LOCUS       NM_002567               1431 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens phosphatidylethanolamine binding protein 1 (PEBP1),
            mRNA.
ACCESSION   NM_002567 XR_109136 XR_109137 XR_111344 XR_114620
VERSION     NM_002567.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Li,Q., Fu,T., Wei,N., Wang,Q. and Zhang,X.
  TITLE     Bmi-1 promotes the proliferation, migration and invasion, and
            inhibits cell apoptosis of human retinoblastoma cells via RKIP
  JOURNAL   Sci Rep 14 (1), 14544 (2024)
   PUBMED   38914697
  REMARK    GeneRIF: Bmi-1 promotes the proliferation, migration and invasion,
            and inhibits cell apoptosis of human retinoblastoma cells via RKIP.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Greco,S., Pinheiro,J., Cardoso-Carneiro,D., Giantomassi,F.,
            Pellegrino,P., Scaglione,G., Delli Carpini,G., Ciavattini,A.,
            Zannoni,G.F., Goteri,G., Martinho,O. and Ciarmela,P.
  TITLE     Raf kinase inhibitor protein expression in smooth muscle tumours of
            the uterus: a diagnostic marker for leiomyosarcoma?
  JOURNAL   Reprod Biomed Online 48 (6), 103816 (2024)
   PUBMED   38608337
  REMARK    GeneRIF: Raf kinase inhibitor protein expression in smooth muscle
            tumours of the uterus: a diagnostic marker for leiomyosarcoma?
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Luo,T., Xu,T., Ou,Y., Ci,H. and Sun,J.
  TITLE     Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral
            squamous cell carcinoma
  JOURNAL   Medicine (Baltimore) 103 (7), e37278 (2024)
   PUBMED   38363884
  REMARK    GeneRIF: Prognostic significance of RKIP, TGM2, and CMTM4
            expression in oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Bharti,A., Ansari,M.A., Tewari,M., Narayan,G. and Singh,S.
  TITLE     Clinical Significance of Frequently Down-Regulated
            Phosphatidylethanolamine-Binding Protein-1 in Gallbladder Cancer
  JOURNAL   Dig Dis Sci 69 (2), 502-509 (2024)
   PUBMED   38135812
  REMARK    GeneRIF: Clinical Significance of Frequently Down-Regulated
            Phosphatidylethanolamine-Binding Protein-1 in Gallbladder Cancer.
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Qu,W.Z., Wang,L., Chen,J.J. and Wang,Y.
  TITLE     Raf kinase inhibitor protein combined with phosphorylated
            extracellular signal-regulated kinase offers valuable prognosis in
            gastrointestinal stromal tumor
  JOURNAL   World J Gastroenterol 29 (26), 4200-4213 (2023)
   PUBMED   37475847
  REMARK    GeneRIF: Raf kinase inhibitor protein combined with phosphorylated
            extracellular signal-regulated kinase offers valuable prognosis in
            gastrointestinal stromal tumor.
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Moore,C., Perry,A.C., Love,S. and Hall,L.
  TITLE     Sequence analysis and immunolocalisation of
            phosphatidylethanolamine binding protein (PBP) in human brain
            tissue
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 74-78 (1996)
   PUBMED   8738137
REFERENCE   7  (bases 1 to 1431)
  AUTHORS   Schoentgen,F. and Jolles,P.
  TITLE     From structure to function: possible biological roles of a new
            widespread protein family binding hydrophobic ligands and
            displaying a nucleotide binding site
  JOURNAL   FEBS Lett 369 (1), 22-26 (1995)
   PUBMED   7641877
  REMARK    Review article
REFERENCE   8  (bases 1 to 1431)
  AUTHORS   Tohdoh,N., Tojo,S., Agui,H. and Ojika,K.
  TITLE     Sequence homology of rat and human HCNP precursor proteins, bovine
            phosphatidylethanolamine-binding protein and rat 23-kDa protein
            associated with the opioid-binding protein
  JOURNAL   Brain Res Mol Brain Res 30 (2), 381-384 (1995)
   PUBMED   7637590
REFERENCE   9  (bases 1 to 1431)
  AUTHORS   Seddiqi,N., Bollengier,F., Alliel,P.M., Perin,J.P., Bonnet,F.,
            Bucquoy,S., Jolles,P. and Schoentgen,F.
  TITLE     Amino acid sequence of the Homo sapiens brain 21-23-kDa protein
            (neuropolypeptide h3), comparison with its counterparts from Rattus
            norvegicus and Bos taurus species, and expression of its mRNA in
            different tissues
  JOURNAL   J Mol Evol 39 (6), 655-660 (1994)
   PUBMED   7807553
REFERENCE   10 (bases 1 to 1431)
  AUTHORS   Hori,N., Chae,K.S., Murakawa,K., Matoba,R., Fukushima,A., Okubo,K.
            and Matsubara,K.
