LOCUS       NM_001080471            4874 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens platelet endothelial aggregation receptor 1 (PEAR1),
            transcript variant 1, mRNA.
ACCESSION   NM_001080471 XM_371320
VERSION     NM_001080471.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4874)
  AUTHORS   Zhang,L., Meng,Z., Wang,H. and Miao,Y.
  TITLE     Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of
            aspirin-treated patients with ischemic stroke in the Han population
            of China: A 4-year follow-up study
  JOURNAL   Medicine (Baltimore) 103 (19), e38031 (2024)
   PUBMED   38728491
  REMARK    GeneRIF: Effect of PEAR1, PTGS1 gene polymorphisms on the
            recurrence of aspirin-treated patients with ischemic stroke in the
            Han population of China: A 4-year follow-up study.
REFERENCE   2  (bases 1 to 4874)
  AUTHORS   Tang,R., Lyu,X., Sun,J. and Li,H.
  TITLE     Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be Associated
            with Serum sIgE and Blood Eosinophil Levels in Chinese Patients
            with Allergic Diseases
  JOURNAL   Endocr Metab Immune Disord Drug Targets 24 (10), 1215-1223 (2024)
   PUBMED   38299390
  REMARK    GeneRIF: Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be
            Associated with Serum sIgE and Blood Eosinophil Levels in Chinese
            Patients with Allergic Diseases.
REFERENCE   3  (bases 1 to 4874)
  AUTHORS   Elenbaas,J.S., Pudupakkam,U., Ashworth,K.J., Kang,C.J., Patel,V.,
            Santana,K., Jung,I.H., Lee,P.C., Burks,K.H., Amrute,J.M.,
            Mecham,R.P., Halabi,C.M., Alisio,A., Di Paola,J. and Stitziel,N.O.
  TITLE     SVEP1 is an endogenous ligand for the orphan receptor PEAR1
  JOURNAL   Nat Commun 14 (1), 850 (2023)
   PUBMED   36792666
  REMARK    Erratum:[Nat Commun. 2023 Mar 17;14(1):1511. doi:
            10.1038/s41467-023-37005-x.. PMID: 36932061]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4874)
  AUTHORS   Zhang,S., Qu,K., Lyu,S., Hoyle,D.L., Smith,C., Cheng,L., Cheng,T.,
            Shen,J. and Wang,Z.Z.
  TITLE     PEAR1 is a potential regulator of early hematopoiesis of human
            pluripotent stem cells
  JOURNAL   J Cell Physiol 238 (1), 179-194 (2023)
   PUBMED   36436185
  REMARK    GeneRIF: PEAR1 is a potential regulator of early hematopoiesis of
            human pluripotent stem cells.
REFERENCE   5  (bases 1 to 4874)
  AUTHORS   Zhang,X., Li,S., Zhao,Y., Tang,N., Jia,T., Zhou,P., Liu,J., Shi,L.,
            Lu,C.Y. and Nie,X.
  TITLE     Genetic variants of PEAR1 and ischemic clinical outcomes in
            coronary artery disease patients: a systematic review and
            meta-analysis
  JOURNAL   Pharmacogenomics 22 (10), 641-648 (2021)
   PUBMED   34075782
  REMARK    GeneRIF: Genetic variants of PEAR1 and ischemic clinical outcomes
            in coronary artery disease patients: a systematic review and
            meta-analysis.
REFERENCE   6  (bases 1 to 4874)
  AUTHORS   Faraday,N., Yanek,L.R., Yang,X.P., Mathias,R.,
            Herrera-Galeano,J.E., Suktitipat,B., Qayyum,R., Johnson,A.D.,
            Chen,M.H., Tofler,G.H., Ruczinski,I., Friedman,A.D., Gylfason,A.,
            Thorsteinsdottir,U., Bray,P.F., O'Donnell,C.J., Becker,D.M. and
            Becker,L.C.
