LOCUS       NM_000442               6813 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens platelet and endothelial cell adhesion molecule 1
            (PECAM1), mRNA.
ACCESSION   NM_000442 XR_108267 XR_109420
VERSION     NM_000442.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6813)
  AUTHORS   Mariappan,V., Shanmugam,L., Ranganathan Green,S., Easow,J.M.,
            Mutheneni,S.R., Thirugnanasambandhar Sivasubramanian,A. and
            Balakrishna Pillai,A.
  TITLE     Increased shedding of PECAM-1 associated with elevated serum MMP-14
            levels as new blood indicators of dengue disease manifestation
  JOURNAL   Infect Dis Now 54 (7), 104964 (2024)
   PUBMED   39181201
  REMARK    GeneRIF: Increased shedding of PECAM-1 associated with elevated
            serum MMP-14 levels as new blood indicators of dengue disease
            manifestation.
REFERENCE   2  (bases 1 to 6813)
  AUTHORS   Wang,J., Lai,D.A., Wang,J.J. and Zhang,S.X.
  TITLE     Effects of Nox4 upregulation on PECAM-1 expression in a mouse model
            of diabetic retinopathy
  JOURNAL   PLoS One 19 (5), e0303010 (2024)
   PUBMED   38748682
  REMARK    GeneRIF: Effects of Nox4 upregulation on PECAM-1 expression in a
            mouse model of diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6813)
  AUTHORS   Tenyi,A., Milutinovic,A. and Nemeth,L.
  TITLE     Expression of CD31, CD34, and smooth muscle actin (SMA) in
            endothelial cells of dental pulp vessels
  JOURNAL   Biomol Biomed 24 (4), 821-826 (2023)
   PUBMED   38153414
  REMARK    GeneRIF: Expression of CD31, CD34, and smooth muscle actin (SMA) in
            endothelial cells of dental pulp vessels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6813)
  AUTHORS   Dhumale,P., Nielsen,J.V., Hansen,A.C.S., Burton,M., Beck,H.C.,
            Jorgensen,M.G., Toyserkani,N.M., Haahr,M.K., Hansen,S.T., Lund,L.,
            Thomassen,M., Sorensen,J.A., Andersen,D.C., Jensen,C.H. and
            Sheikh,S.P.
  TITLE     CD31 defines a subpopulation of human adipose-derived regenerative
            cells with potent angiogenic effects
  JOURNAL   Sci Rep 13 (1), 14401 (2023)
   PUBMED   37658225
  REMARK    GeneRIF: CD31 defines a subpopulation of human adipose-derived
            regenerative cells with potent angiogenic effects.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6813)
  AUTHORS   Wu,Q., Du,X., Cheng,J., Qi,X., Liu,H., Lv,X., Gong,X., Shao,C.,
            Wang,M., Yue,L., Yang,X., Li,S., Zhang,Y., Li,X. and Yang,H.
  TITLE     PECAM-1 drives beta-catenin-mediated EndMT via internalization in
            colon cancer with diabetes mellitus
  JOURNAL   Cell Commun Signal 21 (1), 203 (2023)
   PUBMED   37580771
  REMARK    GeneRIF: PECAM-1 drives beta-catenin-mediated EndMT via
            internalization in colon cancer with diabetes mellitus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6813)
  AUTHORS   Ferrero,E., Ferrero,M.E., Pardi,R. and Zocchi,M.R.
  TITLE     The platelet endothelial cell adhesion molecule-1 (PECAM1)
            contributes to endothelial barrier function
  JOURNAL   FEBS Lett 374 (3), 323-326 (1995)
   PUBMED   7589563
REFERENCE   7  (bases 1 to 6813)
  AUTHORS   Albelda,S.M., Muller,W.A., Buck,C.A. and Newman,P.J.
  TITLE     Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a
            novel vascular cell-cell adhesion molecule
  JOURNAL   J Cell Biol 114 (5), 1059-1068 (1991)
   PUBMED   1874786
REFERENCE   8  (bases 1 to 6813)
  AUTHORS   Stockinger,H., Gadd,S.J., Eher,R., Majdic,O., Schreiber,W.,
            Kasinrerk,W., Strass,B., Schnabl,E. and Knapp,W.