  TITLE     A human cDNA sequence homologue of bovine
            phosphatidylethanolamine-binding protein
  JOURNAL   Gene 140 (2), 293-294 (1994)
   PUBMED   8144042
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF978793.1, X75252.1 and
            BC031102.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002567.3.
            
            Summary: This gene encodes a member of the
            phosphatidylethanolamine-binding family of proteins and has been
            shown to modulate multiple signaling pathways, including the MAP
            kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3)
            signaling pathways. The encoded protein can be further processed to
            form a smaller cleavage product, hippocampal cholinergic
            neurostimulating peptide (HCNP), which may be involved in neural
            development. This gene has been implicated in numerous human
            cancers and may act as a metastasis suppressor gene. Multiple
            pseudogenes of this gene have been identified in the genome.
            [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226006.1, SRR3476690.1129091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261313.3/ ENSP00000261313.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-543               BF978793.1         83-625
            544-1281            X75252.1           568-1305
            1282-1431           BC031102.1         1284-1433
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..1431
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /note="phosphatidylethanolamine binding protein 1"
                     /db_xref="GeneID:5037"
                     /db_xref="HGNC:HGNC:8630"
                     /db_xref="MIM:604591"
     exon            1..221
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..650
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /note="prostatic binding protein; hippocampal cholinergic
                     neurostimulating peptide; Raf kinase inhibitory protein;
                     epididymis secretory protein Li 34; epididymis luminal
                     protein 210; neuropolypeptide h3; raf kinase inhibitor
                     protein; epididymis secretory protein Li 96"
                     /codon_start=1
                     /product="phosphatidylethanolamine-binding protein 1"
                     /protein_id="NP_002558.1"
                     /db_xref="CCDS:CCDS9187.1"
                     /db_xref="GeneID:5037"
                     /db_xref="HGNC:HGNC:8630"
                     /db_xref="MIM:604591"
                     /translation="MPVDLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPT
                     QVKNRPTSISWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTV
                     LSDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVASFRKKYEL
                     RAPVAGTCYQAEWDDYVPKLYEQLSGK"
     exon            222..331
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            332..432
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /inference="alignment:Splign:2.1.0"
     exon            433..1431
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1426..1431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /note="hexamer: AATGAA"
     polyA_site      1431
                     /gene="PEBP1"
                     /gene_synonym="HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96;
                     PBP; PEBP; PEBP-1; RKIP"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgctga gctctccgcg tcgcctctgt cgcccgcgcc tggcctaccg cggcactccc
       61 ggctgcacgc tctgcttggc ctcgccatgc cggtggacct cagcaagtgg tccgggccct
      121 tgagcctgca agaagtggac gagcagccgc agcacccgct gcatgtcacc tacgccgggg
      181 cggcggtgga cgagctgggc aaagtgctga cgcccaccca ggttaagaat agacccacca
      241 gcatttcgtg ggatggtctt gattcaggga agctctacac cttggtcctg acagacccgg
      301 atgctcccag caggaaggat cccaaataca gagaatggca tcatttcctg gtggtcaaca
      361 tgaagggcaa tgacatcagc agtggcacag tcctctccga ttatgtgggc tcggggcctc
      421 ccaagggcac aggcctccac cgctatgtct ggctggttta cgagcaggac aggccgctaa
      481 agtgtgacga gcccatcctc agcaaccgat ctggagacca ccgtggcaaa ttcaaggtgg
      541 cgtccttccg taaaaagtat gagctcaggg ccccggtggc tggcacgtgt taccaggccg
      601 agtgggatga ctatgtgccc aaactgtacg agcagctgtc tgggaagtag ggggttagct
      661 tggggacctg aactgtcctg gaggccccaa gccatgttcc ccagttcagt gttgcatgta
      721 taatagattt ctcctcttcc tgcccccctt ggcatgggtg agacctgacc agtcagatgg
      781 tagttgaggg tgacttttcc tgctgcctgg cctttataat tttactcact cactctgatt
      841 tatgttttga tcaaatttga acttcatttt ggggggtatt ttggtactgt gatggggtca
      901 tcaaattatt aatctgaaaa tagcaaccca gaatgtaaaa aagaaaaaac tggggggaaa
      961 aagaccaggt ctacagtgat agagcaaagc atcaaagaat ctttaaggga ggtttaaaaa
     1021 aaaaaaaaaa aaaaaagatt ggttgcctct gcctttgtga tcctgagtcc agaatggtac
     1081 acaatgtgat tttatggtga tgtcactcac ctagacaacc agaggctggc attgaggcta
     1141 acctccaaca cagtgcatct cagatgcctc agtaggcatc agtatgtcac tctggtccct
     1201 ttaaagagca atcctggaag aagcaggagg gagggtggct ttgctgttgt tgggacatgg
     1261 caatctagac cggtagcagc gctcgctgac agcttgggag gaaacctgag atctgtgttt
     1321 tttaaattga tcgttcttca tgggggtaag aaaagctggt ctggagttgc tgaatgttgc
     1381 attaattgtg ctgtttgctt gtagttgaat aaaaatagaa acctgaatga a
//
