LOCUS       NM_015946               4371 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens pelota mRNA surveillance and ribosome rescue factor
            (PELO), mRNA.
ACCESSION   NM_015946 NM_014100 XM_005248543
VERSION     NM_015946.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4371)
  AUTHORS   Wu,X., Yang,Z.H., Wu,J. and Han,J.
  TITLE     Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like
            receptor family proteins via activating their ATPase enzymatic
            activity
  JOURNAL   Immunity 56 (5), 926-943 (2023)
   PUBMED   36948192
  REMARK    GeneRIF: Ribosome-rescuer PELO catalyzes the oligomeric assembly of
            NOD-like receptor family proteins via activating their ATPase
            enzymatic activity.
REFERENCE   2  (bases 1 to 4371)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4371)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4371)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4371)
  AUTHORS   Mills,E.W., Green,R. and Ingolia,N.T.
  TITLE     Slowed decay of mRNAs enhances platelet specific translation
  JOURNAL   Blood 129 (17), e38-e48 (2017)
   PUBMED   28213379
  REMARK    GeneRIF: The data suggest that the decay of platelet mRNAs is
            slowed by the natural loss of the mRNA surveillance and ribosome
            rescue factor Pelota.
REFERENCE   6  (bases 1 to 4371)
  AUTHORS   Davis,O.S., Butcher,L.M., Docherty,S.J., Meaburn,E.L., Curtis,C.J.,
            Simpson,M.A., Schalkwyk,L.C. and Plomin,R.
  TITLE     A three-stage genome-wide association study of general cognitive
            ability: hunting the small effects
  JOURNAL   Behav Genet 40 (6), 759-767 (2010)
   PUBMED   20306291
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4371)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4371)
  AUTHORS   Cheli,Y., Kanaji,S., Jacquelin,B., Chang,M., Nugent,D.J. and
            Kunicki,T.J.
  TITLE     Transcriptional and epigenetic regulation of the integrin collagen
            receptor locus ITGA1-PELO-ITGA2
  JOURNAL   Biochim Biophys Acta 1769 (9-10), 546-558 (2007)
   PUBMED   17669516
  REMARK    GeneRIF: thrombopoietin-induced in vitro differentiation of primary
            human cord blood mononuclear cells into megakaryocytes, we observed
            rapid, progressive CpG methylation of ITGA1, but not PELO or ITGA2.
REFERENCE   9  (bases 1 to 4371)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   10 (bases 1 to 4371)
  AUTHORS   Shamsadin,R., Adham,I.M., von Beust,G. and Engel,W.
  TITLE     Molecular cloning, expression and chromosome location of the human
            pelota gene PELO
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 75-78 (2000)
   PUBMED   11060452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026230.5.
            
            On Nov 26, 2018 this sequence version replaced NM_015946.4.
            
            Summary: This gene encodes a protein which contains a conserved
            nuclear localization signal. The encoded protein may have a role in
            spermatogenesis, cell cycle control, and in meiotic cell division.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY117399.1, AK056144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274311.3/ ENSP00000274311.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               AC026230.5         58150-58648
            500-1735            AC026230.5         70119-71354
            1736-4371           AC026230.5         71643-74278
FEATURES             Location/Qualifiers
     source          1..4371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..4371
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /note="pelota mRNA surveillance and ribosome rescue
                     factor"
