LOCUS       NM_198532               2564 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PEAK family member 3 (PEAK3), mRNA.
ACCESSION   NM_198532 XM_353169
VERSION     NM_198532.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2564)
  AUTHORS   Lopez,M.L., Lo,M., Kung,J.E., Dudkiewicz,M., Jang,G.M., Von
            Dollen,J., Johnson,J.R., Krogan,N.J., Pawlowski,K. and Jura,N.
  TITLE     PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member,
            inhibits CrkII through dimerization
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15495-15504 (2019)
   PUBMED   31311869
  REMARK    GeneRIF: by binding to CrkII, PEAK3 prevents the formation of
            CrkII-dependent membrane ruffling.
REFERENCE   2  (bases 1 to 2564)
  AUTHORS   Roche,S., Lecointre,C., Simon,V. and Labesse,G.
  TITLE     SHEDding light on the role of Pragmin pseudo-kinases in cancer
  JOURNAL   Am J Cancer Res 9 (2), 449-454 (2019)
   PUBMED   30906642
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2564)
  AUTHORS   Lecointre,C., Simon,V., Kerneur,C., Allemand,F., Fournet,A.,
            Montarras,I., Pons,J.L., Gelin,M., Brignatz,C., Urbach,S.,
            Labesse,G. and Roche,S.
  TITLE     Dimerization of the Pragmin Pseudo-Kinase Regulates Protein
            Tyrosine Phosphorylation
  JOURNAL   Structure 26 (4), 545-554 (2018)
   PUBMED   29503074
  REMARK    Erratum:[Structure. 2018 Nov 6;26(11):1563. doi:
            10.1016/j.str.2018.10.020.. PMID: 30403993]
REFERENCE   4  (bases 1 to 2564)
  AUTHORS   N'Diaye,A., Chen,G.K., Palmer,C.D., Ge,B., Tayo,B., Mathias,R.A.,
            Ding,J., Nalls,M.A., Adeyemo,A., Adoue,V., Ambrosone,C.B.,
            Atwood,L., Bandera,E.V., Becker,L.C., Berndt,S.I., Bernstein,L.,
            Blot,W.J., Boerwinkle,E., Britton,A., Casey,G., Chanock,S.J.,
            Demerath,E., Deming,S.L., Diver,W.R., Fox,C., Harris,T.B.,
            Hernandez,D.G., Hu,J.J., Ingles,S.A., John,E.M., Johnson,C.,
            Keating,B., Kittles,R.A., Kolonel,L.N., Kritchevsky,S.B., Le
            Marchand,L., Lohman,K., Liu,J., Millikan,R.C., Murphy,A.,
            Musani,S., Neslund-Dudas,C., North,K.E., Nyante,S., Ogunniyi,A.,
            Ostrander,E.A., Papanicolaou,G., Patel,S., Pettaway,C.A.,
            Press,M.F., Redline,S., Rodriguez-Gil,J.L., Rotimi,C.,
            Rybicki,B.A., Salako,B., Schreiner,P.J., Signorello,L.B.,
            Singleton,A.B., Stanford,J.L., Stram,A.H., Stram,D.O., Strom,S.S.,
            Suktitipat,B., Thun,M.J., Witte,J.S., Yanek,L.R., Ziegler,R.G.,
            Zheng,W., Zhu,X., Zmuda,J.M., Zonderman,A.B., Evans,M.K., Liu,Y.,
            Becker,D.M., Cooper,R.S., Pastinen,T., Henderson,B.E.,
            Hirschhorn,J.N., Lettre,G. and Haiman,C.A.
  TITLE     Identification, replication, and fine-mapping of Loci associated
            with adult height in individuals of african ancestry
  JOURNAL   PLoS Genet 7 (10), e1002298 (2011)
   PUBMED   21998595
  REMARK    Erratum:[PLoS Genet. 2011 Nov;7(11).
            doi:10.1371/annotation/58c67154-3f10-4155-9085-dcd6e3689008]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127680.1 and AC004152.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198532.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127680.1, DRR138518.49765.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342063.5/ ENSP00000345102.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2263              AK127680.1         2-2264
            2264-2563           AK127680.1         2266-2565
            2564-2564           AC004152.1         19829-19829         c
FEATURES             Location/Qualifiers
     source          1..2564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2564
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /note="PEAK family member 3"
                     /db_xref="GeneID:374872"
                     /db_xref="HGNC:HGNC:24793"
                     /db_xref="MIM:618526"
     exon            1..89
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            90..175
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1515
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /codon_start=1
                     /product="protein PEAK3"
                     /protein_id="NP_940934.1"
                     /db_xref="CCDS:CCDS12087.1"
                     /db_xref="GeneID:374872"
                     /db_xref="HGNC:HGNC:24793"
