LOCUS       NM_006210               8754 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens paternally expressed 3 (PEG3), transcript variant 1,
            mRNA.
ACCESSION   NM_006210
VERSION     NM_006210.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8754)
  AUTHORS   Qiu,T., Ding,Y., Qin,J., Ren,D., Xie,M., Qian,Q., Wang,Y., Ma,L.,
            Jing,A., Yang,J., Ma,S., Wang,X., Wang,W., Ji,J. and Li,G.
  TITLE     Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal
            clear cell carcinoma progress
  JOURNAL   Cell Signal 107, 110662 (2023)
   PUBMED   37001595
  REMARK    GeneRIF: Epigenetic reactivation of PEG3 by EZH2 inhibitors
            suppresses renal clear cell carcinoma progress.
REFERENCE   2  (bases 1 to 8754)
  AUTHORS   Wu,H., Wu,H., Sun,P., Zhu,D., Ma,M. and Fan,W.
  TITLE     miR-155-5p Promotes Cell Proliferation and Migration of Clear Cell
            Renal Cell Carcinoma by Targeting PEG3
  JOURNAL   Urol Int 105 (9-10), 906-915 (2021)
   PUBMED   34192708
  REMARK    GeneRIF: miR-155-5p Promotes Cell Proliferation and Migration of
            Clear Cell Renal Cell Carcinoma by Targeting PEG3.
REFERENCE   3  (bases 1 to 8754)
  AUTHORS   Zhang,M. and Zhang,J.
  TITLE     PEG3 mutation is associated with elevated tumor mutation burden and
            poor prognosis in breast cancer
  JOURNAL   Biosci Rep 40 (8) (2020)
   PUBMED   32729618
  REMARK    GeneRIF: PEG3 mutation is associated with elevated tumor mutation
            burden and poor prognosis in breast cancer.
REFERENCE   4  (bases 1 to 8754)
  AUTHORS   Cao,C., Hong,P., Huang,X., Lin,D., Cao,G., Wang,L., Feng,B., Wu,P.,
            Shen,H., Xu,Q., Ren,C., Meng,Y., Zhi,W., Yu,R., Wei,J., Ding,W.,
            Tian,X., Zhang,Q., Li,W., Gao,Q., Chen,G., Li,K., Sung,W.K., Hu,Z.,
            Wang,H., Li,G. and Wu,P.
  TITLE     HPV-CCDC106 integration alters local chromosome architecture and
            hijacks an enhancer by three-dimensional genome structure
            remodeling in cervical cancer
  JOURNAL   J Genet Genomics 47 (8), 437-450 (2020)
   PUBMED   33023834
  REMARK    GeneRIF: HPV-CCDC106 integration alters local chromosome
            architecture and hijacks an enhancer by three-dimensional genome
            structure remodeling in cervical cancer.
REFERENCE   5  (bases 1 to 8754)
  AUTHORS   Buraschi,S., Neill,T. and Iozzo,R.V.
  TITLE     Decorin is a devouring proteoglycan: Remodeling of intracellular
            catabolism via autophagy and mitophagy
  JOURNAL   Matrix Biol 75-76, 260-270 (2019)
   PUBMED   29080840
  REMARK    GeneRIF: Soluble matrix-derived cues being transduced downstream of
            receptor engagement converge upon a newly-discovered nexus of
            autophagic machinery consisting of Peg3 for endothelial cell
            autophagy and mitostatin for tumor cell mitophagy.
            Review article
REFERENCE   6  (bases 1 to 8754)
  AUTHORS   Hiby,S.E., Lough,M., Keverne,E.B., Surani,M.A., Loke,Y.W. and
            King,A.
  TITLE     Paternal monoallelic expression of PEG3 in the human placenta
  JOURNAL   Hum Mol Genet 10 (10), 1093-1100 (2001)
   PUBMED   11331620
  REMARK    GeneRIF: PEG3 gene is imprinted, with preferential expression from
            the paternal allele in human placenta.