                     /db_xref="GeneID:53918"
                     /db_xref="HGNC:HGNC:8829"
                     /db_xref="MIM:605757"
     exon            1..499
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1735
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /inference="alignment:Splign:2.1.0"
     CDS             1010..2167
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /note="pelota homolog; hPelota; protein Dom34 homolog"
                     /codon_start=1
                     /product="protein pelota homolog"
                     /protein_id="NP_057030.3"
                     /db_xref="CCDS:CCDS3956.1"
                     /db_xref="GeneID:53918"
                     /db_xref="HGNC:HGNC:8829"
                     /db_xref="MIM:605757"
                     /translation="MKLVRKNIEKDNAGQVTLVPEEPEDMWHTYNLVQVGDSLRASTI
                     RKVQTESSTGSVGSNRVRTTLTLCVEAIDFDSQACQLRVKGTNIQENEYVKMGAYHTI
                     ELEPNRQFTLAKKQWDSVVLERIEQACDPAWSADVAAVVMQEGLAHICLVTPSMTLTR
                     AKVEVNIPRKRKGNCSQHDRALERFYEQVVQAIQRHIHFDVVKCILVASPGFVREQFC
                     DYLFQQAVKTDNKLLLENRSKFLQVHASSGHKYSLKEALCDPTVASRLSDTKAAGEVK
                     ALDDFYKMLQHEPDRAFYGLKQVEKANEAMAIDTLLISDELFRHQDVATRSRYVRLVD
                     SVKENAGTVRIFSSLHVSGEQLSQLTGVAAILRFPVPELSDQEGDSSSEED"
     exon            1736..4371
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /note="hexamer: AATAAA"
     polyA_site      2375
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /note="major polyA site"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /note="hexamer: ATTAAA"
     polyA_site      2944
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
     regulatory      4342..4347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
                     /note="hexamer: AATAAA"
     polyA_site      4371
                     /gene="PELO"
                     /gene_synonym="CGI-17; PRO1770"
ORIGIN      
        1 acccgccttc ctaccacctt aggggatttg gcccggagaa cgagatcacc ctctcaatga
       61 aaggcagatg tccctttaag gtttgcttct acagcccgtg gactttagcc taaacacgga
      121 cccgcgaagc tggctttatt tgtccatgtc tcggacagag cctgggaagc tgccagtgag
      181 atttcagaga ccaagagcgc gaaggggcgg gcgatgtggc aatccgtctg ggatgtgaaa
      241 agcgtggagc gcatttagag gaattcgacg aaaacacagg aaatcactcc tctcccgctc
      301 ctgggcgccg ctgccactgg ggcagaggac tgggaaccgc ggcagcggga taagtggccc
      361 agccagagag cgcagctccc gcgcccggtc ctgccctgcg aaccagcgcg gccccctggc
      421 gctgaggctg ctccggccat ggcccctcgg ccccgcgccc gcccaggggt cgctgtcgcc
      481 tgctgctggc tcctcactga cagggatgga agagaaaact taggaagttg aagtttggca
      541 ttaaaataaa ggactcgcca ccactctgtg caccttcttg agggagttca ttcgtccgga
      601 gcgcctcaca gcttagtgcg cctgcgcacg cgcgaactgc ggccccgcct ctcctttggg
      661 gacgggagac gtgcgtcggg tcgcgggacg ggggctgcgc atgcgccttc atttcgtcag
      721 cccgctgttg cgtgctgcca gcgggaactg tgtaggggta gattttcgct gcagtgttcc
      781 ccgagcctgt tagacgcagc gcgccgggag actgagagag gaaaggatag aggaagtgct
      841 gccctaggct gcatgagtcg aagcaagcgt gtttccttcc cgccaggcaa gtgcccttag
      901 aaaccgggcc ccgccccctt cctggcctgc attcccatcc cctctcccgg ggcggaggtg
      961 aggacctcct tggttccttt ggttctgtca gtgagcccct tccttggcca tgaagctcgt
     1021 gaggaagaac atcgagaagg acaatgcggg ccaggtgacc ctggtccccg aggagcctga
     1081 ggacatgtgg cacacttaca acctcgtgca ggtgggcgac agcctgcgcg cctccaccat
     1141 ccgcaaggta cagacagagt cctccacggg cagcgtgggc agcaaccggg tccgcactac
     1201 cctcactctc tgcgtggagg ccatcgactt cgactctcaa gcctgccagc tgcgggttaa
     1261 ggggaccaac atccaagaga atgagtatgt caagatgggg gcttaccaca ccatcgagct
     1321 ggagcccaac cgccagttca ccctggccaa gaagcagtgg gatagtgtgg tactggagcg
     1381 catcgagcag gcctgtgacc cagcctggag cgctgatgtg gcggctgtgg tcatgcagga
