LOCUS       NM_016484                991 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens PDZ domain containing 11 (PDZD11), transcript variant
            1, mRNA.
ACCESSION   NM_016484
VERSION     NM_016484.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Sluysmans,S., Salmaso,A., Rouaud,F., Mean,I., Brini,M. and Citi,S.
  TITLE     The PLEKHA7-PDZD11 complex regulates the localization of the
            calcium pump PMCA and calcium handling in cultured cells
  JOURNAL   J Biol Chem 298 (8), 102138 (2022)
   PUBMED   35714771
  REMARK    GeneRIF: The PLEKHA7-PDZD11 complex regulates the localization of
            the calcium pump PMCA and calcium handling in cultured cells.
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Rouaud,F., Tessaro,F., Aimaretti,L., Scapozza,L. and Citi,S.
  TITLE     Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11
            promotes conformation-dependent interaction with tetraspanin 33
  JOURNAL   J Biol Chem 295 (28), 9299-9312 (2020)
   PUBMED   32371390
  REMARK    GeneRIF: Cooperative binding of the tandem WW domains of PLEKHA7 to
            PDZD11 promotes conformation-dependent interaction with tetraspanin
            33.
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 991)
  AUTHORS   Shah,J., Rouaud,F., Guerrera,D., Vasileva,E., Popov,L.M.,
            Kelley,W.L., Rubinstein,E., Carette,J.E., Amieva,M.R. and Citi,S.
  TITLE     A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to
            Promote alpha-Toxin Cytotoxicity
  JOURNAL   Cell Rep 25 (8), 2132-2147 (2018)
   PUBMED   30463011
REFERENCE   5  (bases 1 to 991)
  AUTHORS   Guerrera,D., Shah,J., Vasileva,E., Sluysmans,S., Mean,I., Jond,L.,
            Poser,I., Mann,M., Hyman,A.A. and Citi,S.
  TITLE     PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins
  JOURNAL   J Biol Chem 291 (21), 11016-11029 (2016)
   PUBMED   27044745
  REMARK    GeneRIF: PDZD11 forms a complex with nectin-1 and nectin-3, and its
            PDZ domain interacts directly with the PDZ-binding motif of
            nectin-1.
REFERENCE   6  (bases 1 to 991)
  AUTHORS   Nabokina,S.M., Subramanian,V.S. and Said,H.M.
  TITLE     Association of PDZ-containing protein PDZD11 with the human
            sodium-dependent multivitamin transporter
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 300 (4), G561-G567 (2011)
   PUBMED   21183659
  REMARK    GeneRIF: PDZD11 is an interacting partner with sodium-dependent
            multivitamin transporter in intestinal epithelial cells and that
            this interaction affects SMVT function and cell biology.
REFERENCE   7  (bases 1 to 991)
  AUTHORS   Stephenson,S.E., Dubach,D., Lim,C.M., Mercer,J.F. and La
            Fontaine,S.
  TITLE     A single PDZ domain protein interacts with the Menkes copper
            ATPase, ATP7A. A new protein implicated in copper homeostasis
  JOURNAL   J Biol Chem 280 (39), 33270-33279 (2005)
   PUBMED   16051599
REFERENCE   8  (bases 1 to 991)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   9  (bases 1 to 991)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 991)
  AUTHORS   Goellner,G.M., DeMarco,S.J. and Strehler,E.E.
  TITLE     Characterization of PISP, a novel single-PDZ protein that binds to
            all plasma membrane Ca2+-ATPase b-splice variants
  JOURNAL   Ann N Y Acad Sci 986, 461-471 (2003)
   PUBMED   12763866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357752.19.
            
            On May 2, 2019 this sequence version replaced NM_016484.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.131772.1,
                                           SRR1660805.64390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239666.9/ ENSP00000239666.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL357752.19        89662-89729
            69-168              AL357752.19        90235-90334
            169-252             AL357752.19        91076-91159
            253-309             AL357752.19        91416-91472
            310-408             AL357752.19        91759-91857
            409-469             AL357752.19        92253-92313
            470-991             AL357752.19        92473-92994
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..991
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /note="PDZ domain containing 11"
                     /db_xref="GeneID:51248"
                     /db_xref="HGNC:HGNC:28034"
                     /db_xref="MIM:300632"
     exon            1..68
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /inference="alignment:Splign:2.1.0"
     exon            69..168
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..504
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATPase-interacting PDZ protein; PDZ domain-containing
                     protein 11; PMCA-interacting single-PDZ protein; plasma
                     membrane calcium ATPase-interacting single-PDZ protein"
                     /codon_start=1
                     /product="PDZ domain-containing protein 11 isoform 1"
                     /protein_id="NP_057568.1"
                     /db_xref="CCDS:CCDS14400.1"
                     /db_xref="GeneID:51248"
                     /db_xref="HGNC:HGNC:28034"
                     /db_xref="MIM:300632"
                     /translation="MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFL
                     PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDF
                     QDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH"
     exon            169..252
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /inference="alignment:Splign:2.1.0"
     exon            253..309
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /inference="alignment:Splign:2.1.0"
     exon            310..408
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /inference="alignment:Splign:2.1.0"
     exon            409..469
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /inference="alignment:Splign:2.1.0"
     exon            470..991
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      969..974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /note="hexamer: AGTAAA"
     polyA_site      991
                     /gene="PDZD11"
                     /gene_synonym="AIPP1; PDZK11; PISP"
                     /note="major polyA site"
ORIGIN      
        1 atccgcttcc ggttcccaga ctgaattgtc agtgagcgga gtctgaggtc gctgtggact
       61 gcccactggg ccttgcccga gatggacagc cggattcctt atgatgacta cccggtggtt
      121 ttcttgcctg cctatgagaa tcctccagca tggattcctc ctcatgagag ggtacaccac
      181 ccggactaca acaatgagtt gacccagttt ctgccccgaa ccatcacact gaagaagcct
      241 cctggagctc agttgggatt taacatccga ggaggaaagg cctcccagct aggcatcttc
      301 atctccaagg tgattcctga ctctgatgca catagagcag gactgcagga aggggaccaa
      361 gttctagctg tgaatgatgt ggatttccaa gatattgagc acagcaaggc tgttgagatc
      421 ctgaagacag ctcgtgaaat cagcatgcgt gtgcgcttct ttccctacaa ttatcatcgc
      481 caaaaagaga ggactgtgca ctagaaagtt gcagcccaca gcccttcatg tggactctgt
      541 catgacatgc taactagact tcaggggagc cacttctgtt ttcagcccct ccctggaata
      601 gtgagttggg aggatgggga gacagctaac caactgcatt acccaaacca tattgcactt
      661 ttagttccct agttttctag gtgagcttca ttccctgaaa ggaggatgat gatatctagg
      721 cataacctag cctgtgagga acctagttag gaaagacaac tgacatttat tgaatatcat
      781 gcactagtcc cttacatatg tcatatttta attatagaaa tcagtagcaa aaagaatctt
      841 ggggattttc catctgactt ccctggccat cttatcccat ccttgcacta ccagaagatt
      901 catacacttt tgagactcca gtgagacgct gttttcaccc cttcctcctc ctagcctctc
      961 tcccaaaaag taaaacacaa tgctgaagaa a
//
