LOCUS       NM_021255               5871 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens pellino E3 ubiquitin protein ligase family member 2
            (PELI2), mRNA.
ACCESSION   NM_021255
VERSION     NM_021255.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5871)
  AUTHORS   Ritchie,C. and Li,L.
  TITLE     PELI2 is a negative regulator of STING signaling that is
            dynamically repressed during viral infection
  JOURNAL   Mol Cell 84 (13), 2423-2435 (2024)
   PUBMED   38917796
  REMARK    GeneRIF: PELI2 is a negative regulator of STING signaling that is
            dynamically repressed during viral infection.
REFERENCE   2  (bases 1 to 5871)
  AUTHORS   Xu,Y., Zhou,Q., Wang,X., Zhang,A., Qi,W., Li,Y., Zheng,C., Guan,J.,
            Sun,T., Li,J., Lu,C., Shen,Y. and Zhao,B.
  TITLE     PELI2 regulates early B-cell progenitor differentiation and related
            leukemia via the IL-7R expression
  JOURNAL   Haematologica 109 (6), 1800-1814 (2024)
   PUBMED   38058209
  REMARK    GeneRIF: PELI2 regulates early B-cell progenitor differentiation
            and related leukemia via the IL-7R expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5871)
  AUTHORS   Cristea,I., Abarca,H., Christensen Mellgren,A.E., Trubnykova,M.,
            Mehrasa,R., Peters,D.J.M., Houge,G., Hennekam,R.C.M., Rodahl,E.,
            Bruland,O. and Bredrup,C.
  TITLE     A Pellino-2 variant is associated with constitutive NLRP3
            inflammasome activation in a family with ocular pterygium-digital
            keloid dysplasia
  JOURNAL   FEBS Lett 597 (9), 1290-1299 (2023)
   PUBMED   36776133
  REMARK    GeneRIF: A Pellino-2 variant is associated with constitutive NLRP3
            inflammasome activation in a family with ocular pterygium-digital
            keloid dysplasia.
REFERENCE   4  (bases 1 to 5871)
  AUTHORS   Cristea,I., Bruland,O., Aukrust,I., Rodahl,E. and Bredrup,C.
  TITLE     Pellino-2 in nonimmune cells: novel interaction partners and
            intracellular localization
  JOURNAL   FEBS Lett 595 (23), 2909-2921 (2021)
   PUBMED   34674267
  REMARK    GeneRIF: Pellino-2 in nonimmune cells: novel interaction partners
            and intracellular localization.
REFERENCE   5  (bases 1 to 5871)
  AUTHORS   Cristea,I., Bruland,O., Rodahl,E. and Bredrup,C.
  TITLE     K+ regulates relocation of Pellino-2 to the site of NLRP3
            inflammasome activation in macrophages
  JOURNAL   FEBS Lett 595 (19), 2437-2446 (2021)
   PUBMED   34387857
  REMARK    GeneRIF: K(+) regulates relocation of Pellino-2 to the site of
            NLRP3 inflammasome activation in macrophages.
REFERENCE   6  (bases 1 to 5871)
  AUTHORS   Liu,Y., Dong,W., Chen,L., Xiang,R., Xiao,H., De,G., Wang,Z. and
            Qi,Y.
  TITLE     BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling
            through interaction with Pellino2
  JOURNAL   J Biol Chem 279 (36), 37436-37444 (2004)
   PUBMED   15213237
REFERENCE   7  (bases 1 to 5871)
  AUTHORS   Strelow,A., Kollewe,C. and Wesche,H.
  TITLE     Characterization of Pellino2, a substrate of IRAK1 and IRAK4
  JOURNAL   FEBS Lett 547 (1-3), 157-161 (2003)
   PUBMED   12860405
  REMARK    GeneRIF: Pellino2 interacts with kinase-active as well as
            kinase-inactive IRAK1 and IRAK4
REFERENCE   8  (bases 1 to 5871)
  AUTHORS   Jensen,L.E. and Whitehead,A.S.
  TITLE     Pellino2 activates the mitogen activated protein kinase pathway
  JOURNAL   FEBS Lett 545 (2-3), 199-202 (2003)
   PUBMED   12804775
  REMARK    GeneRIF: interacts with TRAF6 (tumor necrosis factor receptor
            associated factor 6) and TAK1 (transforming growth factor-beta
            activated kinase 1); can activate the mitogen activated protein
            kinase pathway
REFERENCE   9  (bases 1 to 5871)
  AUTHORS   Yu,K.Y., Kwon,H.J., Norman,D.A., Vig,E., Goebl,M.G. and
            Harrington,M.A.