     1441 aggcctcgcc catatctgct tagtcactcc cagcatgacc ctcactcggg ccaaggtgga
     1501 ggtgaacatc cctaggaaaa ggaaaggcaa ttgctctcag catgaccggg ccttggagcg
     1561 gttctatgaa caggtggtcc aggctatcca gcgccacata cactttgatg ttgtaaagtg
     1621 catcctggtg gccagcccag gatttgtgag ggagcagttc tgcgactacc tgtttcaaca
     1681 agcagtgaag accgacaaca aactgctcct ggaaaaccgg tccaaatttc ttcaggtaca
     1741 tgcctcctcc ggacacaagt actccctgaa agaggccctt tgtgacccta ctgtggctag
     1801 ccgcctttca gacactaaag ctgctgggga agtcaaagcc ttggatgact tctataaaat
     1861 gttacagcat gaaccggatc gagctttcta tggactcaag caggtggaga aggccaatga
     1921 agccatggca attgacacat tgctcatcag cgatgagctc ttcaggcatc aggatgtagc
     1981 cacacggagc cggtatgtga ggctggtgga cagtgtgaaa gagaatgcag gcaccgttag
     2041 gatattctct agtcttcacg tttctgggga acagctcagc cagttgactg gggtagctgc
     2101 cattctccgc ttccctgttc ccgaactttc tgaccaagag ggtgattcca gttctgaaga
     2161 ggattaatga ttgaaactta aaattgagac aatcttgtgt ttcctaaact gttacagtac
     2221 atttctcagc atccttgtga cagaaagctg caagaatggc actttttgat tcatacaggg
     2281 atttcttatg tctttggcta cactagatat tttgtgattg gcaagacatg tatttaaaca
     2341 ataaactaaa aggaaataat ctccacgtac taccatcttg attaaattgt gtaatttttt
     2401 ataggaatta tgagttatct gtagtacttg gaaacagaaa atgtgtgtat ttaaagacga
     2461 tgcctatgca gtatattgtt tgggatagat tgcaaaattt cacactgcat gctttgaaac
     2521 agttttcctt agaaaaagct tttgctatct tatcctgttt acattatttc tttattttaa
     2581 ttctgcttgg tgttcttgca ttgcatttaa tgatcccttt tctccccacc tccacacact
     2641 acattttttt tagatttaaa tagttttact attttaaatg attgccgtac aattagtaga
     2701 cttgaagaca agttttaaat atttttcttc aaaggcttgt taaaccaatc atgttaaaag
     2761 gaaattcttg gttttggttt gttgttgtta gcattagtca tatttgattt agagggtaac
     2821 ttaaatcagt tatttttagc tttttagaac tttgatctgc tagggattgt caaaataatc
     2881 tccttgaggc atctttattt ttaaaatgag attaaagtat gtgatttgct tgttatgtgg
     2941 ctaattagtg gcaaagctgg aagtcattcc cagtctggac tttagttctt tgcgccaaaa
     3001 catgctatat tatttattta tttttttgct tgtcaaagtt atacttaatt ctgttttata
     3061 tttgtatgtg gcattaattt gggtttgcac atttttattg gactatttta gttgtgaaga
     3121 agcctgttct aaagtttaag tcacatgact agtatgtggc agttgactta aactccaata
     3181 ctctttacta tcattgactt aaactctgat actctttact ataattatgg aattgtgcaa
     3241 atacctctga gtttaaaata ttatttttat tatttttggt gcacattcct aaaagttaag
     3301 gaaggagcct cagtaatgga attgcttctt gaccttttgc aaacctcaat ttagcaaaat
     3361 aattaggaac gatctaatag tgatgataca gtttttaact gctggatcag cgacgcctat
     3421 ttcaagtagt gatactaact aaactttcgc cggtctttcc tgtgtctgtg ggccttcctc
     3481 ctggtgtgac agacttgggg atttcttgta aacttcctaa ctagtctgaa cctttttatt
     3541 tcttattggg aactgacact tccctatact ttaaaactca catatgtata tttttgtaca
     3601 tctatctcct aattcaaaag taattgagat tgtcatttca ttataattcc gtgagtatct
     3661 ttaaattact atcaaatatg ttactaaata atttaataag aatatagaaa tgaagccact
     3721 gagatcctta aagttgaaac ctgattgtta ttatattttc agtaaggatt tggagatttt
     3781 tggacatttt tactctcata atctatgcag tactgaaatg aggtctaata aatataacca
     3841 atacatgtta ggccataggt tcttaaattt agctacctgt tcacctcaac ttgagagctc
     3901 ttaaaaccct cagtgtccag gttgcagctc agactagtta aataacgttt tatccctaga
     3961 aatgtttttt ttaaagctac ccagatgatt ccaataggcg tcaaggctaa tagccactga
     4021 ttcaggcctt gctattcaaa agtatggtcc gtaaaccagc agcatccctg agagcttgtt
     4081 ggaaactaga attcagggat cttttgtaga cctactgaga caggcgctac ctgtaccaac
     4141 atctctagat gattcctgtg cataataaaa tctgataaac aaaggcaata ggttattctt
     4201 cctgtgctgg taaatctctg gcaggggtcc ccagtcagga aaaagatttg agtattaagg
     4261 tctttcaaaa aagttaactg gccatactca actgtctata aaacctctat aaatttctgt
     4321 ttttatgtct atgaattatt aaataaaatt taactcattt ttaagaaatt a
//