  TITLE     Identification of a specific intronic PEAR1 gene variant associated
            with greater platelet aggregability and protein expression
  JOURNAL   Blood 118 (12), 3367-3375 (2011)
   PUBMED   21791418
  REMARK    GeneRIF: A specific intronic PEAR1 gene variant is ientified that
            associated with greater platelet aggregability and protein
            expression.
REFERENCE   7  (bases 1 to 4874)
  AUTHORS   Johnson,A.D., Yanek,L.R., Chen,M.H., Faraday,N., Larson,M.G.,
            Tofler,G., Lin,S.J., Kraja,A.T., Province,M.A., Yang,Q.,
            Becker,D.M., O'Donnell,C.J. and Becker,L.C.
  TITLE     Genome-wide meta-analyses identifies seven loci associated with
            platelet aggregation in response to agonists
  JOURNAL   Nat Genet 42 (7), 608-613 (2010)
   PUBMED   20526338
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 4874)
  AUTHORS   Jones,C.I., Bray,S., Garner,S.F., Stephens,J., de Bono,B.,
            Angenent,W.G., Bentley,D., Burns,P., Coffey,A., Deloukas,P.,
            Earthrowl,M., Farndale,R.W., Hoylaerts,M.F., Koch,K., Rankin,A.,
            Rice,C.M., Rogers,J., Samani,N.J., Steward,M., Walker,A.,
            Watkins,N.A., Akkerman,J.W., Dudbridge,F., Goodall,A.H. and
            Ouwehand,W.H.
  CONSRTM   Bloodomics Consortium
  TITLE     A functional genomics approach reveals novel quantitative trait
            loci associated with platelet signaling pathways
  JOURNAL   Blood 114 (7), 1405-1416 (2009)
   PUBMED   19429868
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4874)
  AUTHORS   Herrera-Galeano,J.E., Becker,D.M., Wilson,A.F., Yanek,L.R.,
            Bray,P., Vaidya,D., Faraday,N. and Becker,L.C.
  TITLE     A novel variant in the platelet endothelial aggregation receptor-1
            gene is associated with increased platelet aggregability
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1484-1490 (2008)
   PUBMED   18511696
  REMARK    GeneRIF: C allele of PEAR1 (Platelet endothelial aggregation
            receptor-1)was generally associated in both ethnic groups with
            increased aggregation of native platelets
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 4874)
  AUTHORS   Nanda,N., Bao,M., Lin,H., Clauser,K., Komuves,L., Quertermous,T.,
            Conley,P.B., Phillips,D.R. and Hart,M.J.
  TITLE     Platelet endothelial aggregation receptor 1 (PEAR1), a novel
            epidermal growth factor repeat-containing transmembrane receptor,
            participates in platelet contact-induced activation
  JOURNAL   J Biol Chem 280 (26), 24680-24689 (2005)
   PUBMED   15851471
  REMARK    GeneRIF: PEAR1 is a novel platelet receptor that signals secondary
            to alpha(IIb)beta(3)-mediated platelet-platelet contacts
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158169.17 and AL356104.6.
            
            On May 20, 2020 this sequence version replaced NM_001080471.2.