  TITLE     Molecular characterization and functional analysis of the leukocyte
            surface protein CD31
  JOURNAL   J Immunol 145 (11), 3889-3897 (1990)
   PUBMED   1700999
REFERENCE   9  (bases 1 to 6813)
  AUTHORS   Simmons,D.L., Walker,C., Power,C. and Pigott,R.
  TITLE     Molecular cloning of CD31, a putative intercellular adhesion
            molecule closely related to carcinoembryonic antigen
  JOURNAL   J Exp Med 171 (6), 2147-2152 (1990)
   PUBMED   2351935
REFERENCE   10 (bases 1 to 6813)
  AUTHORS   Newman,P.J., Berndt,M.C., Gorski,J., White,G.C. 2nd, Lyman,S.,
            Paddock,C. and Muller,W.A.
  TITLE     PECAM-1 (CD31) cloning and relation to adhesion molecules of the
            immunoglobulin gene superfamily
  JOURNAL   Science 247 (4947), 1219-1222 (1990)
   PUBMED   1690453
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC051822.1, AF281298.1 and
            AC016489.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000442.4.
            
            Summary: The protein encoded by this gene is found on the surface
            of platelets, monocytes, neutrophils, and some types of T-cells,
            and makes up a large portion of endothelial cell intercellular
            junctions. The encoded protein is a member of the immunoglobulin
            superfamily and is likely involved in leukocyte migration,
            angiogenesis, and integrin activation. [provided by RefSeq, May
            2010].
            
            Sequence Note: Due to a gap in the GRCh37 reference genome
            sequence, only a portion of the 3'-most exon of NM_000442.4 aligns
            to the reference genome sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.54540.1,
                                           SRR1803612.169808.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563924.6/ ENSP00000457421.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               BC051822.1         19-130
            113-2398            AF281298.1         1-2286
            2399-6813           AC016489.18        165234-169648       c
FEATURES             Location/Qualifiers
     source          1..6813
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..6813
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /note="platelet and endothelial cell adhesion molecule 1"
                     /db_xref="GeneID:5175"
                     /db_xref="HGNC:HGNC:8823"
                     /db_xref="MIM:173445"
     exon            1..259
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2412
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /note="CD31 antigen; platelet endothelial cell adhesion
                     molecule-1"
                     /codon_start=1
                     /product="platelet endothelial cell adhesion molecule
                     precursor"
                     /protein_id="NP_000433.4"
                     /db_xref="CCDS:CCDS74132.1"
                     /db_xref="GeneID:5175"
                     /db_xref="HGNC:HGNC:8823"
                     /db_xref="MIM:173445"
                     /translation="MQPRWAQGATMWLGVLLTLLLCSSLEGQENSFTINSVDMKSLPD
                     WTVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIY
                     DSGTYKCTVIVNNKEKTTAEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAP
                     IHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQT
                     SESTKSELVTVTESFSTPKFHISPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDK
                     AIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIVVNITELFSKPELESSF
                     THLDQGERLNLSCSIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGTYICTAGIDK
                     VVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQLLKTSKV
                     LENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISIL
                     SSKVVESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKASKEQ
                     EGEYYCTAFNRANHASSVPRSKILTVRVILAPWKKGLIAVVIIGVIIALLIIAAKCYF
                     LRKAKAKQMPVEMSRPAVPLLNSNNEKMSDPNMEANSHYGHNDDVRNHAMKPINDNKE
                     PLNSDVQYTEVQVSSAESHKDLGKKDTETVYSEVRKAVPDAVESRYSRTEGSLDGT"
     exon            260..286
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..580
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..886
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1162
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1411
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1687
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1975
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2083
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2111
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2185
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2239
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2302
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2359
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2382
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..6813
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3178
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /note="major polyA site"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /note="hexamer: AATAAA"
     polyA_site      3725
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /note="major polyA site"
     regulatory      6788..6793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
                     /note="hexamer: AATAAA"
     polyA_site      6813
                     /gene="PECAM1"
                     /gene_synonym="CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1;
                     PECAM-1"
ORIGIN      
        1 ggtttccagc catggctgcc attacctgac cagcgccaca gccggtctct ctgcaggcgc
       61 cgggagaagt gaccagagca atttctgctt ttcacagggc gggtttctca acggtgactt
      121 gtgggcagtg ccttctgctg agcgagtcat ggcccgaagg cagaactaac tgtgcctgca
      181 gtcttcactc tcaggatgca gccgaggtgg gcccaagggg ccacgatgtg gcttggagtc
      241 ctgctgaccc ttctgctctg ttcaagcctt gagggtcaag aaaactcttt cacaatcaac
      301 agtgttgaca tgaagagcct gccggactgg acggtgcaaa atgggaagaa cctgaccctg
      361 cagtgcttcg cggatgtcag caccacctct cacgtcaagc ctcagcacca gatgctgttc
      421 tataaggatg acgtgctgtt ttacaacatc tcctccatga agagcacaga gagttatttt
      481 attcctgaag tccggatcta tgactcaggg acatataaat gtactgtgat tgtgaacaac
      541 aaagagaaaa ccactgcaga gtaccaggtg ttggtggaag gagtgcccag tcccagggtg
      601 acactggaca agaaagaggc catccaaggt gggatcgtga gggtcaactg ttctgtccca
      661 gaggaaaagg ccccaataca cttcacaatt gaaaaacttg aactaaatga aaaaatggtc
      721 aagctgaaaa gagagaagaa ttctcgagac cagaattttg tgatactgga attccccgtt
      781 gaggaacagg accgcgtttt atccttccga tgtcaagcta ggatcatttc tgggatccat
      841 atgcagacct cagaatctac caagagtgaa ctggtcaccg tgacggaatc cttctctaca
      901 cccaagttcc acatcagccc caccggaatg atcatggaag gagctcagct ccacattaag
      961 tgcaccattc aagtgactca cctggcccag gagtttccag aaatcataat tcagaaggac
     1021 aaggcgattg tggcccacaa cagacatggc aacaaggctg tgtactcagt catggccatg
     1081 gtggagcaca gtggcaacta cacgtgcaaa gtggagtcca gccgcatatc caaggtcagc
