)
  AUTHORS   Regnier,C.H., Tomasetto,C., Moog-Lutz,C., Chenard,M.P.,
            Wendling,C., Basset,P. and Rio,M.C.
  TITLE     Presence of a new conserved domain in CART1, a novel member of the
            tumor necrosis factor receptor-associated protein family, which is
            expressed in breast carcinoma
  JOURNAL   J Biol Chem 270 (43), 25715-25721 (1995)
   PUBMED   7592751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012485.13, DA226434.1 and
            AB002345.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022817.2.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            CLOCK/ARNTL heterodimers but then represses this upregulation in a
            feedback loop using PER/CRY heterodimers to interact with
            CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of
            getting certain cancers and have been linked to sleep disorders.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002345.2, SRR14038196.1109291.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254657.8/ ENSP00000254657.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC012485.13        46616-46659         c
            45-159              DA226434.1         1-115
            160-5380            AB002345.2         1-5221
            5381-6380           AC012485.13        2093-3092           c
FEATURES             Location/Qualifiers
     source          1..6380
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..6380
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /note="period circadian regulator 2"
                     /db_xref="GeneID:8864"
                     /db_xref="HGNC:HGNC:8846"
                     /db_xref="MIM:603426"
     exon            1..262
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            263..511
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..4049
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /note="period circadian protein 2; period circadian clock
                     2; period 2; hPER2; circadian clock protein PERIOD 2;
                     period homolog 2"
                     /codon_start=1
                     /product="period circadian protein homolog 2"
                     /protein_id="NP_073728.1"
                     /db_xref="CCDS:CCDS2528.1"
                     /db_xref="GeneID:8864"
                     /db_xref="HGNC:HGNC:8846"
                     /db_xref="MIM:603426"
                     /translation="MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETN
                     ENCSTGRDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQS
                     SKVDTHKELIKTLKELKVHLPADKKAKGKASTLATLKYALRSVKQVKANEEYYQLLMS
                     SEGHPCGADVPSYTVEEMESVTSEHIVKNADMFAVAVSLVSGKILYISDQVASIFHCK
                     RDAFSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMCSGADSFTQECMEEKSFFCRVSV
                     RKSHENEIRYHPFRMTPYLVKVRDQQGAESQLCCLLLAERVHSGYEAPRIPPEKRIFT
                     TTHTPNCLFQDVDERAVPLLGYLPQDLIETPVLVQLHPSDRPLMLAIHKKILQSGGQP
                     FDYSPIRFRARNGEYITLDTSWSSFINPWSRKISFIIGRHKVRVGPLNEDVFAAHPCT
                     EEKALHPSIQELTEQIHRLLLQPVPHSGSSGYGSLGSNGSHEHLMSQTSSSDSNGHED
                     SRRRRAEICKNGNKTKNRSHYSHESGEQKKKSVTEMQTNPPAEKKAVPAMEKDSLGVS
                     FPEELACKNQPTCSYQQISCLDSVIRYLESCNEAATLKRKCEFPANVPALRSSDKRKA
                     TVSPGPHAGEAEPPSRVNSRTGVGTHLTSLALPGKAESVASLTSQCSYSSTIVHVGDK
                     KPQPELEMVEDAASGPESLDCLAGPALACGLSQEKEPFKKLGLTKEVLAAHTQKEEQS