REFERENCE   7  (bases 1 to 8754)
  AUTHORS   Relaix,F., Wei,Xj., Li,W., Pan,J., Lin,Y., Bowtell,D.D.,
            Sassoon,D.A. and Wu,X.
  TITLE     Pw1/Peg3 is a potential cell death mediator and cooperates with
            Siah1a in p53-mediated apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2105-2110 (2000)
   PUBMED   10681424
REFERENCE   8  (bases 1 to 8754)
  AUTHORS   Kim,J., Bergmann,A. and Stubbs,L.
  TITLE     Exon sharing of a novel human zinc-finger gene, ZIM2, and
            paternally expressed gene 3 (PEG3)
  JOURNAL   Genomics 64 (1), 114-118 (2000)
   PUBMED   10708526
REFERENCE   9  (bases 1 to 8754)
  AUTHORS   Relaix,F., Wei,X.J., Wu,X. and Sassoon,D.A.
  TITLE     Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal
            transduction pathway
  JOURNAL   Nat Genet 18 (3), 287-291 (1998)
   PUBMED   9500555
REFERENCE   10 (bases 1 to 8754)
  AUTHORS   Kim,J., Ashworth,L., Branscomb,E. and Stubbs,L.
  TITLE     The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc
            finger gene-rich region of human chromosome 19q13.4
  JOURNAL   Genome Res 7 (5), 532-540 (1997)
   PUBMED   9149948
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK295679.1, AF208967.1,
            BC037330.2, CR933682.1 and AI089069.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006210.2.
            
            Summary: In human, ZIM2 and PEG3 are treated as two distinct genes
            though they share multiple 5' exons and a common promoter and both
            genes are paternally expressed (PMID:15203203). Alternative
            splicing events connect their shared 5' exons either with the
            remaining 4 exons unique to ZIM2, or with the remaining 2 exons
            unique to PEG3. In contrast, in other mammals ZIM2 does not undergo
            imprinting and, in mouse, cow, and likely other mammals as well,
            the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein
            belongs to the Kruppel C2H2-type zinc finger protein family. PEG3
            may play a role in cell proliferation and p53-mediated apoptosis.
            PEG3 has also shown tumor suppressor activity and tumorigenesis in
            glioma and ovarian cells. Alternative splicing of this PEG3 gene
            results in multiple transcript variants encoding distinct isoforms.
            [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 2 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208967.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2145245,
                                           SAMEA2145743 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 11331620
            MANE Ensembl match     :: ENST00000326441.15/ ENSP00000326581.7
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK295679.1         1-30
            31-6401             AF208967.1         1-6371
            6402-7768           BC037330.2         1379-2745
            7769-8632           CR933682.1         4949-5812
            8633-8754           AI089069.1         12-133              c
