LOCUS       NM_144962                901 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens phosphatidylethanolamine binding protein 4 (PEBP4),
            transcript variant 1, mRNA.
ACCESSION   NM_144962
VERSION     NM_144962.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 901)
  AUTHORS   Huang,R.Q., Chen,F., Jiang,Y.B., Jin,Y.M., Wang,S.Q., Liang,H.H.,
            Chen,Z.P. and Qian,J.
  TITLE     Overexpression of phosphatidylethanolamine-binding protein 4
            (PEBP4) associates with recurrence of meningiomas
  JOURNAL   Clin Neurol Neurosurg 214, 107148 (2022)
   PUBMED   35158167
  REMARK    GeneRIF: Overexpression of phosphatidylethanolamine-binding protein
            4 (PEBP4) associates with recurrence of meningiomas.
REFERENCE   2  (bases 1 to 901)
  AUTHORS   He,P., Zhou,C. and Shen,H.
  TITLE     Diagnostic value of phosphatidylethanolamine binding protein 4
            levels in patients receiving nursing interventions for advanced
            chronic kidney disease
  JOURNAL   J Int Med Res 49 (3), 300060521996179 (2021)
   PUBMED   33752499
  REMARK    GeneRIF: Diagnostic value of phosphatidylethanolamine binding
            protein 4 levels in patients receiving nursing interventions for
            advanced chronic kidney disease.
REFERENCE   3  (bases 1 to 901)
  AUTHORS   Taylor,S., Pieri,K., Nanni,P., Tica,J., Barratt,J. and
            Didangelos,A.
  TITLE     Phosphatidylethanolamine binding protein-4 (PEBP4) is increased in
            IgA nephropathy and is associated with IgA-positive B-cells in
            affected kidneys
  JOURNAL   J Autoimmun 105, 102309 (2019)
   PUBMED   31402200
  REMARK    GeneRIF: PEBP4 colocalised with IgA and CD19.
REFERENCE   4  (bases 1 to 901)
  AUTHORS   Jian,W., Bai,Y., Li,X., Kang,J., Lei,Y. and Xue,Y.
  TITLE     Phosphatidylethanolamine-binding protein 4 promotes the
            epithelial-to-mesenchymal transition in non-small cell lung cancer
            cells by activating the sonic hedgehog signaling pathway
  JOURNAL   J Cell Biochem 120 (4), 5386-5395 (2019)
   PUBMED   30367510
  REMARK    GeneRIF: these results suggest that PEBP4 may promote tumorigenesis
            in non-small cell lung cancer by regulating cell proliferation and
            epithelial-to-mesenchymal transition via activation of the Shh
            signaling pathway.
REFERENCE   5  (bases 1 to 901)
  AUTHORS   Huang,R.Q., Wang,S.Q., Zhu,Q.B., Guo,S.C., Shi,D.L., Chen,F.,
            Fang,Y.C., Chen,R. and Lu,Y.C.
  TITLE     Knockdown of PEBP4 inhibits human glioma cell growth and invasive
            potential via ERK1/2 signaling pathway
  JOURNAL   Mol Carcinog 58 (1), 135-143 (2019)
   PUBMED   30255656
  REMARK    GeneRIF: High PEBP4 expression is associated with glioma cell
            growth and invasiveness.
REFERENCE   6  (bases 1 to 901)
  AUTHORS   Garcia,R., Grindlay,J., Rath,O., Fee,F. and Kolch,W.
  TITLE     Regulation of human myoblast differentiation by PEBP4
  JOURNAL   EMBO Rep 10 (3), 278-284 (2009)
   PUBMED   19197339
  REMARK    GeneRIF: Data show that PEBP4 participates in the control of muscle
            cell differentiation by modulating the activity of MEK and ERK.
REFERENCE   7  (bases 1 to 901)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   8  (bases 1 to 901)
  AUTHORS   Li,P., Wang,X., Li,N., Kong,H., Guo,Z., Liu,S. and Cao,X.
  TITLE     Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of
            human ovarian cancer cells by activating ERK and JNK pathways
  JOURNAL   Int J Mol Med 18 (3), 505-510 (2006)
   PUBMED   16865237
  REMARK    GeneRIF: Silencing of hPEBP4, an important potential target, may be
            a promising approach for the treatment of ovarian cancer.
REFERENCE   9  (bases 1 to 901)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 901)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC037441.12, BF853000.1, AY359109.1, AY037148.1 and AC105046.10.
