LOCUS       NM_178140              11984 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens PDZ domain containing 2 (PDZD2), mRNA.
ACCESSION   NM_178140 XM_005248270
VERSION     NM_178140.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11984)
  AUTHORS   He,F., Fang,L. and Yin,Q.
  TITLE     miR-363 acts as a tumor suppressor in osteosarcoma cells by
            inhibiting PDZD2
  JOURNAL   Oncol Rep 41 (5), 2729-2738 (2019)
   PUBMED   30896877
  REMARK    GeneRIF: Study results revealed that MG-63 osteosarcoma cells
            contained low levels of miR-363, and that overexpression of miR-363
            in MG-63 cells significantly inhibited the vitality, proliferation,
            and colony formation ability of the cells. Bioinformatics analysis
            and luciferase reporter assay indicated that PDZD2 was a direct
            target of miR-363. In vivo xenograft model further confirmed that
            miR-363 functioned as tumor suppressor.
REFERENCE   2  (bases 1 to 11984)
  AUTHORS   Zhang,N., Wu,Y., Gong,J., Li,K., Lin,X., Chen,H., Yu,Y., Gou,Y.,
            Hou,J., Jiang,D., Na,R., Wang,X., Ding,Q. and Xu,J.
  TITLE     Germline genetic variations in PDZD2 and ITPR2 genes are associated
            with clear cell renal cell carcinoma in Chinese population
  JOURNAL   Oncotarget 8 (15), 24196-24201 (2017)
   PUBMED   26918600
  REMARK    GeneRIF: we systematically evaluating RCC risk-associated SNPs
            indentified from previous GWAS in a Chinese population, finding
            that one SNP located in PDZD2 and two SNPs located in ITPR2 were
            ccRCC-risk associated in Chinese population.
REFERENCE   3  (bases 1 to 11984)
  AUTHORS   Nagirnaja,L., Palta,P., Kasak,L., Rull,K., Christiansen,O.B.,
            Nielsen,H.S., Steffensen,R., Esko,T., Remm,M. and Laan,M.
  TITLE     Structural genomic variation as risk factor for idiopathic
            recurrent miscarriage
  JOURNAL   Hum Mutat 35 (8), 972-982 (2014)
   PUBMED   24827138
  REMARK    GeneRIF: The DNA copy number variations disrupt PDZD2 and GOLPH3
            genes predominantly expressed in placenta, and it may represent a
            novel risk factor for recurrent miscarriage.
REFERENCE   4  (bases 1 to 11984)
  AUTHORS   Ritter,B.P., Angelo,G.W., Durner,M., Rossy-Fullana,E.,
            Carrion-Baralt,J., Silverman,J.M. and Bespalova,I.N.
  TITLE     Mutation screening of PDZD2, GOLPH3, and MTMR12 genes in patients
            with schizophrenia
  JOURNAL   Psychiatr Genet 22 (1), 51-52 (2012)
   PUBMED   21451436
  REMARK    GeneRIF: This study does not support the association of PDZD2,
            GOLPH3, and MTMR12 genes with schizophrenia.
REFERENCE   5  (bases 1 to 11984)
  AUTHORS   Plant,D., Bowes,J., Potter,C., Hyrich,K.L., Morgan,A.W.,
            Wilson,A.G., Isaacs,J.D. and Barton,A.
  CONSRTM   Wellcome Trust Case Control Consortium; British Society for
            Rheumatology Biologics Register
  TITLE     Genome-wide association study of genetic predictors of anti-tumor
            necrosis factor treatment efficacy in rheumatoid arthritis
            identifies associations with polymorphisms at seven loci
  JOURNAL   Arthritis Rheum 63 (3), 645-653 (2011)
   PUBMED   21061259
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   6  (bases 1 to 11984)
  AUTHORS   Ma,R.Y., Tam,T.S., Suen,A.P., Yeung,P.M., Tsang,S.W., Chung,S.K.,
            Thomas,M.K., Leung,P.S. and Yao,K.M.
