LOCUS       NM_018441               1867 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens peroxisomal trans-2-enoyl-CoA reductase (PECR), mRNA.
ACCESSION   NM_018441
VERSION     NM_018441.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1867)
  AUTHORS   Uchida,Y., Yamamoto,Y. and Sakisaka,T.
  TITLE     Trans-2-enoyl-CoA reductase limits Ca2+ accumulation in the
            endoplasmic reticulum by inhibiting the Ca2+ pump SERCA2b
  JOURNAL   J Biol Chem 296, 100310 (2021)
   PUBMED   33482198
  REMARK    GeneRIF: Trans-2-enoyl-CoA reductase limits Ca(2+) accumulation in
            the endoplasmic reticulum by inhibiting the Ca(2+) pump SERCA2b.
REFERENCE   2  (bases 1 to 1867)
  AUTHORS   Hua,T., Wu,D., Ding,W., Wang,J., Shaw,N. and Liu,Z.J.
  TITLE     Studies of human 2,4-dienoyl CoA reductase shed new light on
            peroxisomal beta-oxidation of unsaturated fatty acids
  JOURNAL   J Biol Chem 287 (34), 28956-28965 (2012)
   PUBMED   22745130
  REMARK    GeneRIF: Biochemical studies and structural analysis suggest that
            pDCRs can catalyze the shortening of six-carbon-long substrates in
            vitro.
REFERENCE   3  (bases 1 to 1867)
  AUTHORS   Hersh,C.P., Pillai,S.G., Zhu,G., Lomas,D.A., Bakke,P., Gulsvik,A.,
            DeMeo,D.L., Klanderman,B.J., Lazarus,R., Litonjua,A.A., Sparrow,D.,
            Reilly,J.J., Agusti,A., Calverley,P.M., Donner,C.F., Levy,R.D.,
            Make,B.J., Pare,P.D., Rennard,S.I., Vestbo,J., Wouters,E.F.,
            Scholand,M.B., Coon,H., Hoidal,J. and Silverman,E.K.
  TITLE     Multistudy fine mapping of chromosome 2q identifies XRCC5 as a
            chronic obstructive pulmonary disease susceptibility gene
  JOURNAL   Am J Respir Crit Care Med 182 (5), 605-613 (2010)
   PUBMED   20463177
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1867)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   5  (bases 1 to 1867)
  AUTHORS   Treutlein,J., Cichon,S., Ridinger,M., Wodarz,N., Soyka,M., Zill,P.,
            Maier,W., Moessner,R., Gaebel,W., Dahmen,N., Fehr,C., Scherbaum,N.,
            Steffens,M., Ludwig,K.U., Frank,J., Wichmann,H.E., Schreiber,S.,
            Dragano,N., Sommer,W.H., Leonardi-Essmann,F., Lourdusamy,A.,
            Gebicke-Haerter,P., Wienker,T.F., Sullivan,P.F., Nothen,M.M.,
            Kiefer,F., Spanagel,R., Mann,K. and Rietschel,M.
  TITLE     Genome-wide association study of alcohol dependence
  JOURNAL   Arch Gen Psychiatry 66 (7), 773-784 (2009)
   PUBMED   19581569
REFERENCE   6  (bases 1 to 1867)
  AUTHORS   Braastad,C.D., Leguia,M. and Hendrickson,E.A.
  TITLE     Ku86 autoantigen related protein-1 transcription initiates from a
            CpG island and is induced by p53 through a nearby p53 response
            element
  JOURNAL   Nucleic Acids Res 30 (8), 1713-1724 (2002)
   PUBMED   11937624
REFERENCE   7  (bases 1 to 1867)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
REFERENCE   8  (bases 1 to 1867)
  AUTHORS   Amery,L., Mannaerts,G.P., Subramani,S., Van Veldhoven,P.P. and
            Fransen,M.
  TITLE     Identification of a novel human peroxisomal 2,4-dienoyl-CoA
            reductase related protein using the M13 phage protein VI phage
            display technology
  JOURNAL   Comb Chem High Throughput Screen 4 (7), 545-552 (2001)
   PUBMED   11669066
REFERENCE   9  (bases 1 to 1867)
  AUTHORS   Gay,F., Anglade,I., Gong,Z. and Salbert,G.
  TITLE     The LIM/homeodomain protein islet-1 modulates estrogen receptor
            functions
  JOURNAL   Mol Endocrinol 14 (10), 1627-1648 (2000)
   PUBMED   11043578
REFERENCE   10 (bases 1 to 1867)
  AUTHORS   Das,A.K., Uhler,M.D. and Hajra,A.K.
  TITLE     Molecular cloning and expression of mammalian peroxisomal
            trans-2-enoyl-coenzyme A reductase cDNAs
  JOURNAL   J Biol Chem 275 (32), 24333-24340 (2000)
   PUBMED   10811639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU151224.1, AF212234.1 and AC010686.9.
