LOCUS       NM_145065               2704 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens pellino E3 ubiquitin protein ligase family member 3
            (PELI3), transcript variant 1, mRNA.
ACCESSION   NM_145065
VERSION     NM_145065.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Kula,A., Makuch,E., Lisowska,M., Reniewicz,P., Lipinski,T. and
            Siednienko,J.
  TITLE     Pellino3 ligase negatively regulates influenza B dependent RIG-I
            signalling through downregulation of TRAF3-mediated induction of
            the transcription factor IRF3 and IFNbeta production
  JOURNAL   Immunology 169 (3), 369-383 (2023)
   PUBMED   36861386
  REMARK    GeneRIF: Pellino3 ligase negatively regulates influenza B dependent
            RIG-I signalling through downregulation of TRAF3-mediated induction
            of the transcription factor IRF3 and IFNbeta production.
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Li,F., Li,H., Li,S., Lv,B., Shi,J., Yan,H., Zhang,H. and He,Y.
  TITLE     Long Non-coding RNA MIAT Mediates Non-small Cell Lung Cancer
            Development Through Regulating the miR-128-3p/PELI3 Axis
  JOURNAL   Biochem Genet 58 (6), 867-882 (2020)
   PUBMED   32556677
  REMARK    GeneRIF: Long Non-coding RNA MIAT Mediates Non-small Cell Lung
            Cancer Development Through Regulating the miR-128-3p/PELI3 Axis.
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Li,F., Li,H., Li,S., Lv,B., Shi,J., Yan,H., Zhang,H. and He,Y.
  TITLE     miR-365a-5p suppresses gefitinib resistance in non-small-cell lung
            cancer through targeting PELI3
  JOURNAL   Pharmacogenomics 21 (11), 771-783 (2020)
   PUBMED   32635799
  REMARK    GeneRIF: miR-365a-5p suppresses gefitinib resistance in
            non-small-cell lung cancer through targeting PELI3.
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   El-Shal,A.S., Matboli,M., Abdelaziz,A.M., Morsy,A.A. and
            Abdelbary,E.H.
  TITLE     Role of a novel circulatory RNA-based biomarker panel expression in
            ovarian cancer
  JOURNAL   IUBMB Life 71 (12), 2031-2047 (2019)
   PUBMED   31520466
  REMARK    GeneRIF: PELI3 gene expression in blood and ovarian cancer.
REFERENCE   6  (bases 1 to 2704)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Lin,C.C., Huoh,Y.S., Schmitz,K.R., Jensen,L.E. and Ferguson,K.M.
  TITLE     Pellino proteins contain a cryptic FHA domain that mediates
            interaction with phosphorylated IRAK1
  JOURNAL   Structure 16 (12), 1806-1816 (2008)
   PUBMED   19081057
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Xiao,H., Qian,W., Staschke,K., Qian,Y., Cui,G., Deng,L., Ehsani,M.,
            Wang,X., Qian,Y.W., Chen,Z.J., Gilmour,R., Jiang,Z. and Li,X.
  TITLE     Pellino 3b negatively regulates interleukin-1-induced
            TAK1-dependent NF kappaB activation
  JOURNAL   J Biol Chem 283 (21), 14654-14664 (2008)
   PUBMED   18326498
  REMARK    GeneRIF: suggest that Pellino 3b acts as a negative regulator for
            IL-1 signaling by regulating IRAK degradation through its ubiquitin
            protein ligase activity [Pellino 3b]
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   Butler,M.P., Hanly,J.A. and Moynagh,P.N.
  TITLE     Pellino3 is a novel upstream regulator of p38 MAPK and activates
            CREB in a p38-dependent manner
  JOURNAL   J Biol Chem 280 (30), 27759-27768 (2005)
   PUBMED   15917247
  REMARK    GeneRIF: Pellino3 is a novel upstream regulator of p38 MAPK that
            activates CREB in a p38-dependent manner
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   Jensen,L.E. and Whitehead,A.S.
  TITLE     Pellino3, a novel member of the Pellino protein family, promotes
            activation of c-Jun and Elk-1 and may act as a scaffolding protein
  JOURNAL   J Immunol 171 (3), 1500-1506 (2003)
   PUBMED   12874243
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA203229.1 and AL834395.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_145065.2.