  TITLE     Secreted PDZD2 exerts concentration-dependent effects on the
            proliferation of INS-1E cells
  JOURNAL   Int J Biochem Cell Biol 38 (5-6), 1015-1022 (2006)
   PUBMED   16413998
  REMARK    GeneRIF: The mitogenic effect of secreted PDZD2 was
            concentration-dependent, and was associated with a slight
            inhibition of the insulin promoter activity at high sPDZD2
            concentrations.
REFERENCE   7  (bases 1 to 11984)
  AUTHORS   Yeung,M.L., Tam,T.S., Tsang,A.C. and Yao,K.M.
  TITLE     Proteolytic cleavage of PDZD2 generates a secreted peptide
            containing two PDZ domains
  JOURNAL   EMBO Rep 4 (4), 412-418 (2003)
   PUBMED   12671685
  REMARK    GeneRIF: the first reported multi-PDZ protein that is processed by
            proteolytic cleavage to generate a secreted peptide containing two
            PDZ domains
REFERENCE   8  (bases 1 to 11984)
  AUTHORS   Ohno,H., Hirabayashi,S., Iizuka,T., Ohnishi,H., Fujita,T. and
            Hata,Y.
  TITLE     Localization of p0071-interacting proteins, plakophilin-related
            armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in
            epithelial cells
  JOURNAL   Oncogene 21 (46), 7042-7049 (2002)
   PUBMED   12370826
REFERENCE   9  (bases 1 to 11984)
  AUTHORS   Chaib,H., Rubin,M.A., Mucci,N.R., Li,L., Taylor,J.M.G., Day,M.L.,
            Rhim,J.S. and Macoska,J.A.
  TITLE     Activated in prostate cancer: a PDZ domain-containing protein
            highly expressed in human primary prostate tumors
  JOURNAL   Cancer Res 61 (6), 2390-2394 (2001)
   PUBMED   11289102
REFERENCE   10 (bases 1 to 11984)
  AUTHORS   Deguchi,M., Iizuka,T., Hata,Y., Nishimura,W., Hirao,K., Yao,I.,
            Kawabe,H. and Takai,Y.
  TITLE     PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with
            neural plakophilin-related armadillo repeat protein/delta-catenin
            and p0071
  JOURNAL   J Biol Chem 275 (38), 29875-29880 (2000)
   PUBMED   10896674
  REMARK    Erratum:[J Biol Chem 2002 Sep 20;277(38):35778]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022447.6, AB002298.2,
            AC025178.8 and CA503068.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_178140.3.
            
            Summary: The protein encoded by this gene contains six PDZ domains
            and shares sequence similarity with pro-interleukin-16 (pro-IL-16).
            Like pro-IL-16, the encoded protein localizes to the endoplasmic
            reticulum and is thought to be cleaved by a caspase to produce a
            secreted peptide containing two PDZ domains. In addition, this gene
            is upregulated in primary prostate tumors and may be involved in
            the early stages of prostate tumorigenesis. [provided by RefSeq,
            Dec 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002298.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438447.2/ ENSP00000402033.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AC022447.6         125193-125471       c
            280-2772            AB002298.2         1-2493
            2773-2773           AC025178.8         121188-121188       c
            2774-4365           AB002298.2         2495-4086
            4366-4915           AC025178.8         91501-92050         c
            4916-9642           AB002298.2         4637-9363
            9643-11508          AC025178.8         68741-70606         c
            11509-11984         CA503068.1         18-493              c
FEATURES             Location/Qualifiers
     source          1..11984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.3"
     gene            1..11984