FEATURES             Location/Qualifiers
     source          1..8754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..8754
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /note="paternally expressed 3"
                     /db_xref="GeneID:5178"
                     /db_xref="HGNC:HGNC:8826"
                     /db_xref="MIM:601483"
     exon            1..145
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            146..232
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            233..308
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            309..788
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..5161
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and SCAN domain-containing protein 24; Kruppel-type
                     zinc finger protein; paternally-expressed gene 3 protein"
                     /codon_start=1
                     /product="paternally-expressed gene 3 protein isoform 1"
                     /protein_id="NP_006201.1"
                     /db_xref="CCDS:CCDS12948.1"
                     /db_xref="GeneID:5178"
                     /db_xref="HGNC:HGNC:8826"
                     /db_xref="MIM:601483"
                     /translation="MLPPKHLSATKPKKSWAPNLYELDSDLTKEPDVIIGEGPTDSEF
                     FHQRFRNLIYVEFVGPRKTLIKLRNLCLDWLQPETRTKEEIIELLVLEQYLTIIPEKL
                     KPWVRAKKPENCEKLVTLLENYKEMYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSF
                     SDRDWDRRGRSRDMEPRDRWSHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAY
                     ESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLVQLAEDDGHSHMTQGHSSR
                     SKRSAYPSTSRGLKTMPEAKKSTHRRGICEDESSHGVIMEKFIKDVSRSSKSGRARES
                     SDRSQRFPRMSDDNWKDISLNKRESVIQQRVYEGNAFRGGFRFNSTLVSRKRVLERKR
                     RYHFDTDGKGSIHDQKGCPRKKPFECGSEMRKAMSVSSLSSLSSPSFTESQPIDFGAM
                     PYVCDECGRSFSVISEFVEHQIMHTRENLYEYGESFIHSVAVSEVQKSQVGGKRFECK
                     DCGETFNKSAALAEHRKIHARGYLVECKNQECEEAFMPSPTFSELQKIYGKDKFYECR
                     VCKETFLHSSALIEHQKIHFGDDKDNEREHERERERERGETFRPSPALNEFQKMYGKE
                     KMYECKVCGETFLHSSSLKEHQKIHTRGNPFENKGKVCEETFIPGQSLKRRQKTYNKE
                     KLCDFTDGRDAFMQSSELSEHQKIHSRKNLFEGRGYEKSVIHSGPFTESQKSHTITRP
                     LESDEDEKAFTISSNPYENQKIPTKENVYEAKSYERSVIHSLASVEAQKSHSVAGPSK
                     PKVMAESTIQSFDAINHQRVRAGGNTSEGREYSRSVIHSLVASKPPRSHNGNELVESN
                     EKGESSIYISDLNDKRQKIPARENPCEGGSKNRNYEDSVIQSVFRAKPQKSVPGEGSG
                     EFKKDGEFSVPSSNVREYQKARAKKKYIEHRSNETSVIHSLPFGEQTFRPRGMLYECQ
                     ECGECFAHSSDLTEHQKIHDREKPSGSRNYEWSVIRSLAPTDPQTSYAQEQYAKEQAR
                     NKCKDFRQFFATSEDLNTNQKIYDQEKSHGEESQGENTDGEETHSEETHGQETIEDPV
                     IQGSDMEDPQKDDPDDKIYECEDCGLGFVDLTDLTDHQKVHSRKCLVDSREYTHSVIH
                     THSISEYQRDYTGEQLYECPKCGESFIHSSFLFEHQRIHEQDQLYSMKGCDDGFIALL
                     PMKPRRNRAAERNPALAGSAIRCLLCGQGFIHSSALNEHMRLHREDDLLEQSQMAEEA