  TITLE     Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide
            signaling
  JOURNAL   J Immunol 169 (8), 4075-4078 (2002)
   PUBMED   12370331
REFERENCE   10 (bases 1 to 5871)
  AUTHORS   Resch,K., Jockusch,H. and Schmitt-John,T.
  TITLE     Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for
            the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14
            and human chromosomes 2p13.3 and 14q21, respectively, by physical
            and radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 172-174 (2001)
   PUBMED   11306823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC009476.2, AF302502.1, AL709755.1, AK025208.1 and AL355073.5.
            
            On Nov 23, 2018 this sequence version replaced NM_021255.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.93528.1,
                                           SRR1803611.131586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267460.9/ ENSP00000267460.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1758              BC009476.2         37-1794
            1759-1822           AF302502.1         1685-1748
            1823-2684           AF302502.1         1751-2612
            2685-3374           AF302502.1         2614-3303
            3375-3832           AL709755.1         94-551
            3833-5202           AK025208.1         4-1373
            5203-5649           AF302502.1         5133-5579
            5650-5660           AK025208.1         1821-1831
            5661-5871           AL355073.5         103017-103227
FEATURES             Location/Qualifiers
     source          1..5871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..5871
                     /gene="PELI2"
                     /note="pellino E3 ubiquitin protein ligase family member
                     2"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
     exon            1..327
                     /gene="PELI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1513
                     /gene="PELI2"
                     /EC_number="2.3.2.27"
                     /note="protein pellino homolog 2; pellino-2; RING-type E3
                     ubiquitin transferase pellino homolog 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase pellino homolog 2"
                     /protein_id="NP_067078.1"
                     /db_xref="CCDS:CCDS9726.1"
                     /db_xref="GeneID:57161"
                     /db_xref="HGNC:HGNC:8828"
                     /db_xref="MIM:614798"
                     /translation="MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFA
                     LYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMF
                     QVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGF
                     DSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVY
                     TLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQE
                     INAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERE
                     CPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHA
                     FHAACPFCATQLVGEQNCIKLIFQGPID"
     exon            328..457
                     /gene="PELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..559
                     /gene="PELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..757
                     /gene="PELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..946
                     /gene="PELI2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..5871
                     /gene="PELI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5630..5635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELI2"
                     /note="hexamer: ATTAAA"
     polyA_site      5656
                     /gene="PELI2"
                     /note="major polyA site"