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /note="PDZ domain containing 2"
                     /db_xref="GeneID:23037"
                     /db_xref="HGNC:HGNC:18486"
                     /db_xref="MIM:610697"
     exon            1..307
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..1143
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             668..9187
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /note="activated in prostate cancer protein; PDZ
                     domain-containing protein 3; plakophilin-related armadillo
                     repeat protein-interactive PDZ protein"
                     /codon_start=1
                     /product="PDZ domain-containing protein 2"
                     /protein_id="NP_835260.2"
                     /db_xref="CCDS:CCDS34137.1"
                     /db_xref="GeneID:23037"
                     /db_xref="HGNC:HGNC:18486"
                     /db_xref="MIM:610697"
                     /translation="MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQE
                     YIQLNFAVDESTVPPDHSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRG
                     GKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASY
                     LAEQCWNGGFIYLIMLRRFKHKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRK
                     FGVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEV
                     AGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWK
                     MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL
                     VGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNE
                     DQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGG
                     VHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRS
                     LSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS
                     AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCS
                     TPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG
                     IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAIL
                     SKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKK
                     DSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPG
                     KPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASD
                     EEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAI
                     SAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLE
                     YTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLT
                     GRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSH
                     LDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRP
                     ENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
                     AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSL
                     LEGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDA
                     SAARSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAY
                     PQWASQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMY
                     GDAEDSSSDPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNP
                     PSSPAHLPTQAAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSL
                     LEMSSQEHETHADISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILS
                     SPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLD
                     DLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQK
                     KGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEA
                     PAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVL
                     ESKPPLATSGPLKPSVSDTSIRTFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTT
                     PKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEK
                     GGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQGNCQEKSEIRL
                     YRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYSQGKSSL
                     MSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLGRSRD
                     SQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGDIISVQETSC
                     LVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGASPFLSVS
                     SKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSPSIMT
                     LTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRS
                     KLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCPEKGGNR
                     ACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQSVLSS
                     VGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVF
                     SQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPR
                     PSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSS
                     VTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPV
                     QLLIRKHRNSS"
     exon            1144..1645
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1788
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1921
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2074
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2186
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2332
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2452
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2567
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2641
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2867
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..2985
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3118
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3200
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3235
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3392
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            3393..4204
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4349
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            4350..8394
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            8395..8512
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            8513..8614
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            8615..8885
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            8886..9020
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            9021..11984
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11960..11965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /note="hexamer: AATAAA"
     polyA_site      11984
                     /gene="PDZD2"
                     /gene_synonym="AIPC; PAPIN; PDZK3; PIN1"
                     /note="major polyA site"
ORIGIN      
        1 gaggctcggc ggatcccctg cgcagcgagg cgaggagcgg accccagcgc cggtgcgtgc
       61 cggccccggg cagcgggacg cggcggggcg gcggctgcag gcagccgagg agccgcaggc
      121 cgaacccaag gcaccgggat tgcgcctccc gcggctgccg gcgaaccgcg gctctgcagc
      181 tcggggcagg cgcggcggcg gcaccggtgg tggccgcggt ggcggcagct gcgcggggac
      241 ccgccgggcg gcgcctgggt ctggacgcgc gaggaagccg cgggagcctc ggccaagccg
      301 cgagcaggtg tgaatgagcc cagggaagga cacacggcca ctgctggagg gatcctccat
      361 tcctgtgtca tttgcatggg tcctgctgtg aaatgaacct ggcagggact tgttagacac