            
            Summary: The protein encoded by this gene is a scaffold protein and
            an intermediate signaling protein in the innate immune response
            pathway. The encoded protein helps transmit the immune response
            signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several
            transcript variants encoding different isoforms have been found for
            this gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834395.1, SRR1803611.40254.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320740.12/ ENSP00000322532.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA203229.1         161-173
            14-2704             AL834395.1         1-2691
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..2704
                     /gene="PELI3"
                     /note="pellino E3 ubiquitin protein ligase family member
                     3"
                     /db_xref="GeneID:246330"
                     /db_xref="HGNC:HGNC:30010"
                     /db_xref="MIM:609827"
     exon            1..123
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            124..276
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1534
                     /gene="PELI3"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein pellino homolog 3; E3 ubiquitin-protein ligase
                     pellino homolog 3; RING-type E3 ubiquitin transferase
                     pellino homolog 3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase pellino homolog 3
                     isoform 1"
                     /protein_id="NP_659502.2"
                     /db_xref="CCDS:CCDS31615.1"
                     /db_xref="GeneID:246330"
                     /db_xref="HGNC:HGNC:30010"
                     /db_xref="MIM:609827"
                     /translation="MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKY
                     GELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANG
                     VKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENM
                     IDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGE
                     RAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQ
                     RGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPV
                     GLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGP
                     YVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCG
                     AWLTGEHGCVRLIFQGPLD"
     exon            277..348
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            349..478
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..580
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            581..775
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            776..964
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     exon            965..2704
                     /gene="PELI3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2672..2677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELI3"
                     /note="hexamer: AATAAT"
     polyA_site      2704
                     /gene="PELI3"
                     /note="major polyA site"
ORIGIN      
        1 gtccccgtga cgaggcagcg cggagccgcc gcgggccggg cccatcccgc cgcagcggcc
       61 cggggccgag caggggctag gcggggaggg agcggcgccc agcggggccc ggagcgtggc
      121 cagaatggtg ctggaaggaa accctgaagt ggggtccccc cgaacctcag acctccagca
      181 ccgggggaac aagggctctt gcgttctctc ctctcccggt gaagatgcgc agccaggcga
      241 ggagcccatc aagtatggtg aactcatcgt cctgggatgc tgtgaggaag gaggtgagga
      301 aaccgaggct cagagagggg aagtgactgg cccaagggca cacagctgct acaatggttg
      361 tctggcaagt ggggacaagg gccgccggcg aagccgcctg gcactgagcc gccggtcgca
      421 cgccaacggg gtgaagccag acgtcatgca ccacatctcc acgccgctcg tctccaaggc
      481 actgagtaac cgtggtcagc acagcatctc gtatacactg tcccggagcc actcggtcat
      541 agtggagtat acacatgata gcgacacaga catgttccag attggccgct ccacagagaa
      601 catgattgac ttcgtggtaa cagacacgtc ccctggagga ggggctgccg agggcccttc
      661 tgcccagagc accatctccc gctatgcctg ccgcatcctc tgtgaccgcc ggccacccta
      721 tactgcccgc atctatgccg ctggcttcga tgcctctagc aacatcttcc ttggagagcg
      781 agcggccaaa tggcggaccc cagatggcct gatggatgga ctgaccacca atggagtcct
      841 ggtgatgcac ccggcaggcg gcttctccga ggactcagcc ccgggtgtct ggcgggagat
      901 ctcggtctgt gggaatgtgt acacattgcg ggacagccgc tcagcccagc agcggggcaa
      961 gctggtggaa aacgagtcca acgtgctgca ggacggctct ctcatcgacc tgtgtggggc
     1021 cacactgctg tggcgcacac cggcggggct gctgcgggct cccacactga agcaactgga
     1081 ggcccagcgg caggaggcaa atgcagcgcg gccccagtgc cccgtgggcc tcagcactct
     1141 ggccttcccc agcccagccc gtggccgcac agcgcccgac aaacagcagc cctgggtcta
     1201 cgtccgctgc gggcacgtcc atggctacca cggctggggc tgccggcggg agcggggccc
     1261 ccaggagcgc gaatgtcctc tctgccgcct tgtggggcct tatgtgcctc tatggcttgg
     1321 ccaggaggcc ggcctctgcc tggaccctgg gccgcctagc catgcctttg caccttgcgg
     1381 ccacgtctgc tctgagaaga ctgcccgcta ctgggcccag acaccactgc cccacggcac
     1441 ccatgctttc catgccgcct gccccttttg cggggcctgg cttaccggcg agcatggctg
     1501 cgtccgcctc attttccagg gcccgctgga ttaggctccc tggggccccc tgctgctgtg
     1561 cccacctgcc cacccaggtc cccacctcct gcagcccaga gggagctctg catgtgggac
     1621 actccctgct ggcacagcca caccagatgg acatgttgga tgggctgtgc ccttcccccc
     1681 aactgtggcc ccccaaggag gtccccaaga tctccacccc agtcatgctg atggggcctt
     1741 cagcaccagc tctgtcctgg gtcgatggag gaaagcccag ccccatggcc ttgcccttcc
     1801 tggggcatcc cacatcgtgc cgccgacact gtgtgcccct gggggagtga aggggccagg
     1861 ggcctttgac ccccagctta ggctggctat gccctgagcc tgccaaccca gtttcagaca
     1921 ctcatccttc atccttcctg ctgccgccct gggttcctct ataaacctcg ctgctcagct
     1981 gcccccacaa gtcccacatg ccccgcatgc gtgcaatgcc tccagccccc aagtgagtgg
     2041 tgggtgggtg gcaggctggg cctagcactt gctgatagcc actatgggct cgactctgtg
     2101 ctaagtggta tctggggaca cagaggcaat cagacctggt tccccccctg gtggagttca
     2161 cagtctagtg gaggacagac tgttaacaaa tggcaacacg gcttcatgcg tgccaggatc
     2221 agagtacaaa tcaggctgtg gcaggcctca ctggtaatgg aaaagtgagg gaggcttcac
     2281 ggaggaggtg tcataggagc tcagcctcaa cggctgctcg gaaccctccg agtccacaag
     2341 atgggaagca agtccacaag atgggaagcg tgctctatac agaagggagg gcctgtgcac
     2401 aggctcaggt gtcagtaagc cagaaatcca gggacagagt caggatggct ggagcatgga
     2461 ctgcgggggg aacagagaag ggggtggagc aaaaggttgg gaccatgtga ccagggaaga
     2521 tgctggatgg aggattctga acctcatttg tggacggtca ggagtcaaca aagggaggag
     2581 agaggactca ctggtcaaga gtgtcggctg tgacacaagg gccatcatcc ctgaatgccc
     2641 accatgtgcc ccgcactgtg ctgatgatga taataataac tacgtccatt gagcactctc
     2701 caga
//