            
            On Nov 23, 2018 this sequence version replaced NM_144962.2.
            
            Summary: The phosphatidylethanolamine (PE)-binding proteins,
            including PEBP4, are an evolutionarily conserved family of proteins
            with pivotal biologic functions, such as lipid binding and
            inhibition of serine proteases (Wang et al., 2004 [PubMed
            15302887]).[supplied by OMIM, Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.220788.1,
                                           SRR5189655.192308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256404.8/ ENSP00000256404.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC037441.12        159849-159854       c
            7-10                BF853000.1         1-4
            11-646              AY359109.1         1-636
            647-900             AY037148.1         614-867
            901-901             AC105046.10        12702-12702
FEATURES             Location/Qualifiers
     source          1..901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..901
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /note="phosphatidylethanolamine binding protein 4"
                     /db_xref="GeneID:157310"
                     /db_xref="HGNC:HGNC:28319"
                     /db_xref="MIM:612473"
     exon            1..92
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /inference="alignment:Splign:2.1.0"
     exon            93..229
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..782
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /note="cousin-of-RKIP 1 protein; protein cousin-of-RKIP 1;
                     epididymis secretory protein Li 300; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="phosphatidylethanolamine-binding protein 4
                     precursor"
                     /protein_id="NP_659399.2"
                     /db_xref="CCDS:CCDS43724.1"
                     /db_xref="GeneID:157310"
                     /db_xref="HGNC:HGNC:28319"
                     /db_xref="MIM:612473"
                     /translation="MGWTMRLVTAALLLGLMMVVTGDEDENSPCAHEALLDEDTLFCQ
                     GLEVFYPELGNIGCKVVPDCNNYRQKITSWMEPIVKFPGAVDGATYILVMVDPDAPSR
                     AEPRQRFWRHWLVTDIKGADLKKGKIQGQELSAYQAPSPPAHSGFHRYQFFVYLQEGK
                     VISLLPKENKTRGSWKMDRFLNRFHLGEPEASTQFMTQNYQDSPTLQAPRERASEPKH
                     KNQAEIAAC"
     exon            230..356
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /inference="alignment:Splign:2.1.0"
     exon            357..455
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /inference="alignment:Splign:2.1.0"
     exon            456..501
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /inference="alignment:Splign:2.1.0"
     exon            502..615
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /inference="alignment:Splign:2.1.0"
     exon            616..901
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /inference="alignment:Splign:2.1.0"
     regulatory      879..884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /note="hexamer: AATAAA"
     polyA_site      901
                     /gene="PEBP4"
                     /gene_synonym="CORK-1; CORK1; GWTM1933; HEL-S-300; hPEBP4;
                     PEBP-4; PRO4408"
                     /note="major polyA site"
ORIGIN      
        1 agtcctccca aagtacttgt gtccgggtgg tggactggat tagctgcgga gccctggaag
       61 ctgcctgtcc ttctccctgt gcttaaccag aggtgcccat gggttggaca atgaggctgg
      121 tcacagcagc actgttactg ggtctcatga tggtggtcac tggagacgag gatgagaaca
      181 gcccgtgtgc ccatgaggcc ctcttggacg aggacaccct cttttgccag ggccttgaag
      241 ttttctaccc agagttgggg aacattggct gcaaggttgt tcctgattgt aacaactaca
      301 gacagaagat cacctcctgg atggagccga tagtcaagtt cccgggggcc gtggacggcg
      361 caacctatat cctggtgatg gtggatccag atgcccctag cagagcagaa cccagacaga
      421 gattctggag acattggctg gtaacagata tcaagggcgc cgacctgaag aaagggaaga
      481 ttcagggcca ggagttatca gcctaccagg ctccctcccc accggcacac agtggcttcc
      541 atcgctacca gttctttgtc tatcttcagg aaggaaaagt catctctctc cttcccaagg
      601 aaaacaaaac tcgaggctct tggaaaatgg acagatttct gaaccgtttc cacctgggcg
      661 aacctgaagc aagcacccag ttcatgaccc agaactacca ggactcacca accctccagg
      721 ctcccagaga aagggccagc gagcccaagc acaaaaacca ggcggagata gctgcctgct
      781 agatagccgg ctttgccatc cgggcatgtg gccacactgc ccaccaccga cgatgtgggt
      841 atggaacccc ctctggatac agaacccctt cttttccaaa taaaaaaaaa atcatccagg
      901 g
//