      421 ttccttcctt ccctcattga gcactccagt gccattgttc cacagttgtt ctaattgggt
      481 cctagcttcc tcctgccaag gcaaacagca tagtctcgag taggtgtccc taggctcatc
      541 tgccagcctg aacatgaaca caggcaaagc tgatgatggc cagggacccc aggggacgtg
      601 gggccctgtg gggtctggcc cccaggagca agacctctga tgatgctggt gtctgggagt
      661 gagcaccatg cccatcaccc aggacaatgc cgtgctgcac ctgcccctcc tctaccagtg
      721 gctgcagaac agcctgcagg aaggtgggga tgggccggag cagcggctct gccaggcggc
      781 catccagaag ctgcaggagt acatccagct gaactttgct gtggatgaga gtacggtccc
      841 acctgatcac agcccccccg aaatggagat ctgtactgtg tacctcacca aggagctggg
      901 ggacacagag actgtgggcc tgagttttgg gaacatccct gttttcgggg actatggtga
      961 aaagcgcagg gggggcaaga agaggaaaac ccaccagggt cctgtgctgg atgtgggctg
     1021 catctgggtg acagagctga ggaagaacag cccagcaggg aagagtggga aggtccgact
     1081 gcgggatgag atcctctcac tgaatgggca gctgatggtt ggagttgatg tcagtggggc
     1141 cagttacctg gctgagcagt gctggaatgg cggctttatc tacctgatca tgctgcgtcg
     1201 ctttaagcac aaagcccact ccacttataa tggcaacagt agcaacagct ctgaaccagg
     1261 agaaacacct accttggagc tgggtgaccg aactgcgaaa aaggggaaac gaaccagaaa
     1321 gtttggggtc atctccaggc ctcctgccaa caaggcccct gaagaatcca agggcagcgc
     1381 tggctgtgag gtgtccagtg accccagcac tgagctggag aacggccctg accctgaact
     1441 tggaaacggc catgtctttc agctagaaaa tggcccagat tctctcaagg aggtggctgg
     1501 accccatcta gagaggtcag aagtggacag agggacagag catagaattc caaagacaga
     1561 tgctcctctg accacaagca atgacaaacg ccgcttctca aaaggtggga agacggactt
     1621 ccaatcgagt gactgcctgg cacgggagga agttggccga atatggaaga tggagctgct
     1681 caaagaatcg gatgggctgg gaattcaggt tagtggaggc cgaggatcaa agcgctcacc
     1741 tcacgctatc gttgtcactc aagtgaagga aggaggtgcc gctcacaggg atggcaggct
     1801 gtccttagga gatgagctgc tggtaatcaa tggtcattta ctggtcgggc tctcccacga
     1861 ggaagcagtg gccattcttc gctccgccac gggaatggtg cagcttgtgg tggccagcaa
     1921 ggaaaactcc gcagaggacc tcctcaggtt aacatctaag agcttgccag atctgaccag
     1981 ctcggtagaa gatgtgtcct cctggactga taacgaagac caggaggcag acggggaaga
     2041 ggacgaagga accagctctt ctgtccagag agcaatgcct gggacagatg aaccccaaga
     2101 tgtgtgcggt gctgaggaat ccaaggggaa cttggaaagt cccaaacagg gcagcaataa
     2161 aatcaagctc aagagtcgcc tttcaggggg tgtacaccgc cttgagtcag ttgaagaata
     2221 taacgagctg atggtgcgga atggggaccc ccggatccgg atgttggagg tctcccgaga
     2281 tggccggaaa cactccctcc cgcagctgct ggactcttcc agtgcctcac aggaatacca
     2341 cattgtgaag aagtctaccc gctccttaag cacgactcag gtggaatctc cttggaggct
     2401 cattcggcca tccgtcatct cgatcattgg gttgtacaaa gaaaaaggca agggccttgg
     2461 ctttagtatt gctggaggtc gagactgcat tcgtggacag atggggattt ttgtcaagac
     2521 catcttccca aatggatcag ctgcagagga cggaagactt aaagaagggg atgaaatcct
     2581 agatgtaaat ggaataccaa taaagggctt gacatttcaa gaagccattc atacctttaa
     2641 gcaaatccgg agtggattat ttgttttaac ggtacgcaca aagttggtga gccccagcct
     2701 cacaccctgc tcgacaccca cacacatgag cagatccgcc tccccgaact tcaataccag
     2761 tgggggagcc tcagcgggag gttccgatga aggcagttct tcatccctgg gtcggaagac
     2821 ccctgggccc aaggacagga tcgtcatgga agtaacactc aacaaagagc caagagttgg
     2881 attaggcatt ggtgcctgct gcttggctct ggaaaacagt cctcctggca tctacattca
     2941 cagccttgct ccaggatcag tggccaagat ggagagcaac ctgagccgcg gggatcaaat
     3001 cctggaagtg aactccgtca acgtccgcca tgctgcttta agcaaagtcc acgccatctt
     3061 gagtaaatgc cctccaggac ccgttcgcct tgtcatcggc cggcacccta atccaaaggt
     3121 ttccgagcag gaaatggatg aagtcatagc acgcagcact tatcaggaga gcaaagaggc
     3181 caattcctct cctggcttag gtaccccctt gaagagtccc tctcttgcaa aaaaggactc
     3241 ccttatttct gaatctgaac tctcccagta ctttgcccac gatgtccctg gccccttgtc