     regulatory      5847..5852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELI2"
                     /note="hexamer: ATTAAA"
     polyA_site      5871
                     /gene="PELI2"
ORIGIN      
        1 cccatttgtt gccggctctg actcggggcg gccgcggcgc gcggagctcc ggggagtcag
       61 gcggagcagc cgcgcagcca cgacggagca gcagcgggac tggccgcccc gcgccccctt
      121 cgccgccgtg cccttccccg gcgcgctcac cccgttctcg ggatgggatt gtagcggcgg
      181 cgcggactcg gcggggatcg cggcggaggc ggcggcgtcg gcggcggcgt cggcggccga
      241 gcggggctcc atgttttccc ctggccagga ggaacactgc gcccccaata aggagccagt
      301 gaaatacggg gagctggtgg tgctcgggta caatggtgct ttacccaatg gagatagagg
      361 acggaggaaa agtagatttg ccctctacaa gcggcccaag gcaaatggtg tcaaacccag
      421 caccgtccat gtgatatcca cgccccaggc atccaaggct atcagctgca aaggtcaaca
      481 cagtatatcc tacactttgt caaggaatca gactgtggtg gtggagtaca cacatgataa
      541 ggatacggat atgtttcagg tgggcagatc aacagaaagc cctatcgact tcgttgtcac
      601 agacacgatt tctggcagcc agaacacgga cgaagcccag atcacacaga gcaccatatc
      661 caggttcgcc tgcaggatcg tgtgcgacag gaatgaacct tacacagcac ggatattcgc
      721 cgccggattt gactcttcca aaaacatatt tcttggagaa aaggcagcaa agtggaaaaa
      781 ccccgacggc cacatggatg ggctcactac taatggcgtc ctggtgatgc atccacgagg
      841 gggcttcacc gaggagtccc agcccggggt ctggcgcgag atctctgtct gtggagatgt
      901 gtacaccttg cgagaaacca ggtcggccca gcaacgagga aagctggtgg aaagtgagac
      961 caacgtcctg caggacggct ccctcattga cctgtgtggg gccactctcc tctggagaac
     1021 agcagatggg ctttttcata ctccaactca gaagcacata gaagccctcc ggcaggagat
     1081 taacgccgcc cggcctcagt gtcctgtggg gctcaacacc ctggccttcc ccagcatcaa
     1141 caggaaagag gtggtggagg agaagcagcc ctgggcatat ctcagttgtg gccacgtgca
     1201 cgggtaccac aactggggcc atcggagtga cacggaggcc aacgagaggg agtgtcccat
     1261 gtgcaggact gtgggcccct atgtgcctct ctggcttggc tgtgaggcag gattttatgt
     1321 agacgcagga ccgccaactc atgctttcac tccctgtgga cacgtgtgct cggagaagtc
     1381 tgcaaaatac tggtctcaga tcccgttgcc tcatggaact catgcatttc acgctgcttg
     1441 ccctttctgt gctacacagc tggttgggga gcaaaactgc atcaaattaa ttttccaagg
     1501 tccaattgac tgacgccctt gacagccatc tacgacttta ttaacaggtt actgtgaaga
     1561 ttttgccact aactctagat tttacctttt tgtaatgctg tttatcagag gagggtgaca
     1621 ggggctggaa ataaagagag gggacatggt gatgaaacat ggcaggagtg taacagatac
     1681 cagtggtgtg ttgcatgctc aaaacagcag cgtcgtcatt gaagtctgct tgattaaacc
     1741 ataatatctt tgtaataatt ggatttaaaa tgctatgctt ctatttttaa ccttgggttt
     1801 ttaaccaagt tttttttttt ttgtaatctt ggacaagact ttaaatcata ttttacagat
     1861 gtagaagaaa tttattcaaa agtgtgggct catgaagttc acttcagtgc agtgtggtgt
     1921 aggtgttacg cgaagggcgc acagtgtcta gaaatacttg atcgtggctc aaacctgacc
     1981 agacagcaga ggggcggctc tgtacagtgt gactggtgga cagatggcct taggcacagg
     2041 tggttttgaa atctggggct ttttctgatt tatttttctg acttgttggg ggagagaata
     2101 ttcataactt gtgggctttt ttttttttta acttcagtgg aatttacttt agatattcat
     2161 tcatcaaata catgggactt cacaaacaat tttccataac tttttagcct gtcttttgtt
     2221 atttctgcct aatatgattt gccccgatac tcatcttgca cggccagaac tgtttggttg
     2281 attaaaatac atcagctctt aaaaactcat taactgaggg taattacagt agtagacatg
     2341 gtctgggtac tatactacca tgtttatttg ctgactgaat taagatttaa gaatgattaa
     2401 aaataagctt ttacttttta aaaccacttg aggtttcata aagcttgggg tttttttttt
     2461 tcctttgtta agaaagccaa ccaatcacaa tgatatagtc attgttgtgc actccctttt
     2521 caccatctgt caccttccct tgcagcttaa ggagcccagt aagttttgaa aatgtttgcg
     2581 aatcaaacta aatttaagtg ggatgattag atatacacaa caccaagtgg tacatctgca
     2641 gagataattc aaaattcctg cttttgagag agcaaatgag tgttgctgag gaataattaa
     2701 atgagaattt cataggagct ccaccattcc tgttactttc atttcatttt gattaataat
     2761 tcttggatgc ttggcatcga tcgtatcact gctcctagaa ggtaaagatc ctttaggaca
     2821 tgagactggt agaagctggc tgagataaaa taagtattta tttaaactaa tgttctctta
