LOCUS       NM_199129               7703 bp    mRNA    linear   PRI 26-FEB-2025
DEFINITION  Homo sapiens plasmanylethanolamine desaturase 1 (PEDS1), transcript
            variant 1, mRNA.
ACCESSION   NM_199129
VERSION     NM_199129.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7703)
  AUTHORS   Liu,J., Sun,M., Sun,Y. and Li,H.
  TITLE     TMEM189 promotes breast cancer through inhibition of
            autophagy-regulated ferroptosis
  JOURNAL   Biochem Biophys Res Commun 622, 37-44 (2022)
   PUBMED   35843092
  REMARK    GeneRIF: TMEM189 promotes breast cancer through inhibition of
            autophagy-regulated ferroptosis.
REFERENCE   2  (bases 1 to 7703)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 7703)
  AUTHORS   Werner,E.R., Keller,M.A., Sailer,S., Lackner,K., Koch,J.,
            Hermann,M., Coassin,S., Golderer,G., Werner-Felmayer,G.,
            Zoeller,R.A., Hulo,N., Berger,J. and Watschinger,K.
  TITLE     The TMEM189 gene encodes plasmanylethanolamine desaturase which
            introduces the characteristic vinyl ether double bond into
            plasmalogens
  JOURNAL   Proc Natl Acad Sci U S A 117 (14), 7792-7798 (2020)
   PUBMED   32209662
  REMARK    GeneRIF: these results assign the TMEM189 gene to
            plasmanylethanolamine desaturase and suggest that the previously
            characterized phenotype of Tmem189-deficient mice may be caused by
            a lack of plasmalogens.
REFERENCE   4  (bases 1 to 7703)
  AUTHORS   Gallego-Garcia,A., Monera-Girona,A.J., Pajares-Martinez,E.,
            Bastida-Martinez,E., Perez-Castano,R., Iniesta,A.A., Fontes,M.,
            Padmanabhan,S. and Elias-Arnanz,M.
  TITLE     A bacterial light response reveals an orphan desaturase for human
            plasmalogen synthesis
  JOURNAL   Science 366 (6461), 128-132 (2019)
   PUBMED   31604315
  REMARK    GeneRIF: TMEM189 could functionally replace CarF in M. xanthus, and
            knockout of TMEM189 in a human cell line eliminated plasmalogens;
            study reveals TMEM189 as the long-sought desaturase for animal
            plasmalogen biosynthesis
REFERENCE   5  (bases 1 to 7703)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   6  (bases 1 to 7703)
  AUTHORS   Ito,M., Shichijo,S., Tsuda,N., Ochi,M., Harashima,N., Saito,N. and
            Itoh,K.
  TITLE     Molecular basis of T cell-mediated recognition of pancreatic cancer
            cells
  JOURNAL   Cancer Res 61 (5), 2038-2046 (2001)
   PUBMED   11280764
REFERENCE   7  (bases 1 to 7703)
  AUTHORS   Thomson,T.M., Lozano,J.J., Loukili,N., Carrio,R., Serras,F.,
            Cormand,B., Valeri,M., Diaz,V.M., Abril,J., Burset,M., Merino,J.,
            Macaya,A., Corominas,M. and Guigo,R.
  TITLE     Fusion of the human gene for the polyubiquitination coeffector UEV1
            with Kua, a newly identified gene
  JOURNAL   Genome Res 10 (11), 1743-1756 (2000)
   PUBMED   11076860
REFERENCE   8  (bases 1 to 7703)
  AUTHORS   Long,M.
  TITLE     A new function evolved from gene fusion
  JOURNAL   Genome Res 10 (11), 1655-1657 (2000)
   PUBMED   11076848
  REMARK    Review article
            Erratum:[Genome Res 2001 Feb;11(2):308]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034423.21.
            
            On May 21, 2020 this sequence version replaced NM_199129.3.