     3301 agacttcatg gtggccggtt ctgaggacga ggatcacccg ggaagtggct gcagcacgtc
     3361 ggaggagggc agcctgcctc ccagcacctc cactcacaag gagcctggaa aacccagagc
     3421 caacagcctc gtgactcttg ggagccatcg ggcttctggg ctcttccaca agcaggtgac
     3481 agttgccaga caagccagtc tccccggaag cccacaggcc ctccgaaacc ctctcctccg
     3541 ccagaggaag gtaggctgct acgatgccaa cgatgccagt gatgaggaag agtttgacag
     3601 agaaggggac tgcatttcac tcccaggggc cctcccgggt cccatcaggc ctctgtcaga
     3661 ggatgacccg aggcgtgtct caatttcctc ttccaagggc atggacgtcc acaaccaaga
     3721 ggaacgaccc cggaaaacac tggtgagcaa ggccatctcg gcacctcttc ttggtagctc
     3781 agtggactta gaggagagta tcccagaggg catggtggat gctgcgtcct atgcagccaa
     3841 cctcacggac tctgcagagg cccccaaggg gagccctgga agctggtgga agaaggaact
     3901 gtcaggatca agtagcgcac ccaaattgga atacacagtc cgtacagaca cccagagtcc
     3961 gacgaacact gggagcccca gttcccccca gcagaaaagt gaaggcctgg gctccaggca
     4021 cagaccagtg gccagggtaa gcccccactg caagagatcc gaggctgagg ccaagcccag
     4081 tggctcacag acagtgaacc tgactggcag agccaatgat ccatgcgatc tggactcgag
     4141 agtccaggcc acttctgtca aagtgactgt cgctggcttt cagccaggtg gagctgtgga
     4201 gaaggaatct ctgggaaagc tgaccactgg agatgcttgt gtctctacca gctgtgaact
     4261 agccagtgct ctgtcccatc tggatgccag ccacctcaca gagaacctgc ccaaagctgc
     4321 atcagagctg gggcaacaac ccatgactga actggacagc tcctcagacc tcatctcttc
     4381 cccagggaag aagggggccg ctcatcctga ccccagcaag acctctgtag acacagggca
     4441 agtcagtcgg ccagagaatc ccagccagcc tgcatcgccc agggtcacca agtgcaaggc
     4501 caggtctcca gtcaggctcc cccatgaggg cagcccctcc ccgggggaga aagcagcggc
     4561 tccccctgac tacagcaaga ctcgatcagc atcggaaacc agcacacccc acaataccag
     4621 gagggtggct gccctcaggg gagcgggacc tggagcagag ggaatgacac cagctggtgc
     4681 tgtcctgcca ggagaccccc tcacatccca ggagcagaga cagggagctc caggtaacca
     4741 cagtaaggct ctggaaatga caggaatcca tgcacctgaa agctcccagg agccttccct
     4801 gctggaggga gcagattctg tgtcctcaag ggcaccgcag gccagcctct ccatgctgcc
     4861 atccactgac aacaccaaag aagcatgtgg ccatgtctcg gggcactgct gcccaggggg
     4921 gagtagagag agccctgtga cggacattga cagcttcatc aaggagctgg atgcttctgc
     4981 agcaaggtct ccgtcttccc agacggggga cagtggctct caggagggca gtgctcaggg
     5041 ccacccacca gccggggctg gaggtgggag ctcctgccgt gccgaaccag tcccgggggg
     5101 ccagacctcc tccccgagga gggcctgggc tgctggtgcc cccgcctacc cacaatgggc
     5161 ctcccagcct tcggttttag attcaattaa tcccgacaaa cattttactg tgaacaaaaa
     5221 ctttctgagc aactactcta gaaattttag cagttttcat gaagacagca cctccctatc
     5281 aggcctgggt gacagcacgg agccgtctct gtcatccatg tatggcgatg ctgaggattc
     5341 ttcttctgac cctgagtcac tcactgaagc cccacgagct tctgccaggg acggctggtc
     5401 ccctcctcgt tcccgtgtgt ctttgcacaa ggaagatcct tcggagtcag aagaggaaca
     5461 gattgagatt tgttccacac gtggctgccc caatccaccc tcgagtcctg ctcatcttcc
     5521 cacccaggct gccatctgtc ctgcctcagc caaagttctg tcattaaaat acagcactcc
     5581 gagagagtcg gtggccagtc cccgtgagaa ggccgcctgc ttgccaggct catacacttc
     5641 aggcccagac tcttcccagc catcatcact cttggagatg agctctcagg agcatgaaac
     5701 tcatgcggac ataagcactt cacagaacca caggccctcg tgtgcagaag aaaccacaga
     5761 agtcaccagc gctagctcag ccatggaaaa cagtccgctg tctaaagtag ccaggcattt
     5821 tcacagtccg cccatcattc tcagctcccc caacatggta aatggcttgg aacatgacct
     5881 gctagatgac gaaaccctga atcaatacga aacaagcatt aatgcagctg ccagtctgtc
     5941 ctccttcagt gtggatgtcc ctaagaatgg agaatctgtt ttggaaaacc tccacatctc
     6001 tgaaagtcaa gacctggatg acttgctaca gaaaccaaaa atgatcgcta ggaggcccat
     6061 catggcctgg tttaaagaaa taaataaaca taaccaaggc acacatttga ggagcaaaac
     6121 cgagaaggaa caacctctaa tgcctgccag aagtcccgac tccaagattc agatggtgag
