LOCUS       NM_001303513            4004 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens PDZ domain containing 4 (PDZD4), transcript variant 3,
            mRNA.
ACCESSION   NM_001303513
VERSION     NM_001303513.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4004)
  AUTHORS   Nagayama,S., Iiizumi,M., Katagiri,T., Toguchida,J. and Nakamura,Y.
  TITLE     Identification of PDZK4, a novel human gene with PDZ domains, that
            is upregulated in synovial sarcomas
  JOURNAL   Oncogene 23 (32), 5551-5557 (2004)
   PUBMED   15077175
  REMARK    GeneRIF: Might play an important role in the proliferation of SS
            cells and might be a suitable target for SS drugs.
REFERENCE   2  (bases 1 to 4004)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human PDZRN4L gene and mouse
            Pdzrn4l gene in silico
  JOURNAL   Int J Mol Med 13 (6), 923-927 (2004)
   PUBMED   15138636
  REMARK    GeneRIF: PDZRN4L showed 49.9% total-amino-acid identity with PDZRN4
            short isoform (PDZRN4S).  PDZ, PR34H1 and PR34H2 domains were
            conserved between PDZRN4L and PDZRN4S.
REFERENCE   3  (bases 1 to 4004)
  AUTHORS   Sandoval,N., Bauer,D., Brenner,V., Coy,J.F., Drescher,B.,
            Kioschis,P., Korn,B., Nyakatura,G., Poustka,A., Reichwald,K.,
            Rosenthal,A. and Platzer,M.
  TITLE     The genomic organization of a human creatine transporter (CRTR)
            gene located in Xq28
  JOURNAL   Genomics 35 (2), 383-385 (1996)
   PUBMED   8661155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52111.3.
            
            On Apr 23, 2020 this sequence version replaced NM_001303513.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3026728.1, BC143542.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               U52111.3           213448-213753       c
            307-560             U52111.3           191551-191804       c
            561-803             U52111.3           191106-191348       c
            804-894             U52111.3           190488-190578       c
            895-993             U52111.3           189951-190049       c
            994-1056            U52111.3           189280-189342       c
            1057-1158           U52111.3           188714-188815       c
            1159-1269           U52111.3           188306-188416       c
            1270-4004           U52111.3           185375-188109       c
FEATURES             Location/Qualifiers
     source          1..4004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..4004
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="PDZ domain containing 4"
                     /db_xref="GeneID:57595"
                     /db_xref="HGNC:HGNC:21167"
                     /db_xref="MIM:300634"
     exon            1..306
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            307..560
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            561..803
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             796..2817
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="isoform 3 is encoded by transcript variant 3; PDZ
                     domain-containing protein 4; PDZ domain-containing RING
                     finger protein 4-like protein"
                     /codon_start=1
                     /product="PDZ domain-containing protein 4 isoform 3"
                     /protein_id="NP_001290442.1"
                     /db_xref="GeneID:57595"
                     /db_xref="HGNC:HGNC:21167"
                     /db_xref="MIM:300634"
                     /translation="MTAPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSSHRD
                     KLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAI
                     LSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPG
                     NEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRK
                     FGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYRELLEIKCHLENGNQ
                     LGLLFPRASGGNSALDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQKMQQLRERCM
                     KAWLLEEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYNTGESCRSTPLLVEPLP
                     ESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQHAEERG
                     RRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGPLSLA
                     GGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGMTT
                     DDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNI
                     IALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV"
     exon            804..894
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            895..993
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1056
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1158
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1269
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..4004
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3973..3978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="hexamer: AATAAA"
     polyA_site      4004
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="major polyA site"