            
            Summary: Co-transcription of this gene and the neighboring
            downstream gene (ubiquitin-conjugating enzyme E2 variant 1)
            generates a rare read-through transcript, which encodes a fusion
            protein comprised of sequence sharing identity with each individual
            gene product. The protein encoded by this individual gene lacks a
            UEV1 domain but includes three transmembrane regions. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023028.1, BC018893.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371652.9/ ENSP00000360715.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AL034423.21        111611-111817       c
            208-327             AL034423.21        101596-101715       c
            328-419             AL034423.21        88950-89041         c
            420-564             AL034423.21        87640-87784         c
            565-777             AL034423.21        86069-86281         c
            778-7703            AL034423.21        76348-83273         c
FEATURES             Location/Qualifiers
     source          1..7703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..7703
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /note="plasmanylethanolamine desaturase 1"
                     /db_xref="GeneID:387521"
                     /db_xref="HGNC:HGNC:16735"
                     /db_xref="MIM:610994"
     exon            1..207
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..899
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /EC_number="1.14.19.77"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 189; CarF homolog"
                     /codon_start=1
                     /product="plasmanylethanolamine desaturase 1 isoform 1"
                     /protein_id="NP_954580.2"
                     /db_xref="CCDS:CCDS13428.1"
                     /db_xref="GeneID:387521"
                     /db_xref="HGNC:HGNC:16735"
                     /db_xref="MIM:610994"
                     /translation="MAGAENWPGQQLELDEDEASCCRWGAQHAGARELAALYSPGKRL
                     QEWCSVILCFSLIAHNLVHLLLLARWEDTPLVILGVVAGALIADFLSGLVHWGADTWG
                     SVELPIVGKAFIRPFREHHIDPTAITRHDFIETNGDNCLVTLLPLLNMAYKFRTHSPE
                     ALEQLYPWECFVFCLIIFGTFTNQIHKWSHTYFGLPRWVTLLQDWHVILPRKHHRIHH
                     VSPHETYFCITTGWLNYPLEKIGFWRRLEDLIQGLTGEKPRADDMKWAQKIK"
     exon            208..327
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /inference="alignment:Splign:2.1.0"
     exon            328..419
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /inference="alignment:Splign:2.1.0"
     exon            420..564
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /inference="alignment:Splign:2.1.0"
     exon            565..777
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /inference="alignment:Splign:2.1.0"
     exon            778..7703
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /note="hexamer: AACAAA"
     polyA_site      1789
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /note="major polyA site"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
     regulatory      7680..7685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
                     /note="hexamer: AATAAA"
     polyA_site      7703
