LOCUS       NM_003768               2420 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens proliferation and apoptosis adaptor protein 15
            (PEA15), transcript variant 2, mRNA.
ACCESSION   NM_003768 NM_013287
VERSION     NM_003768.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2420)
  AUTHORS   Li,L., Wang,N., Xiong,Y., Guo,G., Zhu,M. and Gu,Y.
  TITLE     Transcription Factor FOSL1 Enhances Drug Resistance of Breast
            Cancer through DUSP7-Mediated Dephosphorylation of PEA15
  JOURNAL   Mol Cancer Res 20 (4), 515-526 (2022)
   PUBMED   34907034
  REMARK    GeneRIF: Transcription Factor FOSL1 Enhances Drug Resistance of
            Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
REFERENCE   2  (bases 1 to 2420)
  AUTHORS   Ikedife,J., He,J. and Wei,Y.
  TITLE     PEA-15 engages in allosteric interactions using a common scaffold
            in a phosphorylation-dependent manner
  JOURNAL   Sci Rep 12 (1), 116 (2022)
   PUBMED   34997083
  REMARK    GeneRIF: PEA-15 engages in allosteric interactions using a common
            scaffold in a phosphorylation-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2420)
  AUTHORS   Caliva,M.J., Yang,W.S., Young-Robbins,S., Zhou,M., Yoon,H.,
            Matter,M.L., Grimes,M.L., Conrads,T. and Ramos,J.W.
  TITLE     Proteomics analysis identifies PEA-15 as an endosomal
            phosphoprotein that regulates alpha5beta1 integrin endocytosis
  JOURNAL   Sci Rep 11 (1), 19830 (2021)
   PUBMED   34615962
  REMARK    GeneRIF: Proteomics analysis identifies PEA-15 as an endosomal
            phosphoprotein that regulates alpha5beta1 integrin endocytosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2420)
  AUTHORS   Fiory,F., Formisano,P., Perruolo,G. and Beguinot,F.
  TITLE     Frontiers: PED/PEA-15, a multifunctional protein controlling cell
            survival and glucose metabolism
  JOURNAL   Am J Physiol Endocrinol Metab 297 (3), E592-E601 (2009)
   PUBMED   19531639
  REMARK    GeneRIF: Strategies are being devised to target key signaling
            events in PED/PEA-15 action aimed at improving glucose tolerance
            and at facilitating cancer cell death.
            Review article
REFERENCE   5  (bases 1 to 2420)
  AUTHORS   Wolford,J.K., Bogardus,C., Ossowski,V. and Prochazka,M.
  TITLE     Molecular characterization of the human PEA15 gene on 1q21-q22 and
            association with type 2 diabetes mellitus in Pima Indians
  JOURNAL   Gene 241 (1), 143-148 (2000)
   PUBMED   10607908
REFERENCE   6  (bases 1 to 2420)
  AUTHORS   Condorelli,G., Vigliotta,G., Iavarone,C., Caruso,M.,
            Tocchetti,C.G., Andreozzi,F., Cafieri,A., Tecce,M.F., Formisano,P.,
            Beguinot,L. and Beguinot,F.
  TITLE     PED/PEA-15 gene controls glucose transport and is overexpressed in
            type 2 diabetes mellitus
  JOURNAL   EMBO J 17 (14), 3858-3866 (1998)
   PUBMED   9670003
REFERENCE   7  (bases 1 to 2420)
  AUTHORS   Hwang,S., Kuo,W.L., Cochran,J.F., Guzman,R.C., Tsukamoto,T.,
            Bandyopadhyay,G., Myambo,K. and Collins,C.C.
  TITLE     Assignment of HMAT1, the human homolog of the murine mammary
            transforming gene (MAT1) associated with tumorigenesis, to 1q21.1,
            a region frequently gained in human breast cancers
  JOURNAL   Genomics 42 (3), 540-542 (1997)
   PUBMED   9205133
REFERENCE   8  (bases 1 to 2420)
  AUTHORS   Estelles,A., Yokoyama,M., Nothias,F., Vincent,J.D., Glowinski,J.,
            Vernier,P. and Chneiweiss,H.
