LOCUS       NM_020651               3716 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens pellino E3 ubiquitin protein ligase 1 (PELI1), mRNA.
ACCESSION   NM_020651
VERSION     NM_020651.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3716)
  AUTHORS   Zhou,W., Deng,X., Liu,L., Yuan,Y., Meng,X. and Ma,J.
  TITLE     PELI1 overexpression contributes to pancreatic cancer progression
            through upregulating ubiquitination-mediated INPP5J degradation
  JOURNAL   Cell Signal 120, 111194 (2024)
   PUBMED   38685520
  REMARK    GeneRIF: PELI1 overexpression contributes to pancreatic cancer
            progression through upregulating ubiquitination-mediated INPP5J
            degradation.
REFERENCE   2  (bases 1 to 3716)
  AUTHORS   Jia,Y., Zhu,G., Qiu,C., Lai,J.M., Shen,Y., Jin,S.W., Yang,X.,
            Zhu,H.P., Hu,B.C., Ye,X.M. and Mo,S.J.
  TITLE     Pellino1 orchestrates gut-kidney axis to perpetuate septic acute
            kidney injury through activation of STING pathway and NLRP3
            inflammasome
  JOURNAL   Life Sci 345, 122604 (2024)
   PUBMED   38580196
  REMARK    GeneRIF: Pellino1 orchestrates gut-kidney axis to perpetuate septic
            acute kidney injury through activation of STING pathway and NLRP3
            inflammasome.
REFERENCE   3  (bases 1 to 3716)
  AUTHORS   Fei,X., Zhu,C., Liu,P., Liu,S., Ren,L., Lu,R., Hou,J., Gao,Y.,
            Wang,X. and Pan,Y.
  TITLE     PELI1: key players in the oncogenic characteristics of pancreatic
            Cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 91 (2024)
   PUBMED   38528516
  REMARK    GeneRIF: PELI1: key players in the oncogenic characteristics of
            pancreatic Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3716)
  AUTHORS   Zhou,W., Hu,Y., Wang,B., Yuan,L., Ma,J. and Meng,X.
  TITLE     Aberrant expression of PELI1 caused by Jagged1 accelerates the
            malignant phenotype of pancreatic cancer
  JOURNAL   Cell Signal 111, 110877 (2023)
   PUBMED   37657587
  REMARK    GeneRIF: Aberrant expression of PELI1 caused by Jagged1 accelerates
            the malignant phenotype of pancreatic cancer.
REFERENCE   5  (bases 1 to 3716)
  AUTHORS   Tang,C., Hou,Y.X., Shi,P.X., Zhu,C.H., Lu,X., Wang,X.L., Que,L.L.,
            Zhu,G.Q., Liu,L., Chen,Q., Li,C.F., Xu,Y., Li,J.T. and Li,Y.H.
  TITLE     Cardiomyocyte-specific Peli1 contributes to the pressure
            overload-induced cardiac fibrosis through miR-494-3p-dependent
            exosomal communication
  JOURNAL   FASEB J 37 (1), e22699 (2023)
   PUBMED   36520055
  REMARK    GeneRIF: Cardiomyocyte-specific Peli1 contributes to the pressure
            overload-induced cardiac fibrosis through miR-494-3p-dependent
            exosomal communication.
            Erratum:[FASEB J. 2023 Apr;37(4):e22860. doi: 10.1096/fsb2.22860..
            PMID: 36917079]
REFERENCE   6  (bases 1 to 3716)
  AUTHORS   Gangloff,M. and Gay,N.J.
  TITLE     MD-2: the Toll 'gatekeeper' in endotoxin signalling
  JOURNAL   Trends Biochem Sci 29 (6), 294-300 (2004)
   PUBMED   15276183
REFERENCE   7  (bases 1 to 3716)
  AUTHORS   Jensen,L.E. and Whitehead,A.S.
  TITLE     Pellino2 activates the mitogen activated protein kinase pathway
  JOURNAL   FEBS Lett 545 (2-3), 199-202 (2003)
   PUBMED   12804775
REFERENCE   8  (bases 1 to 3716)
  AUTHORS   Jiang,Z., Johnson,H.J., Nie,H., Qin,J., Bird,T.A. and Li,X.
  TITLE     Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling
            through its interaction with the IL-1 receptor-associated kinase 4
            (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6
            (TRAF6) complex
  JOURNAL   J Biol Chem 278 (13), 10952-10956 (2003)
   PUBMED   12496252
  REMARK    GeneRIF: role in interleukin-1-mediated signalling through
            interaction with interleukin-1 receptor-associated kinase
            4-IRAK-tumor necrosis factor receptor-associated factor 6 complex
REFERENCE   9  (bases 1 to 3716)
  AUTHORS   Resch,K., Jockusch,H. and Schmitt-John,T.