                     /gene="PEDS1"
                     /gene_synonym="CarF; KUA; TMEM189"
ORIGIN      
        1 attgggcggc gtgatctcgc cgcggttccg cggccctgcc gccgccgccg ccagcagagc
       61 gcaccgggcc gatcgggcga gtggccatgg cgggcgccga gaactggccg ggccagcagc
      121 tggagctgga cgaggacgag gcgtcttgtt gccgctgggg cgcgcagcac gccggggccc
      181 gcgagctggc tgcgctctac tcgccaggca agcgcctcca ggagtggtgc tctgtgatcc
      241 tgtgcttcag cctcatcgcc cacaacctgg tccatctcct gctgctggcc cgctgggagg
      301 acacacccct cgtcatactc ggtgttgttg caggggctct cattgctgac ttcttgtctg
      361 gcctggtaca ctggggtgct gacacatggg gctctgtgga gctgcccatt gtggggaagg
      421 ctttcatccg acccttccgg gagcaccaca ttgacccgac agctatcaca cggcacgact
      481 tcatcgagac caacggggac aactgcctgg tgacactgct gccgctgcta aacatggcct
      541 acaagttccg cacccacagc cctgaagccc tggagcagct atacccctgg gagtgcttcg
      601 tcttctgcct gatcatcttc ggcaccttca ccaaccagat ccacaagtgg tcgcacacgt
      661 actttgggct gccacgctgg gtcaccctcc tgcaggactg gcatgtcatc ctgccacgta
      721 aacaccatcg catccaccac gtctcacccc acgagaccta cttctgcatc accacaggct
      781 ggctcaacta ccctctggag aagataggct tctggcgacg cctggaggac ctcatccagg
      841 gcctgacggg cgagaagcct cgggcagatg acatgaaatg ggcccagaag atcaaataac
      901 ttctccgagc ctgctacctg gttgccaacc ttccctagcc cccaaaccga agccatctgc
      961 caaattccag cctctttgag ctggcccctc cagatggaga ggacatctcc tgggctgggc
     1021 ccaggtaccc cagcccaccc ctcatgacac agaatacttg agccactgat ttttcatttc
     1081 tttttttttt ttttcctcgg cccctcctca gccacctgag ttgctctatc tgcaagcctg
     1141 actctgccag cctcccctgg tagagaggag gtttacccac tccctgcacg cctgccgtcc
     1201 ctgccccgct gggcagccct tcagtgtggc tggcgttggg gccagtgagt tgcctctttc
     1261 cctccttgtc tggccccagt ggtctgggga gcccccaggc acacctaagc gtcgtggagc
     1321 attgttctgc cacagccctg catactgacc ccgggaggct gggcaggtgg acagccccag
     1381 ccaccacctt cagcctagcc tgtcccccaa ggatggtgaa gctcagcagg ggtctgaggg
     1441 tagccggcca gaagaggctg gaacctcctg ctcaagtcta gacccctact tctctgctgc
     1501 ccccaccctg ccagagctga tgtttccaat accaagatgt cttcacaggg cacagcccct
     1561 gcagagcatc ttggtcattt ggaagaggac acggtatccc ctctggccag agtatgtcag
     1621 agaaggaaga gtagggcttt tttgttttgt ttttttttaa aggtgcttgc ttgtttaatg
     1681 taaataatag aaagccttaa tatcttttct gtaacacgga gtaatatttt aatgtcatgt
     1741 tttggatgta cataatatat ttataacaaa gcagcaagag tctacttaac cttggctgcc
     1801 tcgtggtgtt tcctggctgg gtggggtggg gggtatcaag gagcctggga cgtgaggccc
     1861 cactctcgcc ccattcccag ctccccccaa ccctggcctc aggatgagag ctgtcacctg
     1921 agacagtgaa ttaatgttga catctgctcc aaagcctttt ggaggggatt gggtgaggac
     1981 agtggtcttt cctgttgatc atgatgataa agtaatgatg gctgatccct atttgtgact
     2041 tccttcagca aatattcact ggcacctggt gtgtgccagg ctctgtcctg tacacaggta
     2101 cagcggtgaa agaaccaaca aagacctatc ctggtggagc tgacctcctg ggaaaagagt
     2161 caataaacaa ataaatgcac atggaaattc aggtggtgat ttgtgaagaa aatcaaacag
     2221 gacagaacca cagcggaaaa gcagggtcgg tgctgctttg gcagggtggt catgaagggc
     2281 ctctgagctg agacctgggg gaggagagga ggtcagacac gaaagaagtg agggaagagg
     2341 cctcttgatg ggacagcaag tacacaggcc ctgaggcaag aacaagcttg gggccacgca
     2401 cagtggctca cgccagtaat cccagcactt tgggaggctg aggcggacag atcacctgag
     2461 gtcaggagtt ctagaccagc ctggccaaca tggtgaaacc ctgtctctac taaaatttac