     2881 atttgaccat tgcagatttg ggtgactttt ttttaacctt tgtacatata cgtaatttat
     2941 atgattctaa tgtactatat ccatacttga attggttttt tcgtattttg cctactggca
     3001 aatattttgc ctattttcag tcgttctaac ctatttgaat acgcttttcc ttaaagtgat
     3061 acgataatat tactcttgat tgctgctgct taatttgatg taatatgttt aaagttcagc
     3121 ctctcagttt taatatagct ttatttttca gtggagatca ttgtttagga tgagacattt
     3181 ttggttttgg ttttgtttgg gtaaatttta aatggtgtga aaatcgatga caacagtcct
     3241 cttacagata gcttgctgta ttctgtatag cttactctac ctgcagacag aaaatgaaag
     3301 aaaaaaatgg acttgcctag aataatatat tgaatgcctt ttgatttagc cagagtctct
     3361 gatgattagc tttcactgat agagtatgtc ttttcagcct gtaattcttt gggccccaaa
     3421 gaatgacaaa ggaggcactc gttctctttt cttgctgtat gcctagaaag tggttgaagg
     3481 attcttgatg ccctaaaacc atcttgtaag ctaaatggtc ttgcatccag aaaggccaga
     3541 ttttacctac caagaaaaaa agatattttt ccagagagtt aggtatatca taattttcca
     3601 tttcaagtcc tgtttataag tctagtcatt ctgcaacgtg acatatcccc caaaatgaag
     3661 ttaccttcca agttggacac gtcccgtagt tgggcatatg tctaactaaa agtttctgac
     3721 ttttagtaaa ttcagcttaa atataagttg aaatttggga aataatttcc aagctcttgg
     3781 aaggggtaac agtgaaccgc cctccatggg ctccacatct tttcctttgg cttccaaagt
     3841 caggtcccgc ccaccctgcc taaggaactg cagagaggtg gcaaatcagc aaaaaggaca
     3901 ccaggctctt cttggccact tgtaggaaga tccctttaca attttgacta aggagatttt
     3961 ttttttcaca gttgagttag tttgtgaaaa taaagaactc tgtagctcac caaggtggag
     4021 aaacgcaatt cagaaaagta atttctccaa ggtcacttct ttttttatgt cttgccatca
     4081 ctttaaagga ctagccccac tcccccatgt gtatacacaa ggaaattgca gaccaattag
     4141 ttgtcttggc ctgactctaa tgccttttgc aagtagcttt ccagaagtaa aagtcccagt
     4201 gatgtattcc catagaaata tttttcagtt gtttatgtcg tttactacaa aaaaaaagat
     4261 tcagagtgga tggagtacaa ctctgagtat ttttctagtc cggaattttt tattaataat
     4321 cggtgctgcc gggtcatgca tgctgcaact ctcaacattt cccttatttg gttcagcttt
     4381 tagcaaaaag ggctacagtt caccctgcag agtattaagg tttctggatt tttttctccc
     4441 aactgtggcc caaaagaatt aaaatctgtt aatataaata gagaacatat ttatcattcc
     4501 tcgatagtta attatagact ttggtacctt tgtgcctcag ggaagccacg tgatataact
     4561 ggttatagaa tttcagggtt agggtttaaa gaaaggagaa agccattgga aaaatgatgg
     4621 gctccattaa ggagactaat gaatctggat gcagaaatat gtcagaaact ggcataaaca
     4681 tgattgtagt agaatttatt ttccagtacc aatagggaaa ttattttaag ttattacatt
     4741 tactgtattg ggaaacttga ggagaactct ttagttcata aagcttcaat gtcttttttt
     4801 tttttttcat ggaaaaactc aaacctctgt tatttgggag ctcagtattg tgtggacact
     4861 tacgagagtt ttctgcttaa ttgaagtgta atataggttg tagaattgtt acctgcagtt
     4921 ctatggtttt gtttcacttc ttttcttttt taaagccatt ctgttctttg gatgtgcttg
     4981 aaagggtgtg tgattacacc attgttaatg ctgggtaaaa actatcttct tgcagccttg
     5041 cctcataaca gtggaatttc tgatagacaa accacaggac tttgatttta agccaaatcc
     5101 atctccatcc ctttactgtc aatcttctgt cccagtagtt tagcctttgt ggcttaggtt
     5161 atgatgcgcc tccttctgtg cgaccaatga gacgacttca gcatcttttt aaaataatct
     5221 aagcatcatt gaagcagtaa cacaaaaaaa aggttcagta ttttcttttt agtataactt
     5281 acatcctttc aaataagtct ttgccctcat gaagaatccc tagaggaaga taaggaaaat
     5341 aagtattttc cagttttgct tgacagtttc taaacaaaca aaaataaact caatgaaagg
     5401 aaagatgttt ctttttagct gagatgacag attgcttctc tgtattaaat agtctagaag
     5461 ttaaggggat ggtcacattt accatgtatt gtgttattag cagttaaatt ttatgaatat
     5521 gtttgtaaaa ttgttgtttt atatttcatg tcaaattgaa aagtttattt cttcactatt
     5581 gtacctgtgg aaatacaagc cattttacag gaaaaaatct tcaaaaacta ttaaatggat
     5641 atcagcctgt ttgtgagcca ttgtcttcag attctgtggt tgtcactgag ttcattagga
     5701 catttagtag gttgatacga gtagaactga tttttttcac ttctctaact tccaagttaa
     5761 tctccagctg ttgagtttat taattgtttt atattctgca caatacatat ttaaaccttg
     5821 attctgaaaa tcccctacat tttttaatta aagaaatttc cttggtgcct a
//
