LOCUS       NM_001190900            2487 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens prodynorphin (PDYN), transcript variant 5, mRNA.
ACCESSION   NM_001190900
VERSION     NM_001190900.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Ozkan-Kotiloglu,S., Kaya-Akyuzlu,D., Yurdakul,R., Yildirim,M.A. and
            Ozgur-Ilhan,I.
  TITLE     Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use
            disorder and the intensity of depressive symptoms
  JOURNAL   Alcohol Alcohol 58 (4), 404-414 (2023)
   PUBMED   37177778
  REMARK    GeneRIF: Effect of PDYN and OPRK1 polymorphisms on the risk of
            alcohol use disorder and the intensity of depressive symptoms.
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Senormanci,G., Turan,C., Celik,S.K., Celik,A., Edgunlu,T.G.,
            Akbas,D., Akca,A.S.D. and Senormanci,O.
  TITLE     Prodynorphin (PDYN) gene polymorphisms in Turkish patients with
            methamphetamine use disorder, changes in PDYN serum levels in
            withdrawal and the relationship between PDYN, temperament and
            depression
  JOURNAL   J Ethn Subst Abuse 21 (2), 522-537 (2022)
   PUBMED   32597371
  REMARK    GeneRIF: Prodynorphin (PDYN) gene polymorphisms in Turkish patients
            with methamphetamine use disorder, changes in PDYN serum levels in
            withdrawal and the relationship between PDYN, temperament and
            depression.
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Lim,G.E., Park,J.E., Cho,Y.H., Lim,D.S., Kim,A.J., Moh,S.H.,
            Lee,J.H. and Lee,J.S.
  TITLE     Alpha-neoendorphin can reduce UVB-induced skin photoaging by
            activating cellular autophagy
  JOURNAL   Arch Biochem Biophys 689, 108437 (2020)
   PUBMED   32526201
  REMARK    GeneRIF: Alpha-neoendorphin can reduce UVB-induced skin photoaging
            by activating cellular autophagy.
REFERENCE   5  (bases 1 to 2487)
  AUTHORS   Wang,C.W., Ma,M., Lu,W.G. and Luo,R.Q.
  TITLE     Association between prodynorphin gene polymorphisms and opioid
            dependence susceptibility: a meta-analysis
  JOURNAL   BMC Psychiatry 19 (1), 281 (2019)
   PUBMED   31510971
  REMARK    GeneRIF: In this meta-analysis, a significant association was found
            between rs1022563 prodynorphin gene polymorphism and opioid
            dependence among Asian populations.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2487)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
REFERENCE   7  (bases 1 to 2487)
  AUTHORS   Summar,M.L., Phillips,J.A. 3rd, Battey,J., Castiglione,C.M.,
            Kidd,K.K., Maness,K.J., Weiffenbach,B. and Gravius,T.C.
  TITLE     Linkage relationships of human arginine vasopressin-neurophysin-II
            and oxytocin-neurophysin-I to prodynorphin and other loci on
            chromosome 20
  JOURNAL   Mol Endocrinol 4 (6), 947-950 (1990)
   PUBMED   1978246
REFERENCE   8  (bases 1 to 2487)
  AUTHORS   Litt,M., Buroker,N.E., Kondoleon,S., Douglass,J., Liston,D.,
            Sheehy,R. and Magenis,R.E.
  TITLE     Chromosomal localization of the human proenkephalin and
            prodynorphin genes
  JOURNAL   Am J Hum Genet 42 (2), 327-334 (1988)
   PUBMED   2893547
REFERENCE   9  (bases 1 to 2487)
  AUTHORS   Horikawa,S., Takai,T., Toyosato,M., Takahashi,H., Noda,M.,
            Kakidani,H., Kubo,T., Hirose,T., Inayama,S., Hayashida,H. et al.
  TITLE     Isolation and structural organization of the human preproenkephalin
            B gene
  JOURNAL   Nature 306 (5943), 611-614 (1983)
   PUBMED   6316163
REFERENCE   10 (bases 1 to 2487)
  AUTHORS   Noda,M., Teranishi,Y., Takahashi,H., Toyosato,M., Notake,M.,
            Nakanishi,S. and Numa,S.
  TITLE     Isolation and structural organization of the human preproenkephalin
            gene
  JOURNAL   Nature 297 (5865), 431-434 (1982)
   PUBMED   6281660
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA305883.1, BC026334.1 and
            AL034562.3.