            
            Summary: PEAR1 is a platelet receptor that signals upon the
            formation of platelet-platelet contacts independent of platelet
            activation and secondary to platelet aggregation (Nanda et al.,
            2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2212880.1,
                                           SRR14038195.123446.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292357.8/ ENSP00000292357.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AL158169.17        83746-83865
            121-230             AL158169.17        93946-94055
            231-335             AL158169.17        94776-94880
            336-436             AL158169.17        95352-95452
            437-529             AL158169.17        96304-96396
            530-773             AL158169.17        96665-96908
            774-894             AL158169.17        97638-97758
            895-1031            AL158169.17        97943-98079
            1032-1244           AL158169.17        98156-98368
            1245-1419           AL158169.17        98683-98857
            1420-1540           AL158169.17        98944-99064
            1541-1564           AL158169.17        99779-99802
            1565-1704           AL356104.6         2001-2140
            1705-1807           AL356104.6         2232-2334
            1808-1954           AL356104.6         2460-2606
            1955-2080           AL356104.6         2844-2969
            2081-2209           AL356104.6         4473-4601
            2210-2338           AL356104.6         4720-4848
            2339-2551           AL356104.6         4996-5208
            2552-2640           AL356104.6         5420-5508
            2641-2773           AL356104.6         5617-5749
            2774-2842           AL356104.6         5918-5986
            2843-3091           AL356104.6         6078-6326
            3092-4874           AL356104.6         6873-8655
FEATURES             Location/Qualifiers
     source          1..4874
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..4874
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /note="platelet endothelial aggregation receptor 1"
                     /db_xref="GeneID:375033"
                     /db_xref="HGNC:HGNC:33631"
                     /db_xref="MIM:610278"
     exon            1..120
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            121..230
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3243
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; multiple EGF-like-domains 12; multiple EGF-like
                     domains protein 12; multiple epidermal growth factor-like
                     domains protein 12"
                     /codon_start=1
                     /product="platelet endothelial aggregation receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_001073940.1"
                     /db_xref="CCDS:CCDS30892.1"
                     /db_xref="GeneID:375033"
                     /db_xref="HGNC:HGNC:33631"
                     /db_xref="MIM:610278"
                     /translation="MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHS
                     RPFSLLPSEPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCV
                     PLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKS
                     GVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDV
                     SCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQEC
                     RCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGAC
                     LCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCN
                     ESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSAR
                     CSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGA
                     CTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLS
                     CPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKC
                     ANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCIC
                     PLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQE
                     PFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRHWQKGKEHHHLAVAYSSGR
                     LDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPGPLFASLQNPERPGGAQ
                     GHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGPFYNKGLISEEELGA
                     SVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQP
                     QRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPSP
                     PLRRQDR"
     exon            231..335
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            336..436
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            437..529
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            530..773
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            774..894
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1031
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1244
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1419
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1540
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1704
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1807
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1954
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2080
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2209
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2338
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2551
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2640
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2773
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2842
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3091
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..4874
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4874
                     /gene="PEAR1"
                     /gene_synonym="JEDI; MEGF12"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcaggc tggggctcga agtggggacc ctcgccccgt cctcggctgt ccagtcctcc
       61 tcctcgcaga ccccggcggt tcctacccca ggccgcaggg gagacggggc cccaaggcag
      121 gcctctgcaa tgtcaccgcc tctgtgtccc ctccttctcc tggctgtggg cctgcggctg
      181 gctggaactc tcaaccccag tgatcccaat acctgcagct tctgggaaag cttcactacc
      241 accaccaagg agtcccactc ccgccccttc agcctgctcc cctcagagcc ctgcgagcgg
      301 ccctgggagg gcccccatac ttgcccccag cccacggttg tataccggac cgtgtaccgt
      361 caggtggtga agacggacca ccgccagcgc ctgcagtgct gccatggctt ctatgagagc
      421 agggggttct gtgtcccgct ctgtgcccag gagtgtgtcc atggccgttg tgtggcaccc
      481 aatcagtgcc aatgtgtgcc aggctggcgg ggcgacgact gttccagtga gtgtgcccca
      541 ggaatgtggg ggccacagtg tgacaagccc tgcagctgcg gcaacaacag ctcgtgtgat
      601 cccaagagtg gggtatgttc ttgcccttct ggtctgcagc ccccgaactg ccttcagccc
      661 tgtacccctg gctactatgg ccctgcctgc cagttccgct gccagtgcca tggggcaccc
      721 tgcgatcccc agactggagc ctgcttctgc cccgcagaga gaactgggcc cagctgtgac
      781 gtgtcctgtt cccagggcac ttctggcttc ttctgcccca gcacccattc ttgccaaaat
      841 ggaggtgtct tccaaacccc acagggctcc tgcagctgcc cccctggctg gatgggcacc
      901 atctgctccc tgccctgccc agagggcttt cacggaccca actgctccca ggaatgtcgc
      961 tgccacaacg gcggcctctg tgaccgattc actgggcagt gccgctgcgc tccgggttac
     1021 actggggatc ggtgccggga ggagtgcccg gtgggccgct ttgggcagga ctgtgctgag
     1081 acgtgcgact gcgccccgga cgcccgttgc ttcccggcca acggcgcatg tctgtgcgaa
     1141 cacggcttca ctggggaccg ctgcacggat cgcctctgcc ccgacggctt ctacggtctc
     1201 agctgccagg ccccctgcac ctgcgaccgg gagcacagcc tcagctgcca cccgatgaac
     1261 ggggagtgct cctgcctgcc gggctgggcg ggcctccact gcaacgagag ctgcccgcag
     1321 gacacgcatg ggccagggtg ccaggagcac tgtctctgcc tgcacggtgg cgtctgccag
     1381 gctaccagcg gcctctgtca gtgcgcgccg ggttacacgg gccctcactg tgctagtctt
     1441 tgtcctcctg acacctacgg tgtcaactgt tctgcacgct gctcatgtga aaatgccatc
     1501 gcctgctcac ccatcgacgg cgagtgcgtc tgcaaggaag gttggcagcg tggtaactgc
     1561 tctgtgccct gcccacccgg aacctggggc ttcagttgca atgccagctg ccagtgtgcc
     1621 catgaggcag tctgcagccc ccaaactgga gcctgtacct gcacccctgg gtggcatggg