     1141 agcatcgtgg tcaacataac agaactattt tccaagcccg aactggaatc ttccttcaca
     1201 catctggacc aaggtgaaag actgaacctg tcctgctcca tcccaggagc acctccagcc
     1261 aacttcacca tccagaagga agatacgatt gtgtcacaga ctcaagattt caccaagata
     1321 gcctcaaagt cggacagtgg gacgtatatc tgcactgcag gtattgacaa agtggtcaag
     1381 aaaagcaaca cagtccagat agtcgtatgt gaaatgctct cccagcccag gatttcttat
     1441 gatgcccagt ttgaggtcat aaaaggacag accatcgaag tccgttgcga atcgatcagt
     1501 ggaactttgc ctatttctta ccaactttta aaaacaagta aagttttgga gaatagtacc
     1561 aagaactcaa atgatcctgc ggtattcaaa gacaacccca ctgaagacgt cgaataccag
     1621 tgtgttgcag ataattgcca ttcccatgcc aaaatgttaa gtgaggttct gagggtgaag
     1681 gtgatagccc cggtggatga ggtccagatt tctatcctgt caagtaaggt ggtggagtct
     1741 ggagaggaca ttgtgctgca atgtgctgtg aatgaaggat ctggtcccat cacctataag
     1801 ttttacagag aaaaagaggg caaacccttc tatcaaatga cctcaaatgc cacccaggca
     1861 ttttggacca agcagaaggc tagcaaggaa caggagggag agtattactg cacagccttc
     1921 aacagagcca accacgcctc cagtgtcccc agaagcaaaa tactgacagt cagagtcatt
     1981 cttgccccat ggaagaaagg acttattgca gtggttatca tcggagtgat cattgctctc
     2041 ttgatcattg cggccaaatg ttattttctg aggaaagcca aggccaagca gatgccagtg
     2101 gaaatgtcca ggccagcagt accacttctg aactccaaca acgagaaaat gtcagatccc
     2161 aatatggaag ctaacagtca ttacggtcac aatgacgatg tcagaaacca tgcaatgaaa
     2221 ccaataaatg ataataaaga gcctctgaac tcagacgtgc agtacacgga agttcaagtg
     2281 tcctcagctg agtctcacaa agatctagga aagaaggaca cagagacagt gtacagtgaa
     2341 gtccggaaag ctgtccctga tgccgtggaa agcagatact ctagaacgga aggctccctt
     2401 gatggaactt agacagcaag gccagatgca catccctgga aggacatcca tgttccgaga
     2461 agaacagata atccctgtat ttcaagacct ctgtgcactt atttatgaac ctgccctgct
     2521 cccacagaac acagcaattc ctcaggctaa gctgccggtt cttaaatcca tcctgctaag
     2581 ttaatgttgg gtagaaagag atacagaggg gctgttgaat ttcccacata ccctccttcc
     2641 accaagttgg aacatccttg gaaattggaa gagcacaaga ggagatccag ggcaaggcca
     2701 ttgggatatt ctgaaacttg aatattttgt tttgtgcaga gataaagacc ttttccatgc
     2761 accctcatac acagaaacca attttctttt ttatactcaa tcatttctag cgcatggcct
     2821 ggttagaggc tggttttttc tcttttcctt tggtccttca aaggcttgta gttttggcta
     2881 gtccttgttc tttggaaata cacagtgctg accagacagc ctccccctgt cccctctatg
     2941 acctcgccct ccacaaatgg gaaaaccaga ctacttggga gcaccgcctg tgaaatacca
     3001 acctgaagac accgttcatt caggcaacgc acaaaacaga aaatgaaggt ggaacaagca
     3061 cagatgttct tcaactgttt ttgtctacac tctttctctt ttcctctacc atgctgaagg
     3121 ctgaaagaca ggaagatggt gccatcagca aatattattc ttaattgaaa acttgaaatg
     3181 tgtatgtttc ttactaattt ttaaaaatgt attccttgcc agggcaggca aggtggctca
     3241 cgcctgtaat cccagcactt caggaggctg aggtgggcgg atcacctgag gtcaggagtt
     3301 tgagaccagc ctgatgaaac cctgtctcta ctaaaaatac aagaattagc cgggcgtggt
     3361 ggcgcatgcc tgtagtatca gctactcaag aggctgaggt gagattatcg cttgaaccca
     3421 ggaaacggag gttgtagtga gcggagatcg cgccactgca ctccagcctg agtgacagag
     3481 tgagaatcca tctcaaaaaa aacaaaaaac aaaattgctt gctaaagaag tggtctcctg
     3541 aggtcttaag acattcctga cagtgtcttg agtgggtggg agagaggctg ctgtcattgc
     3601 gctgtggaat ttcacagatg agaaccacgc ctagccaaaa tcacttttcc tgtttgcctc
     3661 agtgacacag ctgcagggac cctcgtggat gttgtattaa ataaatttga cctttgctct
     3721 ttgcagatct gtgaaatgtt gtcttctgag gggccacatg catctatagt gctgaggact
     3781 ccttgggcct ctgaagtcac agagagaacc gagcaggtct atgtttttgt tttgttgttt
     3841 tgagacggag attcgctctt gttgcccggg ctggactgca gcggcgcaac ctctgctcac
     3901 tgcaacctcc gcctcctggg ttcaagcagt tctcctgtct cagcctcccg agtagctggg
     3961 attacaggca catgtcacca cgcctggcta atttttgtat ttttagtaga gatggggttt
