LOCUS       NM_001303512            3761 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens PDZ domain containing 4 (PDZD4), transcript variant 1,
            mRNA.
ACCESSION   NM_001303512
VERSION     NM_001303512.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3761)
  AUTHORS   Nagayama,S., Iiizumi,M., Katagiri,T., Toguchida,J. and Nakamura,Y.
  TITLE     Identification of PDZK4, a novel human gene with PDZ domains, that
            is upregulated in synovial sarcomas
  JOURNAL   Oncogene 23 (32), 5551-5557 (2004)
   PUBMED   15077175
  REMARK    GeneRIF: Might play an important role in the proliferation of SS
            cells and might be a suitable target for SS drugs.
REFERENCE   2  (bases 1 to 3761)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human PDZRN4L gene and mouse
            Pdzrn4l gene in silico
  JOURNAL   Int J Mol Med 13 (6), 923-927 (2004)
   PUBMED   15138636
  REMARK    GeneRIF: PDZRN4L showed 49.9% total-amino-acid identity with PDZRN4
            short isoform (PDZRN4S).  PDZ, PR34H1 and PR34H2 domains were
            conserved between PDZRN4L and PDZRN4S.
REFERENCE   3  (bases 1 to 3761)
  AUTHORS   Sandoval,N., Bauer,D., Brenner,V., Coy,J.F., Drescher,B.,
            Kioschis,P., Korn,B., Nyakatura,G., Poustka,A., Reichwald,K.,
            Rosenthal,A. and Platzer,M.
  TITLE     The genomic organization of a human creatine transporter (CRTR)
            gene located in Xq28
  JOURNAL   Genomics 35 (2), 383-385 (1996)
   PUBMED   8661155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52111.3.
            
            On Apr 23, 2020 this sequence version replaced NM_001303512.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3652591.1, BC117277.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393758.7/ ENSP00000377355.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               U52111.3           213448-213753       c
            307-560             U52111.3           191551-191804       c
            561-651             U52111.3           190488-190578       c
            652-750             U52111.3           189951-190049       c
            751-813             U52111.3           189280-189342       c
            814-915             U52111.3           188714-188815       c
            916-1026            U52111.3           188306-188416       c
            1027-3761           U52111.3           185375-188109       c
FEATURES             Location/Qualifiers
     source          1..3761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..3761
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="PDZ domain containing 4"
                     /db_xref="GeneID:57595"
                     /db_xref="HGNC:HGNC:21167"
                     /db_xref="MIM:300634"
     exon            1..306
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..2574
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="isoform 1 is encoded by transcript variant 1; PDZ
                     domain-containing protein 4; PDZ domain-containing RING
                     finger protein 4-like protein"
                     /codon_start=1
                     /product="PDZ domain-containing protein 4 isoform 1"
                     /protein_id="NP_001290441.1"
                     /db_xref="CCDS:CCDS78518.1"
                     /db_xref="GeneID:57595"
                     /db_xref="HGNC:HGNC:21167"
                     /db_xref="MIM:300634"
                     /translation="MGCNMCVVQKPEEQYKVMLQVNGKELSKLSQEQTLQALRSSKEP
                     LVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEPYVL
                     SELPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEE
                     DLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAILSQEENTNISLLVA
                     RPESQLAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGL
                     SNSQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGLQGDALQSRDFH
                     FSMDSLLAEGAGLGGGDVPGLTDEEYERYRELLEIKCHLENGNQLGLLFPRASGGNSA
                     LDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQKMQQLRERCMKAWLLEEESLYDLA
                     ASEPKKHELSDISELPEKSDKDSTSAYNTGESCRSTPLLVEPLPESPLRRAMAGNSNL
                     NRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQHAEERGRRNPKTGLTLERVG
                     PESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGPLSLAGGPRVGGVAAAATE
                     APRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGMTTDDDAVSEMKMGRYW
                     SKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNIIALSHRKTMKKRNK
                     KILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV"
     exon            307..560
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            561..651
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            652..750
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            751..813
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            814..915
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1026
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..3761