  TITLE     The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs
            conserved on their full length in mouse and human
  JOURNAL   J Biol Chem 271 (25), 14800-14806 (1996)
   PUBMED   8662970
REFERENCE   9  (bases 1 to 2420)
  AUTHORS   Danziger,N., Yokoyama,M., Jay,T., Cordier,J., Glowinski,J. and
            Chneiweiss,H.
  TITLE     Cellular expression, developmental regulation, and phylogenic
            conservation of PEA-15, the astrocytic major phosphoprotein and
            protein kinase C substrate
  JOURNAL   J Neurochem 64 (3), 1016-1025 (1995)
   PUBMED   7861130
REFERENCE   10 (bases 1 to 2420)
  AUTHORS   Araujo,H., Danziger,N., Cordier,J., Glowinski,J. and Chneiweiss,H.
  TITLE     Characterization of PEA-15, a major substrate for protein kinase C
            in astrocytes
  JOURNAL   J Biol Chem 268 (8), 5911-5920 (1993)
   PUBMED   8449955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA131259.1, BC002426.2,
            BC022554.1 and BC010469.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003768.4.
            
            Summary: This gene encodes a death effector domain-containing
            protein that functions as a negative regulator of apoptosis. The
            encoded protein is an endogenous substrate for protein kinase C.
            This protein is also overexpressed in type 2 diabetes mellitus,
            where it may contribute to insulin resistance in glucose uptake.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) lacks two alternate exons in
            the 5' region and initiates translation at a downstream in-frame
            start codon, compared to variant 1. The encoded isoform (b) has a
            shorter N-terminus than isoform a. Variants 2 and 3 encode the same
            isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022554.1, Y13736.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360472.9/ ENSP00000353660.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DA131259.1         50-108
            60-665              BC002426.2         1-606
            666-1821            BC022554.1         718-1873
            1822-2420           BC010469.1         285-883
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..2420
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /note="proliferation and apoptosis adaptor protein 15"
                     /db_xref="GeneID:8682"
                     /db_xref="HGNC:HGNC:8822"
                     /db_xref="MIM:603434"
     exon            1..139
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /inference="alignment:Splign:2.1.0"
     exon            140..313
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..534
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /note="isoform b is encoded by transcript variant 2;
                     homolog of mouse MAT-1 oncogene; astrocytic phosphoprotein
                     PEA-15; phosphoprotein enriched in diabetes; 15 kDa
                     phosphoprotein enriched in astrocytes; mammary
                     transforming gene 1, mouse, homolog of; phosphoprotein
                     enriched in astrocytes 15; proliferation and apoptosis
                     adaptor 15"
                     /codon_start=1
                     /product="astrocytic phosphoprotein PEA-15 isoform b"
                     /protein_id="NP_003759.1"
                     /db_xref="CCDS:CCDS1199.1"
                     /db_xref="GeneID:8682"
                     /db_xref="HGNC:HGNC:8822"
                     /db_xref="MIM:603434"
                     /translation="MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSA
                     WFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRI
                     PSAKKYKDIIRQPSEEEIIKLAPPPKKA"
     exon            314..469
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /inference="alignment:Splign:2.1.0"
     exon            470..2420
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2395..2400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /note="hexamer: AATAAA"
     polyA_site      2420
                     /gene="PEA15"
                     /gene_synonym="HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;
                     PED-PEA15; PED/PEA15"
                     /note="major polyA site"
ORIGIN      
        1 ggctccgcgg gcggaagagg cggcggcggc ggcagaagcg gcggcggcgg cggcgggagc
       61 cgaggaggag gttccggacg ctgcttagga accggggact caggagtgcc cgcgccctga
      121 gcgctcagct ccagaggcgt catggctgag tacgggaccc tcctgcaaga cctgaccaac
      181 aacatcaccc ttgaagatct agaacagctc aagtcggcct gcaaggaaga catccccagc
      241 gaaaagagtg aggagatcac tactggcagt gcctggttta gcttcctgga gagccacaac
      301 aagctggaca aagacaacct ctcctacatt gagcacatct ttgagatctc ccgccgtcct
      361 gacctactca ctatggtggt tgactacaga acccgtgtgc tgaagatctc tgaggaggat
      421 gagctggaca ccaagctaac ccgtatcccc agtgccaaga agtacaaaga cattatccgg
      481 cagccctctg aggaagagat catcaaattg gctcccccac cgaagaaggc ctgagcaagg
      541 gggaggaaga ggaggaaggt tggaccttca tcagaccact cccttccccc atcctccagg
      601 agagggggca agggcaaccc accatctacc cacttactaa cctggtccta acccccttac
      661 tgtgcgcgtg tgtgtgcgtg tgcgcacgct ctggctgttt gtctatatgt ctagctcatc
      721 tagttcctct tcttaagggg atgggggtca ggggctaggg gagggggctg agtttcccca
      781 ctttaggagg aggtgggggc tatttctatg caaatagaaa tcagcacatt cctcctactt
      841 ccctttcctc cactcccccc atatctttaa agtgtggaag cagaaaggac ctgcattttc
      901 ctacattgag gagctgacat aggggtaagg tatgggagag gtaggtggat ccagggaaaa
      961 gcagtgggga cggaaggcaa agagaccact caacccccac ctggaagggg caaagaaaag
     1021 ccagagttcc atgtttgtac tcctgtgctg gactgtttcc tgagtaccag caggtccctt
     1081 tttgtctctc atgggcctag cataggtatg agccagggat cctttcctgg tccctaagat
     1141 caaaccccat ggagcagcca gcgttagatg cccccaccca cctgtactct ggagagactg
     1201 tgctgggaac atgtaccact gagcctgaga tggggatgag ggcagagaga ggggagcccc
     1261 ctcttccact cagttgttcc tactcagact gttgcactct aaacctaggg aggttgaaga
     1321 atgagaccct taggttttaa cacgaatcct gacaccacca tctatagggt cccaacttgg
     1381 ttattgtagg caaccttccc tctctccttg gtgaagaaca tcccaagcca gaaagaagtt
     1441 aactacagtg ttttcctttg caccgatccc caccccaatt caatcccgga agggacttac
     1501 ttaggaaacc cttctttact agatatcctg gccccctggg cttgtgaaca cctcctagcc
     1561 acatcactac agtacagtga gtgaccccag cctcctgcct accccaagat gcccctcccc
     1621 accctgaccg tgctaactgt gtgtacatat atattctaca tatatgtata ttaaaactgc
     1681 actgccatgt ctgccctttt ttgtggtgtc tagcattaac ttattgtcta ggccagagcg
     1741 ggggtgggag gggaatgcca cagtgaaggg agtggcagaa tcaaattgct acatagtcca
     1801 aacaaaaaag aaggcttttt caaaaaacat taaattcaca tgcagtctca gagactattt
     1861 agacaaagtt caagttagga gcttttagga tgtgggagta aaactttaat gggaggggag
     1921 ggctggctgc tggaagaagg aagaagccag actggttaga cagtactctt aactcctagc
     1981 ccagcctagc gtgccctgcc cctctggcca ctgctgcaga cacctgcctt aacacacaca
     2041 cctctaggac tccacagttt tgccttaaag gaccttccca agtctccctt tccctgtctg
     2101 gcttctccct taagaagaga gagatacttg tagaattggg tggggggaat gagcatgaac
     2161 tgtccttcca tttgggatat gttacattag agtgagagag agaataagga gcctttctta
     2221 tggaagaaat gggagaagag agacagggtt cttttcagca gagtctagta gtttctctgt
     2281 aaggcaaaat aatctaaaaa gactaacctg cccacccact ccttatattg ctgtgagatt
     2341 gcccctatct tgtgctcttc tgtctgcagt gtgcacggcc ttgttctaac ccggaataaa
     2401 ggtgattgat tgtattgcaa
//