ORIGIN      
        1 gccctttttc tcctggccgg gtgcgaggga gcatgcccgc gcctggcctc ggccagcgaa
       61 gagttaacct gaggggcgag ccgctgcccc cacctcgggg gcgtgccccc ctcccccgct
      121 aggcggcccg ccccccgcgc cagggtatgg cccctggccc cggcccggga cccgaggtcc
      181 cgcgcccggg tcagtgaaag gcgtcttccc gttcccgccc tccgcctcct ctcgccggcc
      241 agcaacatgg gatgtaatat gtgcgtggtc cagaaaccgg aggagcagta caaagtgatg
      301 ctgcaggtga acgggaagga gctctccaag ctgtctcagg agcaaactct gcaggccctg
      361 cgctcctcca aggagcccct ggtgatccag gtgctgagac gcagcccccg cctccggggg
      421 gacagctcct gtcacgacct gcagctggtg gacagtggca ctcagaccga catcaccttc
      481 gagcatatca tggcgctggg caagctgcgt ccgcccaccc cgcccatggt catcctggag
      541 ccgtacgtcc tctctgagct ggccgaggga ggaccctcct gtccgggacg tcgctgccgg
      601 aagtgccagg gttgagggcc tcagctcctc ctcctccatc ctctctcctc tgccgcctca
      661 caagcatcac tccttgaatc ttcttgcatc ccttgtctgt ctcattcctc tacctgctct
      721 gaatttcctc catctcttca gcttctttct ttggcccgac cggaagaagg gcctttcatc
      781 caggcctggt ggctcatgac cgccccccca atcagccatg agtattatga cccggcggag
      841 tttatggagg gcggcccgca ggaggcagac cgcttggatg agctggagta tgaggaggtg
      901 gagctgtata aaagcagcca ccgggacaag ctgggcctga tggtttgcta ccgcacggac
      961 gacgaggagg acctgggcat ttatgtcgga gaggtaaatc ccaacagcat tgcagccaaa
     1021 gacggccgga tccgtgaggg agaccgcatc atccagatta acggtgtaga cgtccagaac
     1081 cgggaagagg cggtggccat cctgagccag gaagagaaca ccaacatctc cctgctggtg
     1141 gcccgacctg agagtcagct ggcgaaaagg tggaaggaca gcgaccggga tgacttcctg
     1201 gatgactttg gctctgagaa tgagggggag ctgcgtgctc gtaaactgaa atcaccccct
     1261 gcccagcagc ccggaaacga agaggagaag ggggctcccg atgccggccc aggcctgagc
     1321 aacagccagg agctggacag cggggtgggc cggactgacg agagcacccg gaacgaagag
     1381 agctctgagc acgacctgct gggggacgaa cccccgagct ccaccaacac cccgggaagc
     1441 ctgcgcaagt ttggcctgca aggggacgcc ctgcagagcc gggacttcca tttcagcatg
     1501 gactctctgc tggccgaggg ggcggggctg ggagggggcg acgtcccggg cctcacggat
     1561 gaggagtatg agcgctaccg tgagctcctg gagatcaagt gccacctgga gaacggcaac
     1621 cagctgggcc tcctctttcc ccgggcctcc ggaggcaaca gcgccctgga cgtcaaccgc
     1681 aacgagagcc tgggccacga gatggccatg ctggaggagg agctaaggca cctggaattc
     1741 aagtgccgca acatactgcg ggcgcagaag atgcagcagc tgcgtgagcg ctgcatgaag
     1801 gcctggctgc tggaggagga gagcctctac gacctggcgg ccagcgagcc caagaagcac
     1861 gagctgtccg acatctccga gctgcccgag aagtcggaca aggacagcac cagcgcctac
     1921 aacactgggg agagctgccg cagcaccccg ctgcttgtgg agcccctgcc cgagagcccc
     1981 ctgcggcggg ccatggccgg caactccaac ttgaaccgga cccctcccgg ccccgctgtt
     2041 gccacccccg ccaaggcagc tcctccaccg gggagccccg ccaagttccg gtccctctcc
     2101 cgggatcctg aggccggccg gaggcagcac gcggaggagc gcggccgccg caaccccaag
     2161 acggggttga ccctggagcg tgtgggccct gaaagcagcc cttacctctc gcggcgccac
     2221 cgcggccagg gccaggaggg cgagcactac cacagctgcg tgcagctggc cccgacgcga
     2281 ggcctggagg agctgggcca cggccccctg agcttggccg gtggccctcg ggtgggcggg
     2341 gtggcggccg cggccactga agcaccgcgc atggagtgga aagtgaaggt gcgcagcgac
     2401 ggaacccgct acgtggccaa gcggcccgtg cgagatcggc tgctgaaagc ccgtgccctg
     2461 aagatccggg aggagcgcag cggtatgacg accgacgacg acgcggtgag cgagatgaag
     2521 atgggccgct actggagcaa ggaggagcgg aagcagcacc tgatccgggc ccgtgagcag
     2581 cggaagcggc gcgagttcat gatgcagagc cggctggagt gcctgcggga gcagcagaat
     2641 ggcgacagca agcccgagct caacatcatt gccctgagcc accgcaaaac catgaagaag
     2701 cggaacaaga agatcctgga caactggatc accatccagg agatgctggc ccacggcgcg
     2761 cgctccgccg atggcaagcg ggtctacaac cctcttctct cagtcaccac cgtgtgagct
     2821 gcccgggcgg gtacacggcc caggcccagg gaaccccctg gggccccggc cctcactctc
     2881 ctatagagat tgtgtgtgtg tgtgtgtgcg cgcgcgcgtg ctcgctgtgc gcacgcacac
     2941 atctcctcgt ctgggtgtgc gcacagggct ttgttagcag agagaagccc ctgaggagaa
     3001 gggacgcttt tcttccttct gcccaagtaa agtgaccatg ccagtggcca gcactggggg
     3061 cacacctgtg atgggcaccc cttcagctgt gcgtgtgcat tccccatccc ccatgctctt
     3121 gcgtgtgctt gcacgtgcac gcacacacac acccagtgct ctctccaccc gacccgtgta
     3181 cttgcagaca gggaagctga gctgaaagga gcacaagaga gtgtccggct tcgctgctga
     3241 gcgcggcctc tccccgccgc tgcgcactgc agttatttgt agacaaaggc acccctgatt
     3301 tttgtggttt ttctcccttt ctgtgcttgc caatagttgt tttgttttgt ggacctgccc
     3361 tgggggctgg cagctccttc aggcagcctg gcagaagtgg aactcccctc tccactgatg
     3421 gctgggaagg gagttgggga ggaagagtgg gagggagggc tggggatgga tgggagggaa
     3481 ggggagggaa aggtgggagg aatgggaagc agctgttctg gtggcttcca ctctgaggtg
     3541 tgggaacggg gagcctctgg ggggcacctg tttccccagt gactcagaga gagcaagact
     3601 gcaggaacgg aggggtcctg cagggtgtcc accaagaagt cacagagccc gttctgcgcc
     3661 ccacaccatc tggagcaggg gcttctcttc tgagtgaact gaggaaggtg cttagatggt
     3721 gagggctcta gaaaccaagc cccatgagca gcagtggaag acctcgggcc atgcggcctg
     3781 gggaggactt ggtggcgatc cgcaacctgg accccagtga gaggcggtgg gctgactggg
     3841 aaggagaggc ccccaacctc ctcaggattt gcacgtgtga actaggctgc ctgtggggtg
     3901 ccccttaggc ttggagagcc ccagattgga ggcagacaga ctgcaccacc ccttcccccc
     3961 ctgcatctca agaataaagc aagctgcctt tgtacttggt tgaa
//
