LOCUS       NM_001164595            4102 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PDZ domain containing ring finger 4 (PDZRN4),
            transcript variant 1, mRNA.
ACCESSION   NM_001164595
VERSION     NM_001164595.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4102)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4102)
  AUTHORS   Hu,T., Yang,H. and Han,Z.G.
  TITLE     PDZRN4 acts as a suppressor of cell proliferation in human liver
            cancer cell lines
  JOURNAL   Cell Biochem Funct 33 (7), 443-449 (2015)
   PUBMED   26486104
  REMARK    GeneRIF: Results showed that PDZRN4 might be a potential tumour
            suppressor gene and had anti-proliferative effect on hepatocellular
            carcinoma cell proliferation.
REFERENCE   3  (bases 1 to 4102)
  AUTHORS   Chu,M., Ji,X., Chen,W., Zhang,R., Sun,C., Wang,T., Luo,C., Gong,J.,
            Zhu,M., Fan,J., Hou,Z., Dai,J., Jin,G., Wu,T., Chen,F., Hu,Z.,
            Ni,C. and Shen,H.
  TITLE     A genome-wide association study identifies susceptibility loci of
            silica-related pneumoconiosis in Han Chinese
  JOURNAL   Hum Mol Genet 23 (23), 6385-6394 (2014)
   PUBMED   24986923
REFERENCE   4  (bases 1 to 4102)
  AUTHORS   Cavanillas,M.L., Fernandez,O., Comabella,M., Alcina,A., Fedetz,M.,
            Izquierdo,G., Lucas,M., Cenit,M.C., Arroyo,R., Vandenbroeck,K.,
            Alloza,I., Garcia-Barcina,M., Antiguedad,A., Leyva,L., Gomez,C.L.,
            Olascoaga,J., Otaegui,D., Blanco,Y., Saiz,A., Montalban,X.,
            Matesanz,F. and Urcelay,E.
  TITLE     Replication of top markers of a genome-wide association study in
            multiple sclerosis in Spain
  JOURNAL   Genes Immun 12 (2), 110-115 (2011)
   PUBMED   20944657
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4102)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum Mol Genet 18 (4), 767-778 (2009)
   PUBMED   19010793
REFERENCE   6  (bases 1 to 4102)
  AUTHORS   Melzer,D., Perry,J.R., Hernandez,D., Corsi,A.M., Stevens,K.,
            Rafferty,I., Lauretani,F., Murray,A., Gibbs,J.R., Paolisso,G.,
            Rafiq,S., Simon-Sanchez,J., Lango,H., Scholz,S., Weedon,M.N.,
            Arepalli,S., Rice,N., Washecka,N., Hurst,A., Britton,A., Henley,W.,
            van de Leemput,J., Li,R., Newman,A.B., Tranah,G., Harris,T.,
            Panicker,V., Dayan,C., Bennett,A., McCarthy,M.I., Ruokonen,A.,
            Jarvelin,M.R., Guralnik,J., Bandinelli,S., Frayling,T.M.,
            Singleton,A. and Ferrucci,L.
  TITLE     A genome-wide association study identifies protein quantitative
            trait loci (pQTLs)
  JOURNAL   PLoS Genet 4 (5), e1000072 (2008)
   PUBMED   18464913
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4102)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   8  (bases 1 to 4102)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of PDZRN3 and PDZRN4 genes in
            silico
  JOURNAL   Int J Mol Med 13 (4), 607-613 (2004)
   PUBMED   15010864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021651.17, AW297403.1, AK294535.1, AC090531.18 and BX640695.1.