                     /db_xref="MIM:618526"
                     /translation="MSSPEPPTEPPEPDNPTWSTQPTYSNLGQIRAHLLPSKACRLRT
                     PGSLSTNPEPLPPPLPKKILTRTQSLPTRRTLHPSSIQVQPPRRPFLGSHSVDKSQAA
                     VGPACLPAELTFGPADAPLGLSLRDLHSPEAVHTALAARQLQGLRTIYARLRARLMGG
                     HPGPCHPGHSFRLLDSSPCAESGDALYYRVVRAHEDAWHILVAKVPKPGADVPHPWGL
                     ELQASLSPHFNLQGLCGLVPEGTLPGAPWRGAVALAAEVPERTVAQWLAEACTQPPEE
                     FVWAVALLLLQLSAALKFLEAWGAALVELRPENLLLVAPRGCATTGPPRLLLTDFGRV
                     CLQPPGPPGSPGPHAPQLGSLLRALLSLAAPSTTPLAAGLELLAAQLTRLRPSASRTR
                     GALQALLWGPGPELRGRGAPLGPWLRALGPWLRVRRGLLVLRLAERAAGGEAPSLEDW
                     LCCEYLAEATESSMGQALALLWD"
     exon            176..705
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            706..2564
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2527..2532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /note="hexamer: AATAAA"
     polyA_site      2564
                     /gene="PEAK3"
                     /gene_synonym="C19orf35"
                     /note="major polyA site"
ORIGIN      
        1 agacccctcc tgcgaggcca ggggctgtgg ccattgggag tttgtcccca cggacccctc
       61 ctcccccaga gggcacgcca gtcttgaagc aacatgagca gcccggagcc ccccacagag
      121 ccccccgagc ccgacaaccc cacctggtcg actcagccca cgtatagcaa ccttggtcag
      181 atccgtgccc acctgctgcc ctccaaggcc tgccgcctcc ggacccctgg gtccctctcc
      241 accaacccag agcccctgcc cccacccctg cccaagaaga tcctaacccg gacccagtca
      301 ctgcccaccc gcaggaccct ccatcccagc tccatccaag tacagccgcc tcggagaccc
      361 tttctggggt cccacagtgt ggacaagagc caggctgcag tgggaccagc ctgtctccct
      421 gcagagctga cctttggccc ggctgacgcc ccactgggcc tctccctccg cgatctgcac
      481 agcccggagg ctgtgcacac tgcactggct gcgcggcagc tgcagggcct ccgtaccatc
      541 tatgcccggc tccgtgcccg gctcatgggg ggccaccccg ggccctgcca ccccggccac
      601 agcttccgcc tcctagacag ctcaccctgc gcagagagcg gggacgccct gtattaccgc
      661 gtggtgcgcg cgcacgagga cgcctggcac atcctggtcg ccaaggtgcc caagcccggg
      721 gcggacgtgc cccacccgtg gggcctggag ctgcaggcct ccctgtctcc acacttcaat
      781 ctgcaggggc tgtgtggcct ggtgcctgaa ggcacactgc ccggggcgcc ctggagaggc
      841 gcagtggcgc tggcagccga ggttccagag cgcacggtgg cgcagtggct ggcggaggcc
      901 tgcacgcagc cgccggagga gttcgtgtgg gctgtggccc tgctgctgct gcagctgagc
      961 gcggccctga agttcctgga ggcgtggggc gcggccctag tcgagttgcg gccggagaac
     1021 ttgctgctgg tggcacctcg gggctgtgcg acgacggggc ccccacgcct gctcctcact
     1081 gactttggcc gcgtctgtct gcagccccct ggacccccgg gatccccggg cccccacgcg
     1141 ccgcagctgg gcagcctcct ccgagcgctg ctcagccttg ctgcgccctc gaccacgcct
     1201 ttggccgcgg gcctggagct cctggcagca cagctgaccc gcttgcggcc ctcggcgtcc
     1261 cggacgcggg gcgcgctgca ggcgctgctc tgggggcccg ggcctgagct gcgcggccgc
     1321 ggagcaccgc ttggtccctg gctccgagcg ctcgggccct ggctgcgggt gcgccgcggg
     1381 ctgctggtcc tgcgcctagc agagcgggcc gcaggtgggg aagctcccag cctcgaggac
     1441 tggctgtgtt gcgaatacct ggccgaggcc accgagtcct cgatgggcca ggccctggcg
     1501 ctgctgtggg actgacccca acccagggcg aacacacctg gtccaggcct gcccaggagg
     1561 cagggctggg gctgaggtca gcgtctccat gatagccaag acaccctctt cctgcagagt
     1621 ccaggagcgc agcagagaga gcaatgcccc actccagagc ctcccctccc gtgctgggga
     1681 tgtgggtcaa gggcttccca ggaatgcagc tgcccctcca gggctggggg ctggccagcg
     1741 cctcctgtgt tgggcagcag ctctctgaag ccagggcccc cacgccactt ccaggtgtgg
     1801 acaaccccgc tgatcaatgt ctctctgtgt tctgccttcc ccagcagcca gggcgctctt
     1861 ccgcgtgggt tctgtcattg tctccatgag aggccaatgc cgggaccaga ggcattcctg
     1921 gctctggagc acccccttgt gctgaagatg gccagtgatt ttgggcatgt gaatgcccct
     1981 gtccctggtg gagaattgct tggtggtgtc acgggaaggg aaggctccct gggaccttag
     2041 acacccagct catctcagcg gggtctggac tcaccttccc taaaacagtc cccgcggttc
     2101 cctgccacct cccctcaatc cctctgcgcc caccctgcct ccctccctgt tcctccgtga
     2161 cacaccaact tctttcgcgc ccccaagcat ttgtgtaggc tgttccctct gccatactgt
     2221 tccagttcca ctttcttttt cttttttttt tttttttttt tttgagacga tctcggctta
     2281 ctgcaagctc cgcctcccgg gttcacgcca ttctcctgcc tcagcctccc gagtagctgg
     2341 gactacaggc gcccgccacc acgcccggct aattttttgt atttttagta gagacggggt
     2401 ttctccgtgt tagccaggat ggtctccatc tcctgacctc gtgatccgtc cgcctcggcc
     2461 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggctacagtt tcactttctc
     2521 taaacaaata aaggtgccca ctctgggcca tcgctagctc ctta
//