                     IIPGLALTEFQRSQTEERLFECAVCGESFVNPAELADHVTVHKNEPYEYGSSYTHTSF
                     LTEPLKGAIPFYECKDCGKSFIHSTVLTKHKELHLEEEEEDEAAAAAAAAAQEVEANV
                     HVPQVVLRIQGLNVEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPIGEA
                     GQPNGEAEQPNGDADEPDGAGIEDPEERAEEPEGKAEEPEGDADEPDGVGIEDPEEGE
                     DQEIQVEEPYYDCHECTETFTSSTAFSEHLKTHASMIIFEPANAFGECSGYIERASTS
                     TGGANQADEKYFKCDVCGQLFNDRLSLARHQNTHTG"
     exon            789..875
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            876..959
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1063
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1166
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1256
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..8754
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8737..8742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /note="hexamer: AATAAA"
     polyA_site      8754
                     /gene="PEG3"
                     /gene_synonym="PW1; ZKSCAN22; ZNF904; ZSCAN24"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagtct gggcagctgc gggaggagag gtttgggagg cgcgggagat gtccaccctg
       61 ggctggtggc gccgccgggc gccgggcgcc atgagggtgc gctaggcggc tgttcgtgcc
      121 cgaggctgcg cagcactgag gtgagctttg ccttcttgat cttccgtcct tcttggagac
      181 gactggcgag aggaagaggg actaggtcca aacgctaggt ggctgggtcc agatacctgt
      241 gttttgactc tgttcctgtg gatagctgct tggtctgaag ttccagaaag gatcctgttc
      301 ccagacaggt ccctgagtac tgacggtcac aggctgccgc gtctttcctg ttgactcatg
      361 tttggttcct ccagtgaaaa ttttacttag agaaatgctg cctccaaagc acttgtctgc
      421 caccaaacct aagaagtcct gggccccaaa tctgtatgag ctagacagtg acttgactaa
      481 ggagccggat gtcatcatag gagaaggtcc aactgactct gagttttttc atcagaggtt
      541 tcggaaccta atctatgtgg aatttgttgg gcctcggaag accctgatca aactccgaaa
      601 cctctgcctc gattggttgc agccggagac ccgcaccaag gaggagatca tcgagctctt
      661 ggtccttgag cagtacctga ccatcatccc tgaaaagctc aagccttggg tgcgagcaaa
      721 aaagccggag aactgtgaga agctcgtcac tctgctggag aattacaagg agatgtacca
      781 accagaagac gacaacaaca gtgacgtgac cagcgacgac gacatgaccc ggaacagaag
      841 agagtcctca ccacctcact cagtccattc tttcagtgac cgggactggg accggagggg
      901 cagaagcaga gacatggagc cacgagaccg ctggtcccac accaggaacc caagaagcag
      961 gatgcctccg cgggatcttt cccttcctgt ggtggcgaaa acaagctttg aaatggacag
     1021 agaggacgac agggactcca gggcttatga gtcccgatct caggatgctg aatcatacca
     1081 aaatgtggtg gacctcgctg aggacaggaa acctcacaac acaatccagg acaacatgga
     1141 aaactacagg aagctgctct ccctcgtgca gcttgctgaa gacgatggcc actcccacat
     1201 gacgcagggc cactcatcaa gatccaagag aagtgcctac ccaagcacca gtcgaggtct
     1261 aaaaactatg cctgaagcca aaaaatcaac ccaccggcgg gggatttgtg aagatgaatc
     1321 ttcccacgga gtgataatgg aaaaattcat caaggatgtg tcacgcagtt ccaaatcggg
     1381 aagagcaagg gagtcaagcg accggtcaca gagattcccc agaatgtcag atgataactg
     1441 gaaggacatt tcattgaaca agagggagtc agtgatccag cagcgggttt atgaagggaa
     1501 tgcatttagg ggaggcttta ggtttaattc aacccttgtt tccagaaaga gagttcttga