            
            On May 17, 2019 this sequence version replaced NM_001164595.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.166859.1,
                                           SRR1803612.93624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402685.7/ ENSP00000384197.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-588               AC021651.17        35447-36034
            589-665             AW297403.1         1-77
            666-932             AK294535.1         1-267
            933-961             AC021651.17        41269-41297
            962-1143            AK294535.1         297-478
            1144-1144           AC090531.18        123558-123558
            1145-3458           AK294535.1         480-2793
            3459-3947           BX640695.1         2484-2972
            3948-4102           AC090531.18        191529-191683
FEATURES             Location/Qualifiers
     source          1..4102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..4102
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /note="PDZ domain containing ring finger 4"
                     /db_xref="GeneID:29951"
                     /db_xref="HGNC:HGNC:30552"
                     /db_xref="MIM:609730"
     exon            1..784
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..3247
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     IMAGE5767589; PDZ domain-containing RING finger protein 4;
                     SEMACAP3-like protein; ligand of Numb protein X 4"
                     /codon_start=1
                     /product="PDZ domain-containing RING finger protein 4
                     isoform 1"
                     /protein_id="NP_001158067.1"
                     /db_xref="CCDS:CCDS53777.1"
                     /db_xref="GeneID:29951"
                     /db_xref="HGNC:HGNC:30552"
                     /db_xref="MIM:609730"
                     /translation="MGFALERFAEAVDPALECKLCGQVLEEPLCTPCGHVFCASCLLP
                     WAVRRRRCPLQCQPLAPGELYRVLPLRSLIQKLRVQCDYRARGCGHSVRLHELEAHVE
                     HCDFGPARRLRSRGGCASGLGGGEVPARGGCGPTPRAGRGGGARGGPPGGRWGRGRGP
                     GPRVLAWRRREKALLAQLWALQGEVQLTARRYQEKFTQYMAHVRNFVGDLGGGHRRDG
                     EHKPFTIVLERENDTLGFNIIGGRPNQNNQEGTSTEGIYVSKILENGPADRADGLEIH
                     DKIMEVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNAST
                     QTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADA
                     DRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREG
                     DRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELNL
                     EMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDE
                     SSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDEDC
                     ERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELECQN
                     IMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSAYN
                     TAESCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTT
                     EQGCSAESKEKVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQL
                     IQQKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKER
                     ALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLK
                     ESPQSGSEGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDGTRVHNAF
                     LSVTTV"
     exon            785..871
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            872..979
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1236
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1339
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1438
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1501
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1603
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1720
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..4102
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3916..3921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /note="hexamer: AATAAA"
     polyA_site      3944
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /note="major polyA site"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
                     /note="hexamer: AATAAA"
     polyA_site      4102
                     /gene="PDZRN4"
                     /gene_synonym="LNX4; SAMCAP3L"
ORIGIN      
        1 atcacacctc ccacccgcca cctccctcca ctgccgccgc cgcgagacgg ctgccccggg
       61 ggtggcccgg ggaaggcagg ggggctcgga gaagacggac tctgctttcg ctcccccttt
      121 cttccccatc cctaacatgg gctttgccct ggagcgcttc gcagaagccg tggacccggc
      181 tctggagtgc aaactgtgcg gccaggtgct tgaagagccc ctgtgcacgc cgtgcgggca
      241 cgtcttctgc gccagctgcc tgttgccctg ggcggtgcgg aggcgccggt gcccgctgca