                     FLQKFKEIRKLSIFQSHCHYYLQERSKGQPSERTAPGLRNTSGIDSPWKKTGKNRKLK
                     SKRVKPRDSSESTGSGGPVSARPPLVGLNATAWSPSDTSQSSCPAVPFPAPVPAAYSL
                     PVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQPPPFPAPLAPVMAFMLPSYSFP
                     SGTPNLPQAFFPSQPQFPSHPTLTSEMASASQPEFPSRTSIPRQPCACPATRATPPSA
                     MGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTGATETAAVGADCKPGTSRDQ
                     QPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASESLGSGSLGCDASP
                     SGAGSSDTSHTSKYFGSIDSSENNHKAKMNTGMEESEHFIKCVLQDPIWLLMADADSS
                     VMMTYQLPSRNLEAVLKEDREKLKLLQKLQPRFTESQKQELREVHQWMQTGGLPAAID
                     VAECVYCENKEKGNICIPYEEDIPSLGLSEVSDTKEDENGSPLNHRIEEQT"
     exon            512..574
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..729
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..851
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1053
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1105
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1248
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1327
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1434
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1588
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1697
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1823
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1908
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2056
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2181
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2346
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2601
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..3392
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..3555
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3748
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3899
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..6380
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6360..6365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /note="hexamer: AATAAA"
     polyA_site      6380
                     /gene="PER2"
                     /gene_synonym="FASPS; FASPS1"
                     /note="major polyA site"
ORIGIN      
        1 cgtaaccgcc gccggcgcgc gggcctcggg caggtcgggg tcccagcgcc ggctcgggca
       61 gcggaggcgc cgccggaagt tccttgggct gctggactcc tcggcttgaa acggcgccgg
      121 cgtgggggcg tgtgcccttg gccctgtccc aggtggagag tggtcgagcc gcgcgcaggg
      181 tgcgctcgtt tgaactgcgg tgacaccgag ggttggggac tcgaaccccc gcttcgcagc
      241 tcaggagcct gaggtccgaa agcttcgttc cagagcccag catgaatgga tacgcggaat
      301 ttccgcccag ccccagtaac cccaccaagg agcccgtgga gccccagccc agccaggtcc
      361 cactgcagga agatgtggac atgagcagtg gctccagtgg acatgagacc aacgaaaact
      421 gctccacggg gcgggactcg cagggcagtg actgtgacga cagtgggaag gagctgggga
      481 tgctggtgga gccaccggat gcccgccaga gtccagatac ctttagcctg atgatggcaa
      541 aatctgaaca caacccatct acaagtggct gcagtagcga ccagtcttcg aaagtggaca
      601 cacacaaaga actgataaaa acactaaagg agctgaaggt ccacctccct gcagacaaga
      661 aggccaaggg caaggccagt acgctggcca ccttgaagta cgccctcagg agcgtgaagc
      721 aggtgaaagc caatgaagag tattaccagc tgctgatgtc cagcgagggt cacccctgtg
      781 gagcagacgt gccctcctac accgtggagg agatggagag cgttacctct gagcacattg
      841 tgaagaatgc cgatatgttt gcggtggccg tgtccctggt gtctgggaag atcctgtaca