            
            Summary: The protein encoded by this gene is a preproprotein that
            is proteolytically processed to form the secreted opioid peptides
            beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and
            leumorphin. These peptides are ligands for the kappa-type of opioid
            receptor. Dynorphin is involved in modulating responses to several
            psychoactive substances, including cocaine. Multiple alternatively
            spliced transcript variants encoding the same protein have been
            found for this gene. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (5) has an alternate 5' UTR exon,
            as compared to variant 1. Variants 1-5 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA305883.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2145743 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                DA305883.1         1-97
            98-1648             BC026334.1         184-1734
            1649-1936           AL034562.3         59166-59453         c
            1937-2487           BC026334.1         2023-2573
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2487
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /note="prodynorphin"
                     /db_xref="GeneID:5173"
                     /db_xref="HGNC:HGNC:8820"
                     /db_xref="MIM:131340"
     exon            1..62
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /inference="alignment:Splign:2.1.0"
     exon            63..122
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /inference="alignment:Splign:2.1.0"
     exon            123..270
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..906
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /note="preproenkephalin B; leu-enkephalin; rimorphin;
                     leumorphin; preprodynorphin; proenkephalin-B;
                     beta-neoendorphin-dynorphin;
                     neoendorphin-dynorphin-enkephalin prepropeptide"
                     /codon_start=1
                     /product="proenkephalin-B preproprotein"
                     /protein_id="NP_001177829.1"
                     /db_xref="CCDS:CCDS13023.1"
                     /db_xref="GeneID:5173"
                     /db_xref="HGNC:HGNC:8820"
                     /db_xref="MIM:131340"
                     /translation="MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLI
                     CSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSF
                     LKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGT
                     LYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKL
                     KWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA"
     exon            271..2473
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /note="hexamer: AATAAA"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /note="hexamer: AAGAAA"
     polyA_site      2470
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /note="major polyA site"
     polyA_site      2473
                     /gene="PDYN"
                     /gene_synonym="ADCA; PENKB; SCA23"
                     /note="major polyA site"
ORIGIN      
        1 agaccagtga gagactgctc tttggactct ccctttctgc acagtcctgg cttaaacagg
       61 tggtcattta tcttcaggct ttgagatctg cgtgggggga gctgttgcag cagcccaagc
      121 cgcaggaatt gctgagacag gatggcctgg caggggctgg tcctggctgc ctgcctcctc
      181 atgttcccct ccaccacagc ggactgcctg tcgcggtgct ccttgtgtgc tgtaaagacc
      241 caggatggtc ccaaacctat caatcccctg atttgctccc tgcaatgcca ggctgccctg
      301 ctgccctctg aggaatggga gagatgccag agctttctgt cttttttcac cccctccacc
      361 cttgggctca atgacaagga ggacttgggg agcaagtcgg ttggggaagg gccctacagt
      421 gagctggcca agctctctgg gtcattcctg aaggagctgg agaaaagcaa gtttctccca
      481 agtatctcaa caaaggagaa cactctgagc aagagcctgg aggagaagct caggggtctc
      541 tctgacgggt ttagggaggg agcagagtct gagctgatga gggatgccca gctgaacgat
      601 ggtgccatgg agactggcac actctatctc gctgaggagg accccaagga gcaggtcaaa
      661 cgctatgggg gctttttgcg caaatacccc aagaggagct cagaggtggc tggggagggg
      721 gacggggata gcatgggcca tgaggacctg tacaaacgct atgggggctt cttgcggcgc
      781 attcgtccca agctcaagtg ggacaaccag aagcgctatg gcggttttct ccggcgccag
      841 ttcaaggtgg tgactcggtc tcaggaagat ccgaatgctt actctggaga gctttttgat
      901 gcataagcac ctcttttcat ggagtagagt caggagaaac ccctgacacc ttttcaggtt
      961 ggagtgcatt cattcatcct cttatatgtg ccccttcccc atgctcagct cagcattgtg
     1021 tacaaaatat ccaagcccag cctatctctc ttctgcgtgg gagtatgtta tttctctggg
     1081 gtctgtgatg gggaagggtg gatgtccctt ccccacaata ggcttagtgc ttggctcaga
     1141 cacctagact ctaaaactat cagcagcggc agcagcagca gcagcagcag tttgtgatct
     1201 gtccttccaa cctgttcacg tgactcctca attccaggga accagagcga tgtgttcttt
     1261 gtacctgtag gtctatgatg tccaaactta acagatcaca tgcccctctt agaagaaata
     1321 tgagcatgct ccctcatgca gatagtatac acatcataaa caaagagtag aactttaaaa
     1381 gaaggtaaat aatcatacac agaaatccta acattatatt cccaaatctc aaaagatctc
     1441 ctgtgcacct gactttggag acgatgcttt aggtaaaaag cttaaacatt gccttatatt
     1501 ggatcaggaa cccttacagt agagggtcca gtcttctagt gggtttaatg tttagtcagt
     1561 gtactctgag tcctcattgt tcagaaaagc acctcttgaa gaactgactt cctgaactcc
     1621 cagtcatgtt ggtaccctgg acagtgccta actccttaca gaagggagtg aaaacctctt
     1681 tcggaaatga ttgagagcag cctcttgaat gcttaaatga tcaaggaggg agaaaggcaa
     1741 accaatttgt tctgtgcaac aaactcaaaa tgtggaccag ttccctcagc cctcattaaa
     1801 ctaattaaac tgatgggtat catgcttcta ctccatggtg aactgaagca gagtcaagct
     1861 gatgaagtta agcacaacca tgttcttgag cagctgaatt ggctgccaag agtccaagcc
     1921 atctggccca acatacgcac tgggcattgg gtaagggact ccagaagcag cagctagaaa
     1981 gagaaaaagc cctcttcaat ccccataatg cttctttcct cttaatgtct caaaataaaa
     2041 ccagaaagag gaataaaatg attaagtgct tgaggccaaa tgagttccct tgattcaaat
     2101 aaccctgaat cagaggcaga gacctcctga tgtcttggtt tccatcaaag ccctccctgt
     2161 ctgtctgtct ctcttttgct ctctcattcc caggcactct cttttggttt gtgggtccag
     2221 gagatgaggc tggataggag aggaaaaggc ttgagtctgg ataatttgta taagatgctg
     2281 ctgagcacat ctcttcatgc gcagtcccca ggtatctgat gatgttctga aatggataga
     2341 ttgttttaga gttattttgt gtcctttaaa aaaatcccat ttatgcaatt tacttggaat
     2401 ttgcttagcc tttaataggc ttgtgtaatt tcctgctcct ccagtacaat aaataaaaga
     2461 aagatgctga tgaaaaaaaa aaaaaaa
//
