LOCUS       NM_005764                838 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens PDZK1 interacting protein 1 (PDZK1IP1), mRNA.
ACCESSION   NM_005764
VERSION     NM_005764.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 838)
  AUTHORS   Hiraizumi,M., Akashi,T., Murasaki,K., Kishida,H., Kumanomidou,T.,
            Torimoto,N., Nureki,O. and Miyaguchi,I.
  TITLE     Transport and inhibition mechanism of the human SGLT2-MAP17 glucose
            transporter
  JOURNAL   Nat Struct Mol Biol 31 (1), 159-169 (2024)
   PUBMED   38057552
REFERENCE   2  (bases 1 to 838)
  AUTHORS   Hsiao,S.Y., Weng,S.M., Hsiao,J.R., Wu,Y.Y., Wu,J.E., Tung,C.H.,
            Shen,W.L., Sun,S.F., Huang,W.T., Lin,C.Y., Chen,S.H., Hong,T.M.,
            Chen,Y.L. and Chang,J.Y.
  TITLE     MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral
            squamous cell carcinoma and accelerate clinical cancer invasion by
            regulating partial epithelial-to-mesenchymal transition
  JOURNAL   J Exp Clin Cancer Res 42 (1), 40 (2023)
   PUBMED   36737832
  REMARK    GeneRIF: MiR-455-5p suppresses PDZK1IP1 to promote the motility of
            oral squamous cell carcinoma and accelerate clinical cancer
            invasion by regulating partial epithelial-to-mesenchymal
            transition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 838)
  AUTHORS   Wang,K., Liu,S., Tian,Y., Liu,C., Gui,Z., Yu,T. and Zhang,L.
  TITLE     PDZK1 Interacting Protein 1 Promotes the Progression of Papillary
            Thyroid Cancer
  JOURNAL   J Clin Endocrinol Metab 107 (9), 2449-2461 (2022)
   PUBMED   35727731
  REMARK    GeneRIF: PDZK1 Interacting Protein 1 Promotes the Progression of
            Papillary Thyroid Cancer.
REFERENCE   4  (bases 1 to 838)
  AUTHORS   Niu,Y., Liu,R., Guan,C., Zhang,Y., Chen,Z., Hoerer,S., Nar,H. and
            Chen,L.
  TITLE     Structural basis of inhibition of the human SGLT2-MAP17 glucose
            transporter
  JOURNAL   Nature 601 (7892), 280-284 (2022)
   PUBMED   34880493
REFERENCE   5  (bases 1 to 838)
  AUTHORS   Yu,K., Lu,H., Chen,Y., Xin,Y., Tan,Z. and Yang,Q.
  TITLE     80MAP17 promotes the tumorigenesis of papillary thyroid carcinoma
            by reducing the stability of p53
  JOURNAL   Front Biosci (Landmark Ed) 26 (10), 777-788 (2021)
   PUBMED   34719205
  REMARK    GeneRIF: 80MAP17 promotes the tumorigenesis of papillary thyroid
            carcinoma by reducing the stability of p53.
REFERENCE   6  (bases 1 to 838)
  AUTHORS   Silver,D.L., Wang,N. and Vogel,S.
  TITLE     Identification of small PDZK1-associated protein, DD96/MAP17, as a
            regulator of PDZK1 and plasma high density lipoprotein levels
  JOURNAL   J Biol Chem 278 (31), 28528-28532 (2003)
   PUBMED   12754212
REFERENCE   7  (bases 1 to 838)
  AUTHORS   Gottgens,B., Barton,L.M., Chapman,M.A., Sinclair,A.M., Knudsen,B.,
            Grafham,D., Gilbert,J.G., Rogers,J., Bentley,D.R. and Green,A.R.
  TITLE     Transcriptional regulation of the stem cell leukemia gene
            (SCL)--comparative analysis of five vertebrate SCL loci
  JOURNAL   Genome Res 12 (5), 749-759 (2002)
   PUBMED   11997341
REFERENCE   8  (bases 1 to 838)
  AUTHORS   Kocher,O., Comella,N., Tognazzi,K. and Brown,L.F.
  TITLE     Identification and partial characterization of PDZK1: a novel
            protein containing PDZ interaction domains
  JOURNAL   Lab Invest 78 (1), 117-125 (1998)
   PUBMED   9461128
REFERENCE   9  (bases 1 to 838)
  AUTHORS   Kocher,O., Cheresh,P. and Lee,S.W.