     6181 ttcaagccaa aaaaagggcg ttactgtgcc tcatagccct cctcagccga aaacaaacct
     6241 ggaaaataag gacctgtcta agaagagtcc ggcagaaatg cttctgacta atggtcagaa
     6301 ggcaaagtgt ggtccgaagc tgaagaggct cagcctcaag ggcaaggcca aagtcaactc
     6361 tgaggcccct gctgcgaatg ctgtgaaggc tggggggacg gaccacagga aacccttgat
     6421 ctcaccccag acctcccaca aaacactttc taaggcagtg tcacagcggc tccatgtagc
     6481 cgaccacgag gaccctgaca gaaacaccac agctgccccc aggtcccccc agtgtgtgct
     6541 ggaaagcaag ccacctcttg ccacctctgg gccactgaaa ccctcagtgt ctgacacgag
     6601 catcaggaca tttgtctcgc ccctgacctc tcccaagcct gttcctgagc aaggcatgtg
     6661 gagcaggttc cacatggctg tcctctctga acccgacaga ggttgcccaa ccacccctaa
     6721 atctcctaag tgtagagcag agggcagggc gccccgtgct gactccgggc cggtgagtcc
     6781 ggcagcgtct aggaacggca tgtccgtggc agggaacaga cagagtgagc cgcgcctggc
     6841 cagccatgtg gcagcagaca cagcccaacc caggccgact ggcgaaaaag gaggcaacat
     6901 aatggccagc gatcgcctcg aaagaacaaa ccagctgaaa atcgtggaga tttctgctga
     6961 agcagtgtca gagactgtat gtggtaacaa gccagctgaa agcgacagac ggggagggtg
     7021 cttggcccag ggcaactgtc aggagaagag tgaaatcagg ctctatcgcc aggtcgcaga
     7081 atcatccaca agtcatccat cctcactccc atctcatgcc tcccaggcag agcaggaaat
     7141 gtcacgatca ttcagcatgg caaaactggc gtcctcctcc tcctcccttc aaacagccat
     7201 tagaaaggca gaatactccc agggaaaatc aagcctgatg tcagactccc gaggggtgcc
     7261 cagaaacagc attccagggg gcccctcggg ggaggaccat ctctacttca ccccaaggcc
     7321 agcgaccagg acctactcca tgccagccca gttctcaagc cattttggac gggagggtca
     7381 ccccccacac agcctgggtc gctctcggga cagccaggtc cctgtgacaa gcagtgttgt
     7441 ccccgaggca aaggcatcca gaggtggtct tcccagcctg gctaatggac agggcatata
     7501 tagtgtaaag ccgctgctgg acacatcgag gaatcttcca gccacagatg aaggggatat
     7561 catttcagtc caggagacga gctgcctagt cacagacaaa atcaaagtca ccagacgaca
     7621 ctactgctat gagcagaact ggccccatga atctacctca tttttctctg tgaagcagcg
     7681 gatcaagtct tttgagaacc tggccaatgc tgaccggcct gtagccaagt ccggggcttc
     7741 cccatttttg tcggtgagct ccaagcctcc cattgggagg cggtcttccg gcagcattgt
     7801 ttccgggagc ctgggccacc caggtgacgc agcagcaagg ttgttgagac gcagcttgag
     7861 ttcctgcagc gaaaaccaaa gcgaagccgg caccctcctg ccccagatgg ccaagtctcc
     7921 ctcaatcatg acactgacca tctctcggca gaacccacca gagaccagta gcaagggctc
     7981 tgattcggaa ctaaagaaat cacttggtcc tttgggaatt cccaccccaa cgatgaccct
     8041 ggcttctcct gttaagagga acaagtcctc ggtacgccac acgcagccct cgcccgtgtc
     8101 ccgctccaag ctccaggagc tgagagcctt gagcatgcct gaccttgaca agctctgcag
     8161 cgaggattac tcagcagggc cgagcgccgt gctcttcaaa actgagctgg agatcacccc
     8221 caggaggtca cctggccctc ctgctggagg cgtttcgtgt cccgagaagg gcgggaacag
     8281 ggcctgtcca ggaggaagtg gccctaaaac cagtgctgct gagacaccca gttcagccag
     8341 tgatacgggt gaagctgccc aggatctgcc ttttagaaga agctggtcag ttaatttgga
     8401 tcaacttcta gtctcagcgg gggaccagca aagattacag tctgttttat cgtcagtggg
     8461 atcgaaatct accatcctaa ctctcattca ggaagcgaaa gcacaatcag agaatgaaga
     8521 agatgtttgc ttcatagtct tgaatagaaa agaaggctca ggtctgggat tcagtgtggc
     8581 aggagggaca gatgtggagc caaaatcaat cacggtccac agggtgtttt ctcagggggc
     8641 ggcttctcag gaagggacta tgaaccgagg ggatttcctt ctgtcagtca acggcgcctc
     8701 actggctggc ttagcccacg ggaatgtcct gaaggttctg caccaggcac agctgcacaa
     8761 agatgccctc gtggtcatca agaaagggat ggatcagccc aggccctctg cccggcagga
     8821 gcctcccaca gccaatggga agggtttgct gtccagaaag accatccccc tggagcctgg
     8881 cattgggaga agtgtggctg tacacgatgc tctgtgtgtt gaagtgctga agacctcggc
     8941 tgggctggga ctgagtctgg atgggggaaa atcatcggtg acgggagatg ggcccttggt
     9001 cattaaaaga gtgtacaaag gtggtgcggc tgaacaagct ggaataatag aagctggaga
     9061 tgaaattctt gctattaatg ggaaacctct ggttgggctc atgcactttg atgcctggaa