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3730..3735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="hexamer: AATAAA"
     polyA_site      3761
                     /gene="PDZD4"
                     /gene_synonym="LNX5; LU1; PDZK4; PDZRN4L"
                     /note="major polyA site"
ORIGIN      
        1 gccctttttc tcctggccgg gtgcgaggga gcatgcccgc gcctggcctc ggccagcgaa
       61 gagttaacct gaggggcgag ccgctgcccc cacctcgggg gcgtgccccc ctcccccgct
      121 aggcggcccg ccccccgcgc cagggtatgg cccctggccc cggcccggga cccgaggtcc
      181 cgcgcccggg tcagtgaaag gcgtcttccc gttcccgccc tccgcctcct ctcgccggcc
      241 agcaacatgg gatgtaatat gtgcgtggtc cagaaaccgg aggagcagta caaagtgatg
      301 ctgcaggtga acgggaagga gctctccaag ctgtctcagg agcaaactct gcaggccctg
      361 cgctcctcca aggagcccct ggtgatccag gtgctgagac gcagcccccg cctccggggg
      421 gacagctcct gtcacgacct gcagctggtg gacagtggca ctcagaccga catcaccttc
      481 gagcatatca tggcgctggg caagctgcgt ccgcccaccc cgcccatggt catcctggag
      541 ccgtacgtcc tctctgagct ccccccaatc agccatgagt attatgaccc ggcggagttt
      601 atggagggcg gcccgcagga ggcagaccgc ttggatgagc tggagtatga ggaggtggag
      661 ctgtataaaa gcagccaccg ggacaagctg ggcctgatgg tttgctaccg cacggacgac
      721 gaggaggacc tgggcattta tgtcggagag gtaaatccca acagcattgc agccaaagac
      781 ggccggatcc gtgagggaga ccgcatcatc cagattaacg gtgtagacgt ccagaaccgg
      841 gaagaggcgg tggccatcct gagccaggaa gagaacacca acatctccct gctggtggcc
      901 cgacctgaga gtcagctggc gaaaaggtgg aaggacagcg accgggatga cttcctggat
      961 gactttggct ctgagaatga gggggagctg cgtgctcgta aactgaaatc accccctgcc
     1021 cagcagcccg gaaacgaaga ggagaagggg gctcccgatg ccggcccagg cctgagcaac
     1081 agccaggagc tggacagcgg ggtgggccgg actgacgaga gcacccggaa cgaagagagc
     1141 tctgagcacg acctgctggg ggacgaaccc ccgagctcca ccaacacccc gggaagcctg
     1201 cgcaagtttg gcctgcaagg ggacgccctg cagagccggg acttccattt cagcatggac
     1261 tctctgctgg ccgagggggc ggggctggga gggggcgacg tcccgggcct cacggatgag
     1321 gagtatgagc gctaccgtga gctcctggag atcaagtgcc acctggagaa cggcaaccag
     1381 ctgggcctcc tctttccccg ggcctccgga ggcaacagcg ccctggacgt caaccgcaac
     1441 gagagcctgg gccacgagat ggccatgctg gaggaggagc taaggcacct ggaattcaag
     1501 tgccgcaaca tactgcgggc gcagaagatg cagcagctgc gtgagcgctg catgaaggcc
     1561 tggctgctgg aggaggagag cctctacgac ctggcggcca gcgagcccaa gaagcacgag
     1621 ctgtccgaca tctccgagct gcccgagaag tcggacaagg acagcaccag cgcctacaac
     1681 actggggaga gctgccgcag caccccgctg cttgtggagc ccctgcccga gagccccctg
     1741 cggcgggcca tggccggcaa ctccaacttg aaccggaccc ctcccggccc cgctgttgcc
     1801 acccccgcca aggcagctcc tccaccgggg agccccgcca agttccggtc cctctcccgg
     1861 gatcctgagg ccggccggag gcagcacgcg gaggagcgcg gccgccgcaa ccccaagacg
     1921 gggttgaccc tggagcgtgt gggccctgaa agcagccctt acctctcgcg gcgccaccgc
     1981 ggccagggcc aggagggcga gcactaccac agctgcgtgc agctggcccc gacgcgaggc
     2041 ctggaggagc tgggccacgg ccccctgagc ttggccggtg gccctcgggt gggcggggtg
     2101 gcggccgcgg ccactgaagc accgcgcatg gagtggaaag tgaaggtgcg cagcgacgga
     2161 acccgctacg tggccaagcg gcccgtgcga gatcggctgc tgaaagcccg tgccctgaag
     2221 atccgggagg agcgcagcgg tatgacgacc gacgacgacg cggtgagcga gatgaagatg
     2281 ggccgctact ggagcaagga ggagcggaag cagcacctga tccgggcccg tgagcagcgg
     2341 aagcggcgcg agttcatgat gcagagccgg ctggagtgcc tgcgggagca gcagaatggc
     2401 gacagcaagc ccgagctcaa catcattgcc ctgagccacc gcaaaaccat gaagaagcgg
     2461 aacaagaaga tcctggacaa ctggatcacc atccaggaga tgctggccca cggcgcgcgc
     2521 tccgccgatg gcaagcgggt ctacaaccct cttctctcag tcaccaccgt gtgagctgcc
     2581 cgggcgggta cacggcccag gcccagggaa ccccctgggg ccccggccct cactctccta
     2641 tagagattgt gtgtgtgtgt gtgtgcgcgc gcgcgtgctc gctgtgcgca cgcacacatc
     2701 tcctcgtctg ggtgtgcgca cagggctttg ttagcagaga gaagcccctg aggagaaggg
     2761 acgcttttct tccttctgcc caagtaaagt gaccatgcca gtggccagca ctgggggcac
     2821 acctgtgatg ggcacccctt cagctgtgcg tgtgcattcc ccatccccca tgctcttgcg
     2881 tgtgcttgca cgtgcacgca cacacacacc cagtgctctc tccacccgac ccgtgtactt
     2941 gcagacaggg aagctgagct gaaaggagca caagagagtg tccggcttcg ctgctgagcg
     3001 cggcctctcc ccgccgctgc gcactgcagt tatttgtaga caaaggcacc cctgattttt
     3061 gtggtttttc tccctttctg tgcttgccaa tagttgtttt gttttgtgga cctgccctgg
     3121 gggctggcag ctccttcagg cagcctggca gaagtggaac tcccctctcc actgatggct
     3181 gggaagggag ttggggagga agagtgggag ggagggctgg ggatggatgg gagggaaggg
     3241 gagggaaagg tgggaggaat gggaagcagc tgttctggtg gcttccactc tgaggtgtgg
     3301 gaacggggag cctctggggg gcacctgttt ccccagtgac tcagagagag caagactgca
     3361 ggaacggagg ggtcctgcag ggtgtccacc aagaagtcac agagcccgtt ctgcgcccca
     3421 caccatctgg agcaggggct tctcttctga gtgaactgag gaaggtgctt agatggtgag
     3481 ggctctagaa accaagcccc atgagcagca gtggaagacc tcgggccatg cggcctgggg
     3541 aggacttggt ggcgatccgc aacctggacc ccagtgagag gcggtgggct gactgggaag
     3601 gagaggcccc caacctcctc aggatttgca cgtgtgaact aggctgcctg tggggtgccc
     3661 cttaggcttg gagagcccca gattggaggc agacagactg caccacccct tccccccctg
     3721 catctcaaga ataaagcaag ctgcctttgt acttggttga a
//