     1561 aagaaagagg cgctatcatt ttgacacaga tgggaagggc tcgattcacg atcaaaaagg
     1621 ctgtcccagg aagaagccct ttgaatgtgg tagtgagatg agaaaagcca tgagcgtgag
     1681 cagcctgagc agcctcagct ccccctcctt taccgagtca cagccaattg attttggggc
     1741 aatgccatat gtatgtgatg agtgtgggag gtcgttcagt gtcatctcag aatttgttga
     1801 gcaccagatc atgcatacta gagagaacct ctatgagtat ggtgagtcct ttatccacag
     1861 tgtggctgtc agtgaagttc agaaaagtca ggttggaggg aaacgttttg aatgtaagga
     1921 ctgtggagag accttcaata agagtgccgc cttggctgaa catcggaaga ttcatgctag
     1981 aggttatctt gtggaatgta agaatcagga atgtgaggaa gccttcatgc ctagccccac
     2041 ctttagtgag cttcagaaaa tatatggcaa agacaaattc tacgagtgca gggtgtgtaa
     2101 ggaaaccttc cttcatagtt ctgccctgat tgagcaccag aaaatccact ttggggatga
     2161 caaagataat gagcgtgaac atgaacgtga acgtgaacgt gagcgcgggg aaacctttag
     2221 gcccagccca gcccttaatg agtttcagaa aatgtatggt aaagagaaaa tgtacgaatg
     2281 taaggtgtgt ggggagactt tccttcatag ctcatccctg aaagaacatc agaaaatcca
     2341 tactagaggg aacccatttg aaaacaaggg taaagtgtgt gaggaaacct ttattcctgg
     2401 tcagtccctt aaaaggcgtc agaaaactta caataaggag aagctctgtg actttacaga
     2461 tggccgggat gccttcatgc aaagctcaga gctcagtgag catcagaaaa ttcattctcg
     2521 aaagaacctc tttgaaggca gagggtatga gaaatctgtc attcatagtg ggccattcac
     2581 tgaatctcag aagagtcata ctataacaag acctcttgaa agtgatgagg acgaaaaggc
     2641 gttcaccatt agctctaacc cctatgaaaa ccagaagatt cccactaagg aaaatgtcta
     2701 tgaggcaaaa tcatatgaga ggtctgttat tcatagctta gcctctgtgg aagctcagaa
     2761 aagtcacagt gtagcagggc ccagtaaacc aaaagtaatg gcagagtcta ccattcagag
     2821 cttcgatgct atcaaccatc agagagttcg tgctggaggg aacacctctg aaggaaggga
     2881 atacagtagg tctgttatcc atagcttagt ggcttccaaa cctccaagaa gtcacaatgg
     2941 aaatgaattg gtggaatcta atgagaaggg agaatcctcc atttatatct cagaccttaa
     3001 tgataagcga cagaagattc ctgccagaga gaacccttgt gaagggggca gtaagaatcg
     3061 caactatgaa gactctgtca tacagagtgt attccgtgcc aaacctcaga aaagtgttcc
     3121 tggagaggga tctggtgagt ttaagaagga tggcgaattc tctgttccca gctcaaatgt
     3181 ccgtgaatac cagaaggctc gtgctaaaaa gaaatacatt gagcatagga gcaatgagac
     3241 ctctgtaatt cactctctgc cttttggtga acaaacattt cgccctcgag ggatgctcta
     3301 tgaatgtcag gagtgtgggg agtgctttgc tcatagctct gacctcactg agcaccagaa
     3361 gattcatgat agggagaagc cctctggaag cagaaactat gaatggtctg tcattcgcag
     3421 cttggcccct actgaccctc aaacaagtta cgcccaagag cagtatgcta aagagcaagc
     3481 gcggaacaaa tgtaaggact tcagacaatt ttttgctacc agcgaagacc tcaacacaaa
     3541 ccagaaaatc tatgaccaag agaagtctca tggcgaggag tctcaaggcg agaatactga
     3601 tggggaggag acccacagcg aggagaccca tggtcaggag acaattgaag accctgtcat
     3661 tcaaggctca gacatggaag accctcagaa ggatgaccct gatgacaaaa tctatgaatg
     3721 tgaggactgt ggcctgggct ttgtggatct cacagacctc acagaccatc agaaagtcca
     3781 cagcaggaag tgcctggttg acagtcggga gtacacacat tctgtaattc acacccattc
     3841 catcagcgag tatcagagag attacactgg agagcagctg tatgaatgtc caaagtgtgg
     3901 ggaatctttt attcatagct cattcctttt cgagcatcag agaatccatg aacaagacca