     9121 tattatgaag tctgtcccag aaggacctgt gcagttatta attagaaagc ataggaattc
     9181 ttcatgaatt ttaacaagaa tcattttctc agttctcttc tttctttagc aaatcagagt
     9241 gacttcttta aaccacaggt tgttgaaatg gccaacactg gtacagacac ggactataaa
     9301 aatctccaag cttgtgctta cacatgaagc ctgacttaac tgtatgtgca acagcaatga
     9361 aattaactcc agaagccttc cacctgcgtc acccaggccg ggagggttcc ttcgttccag
     9421 tgcctgtccc ctacctttat gttatgttta ctgatgggga tacaagatgt gacacaccct
     9481 tctttatttg aaacaaacaa acatttagct agacctttgc ttccttcttg ccagctctcc
     9541 caacataccc aatcctggtg atcagggaac taaaagtctg agggggacac aaatgtcaca
     9601 cctaagagga caatcaatca ttttgtatga ttttgtaagt aaatgacaga atgcttttag
     9661 gcacattcaa tggaaggagg agatgtaggt ctgtatatgt taccctgaaa agagaataag
     9721 acttacttaa aaaaatgaat tatgacctgt taggctgagc tcaggaattg tccaaaaagg
     9781 aaaaagcaaa ataattaatt gagagtattt tttagtgagt gtaatgtata atgtacgtat
     9841 gcaaagttca actcaatagg ttattgatca ccatgaagta ttgatcattt tctatctcaa
     9901 aagtgtaagc cataaggctg ttttacagaa tagcacttct gataagctgt attaaatagc
     9961 catgagcttc actgcttaga gggagcagaa aggtcaacat ctaaaagcac cttacaacta
    10021 gtttttgaac ctgtcttgat aagtgcttga attcaagact ggtcagtcca agagcagaca
    10081 aaaatatcac aagtcagtca gtcactgggt ttccatttct gaattttatg cactccaacc
    10141 atgaatttaa actaaatttt tagaaatcaa gtatctttct aagtgtcctt ggatttatag
    10201 acaatgtatg tacaatccaa atagaggagc ttaatggaat ccttttagga gactggttgg
    10261 tttttttccc tctttcccaa catgtttaag aaatgtaaca ttctaagtat tggatctctt
    10321 ttcttgacct agtataatga caactgcagt gacttaagtt tttgctgttt tcgttttccc
    10381 gctttgcaat ttcctccttt tgccaaaaat gttttcctac agaagactgt cgtgactcac
    10441 gctacttggg aaactcactc tggccactcc tcctctggtg gcatgagctg cttcccagta
    10501 gctattccga ttggatattc cgttcgtcgt cacatagctg gcttttctct cctcatgatg
    10561 taccttattt tcttaggtaa ataattccaa actctcatcg ggtcataaag aggaggagaa
    10621 acagggtgag tcaaggtaaa ggagcagaaa tgtagttaca agccaggtcg tcttcagtgg
    10681 cacaaaccaa cccgttgagc cctgacaaca tgagtggaga gtgcatttgc catacctgtg
    10741 tgcatgacac taagatttta tgttggagat acttctttaa ataacctaca gcttgggtct
    10801 atggctgtga cccccagatt catggagggg ctttagccat cagctttgta catcatcatt
    10861 tttctgaatg accaatccca ctaaacatct ttgaagtcgg cctagagagg tccttcagat
    10921 gagagagaaa tagctggctt gtctgagtcc agatttctca tcaactggca atacaaagga
    10981 aaatatggta caggagttag ttagaaaggt cttattgatt ttacttctac ttttcactac
    11041 agttacaggt agaatactgt aggaagtcag tgcaaggtgc atgcttgatt gatagatatt
    11101 gattgattgt ttttcagtct ctggggtcag ttttgtggtt tctgctttct tgcctaaatc
    11161 aaagactatt tcaagtcaac aacactgaaa actgcttttc gcctccactc ttacagctgt
    11221 gcctaataat aattaattaa taaacgcaca gccctatgtg aacagacagg aatttcttgt
    11281 gcaatgtgga gcaaatggaa tggtctcctt ccgcaagtct ttttaatcct catatctgga
    11341 gtacaagggt agacctctgg cttaccacat acactatgct aaagtcatca gccactgcta
    11401 ctacatcttg ccagaaggtt tccctcgcca acaaacagtt gaaatttaag ggaagaagca
    11461 aaagctaaac tgtctttgac cctaagatag atagaaagct atttatttgt cttcagtgtt
    11521 caaggcatga ctagtatttc taattagcct aataaattcc cacactttct gaagtgaaca
    11581 ctaatggtat tgtcctacta aaactgtcat tgtttctttt tttttaactg gtcagtcatt
    11641 cacaataagc tatgagggta aataaatatg tgttataaca agtaaaccgt agttgcaaga
    11701 atataccatg aagattaaag taggctgggt ttcatttcca tcttcccaca catctcattg
    11761 aatttgatgg ttgacttaat tggcaccata actttgtatg atattataca ttaaccttta
    11821 tttatgtaaa gtaaaatgcc ttatatatta aagagtaagt gcaataatat gaaatagcct
    11881 gtacatttta aaaatgttgt caccaagtta tataaatcca catctctgta aacaaccttt
    11941 tttaagtaat tttaaaaaaa ataaacactc tgcttactac ttga
//