      901 tctctgacca ggttgcatcc atatttcact gtaaaagaga tgccttcagc gatgccaagt
      961 ttgtggagtt cctggcgcct cacgatgtgg gcgtgttcca cagtttcacc tccccgtaca
     1021 agcttccctt gtggagcatg tgcagtggag cagattcttt tactcaagaa tgcatggagg
     1081 agaaatcttt cttttgccgt gtcagtgtcc ggaaaagcca cgagaatgaa atccgctacc
     1141 accccttccg catgacgccc tacctggtca aggtgcggga ccaacaaggt gctgagagtc
     1201 agctttgctg ccttctgctg gcagagagag tgcactctgg ttatgaagcc cctagaattc
     1261 ctcctgaaaa gagaattttt acaaccaccc atacaccaaa ttgtttgttc caggatgtgg
     1321 atgaaagggc ggtccctctc ctgggctacc tacctcagga cctgattgaa accccagtgc
     1381 tcgtgcagct ccaccctagt gacaggccct tgatgctggc catccacaaa aagatcctgc
     1441 agtcaggcgg gcagcctttc gactattctc ccattcggtt tcgcgcccgg aacggagagt
     1501 acatcacgtt ggacaccagc tggtccagct tcatcaaccc atggagcagg aaaatctcct
     1561 tcatcattgg gaggcacaaa gtcagggtgg gccctttgaa tgaggacgtg tttgcagccc
     1621 acccctgcac agaggagaag gccctgcacc ccagcattca ggagctcaca gagcagatcc
     1681 accggctcct gctgcagccc gtcccccaca gcggctccag tggctacggg agtctgggca
     1741 gcaacgggtc ccacgagcac cttatgagcc agacctcctc cagcgacagc aacggccatg
     1801 aggactcacg ccggaggaga gccgaaattt gtaaaaatgg taacaagacc aaaaatagaa
     1861 gtcattattc tcatgaatct ggagaacaaa agaaaaaatc cgttacagaa atgcaaacta
     1921 atcccccagc tgagaagaaa gctgtccctg ccatggaaaa ggacagcctg ggggtcagct
     1981 tccccgagga gttggcctgc aagaaccagc ccacctgctc ctaccagcag atcagctgct
     2041 tggacagcgt catcaggtac ttggagagct gcaatgaggc tgccaccctg aagaggaaat
     2101 gcgagttccc agcaaacgtc ccagcgctaa ggtccagtga taagcggaag gccacagtca
     2161 gcccagggcc acacgctgga gaggcagagc cgccctccag ggtgaacagc cgcacgggag
     2221 taggtacgca cctgacctcg ctggcactgc cgggcaaggc agagagtgtg gcgtcgctca
     2281 ccagccagtg cagctacagc agcaccatcg tccatgtggg agacaagaag ccgcagccgg
     2341 agttagagat ggtggaagat gctgcgagtg ggccagaatc cctggactgc ctggcgggcc
     2401 ctgccctggc ctgtggtctc agccaagaga aggagccctt caagaagctg ggcctcacca
     2461 aggaggtact cgctgcacac acacagaagg aggagcagag cttcctgcag aagttcaaag
     2521 aaataagaaa actcagcatt ttccagtccc actgccatta ctacttgcaa gaaagatcca
     2581 aggggcagcc aagtgaacga actgcccctg gactaagaaa tacttccgga atagattcac
     2641 cttggaaaaa aacaggaaag aacagaaaat tgaagtccaa gcgggtcaaa cctcgagact
     2701 catctgagag caccggatct ggggggcccg tgtccgcccg gcccccgctg gtgggcttga
     2761 acgccacagc ctggtcaccc tcagacacgt cccagtccag ctgcccagcc gtgccctttc
     2821 ccgccccagt gccagcagct tattcactgc ccgtgtttcc agcgccaggg actgtggcag
     2881 cacccccggc acctccccac gccagcttca cagtgcctgc tgtgcccgtg gacctccagc
     2941 accagtttgc agtccagccc ccacctttcc ctgccccttt ggcgcctgtc atggcattca
     3001 tgctacccag ttattccttc ccctcgggga ccccaaacct gccccaggcc ttcttcccca
     3061 gccagcctca gtttccgagc caccccacac tcacatccga gatggcctct gcctcacagc
     3121 ctgagttccc cagccggacc tcgatcccca gacagccatg tgcttgtcca gccacccggg
     3181 ccaccccacc atcggccatg ggtagggcct ccccaccgct ctttcagtcc cgcagcagct
     3241 cgcccctgca gctcaacctg ctgcagctgg aggaagcccc tgagggtggc actggagcca
     3301 tggggaccac aggggccaca gagacagcag ctgtaggggc ggactgcaaa cctggcactt
     3361 ctcgggacca gcagccgaag gcgcctctga cccgtgatga accctcagac acacagaaca
     3421 gtgacgccct ttccacgtca agcggcctcc taaacctcct gctgaatgag gacctctgct
     3481 cagcctcggg ctctgctgct tcggagtctc tgggctccgg ctcactgggc tgcgacgcct
     3541 ccccgagtgg ggcaggcagt agtgacacaa gtcataccag caaatatttt ggaagcattg
     3601 actcctcaga gaataatcac aaagcaaaaa tgaacactgg tatggaagaa agtgagcatt