     4021 caccacgttg gccaggctga tctcgaatgc ctgacctttg gtgatctgcc cgccttgtcc
     4081 tcatgtgtgc tccacaggcc tttgggttgg gattgcaggc gtgagccacc atgcccagcc
     4141 tagactcttt tgacaatatg atgaaagctg ttggttcctt tccccaacac acacacaccg
     4201 agttgtatca cgaaaatgtc atacaatttc caggttttct gagtggtggg ctcagattga
     4261 ggtcaaagga tcagacgacc tctaacgacc ttcatgtctc tgttgatgat ctggggacag
     4321 ccagatcccc tgtgtccagg gagttcctta gtcccttgcc accaccagag aagggcaatt
     4381 gccacgggag ctgcaaagac cctattccta ctcctggtgc cttacttatg cagcacgact
     4441 gaattttttg ttttgttttg ttttgttgag acaggggctt gctctgttgc ccaggctgga
     4501 gtgcagtggc acaacaatgg ctcaccgcag cctcgaaccc ctgggctcaa gcgatcctcc
     4561 catctcagct tcctgggtag ctgggaccag aggcgtgagc cgccatagct ggctaatttt
     4621 taattttttt tttgcagaga tgaggtttca ccatggtgcc caggctggtc tcgaacttct
     4681 gggctcaagt gatcctccct ccttggcctc gcaaagtgct gggattgcag gcatgagcca
     4741 ccgcccccgg cctgtggagc acacatgagt ttaaaattac tttcccttct gcctatattt
     4801 ccgaggagga aacttcatgc gcagggatct ttcttagtgg atttaatggc taaaaggtct
     4861 gtctgaatcc aggacgctgg ctttagcctt cctcggcagc tgccgtaacc ccggtgtcta
     4921 aacctgaagc atcccaggag cacccactcc aggagttttc tcggccgcgg aactcattag
     4981 ttagagcgcc ctcttgtgtt ctcatgtggt aatcggtcac tgaaggactt aaaatggtcc
     5041 ttagccaaca cacagtaaaa cttttccctc ttctgacccc aagaggtcag ccacccattt
     5101 catgagcata tactggtcgc cccatcagcg ttctctgatt ggctaactga acccactccc
     5161 cgacctagac tcaagacagg cgaagtgacg cttaggtcaa cattcactca ctaaagcaac
     5221 gactgtcggg cgattttgtc tcccgctggt tttggaatgg tgtctggaga catttttggt
     5281 tgtcacagct gggtgggtgt gctcccggca tctggtgggt agaaaccaag catgctccta
     5341 aacatcctac aggcacagaa ccgtctccca cgaccaagca tgatcaagtc ccaaatgcca
     5401 ataatggcca ggttgagaaa ctctgcacag aagcatccag ttatttgtct gtttgctcaa
     5461 caagcttgtg ctcatcatgc tctgtgttcc tgacgctgtg ctgggtgttg gcggtgggaa
     5521 gattacaaga gtcacatggc agctgtcctc ctggaaggta caacccagta gagatgcaga
     5581 ctaacagaga gccaattaca aagcagtgtg acaagcgtca tggtggaaaa ttaaaagctc
     5641 aaacaagggc acatgggagg ggcttccaac acagactttg ggggatccag gaaggtctaa
     5701 gaggaaagtg ggtctcacca aagccttgac cataggcaga gggtaccagt ggaaaaggtg
     5761 gggtgaagaa cattgaggac aaaaggaaga agtgcaggaa ggccctgagg caagggagtg
     5821 gggggtgccc tggagggatg gcagcagggc agtctgtcag acccaagtgg cctccagccc
     5881 tagaagccaa ttagtcctcc tcaaaaagct gtcactgtcc cctaagaatt gctgccaggc
     5941 tcccactggc ctgactcagt ctttgagagt cttaaggagg aggtctctga aaggtacaca
     6001 ccaagaactc tccccagcac agctgttttt aagactctcc accagcgtca ttggcgtgtt
     6061 gggaagaaac cctctgccac agaggccagc ttcagccttt gcctaacacc gcaagggcaa
     6121 atggaaaggt aaacgggaag gagatgtctc cccagcaggc tatttgagga cagtcttccc
     6181 tgcagaagat ctcaacctgg ggtccacaga gtggaaatgt tagagtaggg agctaggcaa
     6241 acatgagcag gacaggtgag ggcccccaca ggaatgtcag gctaccatca ggtgatggtc
     6301 aggtggttgt taaactgtct ctgtaaaata ataattggtt gcagccagct ccaagcaagg
     6361 acagtctctc aatagataca aaacaccctg atctggtgat cagccgcttc ccgataagat
     6421 ctcaggagct gggcaagcag cctggagcat gcgcaccaag aggcaaaatg gcggaattta
     6481 accagtatat gacctacctt cctctgggaa cgcacgactg gtaaggggaa aaatgcctca
     6541 agtgagcatg cgcgcaactt cagtaatcac actgtgcatg cgaccccttc caagtgctgg
     6601 caggtcacca catacgcgga cagcctgctg caagggaaga atcaggggag atgagacgta
     6661 aatcccagaa ctatgccaaa tacataaaac cccaagttaa gggtcaggca gggcacttag
     6721 atctctcaag ttgcctgcct gacccaagtg tagtgtactt ccttttgttc ctgctctaaa
     6781 actttttaat aaactctcac tcctgctcta aaa
//