            
            On Nov 22, 2018 this sequence version replaced NM_018441.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002529.2, AF232009.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000265322.8/
                                                ENSP00000265322.7
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-731               BU151224.1         8-738
            732-1153            AF212234.1         724-1145
            1154-1867           AC010686.9         93079-93792         c
FEATURES             Location/Qualifiers
     source          1..1867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..1867
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /note="peroxisomal trans-2-enoyl-CoA reductase"
                     /db_xref="GeneID:55825"
                     /db_xref="HGNC:HGNC:18281"
                     /db_xref="MIM:605843"
     exon            1..192
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..980
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /EC_number="1.3.1.38"
                     /note="2,4-dienoyl-CoA reductase-related protein; putative
                     short chain alcohol dehydrogenase; DCR-RP; pVI-ARL; short
                     chain dehydrogenase/reductase family 29C member 1"
                     /codon_start=1
                     /product="peroxisomal trans-2-enoyl-CoA reductase"
                     /protein_id="NP_060911.2"
                     /db_xref="CCDS:CCDS33375.1"
                     /db_xref="GeneID:55825"
                     /db_xref="HGNC:HGNC:18281"
                     /db_xref="MIM:605843"
                     /translation="MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSN
                     VVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKIN
                     FLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVP
                     TKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQ
                     SFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPD
                     HDNWPKGAGDLSVVKKMKETFKEKAKL"
     exon            193..326
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            327..492
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            493..574
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            575..671
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            672..782
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            783..894
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1867
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1130..1135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /note="hexamer: AATATA"
     polyA_site      1153
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /note="major polyA site"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /note="hexamer: AACAAA"
     polyA_site      1667
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
     regulatory      1713..1718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /note="hexamer: ATTAAA"
     polyA_site      1736
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
                     /note="hexamer: AAGAAA"
     polyA_site      1867
                     /gene="PECR"
                     /gene_synonym="DCRRP; HPDHASE; HSA250303; PVIARL; SDR29C1;
                     TERP"
ORIGIN      
        1 gcccgcctcg aatgtccctg agacccagaa gggcctgcgc tcagctgctc tggcaccccg
       61 ctgcagggat ggcctcctgg gctaagggca ggagctacct ggcgcctggt ttgctgcagg
      121 gccaagtggc catcgtcacc ggcggggcca cgggcatcgg aaaagccatc gtgaaggagc
      181 tcctggagct ggggagtaat gtggtcattg catcccgtaa gttggagaga ttgaagtctg
      241 cggcagatga actgcaggcc aacctacctc ccacaaagca ggcacgagtc attcccatac
      301 aatgcaacat ccggaatgag gaggaggtga ataatttggt caaatctacc ttagatactt
      361 ttggtaagat caatttcttg gtgaacaatg gaggaggcca gtttctttcc cctgctgaac
      421 acatcagttc taagggatgg cacgctgtgc ttgagaccaa cctgacgggt accttctaca
      481 tgtgcaaagc agtttacagc tcctggatga aagagcatgg aggatctatc gtcaatatca
      541 ttgtccctac taaagctgga tttccattag ctgtgcattc tggagctgca agagcaggtg
      601 tttacaacct caccaaatct ttagctttgg aatgggcctg cagtggaata cggatcaatt
      661 gtgttgcccc tggagttatt tattcccaga ctgctgtgga gaactatggt tcctggggac
      721 aaagcttctt tgaagggtct tttcagaaaa tccccgctaa acgaattggt gttcctgagg
      781 aggtctcctc tgtggtctgc ttcctactgt ctcctgcagc ttccttcatc actggacagt
      841 cggtggatgt ggatgggggc cggagtctct atactcactc gtatgaggta ccagatcatg
      901 acaactggcc caagggagca ggggaccttt ctgttgtcaa aaagatgaag gagaccttta
      961 aggagaaagc taagctctga gctgaggaaa caaggtgtcc tccatccccc agtgccttca
     1021 catcttgagg atatgcttct gtacttttta aaagcttata gttggtatgg aaaacatttt
     1081 tcttattttt aagtgttatt aattatatct atggaaaaac tattcctgaa atatatacag
     1141 tcttatgtcc caatcagagt cttttaacct atgatttaaa aatgtataag taacagaaat
     1201 taacatattt taatgacttt actttttatt tctaagaaaa gtatttgaaa aatggaataa
     1261 ttttaaatca atgataattc tagggatcat gaactcccag aagattttat tatttaattg
     1321 taaaggtaga ggccagacgc agtggctcac gcctgtaatt ccagcacttt gggaggccga
     1381 ggtaggcggg tcagttgagg tcaggagttc aagaccaggc tggccaacat ggtaaaaccc
     1441 tgtctctact gaaaaacaac aaaaacaaaa acacaaatta gtcgggtgtg gtggcacaca
     1501 cctgtagtcc caggtacttg ggaggctgag gcaggaggat cgcttgaacc caggaagcag
     1561 aggttgcagt gagctgagat catgctactg cagtccagcc tgggctacag agtgagactg
     1621 catctcaaaa aaaacccaaa aaacaaaaac aaacaacaac aacaaaatta taaaggtaga
     1681 aaataaacct aaattgtgtc gtaattaaga ttattaaaat tagaattata caatgactta
     1741 tttttggtgg caaatacttt aggagcaata atgccttatg gtaattattg atgtatagtt
     1801 tcttttgttt atgaagtcaa atttgtataa attctcttaa ttcaaagaaa aagttttatg
     1861 tgattta
//