     3661 tcattaagtg cgtcctgcag gatcccatct ggctgctgat ggcagatgcg gacagcagcg
     3721 tcatgatgac gtaccagctg ccttcccgaa atttagaagc ggttttgaag gaggacagag
     3781 agaagctgaa gctcctacag aaactccagc ccaggttcac ggagagtcag aagcaggagc
     3841 tgcgcgaggt ccaccagtgg atgcagacgg gcggcctgcc cgcagccatc gacgtggcag
     3901 aatgtgttta ctgtgaaaac aaggaaaaag gtaatatttg cataccatat gaggaagata
     3961 ttccttctct gggactcagc gaagtgtcgg acaccaaaga agacgaaaat ggatccccct
     4021 tgaatcacag gatcgaagag cagacgtaac ccctgcccca cctcagcccg gcagccagcg
     4081 aggtacacca ggtggtgctt ggaagagatg aaagatcttc atggctgttt ccactgaaat
     4141 ggacacatat gctcatgttg ctttttttgt tttagaaaaa aaaacaacat agttttctga
     4201 aggggcgact taaaactgtg gagagtgggg agagttcgga aagaaatatg tttttatata
     4261 taaaatatat atgtggagtt ttgtgggatg gggaagagat tttagttgtt atttaacttg
     4321 agaaagacta agcgcctctt agtgtcaggg aagttgcctc agtgctccca gaagtcctgt
     4381 gactgtgacg agacctctgt ctgctgcacc agctggggac tctggcttcc agagctttcc
     4441 cagggtgttt ggatcagatc aaattttgtc ctctcttggg gactgctttt tatctgaatt
     4501 atcatttagt caaggtagag tgttttttta tacataccaa atggagatag cagcctctcc
     4561 tagttttatt tcaaaacgtt tcacattaaa tggtgtgaag cgttgtttgg caaaccaaca
     4621 gctttggctt ctggtgtggt caatatttca gtctgacata ggttttgttt gtagtgaaca
     4681 aagttgaaac atttgctctg gactaaagaa gcctagtggt ttgtgtggcc aactccatcg
     4741 gatgaatgca cacgcagaca gaccctctgt atatttctgc attattcttg tctccttttc
     4801 agaccatgat ggccaatatg gagattaaaa tatgtcatca gtcatctctt tatggtgact
     4861 tccctttgca aaccaggctg tgaccaacac atgtgagacc cagtcctgtt tggttttctt
     4921 ccgttggaac cacccagaca tctgcttcca cccagccaag cccacatcac atctcctggc
     4981 cgagagcagc cactgccact cagtctgaca gcttgcgact gcatctgtat tttcaggggt
     5041 gcagtgagct cacctctccc actgcaccct gggttgggtg cacagccctc attcttttca
     5101 tgagcccgac ctctctcgga gcagcttcag gcctctgcca gtgtccccag cacttttagg
     5161 tcatttggac acttggggaa aagtgaggcc agtctgcccg gctttttaca aaacctcatg
     5221 ttgcattgta tattccaaag atggttcaga aaatttaata ttggtccctg gtggaaattc
     5281 aaagttatca ctgaagaaca gttgacttaa aattggacca agactatgag gcttaaaagg
     5341 gaccagggtt ttcttttttt tttttttttt tttttttttt tagatggagt ttctttttgc
     5401 ccaggctgga gtgcagtggc gccatcttgg ctcactgcaa cctctgcctc ccaggttcaa
     5461 gcgattctcc tgcctcagcc tcctgagtag ctgggaccac aggcgactgc caccacaccc
     5521 agctaatttt ttgtattttt agtagagaca gggtttcacc atgttggcca ggctggtctc
     5581 gaactcctga cctcaagcga tccacccacc tcggcctccc aaagtgctgg gattacaggc
     5641 gtgagccacc acgcccaact gggaccaggg ttttctgttt tttgatggag gtgaaatctc
     5701 tttgtaatcc actaggtttt catcgtaaaa ccatcttatg cctgactatt aaacctattc
     5761 ttcataaaca caagaacact ttaatttttc gttaatttac aaagtaacat cagctgccta
     5821 tgcctatgat aaggtagcag tctgcattct tatggccatt agatgttaca aactccttgc
     5881 ctctaaagtc agatcatgaa gggataggtg ttcatctaag gttacagtta tgttaccgaa
     5941 acacaaaact gccaaaatct tactctgctg ttatgaatgt ttaccatcag cattatttta
     6001 tcatttaata tgtgctcact gattgttaac tgtagcttca gcgcgtgcca agcagttgac
     6061 ttaataggat catcttgtga atttgtttac gtgatgccaa gcatcaagtc atgttttctt
     6121 tagtgtgtgt gcttacacag gtgttaaaca gtttttctct attttaaact gagccttctt
     6181 tttaatatat tcccgaagag atatgtaaat aagctctcag agtttctgtg atgatttgtt
     6241 gagccttgct ggacaagtgg tttgtttgtg tgcaaaccaa actttcttta cccagtgcaa
     6301 tagatttgtt tgactgcttg tgtcttttta tgacctgttt gccttttaga aaattggtaa
     6361 ataaagcaag tatattttta
//