      301 gtgccagccc ttggcgcccg gcgagctgta ccgggtgctg ccgctgcgca gcctcatcca
      361 gaagctgcga gtccagtgcg actaccgcgc ccgcggctgc ggccactcgg tcaggctgca
      421 cgagctggag gcgcacgtcg agcactgcga cttcggccct gcccgccggc tccgcagccg
      481 cgggggctgc gcttcggggc tgggcggtgg tgaggtgccc gcgcgggggg gctgcggtcc
      541 gacacccagg gctggccggg gcgggggcgc gcgcgggggg ccgccgggcg gccgctgggg
      601 ccgcgggcgg ggacccgggc ctcgggtcct cgcctggagg cggcgcgaga aggcgctgct
      661 ggcgcagctc tgggcgctgc agggcgaggt gcagctcacg gcgcgcaggt accaggagaa
      721 gttcacccaa tacatggctc acgtccgcaa cttcgtcggc gacctcggtg gcggccaccg
      781 cagggatgga gagcataagc cattcactat tgtgttagaa agagaaaatg acactttggg
      841 attcaatatt ataggaggtc gaccaaatca gaataatcag gaaggaacat cgactgaagg
      901 aatttacgtt tcaaaaattt tagaaaatgg acctgctgac agagcagatg gcctggagat
      961 tcatgacaaa atcatggagg tcaatgggaa ggatctttca aaggccactc atgaagaggc
     1021 agtggaagct tttcgcaatg ccaaggagcc cattgtggtg caggtgttaa ggcgaacacc
     1081 tcttagtaga ccagcctatg ggatggcttc agaagtgcag cttatgaatg ccagcactca
     1141 gacggacatc accttcgaac acatcatggc tctggccaag cttcgtccac ctacccctcc
     1201 agtgccagac atctgtccat tcctgctctc agacagctgc cattctctac atccaatgga
     1261 gcatgaattt tatgaggaca atgagtatat ttccagcttg cctgctgatg cagacagaac
     1321 agaagacttt gaatatgagg aggtcgagtt gtgtcgtgtt agcagtcaag agaagctggg
     1381 cctgacagtc tgttaccgaa cagatgatga agaagacacc ggcatttatg tcagcgaggt
     1441 tgacccaaat agcattgctg ccaaagacgg ccggattcga gaaggggatc ggattttgca
     1501 aataaatggg gaagatgtcc agaatcgaga agaagcagtg gccttgctgt ctaacgatga
     1561 gtgtaagaga atcgtgctgc ttgttgcaag gccagagatt cagctggatg aaggctggct
     1621 ggaagatgaa aggaatgaat tcttagagga gttaaacttg gagatgttgg aagaagagca
     1681 taatgaagca atgcagccca ctgccaatga ggtggagcag ccaaaaaagc aagaagaaga
     1741 agaaggcaca acagacactg caacatcctc atccaacaac catgagaagg acagtggagt
     1801 aggacgtaca gatgaaagct tgcgaaatga tgagagctca gagcaggaga atgcagccga
     1861 ggaccccaat agcacatctt tgaagagcaa gagagacctg gggcagagcc aagacactct
     1921 gggaagtgtt gaacttcagt acaatgagag cctcgtatct ggtgaataca ttgactcaga
     1981 ctgcattggc aacccagatg aggactgtga aagattcagg cagctcttgg agctcaaatg
     2041 caagattcga aatcatggag agtatgacct gtattactca agcagcacaa ttgaatgcaa
     2101 tcaaggggag caagagggag tggagcatga gctacagttg cttaatgaag aactgagaaa
     2161 cattgagctt gagtgtcaga atatcatgca ggctcacagg ctccagaaag tgacagacca
     2221 gtatggagac atctggacat tgcatgatgg aggattccgg aattataaca ccagcataga
     2281 tatgcaaagg ggaaagctag atgacatcat ggagcatcca gaaaagtctg acaaggacag
     2341 ttctagtgct tacaacacag ctgagagctg cagaagtact ccgctcactg tagaccgttc
     2401 ccctgacagt tcccttccaa gggtgatcaa cctcaccaat aagaaaaacc tgagaagcac
     2461 aatggcagcc acccagtcct cttccggaca gagcagtaaa gagtcgacct ccaccaaagc
     2521 caaaaccact gagcaaggtt gtagcgctga aagcaaggag aaggttttag aaggcagcaa
     2581 gcttcctgat caagagaagg cagtcagcga acacatccct tacctctctc cttaccacag
     2641 ctcctcatat agatatgcaa acatcccagc acacgcccgg cattatcaaa gctacatgca
     2701 gttaattcaa cagaaatctg cagtcgagta tgctcagagt cagctcagct tggtgagcat
     2761 gtgcaaggag tctcagaagt gttcagagcc caagatggaa tggaaggtga aaattaggag
     2821 cgacgggaca cggtacatca caaagagacc cgtgcgagac cgaatcctga aggaacgtgc
     2881 cttaaagatc aaggaagagc ggagtggcat gaccacagac gatgacacca tgagcgagat
     2941 gaaaatgggg cgctactgga gcaaagagga gagaaagcag cacctggtta gggccaaaga
     3001 gcagcgccgt cgccgtgagt tcatgatgcg aagcaggtta gagtgtctca aggagagccc
     3061 tcagagcggc agtgagggca agaaggagat caatatcatt gaactgagtc acaaaaagat
     3121 gatgaaaaag agaaacaaga aaattttgga caactggatg acaatccaag aactgatgac
     3181 ccatggggcc aagtctccag atggcacgag agtccataat gccttcttgt cggtgaccac
     3241 tgtatgaccg aatgaatgga atgcatgcga ctgattttag gaggatgcta ccagtttcgg
     3301 tagagtatga ttgcctcgtt caatgtggcg tttttatata tattttgtga ctctttatag
     3361 tttaaatttt ttgtaagcaa aaaatacctg gtaatttttc atttgttttt catatactgg
     3421 taccttcttt ttggctgaga tctttctttt acttgtgata tattcatatt actcgtttat
     3481 aaaaaatcaa aaacaaaagg aaagaaaaca aaaaaaactt gcacaaaaat actgaggagc
     3541 caattaattt cctacttcaa tgtatctaat gtaagtgaaa atctggattt atttctctag
     3601 tttacttatt ttctacttta ataataactc aatgccaaaa tatttctatg cttgtttctt
     3661 ggcataatac attttaaatc aaacctgttc gtaataaatc atgtgccaca tcttgtctta
     3721 cacataaaag ccactgcttt taacatccca ttgtacattt aacacataaa tggtgttaac
     3781 atcccattgt acatttaaca cataaatggc cattgtcttt gtctcagtaa agtgtaggtg
     3841 gacaatcttc ctgtgatatg tagtgacatt ggtcatgtag ctagataatt atggtaattg
     3901 tgacaattaa agagaaataa attattgatt atccttcaga aaaattatca aggagtgttt
     3961 tattttcctt gtccacagtg gttgacagtt ataaagtagt tatatgtgta tactatttag
     4021 aagacgccta attgtggatt ataaaatgtg cacattttct atcacttgtt tccaataaag
     4081 ttgtattgaa acattcccta ta
//