     2521 aaaaattagc caggcgtggt ggcagacgac tttatcccag ctacttggga ggcagaggca
     2581 ggagaatcat ttgaacccgg gaggtgaagg ttgcagtgag ccgagatcga gccattgcac
     2641 tcaaacctgg gggataagag cgagacttcg cttagaaaaa aaaaaaaaga acaagcttgg
     2701 gattttaaga gatggtgagg cagccactgt ggctggacta gagtgagcta aggaaaaatg
     2761 gaagacaagg ttgggaaaac atggatttgg tatacagaga ctcataggct gaggtgagtg
     2821 gggacctgct ggtcatttta tttatttgta tttattacta tgtttttaga gacagggtca
     2881 tgctctgtca cccaggctaa agtgcagagg tgaggtgtaa tagctcacag caaccttgaa
     2941 ctcctggaca caaacgatcc tcatgagtgg ctgggactag cacatgccgc cacacctggc
     3001 ttggctattt tttttttttt ttaaagaaat ggggtctcac tatgttgtcc aggttggtct
     3061 tgaactcctg gcctcaagtg atccgccttg gccttccaaa gtgctggaat tttaggtatg
     3121 agccactgca ccgggtcagg acattataga ccaattagta acttgtttat ttgttgaata
     3181 agtaattata aggcatctcc tatgaactag gtactgcgat tctgtagtga acgctacaga
     3241 catagtcaat agctagtcta ggctagatag tttctgcaat attagccaga aaaaagaaag
     3301 cctgttgggg acagggaaat gcctaaagga ctccagagca gtcacagata atgacatttc
     3361 tgagtagctg ggattacagg cgcccaccac catgcccggc taattttcgt atttttagta
     3421 gagatggggt ttcagcatgt tggccaggct ggtctccaac tcttgacttc aggtgatcca
     3481 cccaccttgg cctcccaaag tgttgggatt acaggcatga gccactgcgt ccagccatga
     3541 catttatttt ttaaaacgtg acccataatg ccattttcct ttgccaacta gacttttgat
     3601 ttgtgactat gcctgagggg accacacaag gaagggtgtt agaattcgac aactcataaa
     3661 tgacagaaat ttaaagtaaa cagctaaaat aatcgtatta gctcataaaa cggaaaagtc
     3721 tacaggtgtt ctgaattaag gtttggcagg acccaggggc tcacatgatt catcaaaacg
     3781 tggtctctct aagctctgtt tttctctttg agttgagact tactagacca gctcagcaat
     3841 ctcagtggaa agtgcattcc cagtagttgc agtggaagtc ccagggcagg ctctcattgg
     3901 tctggactgg gtcacgtgcc catccctgaa ccaatcacat tggccagtgg ggtgaaatgc
     3961 tctggttgcc cagggctgaa aaatgtccat ctggatttgc agggttgtga tcacctcttc
     4021 ctaaggcatt actacaaaaa gaagtcaatg gtggatggga caggcagcta aattctttag
     4081 aggccatagg agtagcctca ccactgtggt gttggtttcc aggccccacc aatctgtgtc
     4141 agttcccctg gagccgacag aaaaaaaacc ctcagcctga gtccagagag gtaaagtgac
     4201 tcccccaagg tcccacaggt agtaagggta gagcagccct cagactcaga ccatttcact
     4261 tctgaattct gggggctgga aaaaaatcct tctcaaaacc agaaggtgcg ctgcattggg
     4321 tctgagagtg ttggggccac ttgtgagatc agggacttgc aaacaagtgc ctatgagggc
     4381 cagacagggg aaaatgctac ttaatattac tgagcactta actttgcacc agactgtgca
     4441 gagagctctg gcatgggtcc tgtcaagcag tccctgcagc tctgagaagt gagtactctt
     4501 tgcaccattt gcagatgggg aaactgaggc acagaggtca tgtaatatgc ccaaggtcac
     4561 acagctggta ggtggcagaa tcaggatttg agccagcgtc tgacccaaag cccctgtgct
     4621 ttaacgctcc cattgtggag agggaggtga gacaggtggc acgtgagaaa tgtgtccact
     4681 atgaggcaac tgcagcatgc ctgagaaagg gccgctgacg ctggggactg ggatgacctg
     4741 gagacatcag gcctaaaggg cagctgctac tcacagcagc tggttaaaca ggagccagaa
     4801 atctaaactt taaaaatgct ggctccgtgt ttaaaacgta ctgtgggcaa aacaaaatga
     4861 gtgcataggc caactgcctg cagcctccct cccagctgct gtgggatggc ttggtttcag
     4921 gtaggcatgt gctgctgtct ggtggtggca cagggtagtg gcatgcaggg caaacatgga
     4981 tttccagctc aaccggggga gctgtagtga acttgcatac ccctgtgtgc tcactgttct
     5041 ttagaagggg cctgggcaca tacctttggg cgcctgcccc caactgaaac tccatcaccc