     3961 gttgtattcc atgaaggggt gtgatgatgg ttttattgcc ctcttgccca tgaagccacg
     4021 gaggaatcgt gctgcagaga ggaatcctgc tcttgctggg tcggccattc gatgcctttt
     4081 gtgtggacaa ggcttcattc atagctctgc ccttaatgag catatgagac ttcataggga
     4141 agatgattta ctggagcaga gccagatggc tgaggaagct atcattccag gcttagccct
     4201 cactgagttt cagagaagtc agaccgaaga gagactcttt gaatgtgcag tctgtggaga
     4261 atctttcgtc aacccagcag aacttgcaga tcacgtaact gttcataaga atgagcccta
     4321 tgagtacggg tcctcctata ctcacacctc atttcttact gagcccctca aaggagctat
     4381 accattctat gaatgcaagg attgtggtaa gtcctttatt catagcacag tcctcactaa
     4441 acataaggag cttcatctgg aagaagaaga agaagatgaa gcagcagcag ctgcagcagc
     4501 agcagcccag gaagttgaag ccaatgtcca tgttccacaa gtagttctga ggattcaggg
     4561 cttaaacgta gaggctgctg agccagaagt ggaggctgcc gagccagaag tggaggctgc
     4621 tgagccagaa gtggaggctg ctgagccaaa cggagaggct gaagggccag atggagaggc
     4681 tgcagagccc attggagagg ctggacagcc aaatggagag gccgagcagc caaatgggga
     4741 tgctgatgag ccagatggtg caggtattga agacccagaa gaaagagctg aagagccaga
     4801 gggaaaagct gaagagccag agggagatgc cgacgagcct gacggtgtgg gaattgaaga
     4861 cccagaagaa ggtgaagatc aagagattca ggtagaagaa ccatactatg actgccatga
     4921 atgcacagaa accttcactt ccagcacagc attcagtgaa cacctgaaaa ctcatgccag
     4981 catgatcata tttgagcctg caaatgcctt tggggagtgc tcaggctaca tcgaacgtgc
     5041 cagcaccagc acaggtggtg ccaatcaagc tgatgagaag tacttcaaat gtgacgtctg
     5101 tgggcagctc ttcaatgacc gcctgtccct cgccagacac cagaataccc acactggctg
     5161 agggcatggg gtaaaggtta gaaaaccttc acctaggact tgacccttac caaaccacag
     5221 agaatccaaa ccaatccatg ataatgtcag taggagactt aaccttagtg tgttacacac
     5281 ctgacttaac atctctaaac tcagattgaa aagagaccga atgtgcagat tccacagtct
     5341 taagctttcc ccttcagatg tcagtgtctg catgtgggaa agccatagca cacatcttac
     5401 ctttccaagt aatcagattg agaaaaccct atgagtattc cagactacag agtttgccca
     5461 aatcaactgt aaatgacact tgtgtaacgt atatatagtg tttcatgagg tgtatataaa
     5521 atagcaaatt atgacagaac agtgatcaca tatatttgga tttatatgat atacagttac
     5581 agtttactct gcagaggtac cttacctggt attctttgaa tttttttttt ttttggagga
     5641 ggaagagagc aacaaatttg attatatttt taagtgtctt agatcctgag aaagatttat
     5701 tgtgcattat ttgaaccctg tcaatatctt tttgagtaat tgttttgttt cttaccctta
     5761 aatagtcttg tgaagctgta ggcatgatag ataacatggc ttttactcct tactgtttga
     5821 aaagataagt actttagctt ctttctgcag ccatttcatc tgcgccaaca ctttggaacc
     5881 taatactgtg taaggcttta caatatacgg attggctttt tgtgacccag attgattggt
     5941 tgccacatgt tatgtttgtt gaagtggttc tcatgcaaaa atattacaca tttgtgttct
     6001 gggttttttt tttttttaac caactcaata tgtgtttgat gatagtgaat tgataaaacc
     6061 cgaagctttt ccctgtaaat cttacatctt tgcctttaaa gaatgggtta caaccatcac
     6121 tagatcacag tagtgcctaa tgaaggttga gaaccgtagg agaggctctc atgctgtaaa
     6181 taatgttgca ggctaataac ctttcatcac ttcctttgtg cgcttcctgc cttaagtgac
     6241 aagtagcaac atggcttggg tcccctgtgc agcatcagct tatgctgcca caagtcagtt
     6301 tgcaccctag gtgcccagga gctagtatcc ttagatcttt ctatcgctaa cttaattctc