  TITLE     Identification and partial characterization of a novel
            membrane-associated protein (MAP17) up-regulated in human
            carcinomas and modulating cell replication and tumor growth
  JOURNAL   Am J Pathol 149 (2), 493-500 (1996)
   PUBMED   8701988
REFERENCE   10 (bases 1 to 838)
  AUTHORS   Kocher,O., Cheresh,P., Brown,L.F. and Lee,S.W.
  TITLE     Identification of a novel gene, selectively up-regulated in human
            carcinomas, using the differential display technique
  JOURNAL   Clin Cancer Res 1 (10), 1209-1215 (1995)
   PUBMED   9815914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM924665.1, BI763294.1 and AL135960.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005764.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG748872.1, BU600457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294338.7/ ENSP00000294338.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-729               BM924665.1         90-818
            730-831             BI763294.1         458-559
            832-838             AL135960.1         94363-94369
FEATURES             Location/Qualifiers
     source          1..838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..838
                     /gene="PDZK1IP1"
                     /gene_synonym="DD96; MAP17; SPAP"
                     /note="PDZK1 interacting protein 1"
                     /db_xref="GeneID:10158"
                     /db_xref="HGNC:HGNC:16887"
                     /db_xref="MIM:607178"
     exon            1..171
                     /gene="PDZK1IP1"
                     /gene_synonym="DD96; MAP17; SPAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..449
                     /gene="PDZK1IP1"
                     /gene_synonym="DD96; MAP17; SPAP"
                     /note="membrane-associated protein 17; epithelial protein
                     up-regulated in carcinoma, membrane associated protein 17;
                     17 kDa membrane-associated protein"
                     /codon_start=1
                     /product="PDZK1-interacting protein 1 precursor"
                     /protein_id="NP_005755.1"
                     /db_xref="CCDS:CCDS546.1"
                     /db_xref="GeneID:10158"
                     /db_xref="HGNC:HGNC:16887"
                     /db_xref="MIM:607178"
                     /translation="MSALSLLILGLLTAVPPASCQQGLGNLQPWMQGLIAVAVFLVLV
                     AIAFAVNHFWCQEEPEPAHMILTVGNKADGVLVGTDGRYSSMAASFRSSEHENAYENV
                     PEEEGKVRSTPM"
     exon            172..280
                     /gene="PDZK1IP1"
                     /gene_synonym="DD96; MAP17; SPAP"
                     /inference="alignment:Splign:2.1.0"
     exon            281..376
                     /gene="PDZK1IP1"
                     /gene_synonym="DD96; MAP17; SPAP"
                     /inference="alignment:Splign:2.1.0"
     exon            377..838
                     /gene="PDZK1IP1"
                     /gene_synonym="DD96; MAP17; SPAP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      838
                     /gene="PDZK1IP1"
                     /gene_synonym="DD96; MAP17; SPAP"
                     /note="major polyA site"
ORIGIN      
        1 agactgagcc caggttgatt tcaggcggac accaatagac tccacagcag ctccaggagc
       61 ccagacaccg gcggccagaa gcaaggctag gagctgctgc agccatgtcg gccctcagcc
      121 tcctcattct gggcctgctc acggcagtgc cacctgccag ctgtcagcaa ggcctgggga
      181 accttcagcc ctggatgcag ggccttatcg cggtggccgt gttcctggtc ctcgttgcaa
      241 tcgcctttgc agtcaaccac ttctggtgcc aggaggagcc ggagcctgca cacatgatcc
      301 tgaccgtcgg aaacaaggca gatggagtcc tggtgggaac agatggaagg tactcttcga
      361 tggcggccag tttcaggtcc agtgagcatg agaatgccta tgagaatgtg cccgaggagg
      421 aaggcaaggt ccgcagcacc ccgatgtaac cttctctgtg gctccaaccc caagactccc
      481 aggcacatgg gatggatgtc cagtgctacc acccaagccc cctccttctt tgtgtggaat
      541 ctgcaatagt gggctgactc cctccagccc catgccggcc ctacccgccc ttgaagtata
      601 gccagccaag gttggagctc agaccgtgtc taggttgggg ctcggctgtg gccctggggt
      661 ctcctgctca gctcagaaga gccttctgga gaggacagtc agctgagcac ctcccatcct
      721 gctcacacgt ccttccccat aactatggaa atggccctaa tttctgtgaa ataaagactt
      781 tttgtatttc tggggctgag gctcagcaac agcccctcag gcttccagtg agtcccca
//