  TITLE     Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for
            the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14
            and human chromosomes 2p13.3 and 14q21, respectively, by physical
            and radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 172-174 (2001)
   PUBMED   11306823
REFERENCE   10 (bases 1 to 3716)
  AUTHORS   Rich,T., Allen,R.L., Lucas,A.M., Stewart,A. and Trowsdale,J.
  TITLE     Pellino-related sequences from Caenorhabditis elegans and Homo
            sapiens
  JOURNAL   Immunogenetics 52 (1-2), 145-149 (2000)
   PUBMED   11132151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050019.1 and BM992606.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020651.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.69064.1,
                                           SRR1660803.201668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358912.5/ ENSP00000351789.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3507              BC050019.1         6-3512
            3508-3716           BM992606.1         14-222              c
FEATURES             Location/Qualifiers
     source          1..3716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..3716
                     /gene="PELI1"
                     /note="pellino E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:57162"
                     /db_xref="HGNC:HGNC:8827"
                     /db_xref="MIM:614797"
     exon            1..340
                     /gene="PELI1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..480
                     /gene="PELI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..1666
                     /gene="PELI1"
                     /EC_number="2.3.2.27"
                     /note="protein pellino homolog 1; pellino-1;
                     pellino-related intracellular-signaling molecule;
                     RING-type E3 ubiquitin transferase pellino homolog 1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase pellino homolog 1"
                     /protein_id="NP_065702.2"
                     /db_xref="CCDS:CCDS1876.1"
                     /db_xref="GeneID:57162"
                     /db_xref="HGNC:HGNC:8827"
                     /db_xref="MIM:614797"
                     /translation="MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALF
                     KRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQI
                     GRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDS
                     SKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSL
                     RETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEIN
                     AARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECP
                     MCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFH
                     AACPFCAHQLAGEQGYIRLIFQGPLD"
     exon            481..610
                     /gene="PELI1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..712
                     /gene="PELI1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..910
                     /gene="PELI1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1099
                     /gene="PELI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..3716
                     /gene="PELI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3488..3493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELI1"
                     /note="hexamer: AGTAAA"
     regulatory      3504..3509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELI1"
                     /note="hexamer: AATACA"
     polyA_site      3512
                     /gene="PELI1"
                     /note="major polyA site"
     polyA_site      3523
                     /gene="PELI1"
     regulatory      3687..3692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PELI1"
                     /note="hexamer: AATAAA"
     polyA_site      3716
                     /gene="PELI1"
ORIGIN      
        1 agtgacccag aggcggtgtg aggcggaggg accgtcgggg ggcgccgccg ccgcctccac
       61 tagcagcagc ggcagcagcc ctagtcccgc ggtgcggtcg aattggtccc cagccctccg
      121 ggagcgcacc acaaagcagc cccaacgcct ctccctgcgt ccgcggctcc tcagcgctcg
      181 gctccgtggt caacttcccc tcgctgggct cggctggcgg gcgcggaggg cagcggcgga
      241 acggcgggct gtctgctcgc gctccccgcg cacaacactt caccctctcg cctcgggtct