     6361 ttcgttattt atctgaccct ctaactccat gtctaacttg cattaaaaaa aaaaaaattc
     6421 tttacagtca acccaagctt aacatggact caggttcccc agcagcctta atttgttttg
     6481 ttaacatctg ttccttcttt ttcagctctc ctagagtatt tctgagtgtt gtgttcatct
     6541 aatcttagta ttcttttaat tacaaattga cctcacagct tgaggtttct tgtgtcctat
     6601 tctgtggact acctgtgctc ctttgcttcc cctcccctcg cataataact atattaagaa
     6661 attttttttg gccttgagtt ggctggaaaa aaaatataaa atttaaaaaa tttaaaaaaa
     6721 aagatttgca aaatgtaagt gtagatcatt tgaacaagca aaattaaagt acccactggg
     6781 ggaaatgtgt ctgaatctta ctcttctgga tctgcaggat tagggcttgg aagtatgtca
     6841 aagatgcagg gagtgtcaaa gtttaggaag attgtagagc tgagagcaag aagcagaaat
     6901 gagtgagtca aagaagggag tcctaatata tcaccagatc taggagggga gaggagacag
     6961 acagaagaaa acaccagagg caagaactgt agaaggccag gtttctgaga atgaattgag
     7021 cggggtgtcc tgagcagttt ggaaaaggag tttttgatgg tatggtgtag gtgagggctg
     7081 gctgcatagg aaggactgag gttggaacgg acatcgggaa agctgagggg cagtgaggtt
     7141 tactacatgg gaaaaggact cttgaaacga gaatcagtgt tgatgtcggg gtgaactttg
     7201 tgggtacatt acttggtgtt aacattgttg gcagtggtag ccccttttca gaaagcaact
     7261 tgctgtaagt cagggtgtcc gttccaacct tcagctagtg aaaaggtagt aacaaatggt
     7321 aaacaagaga atgattgttt aaacctatct gtggacactt aatgcaactg tttaaaaatg
     7381 ataatcacga gttatgtagc aacgtggaaa tatatttaca gaacattaag tggagaaagc
     7441 aggacacgaa agtatattta tactacagtt ataactcaac agttcattta tatgctgttc
     7501 atttaacagt tcatttaaac agttcattat aactgtttaa aaatatatat gcttatagtc
     7561 aaaagctgtt gtggtgttgt tgttgtaggc ttatagttga gcattatttt cttaaatttc
     7621 ttgaatgttc tttatggtag tgttactaaa aagtttatga tcacattttc attgtgaaca
     7681 taatttgaac tcattatcac acacttggaa aatacagaaa agtggaggaa aaaaaatcat
     7741 atccccacca tccaaagaca tatactctcc tcttatcttg ttcattcttg tttctgtgca
     7801 caggtttatg attataactg tgtcaaaatg tatattcaaa atagctgtta cattaccttt
     7861 gtggaattat ggttaaatac tttcacttta attttttcaa atgttcccta taataatgtc
     7921 ctgataacag tgtattatgt gtgtctccat tggtgtgcat aatacatacc cagaggaaaa
     7981 attagaaaat aaagtaaatt attttaaaaa attacctata ttcccaacac ctaacaacta
     8041 ctgctaacat cttgatctgt ttcctctatc ttgtttcagt gcacacgctt gtgataacag
     8101 tgttaaatat gtgtgcataa agtcttaaat gaaaagatgt ggaaaataac taaaatagtg
     8161 ttgtcattgt gggaatttgg ttaaatattt tgtctcaaat tccttaaata atctttggtg
     8221 ttttggtaat aaattttatg tatgtatttt ccattacaaa tataatacat actcatacaa
     8281 aactttggaa attcagtaaa gaaaattcac acatattccc aacacccaac aacaattaac
     8341 tgttaacatc ttgatctgtg cactagtctg tgattattag ggtgttagtg ataagtatgc
     8401 ataaatgtca aagatgggaa gaaagatgaa aaacaagaaa tagttgtgtg gttgttgtgg
     8461 gattatggtt attttgtttc ggtttccttg aaaggtcatc attctagtgt tttggtagtc
     8521 cacctttact acatatattt ccattatata tgaaatgtgt tcattataga aactttgaag
     8581 ttacagaaat gtagaagaga aactcaccca tgttttcacc atccaaagag tgtggttaac
     8641 atcttgatat attttcttca tcttgtttct gtgcacaggt ttttggtttg ttaatatggt
     8701 tgtggtcatt ctatctgtaa tagtgtcaac aataaaaata aagttaaaaa taaa
//