     5101 cgcctttttt ttttcctgga gacggggtct tgctctgtca cccaggctgg aacacagtgg
     5161 catgatctgc gctcactgca gactcaacct cccaggctca agcaatcctc ccatttcagc
     5221 ctcttgaata gcgggaacga cagacatgtg ccaccacccc cagctagttt ctttttgtat
     5281 tttttgtaga gatggggttt caccatgttg cccaggctgg tctcgaacgc ctgagctcaa
     5341 gcgatcggcc cacctcagcc ttcctaagtg ttgggattac aggcatgaac caccgcgccc
     5401 agccaaccct cctttgataa accaaaaata tttttcaagc tacccacata tatatatggg
     5461 tatatatata tatatagcaa tatatatatt gctatataag caataggtaa tgcttgcata
     5521 ggtaaagaat aagaatcacg ccgggtacag tggctcatat caaataatat aaacagggct
     5581 agagtatgga taagctgacc ctggacagtg ggccaaatcc agccacttgc ttttctatag
     5641 ctcagaagct tttgtgggtt gtttgtttgt ttgtttgttt gtttgttttt tagagacagg
     5701 gtcttgctct gttgtccagg ctggagtgca gtggcacaat cacagctcac tgtaacctca
     5761 gactcctggg ctcaagtgat cctcccacct cagcctcctg agtagctagg actacagatg
     5821 gacaccacca catccagcta attttttttt ttttttagag atggggtctc gctatgttgc
     5881 ccagggtagt ctcaaactcc tggcctcaag tgatcctccc acctcaacct cctgaagcac
     5941 tgggattaca ggtgtgagcc accatgtcag ccacgagcat tttttaaatg gctgggggag
     6001 ggggaacaat atttcctaac acagaaaatt caaattccag tttgtaaagc tgaattggca
     6061 cacagccatg cccctcattt acatattgtc cgaggctgct tttgcactgc agtggcagaa
     6121 ttgagtcgtt gcatcggaga ccacgtggtc cacacagcct aaaatattta cgatctggcc
     6181 ctttacagag aaaagttacc aacctctccc tagtctagaa tgaagggtaa attgctcccc
     6241 attcatgttc cctcaggtac tcagttcccc tccttagagg ccatcatttt gacaagacac
     6301 ttgcaatgcc ttatgtaggc agaggggtat gtctgcccca ctccttttca cacaatatgt
     6361 aggatattat gcacacagtt ctgcaccttg ccttttttca cttaatatat tttggagata
     6421 gtgttatcat taatgttcac aaaccattat tattttttac agctgcatag tgttccacct
     6481 tcaggatgga atggacttga cttttttttt tttttttttt tgagacaaag tcttgctcta
     6541 ttacctgggc tagagtgcag tggtgcaatc ccagctcact acagcctctg cctcctgggc
     6601 tcaagctatc ctctctcagc ctcccatccc aagtagttgg gactacaggt gcatgccacc
     6661 atgctgagct aatttttttt tattattttt agagacgggg gtcttgcttt gttgcccaga
     6721 ctcgtctcaa actcctgtgc tcaagcaatc ctcctgcctc agactcccaa actgctggga
     6781 ttacaggctt gaaccacgag tgtgttttaa attttgatag tgcataccaa attgtcttcc
     6841 agaggccatg ccggtttaag ttcacaagtt ttcagagtcc ctgtttcctc acacccttgc
     6901 caacacagcg tgttatcaaa tgttttgttc tttgccaatc tgataggtgg ttttaatttg
     6961 cattcctctt actgtatttc attgattcta agatgtcact gattctaaga tgcatcctga
     7021 tttcagaagt tcacatgtaa aaatgtggct gggtgtggta gctcacgcct gtaatcccag
     7081 cactttgggc ggatcacgag gtcaggaatt caagaccagc ctggccaaca tagtgaaacc
     7141 ccgtctctac caaaaataca aaagaaataa ttagctgggt gtggtggcgg gtgcctgtaa
     7201 tcccagctac ttgggaggct gaggcaggag aattgcttga acccaggagg cggaggttgc
     7261 agtgaactga gatcgcgcca ctgaactcca gcctgggcga cacagcgaga ctctgtctca
     7321 aaaaaaaaac aaaaaaaaag taaaaacgta tagcttcaaa tcactgaaat acaatatgtt
     7381 ttgtgagatt gggtatctta ctgtgagttt aaaatgcatt tgcatttcct catctgttca
     7441 tgtccttttc ctatttttct tggaagggag ggtagcattg gttaagagtg tagggttcaa
     7501 atcccagttc tgccacttac aagcttgtga ctttgggcaa gttacttaac cgttctgtgt
     7561 ctcagtttcc tcacctgcaa aatgggaata ataatggtac ctacctcata ggataggtgt
     7621 gaagattaaa tacattatta tatgcaaaat accatgttcc tggaatatgg caaatgctca
     7681 ataaatattt gctgtaactg tca
//