      301 cgggggccgc tctgggatcc cggccaccag caattgtccg gaaataatgc aaaaggtgtc
      361 ccaaggctcc tgaccagtga acaaagattt gagaaagaca gccaagctca tgttttctcc
      421 tgatcaagaa aatcatccat ctaaagcacc agtaaaatat ggtgaactca ttgtcttagg
      481 gtataatggg tctctcccaa atggcgatag aggaaggagg aaaagtaggt ttgctttgtt
      541 taaaagacct aaggcaaatg gggtgaagcc cagcactgtg catattgctt gtactcctca
      601 ggctgcaaag gcaataagca acaaagacca gcatagcata tcatatactt tatctcgggc
      661 ccagactgtg gtggttgaat atactcatga cagcaacacc gatatgtttc agattggccg
      721 gtcgactgaa agccccattg attttgtagt aactgacacg gttcctggaa gtcaaagtaa
      781 ttctgataca cagtcagtac aaagcactat atcaagattt gcctgcagaa tcatatgtga
      841 acggaatcct ccctttacag cacggattta tgctgcagga tttgactcat caaaaaacat
      901 ctttcttggg gagaaggctg ccaaatggaa gacatcagat ggacagatgg atggcttgac
      961 cactaatggt gttcttgtga tgcatccacg caatgggttc acagaagact ccaagcctgg
     1021 aatatggaga gaaatatcgg tgtgtggaaa tgtatttagc ctacgtgaaa ccagatcggc
     1081 tcagcagaga ggaaaaatgg tggaaattga aaccaatcag ttacaagatg gctcgttaat
     1141 tgacctctgt ggtgcaacat tgttatggcg tactgcagaa ggcctttccc acactcctac
     1201 cgtgaagcat ttagaagctt taagacagga aatcaatgca gcacgacctc agtgccctgt
     1261 agggttcaac acactagcat ttcctagtat gaagaggaaa gacgttgtag atgaaaaaca
     1321 accatgggta tatctaaact gcggccatgt acatggctat cataactggg gaaacaaaga
     1381 agaacgtgat ggaaaagatc gtgaatgtcc tatgtgtagg tctgttggtc cctatgttcc
     1441 tctgtggctt ggatgtgaag ctggatttta tgtggacgcc ggccctccaa cccatgcgtt
     1501 tagcccgtgt gggcatgtgt gttcagaaaa gacaactgcc tattggtccc agatcccact
     1561 tcctcatggt actcatactt ttcatgcagc ctgtcccttt tgtgcacatc agttggctgg
     1621 tgaacaaggc tacatcagac ttatttttca aggacctcta gactaacaga ccattgtctt
     1681 gcaggactac attataaatt tataagctaa gtgagttggg ttttcgaacc tgttgtccac
     1741 gtcacagttt ttctgctctg gtcatttgca ttaagatgaa gaatttttta aaacatttat
     1801 aataaatagt agcaatttct gagcaaaaat ctgggaaact caagcaaagg aatttctgaa
     1861 agtatcagtc ttctgaattc tgagttttga aaatatattt tgaggagaaa aagacatagt
     1921 ctaatttgat gccttccttt tagtgttttt gaatcaccta tcctcagtgc tgaaattgtt
     1981 ttgtataact gagggtactg ttggttcaaa ctatgttagt ttacagtttg ttgcaaacat
     2041 tgtaaaatac agcgacatgt atattaactt ttttctattt atctttatta tagaaaatac
     2101 cttagaatgt tcttgataga gtagcatggt aacgatggtg tcacaccctt ggtgtgaatg
     2161 gtagcttagt gagcaaccta gctcaaggat ttgcaaagtt aggaagaagg acgagagagc
     2221 ctctctcccc accccaatct aaatatggaa tttggtaaat tagaatactt tgtaatttgt
     2281 aagaccaaat tcatactaat tacccgcgtg aaaggtgttt gtttttaaca acattgaaga
     2341 taatcaggaa agattttttc ttaatgtttc tctcgagcgt agtactataa caaaaactta
     2401 atgctaagaa acattttata tgctcctttg gatatgcaat ttaatctaga ttatctattt
     2461 ttctcccatg ataactaatc tgtttttagt atcagcagca tttggcaagt ttattttttg
     2521 gatataaact gtggttcatc tgttcactgt ttctagaaaa aaatcattgc cataagaaaa
     2581 agtataaatt agcaagaaag gagagtgact tgatttgctt ttggaaaaag aaatgcttaa
     2641 ttaattattc tgtatttggc cttattcggg cattaggaaa tctagagatc taaagggttg
     2701 aatgacaata gtgcccccgt ttttagcaga ccagccttaa ctctgggttt gaatcctaag
     2761 gagattgcca cagtgagact taaggaaatg tttggttggc agatgagcac caatgactgc
     2821 agcgtggagt gacgcactgc atggtctgtt tattctctaa ttccaatatg tcttttgctt
     2881 ccagaagcaa gaaaagtttc ttctctcccc tccttcccac ccttttttca aaggcaccac
     2941 aagtatagac agttgcacta catcaaatct ttttttgaca cttgtagaaa ccagtacact
     3001 tttagattag acagtatctt cttttaatat tttgatttgt tttcctttag tttgaaaagt
     3061 tgtataatac ttaactgact gtagcaaagt tttatatgtg gtagcatacc tttaatttat
     3121 cctattacaa aactgttctg aattttcttt tggtttttaa aaaacaaaac ttgttgctta
     3181 gaagccatga attattttat tttacttcaa ctgtcgaaac ttccttgttt taaaaaatga
     3241 tcatttgggt tcactcagga aatgcatgtc aggaaacttg tattataagt ttattagttg
     3301 tgatgtatca gtaactgctg ttaccccttt ttcaaagaaa tgtaattgat tttgaagttt
     3361 tctagattgt cacatgcttt gtgactaatg caagaaagca agtcctgtgt tgtatttgtt
     3421 ctagtcattt ttattcaggc tatatattgt agcttaattt ttatttgcaa ttaatttatt
     3481 taaactaagt aaatactttt caaaatacat aattgaattc gtctctgtga gttcattttt
     3541 gcataatcga gaatgagaaa ccagaagtga aaactgtgaa caactctatt ccacactcca
     3601 aaaatactca tttgaaatag atgaagagtt tgcatttaat gtaacacttt aaagtatctg
     3661 gttctttttt aaaagcatct cttactaata aaggaacttt gttagtggtt gaataa
//