     1681 gcccactgcc agctgccctg tccgaagggg cagtttggag aaggttgtgc cagtcgctgt
     1741 gactgtgacc actctgatgg ctgtgaccct gttcatggac gctgtcagtg ccaggctggc
     1801 tggatgggtg cccgctgcca cctgtcctgc cctgagggct tatggggagt caactgtagc
     1861 aacacctgca cctgcaagaa tgggggcacc tgtctccctg agaatggcaa ctgcgtgtgt
     1921 gcacccggat tccggggccc ctcctgccag agatcctgtc agcctggccg ctatggcaaa
     1981 cgctgtgtgc cctgcaagtg cgctaaccac tccttctgcc acccctcgaa cgggacctgc
     2041 tactgcctgg ctggctggac aggccccgac tgctcccagc catgccctcc aggacactgg
     2101 ggagaaaact gtgcccagac ctgccaatgt caccatggtg ggacctgcca tccccaggat
     2161 gggagctgta tctgccccct aggctggact ggacaccact gcttagaagg ctgccctctg
     2221 gggacatttg gtgctaactg ctcccagcca tgccagtgtg gtcctggaga aaagtgccac
     2281 ccagagactg gggcctgtgt atgtccccca gggcacagtg gtgcaccttg caggattgga
     2341 atccaggagc cctttactgt gatgccgacc actccagtag cgtataactc gctgggtgca
     2401 gtgattggca ttgcagtgct ggggtccctt gtggtagccc tggtggcact gttcattggc
     2461 tatcggcact ggcaaaaagg caaggagcac caccacctgg ctgtggctta cagcagcggg
     2521 cgcctggacg gctccgagta tgtcatgcca gatgtccctc cgagctacag tcactactac
     2581 tccaacccca gctaccacac cctgtcgcag tgctccccaa accccccacc ccctaacaag
     2641 gttccaggcc cgctctttgc cagcctgcag aaccctgagc ggccaggtgg ggcccaaggg
     2701 catgataacc acaccaccct gcctgctgac tggaagcacc gccgggagcc ccctccaggg
     2761 cctctggaca gggggagcag ccgcctggac cgaagctaca gctatagcta cagcaatggc
     2821 ccaggcccat tctacaataa agggctcatc tctgaagagg agctcggggc cagtgtggct
     2881 tccctgagca gtgagaaccc atatgccacc atccgggacc tgcccagctt gccagggggc
     2941 ccccgggaga gcagctacat ggagatgaaa ggccctccct caggatctcc ccccaggcag
     3001 cctcctcagt tctgggacag ccagaggcgg cggcaacccc agccacagag agacagtggc
     3061 acctacgagc agcccagccc cctgatccat gaccgagact ctgtgggctc ccagccccct
     3121 ctgcctccgg gcctaccccc cggccactat gactcaccca agaacagcca catccctgga
     3181 cattatgact tgcctccagt acggcatccc ccatcacctc cacttcgacg ccaggaccgt
     3241 tgaggagcca ggatggtatg gcagaggcca gcacacctgg ctgttgctgc tcaaggctgg
     3301 ggacagagcc tagtgtaccc ctgccaggag cagggagtgg accggcaggc tgtgaacatg
     3361 aacaacgctt aacagagcaa gtgatgggag ccttgttcct gggttctacc atgggagacg
     3421 ctgatcagca ggatgcctgg ctccctttcc caacccactg ctcccaaggc ctccagggcc
     3481 ctgtgtacat aaactggtgg gttggaagtt gctgggtaac tctgatttca gacatgcgtg
     3541 tggggtacct tttctgtgca tgctcagcct gggctctgtg cgtgtgtgtg tttctgtgat
     3601 tttagaaggg taccaggcac aggttctgtc ctagggcact taccatttag tagggagatg
     3661 gaaccaaccc aattaactct agcaatagcc tcctaactgg cctcctccat tgattcagtg
     3721 aaccttccaa tgcatggctc ataatttcaa aatacaggct ggttagttac tccctacctg
     3781 aaagccttca taggtgcctc tttgctcttc tgccagtatc aaaacttttg aaggccttaa
     3841 aggccctgct ttgcctggcc catctgtctc tccagcctca ccttgaactg tgttcctgtc
     3901 actgcacgcc agtcacaccg gcctctaggt cctcctgtag gccactcttc tttctggcac
     3961 agggacctgc acacctggag tgcccttcct cccccactcg cctgttcacc cctgcttttc
     4021 ctttacacct cctcctcagg gaagtgccca ccctccgtac atctttcaca gccctgattg
     4081 cagctgtgtt cactcaccag gtacctgcag aaggcctaca gggtgccagg cacttcttta
     4141 atgtgttctt tctttatgtg attatttgat taatctctgc ctcccccact agactgtaag
     4201 ctccctgaag gcaagaatcc tgtgcttatg ctcaatatta gctctccctt ggcacagagt
     4261 aggcactcaa caaatgctcc ccaaaaggct gagtggctga ctgaattaag taccagtgac
     4321 atgcagtaac tgctaagata gatgagccat ctgtatgctc tgacagttac agactgaata
     4381 agttggagac ttccctaaag ggtggcattt ccccagggta acaacgcaga gctcaggtgt
     4441 gggaaggtgc caggggcagg ggtgcagagg ggctgaggct gaggggggtg cagaggctgg
     4501 agaaaggata acaggagaga gtatacaggc atgccttgat ttattgcact tcacaggtag
     4561 cagaattttt aaagaaattg aaggttttgg gacatatatg tgacagcaat aggttaagaa
     4621 aagcaaagca gagaaattga agatttgtgt caacactgct ttaagcaaat ctgttggcac
     4681 catttttcca atagcatgtg cccattttgg gtctctacat tgcattttgg taattgcttg
     4741 caatatttca agcattttca ttgttattat atgtgttata gtgatctgtg atcagtgatc
     4801 tttgatatat tattgtaatt gtttcggggc gccatgaacc gcacccatat aacacggtaa
     4861 acttaatcag caaa
//
